- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-12-16 14:03:37+13:00
- Desc:
- Init
- Permanent Source URI:
- http://models.cellml.org/workspace/7e8/rawfile/3658dba9638e60010e18bef5e63e81168427d9d8/kraetler_BAR_normalisedHill.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="normalised_hill_B1AR" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<units name="mM">
<unit prefix="milli" units="mole"/>
</units>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_NE_B1AR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_B1ARPA_B1AR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_B1ARPG_B1AR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_B1AR_GRK_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_B1AR_Gsabg_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_GRK_B1ARPG_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_Gsabg_Gsbg_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_Gsabg_Gsa_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_Gsa_AC_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_AC_cAMP_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_FSK_AC_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_IBMX_PDE_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PDE_cAMP_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_cAMP_PKA_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKA_PKAR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKA_PKAC_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKI_PKAC_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP2A_TnI_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP2A_Inhib1_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP2A_ICa_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP2A_RyR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_B1ARPA_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_PLB_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_IKs_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_ICa_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_RyR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_TnI_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PKAC_Inhib1_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_Inhib1_PP1_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP1_RyR_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP1_ICa_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP1_IKs_module"/>
</import>
<import xlink:href="kraetler_functions.cellml">
<component component_ref="f_module" name="f_PP1_PLB_module"/>
</import>
<component name="env">
<!-- guess everything is dimensionless, except Ymax has same units as chemical species A-->
<variable name="time" units="second"/>
<!-- var NE_stim: mM {pub: out};
var NE_sub: mM {init: 0, pub: out};-->
<variable name="NE" public_interface="out" units="mM"/>
<variable initial_value="0" name="B1AR" public_interface="out" units="mM"/>
<variable initial_value="0" name="GRK" public_interface="out" units="mM"/>
<variable initial_value="0" name="B1ARPG" public_interface="out" units="mM"/>
<variable initial_value="0" name="B1ARPA" public_interface="out" units="mM"/>
<variable initial_value="0" name="Gsabg" public_interface="out" units="mM"/>
<variable initial_value="0" name="Gsa" public_interface="out" units="mM"/>
<variable initial_value="0" name="Gsbg" public_interface="out" units="mM"/>
<variable initial_value="0" name="FSK" public_interface="out" units="mM"/>
<variable initial_value="0" name="AC" public_interface="out" units="mM"/>
<variable initial_value="0" name="IBMX" public_interface="out" units="mM"/>
<variable initial_value="0" name="PDE" public_interface="out" units="mM"/>
<variable initial_value="0" name="cAMP" public_interface="out" units="mM"/>
<variable initial_value="0" name="PKA" public_interface="out" units="mM"/>
<variable initial_value="0" name="PKAR" public_interface="out" units="mM"/>
<variable initial_value="0" name="PKI" public_interface="out" units="mM"/>
<variable initial_value="0" name="PKAC" public_interface="out" units="mM"/>
<variable initial_value="0" name="PP2A" public_interface="out" units="mM"/>
<variable initial_value="0" name="IKs" public_interface="out" units="mM"/>
<variable initial_value="0" name="ICa" public_interface="out" units="mM"/>
<variable initial_value="0" name="RyR" public_interface="out" units="mM"/>
<variable initial_value="0" name="Inhib1" public_interface="out" units="mM"/>
<variable initial_value="0" name="TnI" public_interface="out" units="mM"/>
<variable initial_value="0" name="PLB" public_interface="out" units="mM"/>
<variable initial_value="0" name="PP1" public_interface="out" units="mM"/>
<variable initial_value="1" name="tau_NE" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_B1AR" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_GRK" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_B1ARPG" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_B1ARPA" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_Gsabg" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_Gsa" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_Gsbg" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_FSK" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_AC" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_IBMX" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PDE" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_cAMP" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PKA" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PKAR" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PKI" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PKAC" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PP2A" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_IKs" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_ICa" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_RyR" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_Inhib1" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_TnI" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PLB" public_interface="out" units="second"/>
<variable initial_value="1" name="tau_PP1" public_interface="out" units="second"/>
<variable initial_value="1" name="Ymax" public_interface="out" units="mM"/>
<variable initial_value="0.5" name="EC50_NE_B1AR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_B1ARPA_B1AR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_B1ARPG_B1AR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_B1AR_GRK" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_B1AR_Gsabg" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_GRK_B1ARPG" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_Gsabg_Gsbg" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_Gsabg_Gsa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_Gsa_AC" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_AC_cAMP" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_FSK_AC" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_IBMX_PDE" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PDE_cAMP" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_cAMP_PKA" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKA_PKAR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKA_PKAC" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKI_PKAC" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP2A_TnI" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP2A_Inhib1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP2A_ICa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP2A_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_B1ARPA" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_PLB" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_IKs" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_ICa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_TnI" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PKAC_Inhib1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_Inhib1_PP1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP1_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP1_ICa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP1_IKs" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="EC50_PP1_PLB" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_NE_B1AR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_B1ARPA_B1AR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_B1ARPG_B1AR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_B1AR_GRK" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_B1AR_Gsabg" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_GRK_B1ARPG" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_Gsabg_Gsbg" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_Gsabg_Gsa" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_Gsa_AC" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_AC_cAMP" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_FSK_AC" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_IBMX_PDE" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PDE_cAMP" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_cAMP_PKA" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKA_PKAR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKA_PKAC" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKI_PKAC" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP2A_TnI" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP2A_Inhib1" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP2A_ICa" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP2A_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_B1ARPA" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_PLB" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_IKs" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_ICa" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_TnI" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PKAC_Inhib1" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_Inhib1_PP1" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP1_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP1_ICa" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP1_IKs" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="W_PP1_PLB" public_interface="out" units="dimensionless"/>
<variable initial_value="1.4" name="n" public_interface="out" units="dimensionless"/>
<variable name="f_act_NE_B1AR" public_interface="in" units="dimensionless"/>
<variable name="f_act_B1AR_GRK" public_interface="in" units="dimensionless"/>
<variable name="f_act_B1AR_Gsabg" public_interface="in" units="dimensionless"/>
<variable name="f_act_GRK_B1ARPG" public_interface="in" units="dimensionless"/>
<variable name="f_act_Gsabg_Gsbg" public_interface="in" units="dimensionless"/>
<variable name="f_act_Gsabg_Gsa" public_interface="in" units="dimensionless"/>
<variable name="f_act_Gsa_AC" public_interface="in" units="dimensionless"/>
<variable name="f_act_AC_cAMP" public_interface="in" units="dimensionless"/>
<variable name="f_act_FSK_AC" public_interface="in" units="dimensionless"/>
<variable name="f_act_cAMP_PKA" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKA_PKAR" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKA_PKAC" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_B1ARPA" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_PLB" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_IKs" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_ICa" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_RyR" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_TnI" public_interface="in" units="dimensionless"/>
<variable name="f_act_PKAC_Inhib1" public_interface="in" units="dimensionless"/>
<variable name="f_inh_B1ARPA_B1AR" public_interface="in" units="dimensionless"/>
<variable name="f_inh_B1ARPG_B1AR" public_interface="in" units="dimensionless"/>
<variable name="f_inh_IBMX_PDE" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PDE_cAMP" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PKI_PKAC" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP2A_TnI" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP2A_Inhib1" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP2A_ICa" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP2A_RyR" public_interface="in" units="dimensionless"/>
<variable name="f_inh_Inhib1_PP1" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP1_RyR" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP1_ICa" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP1_IKs" public_interface="in" units="dimensionless"/>
<variable name="f_inh_PP1_PLB" public_interface="in" units="dimensionless"/>
<!-- stimuli NE-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>NE</ci>
<piecewise>
<piece>
<cn cellml:units="mM">1</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<cn cellml:units="second">15</cn>
</apply>
<apply>
<leq/>
<ci>time</ci>
<cn cellml:units="second">95</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mM">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<!-- NE = NE_stim + NE_sub;-->
<!-- B = sel
case (time > 50{second}) and (time < 70{second}):
1{mM};
case time > 90{second}:
1{mM};
otherwise:
0{mM};
endsel;-->
<variable name="OR_AC_GSA_FSK" units="dimensionless"/>
<variable name="OR_cAMP_AC_PDE" units="dimensionless"/>
<variable name="OR_PKAC_PKA_PKI" units="dimensionless"/>
<variable name="OR_IKs_PKAC_PP1" units="dimensionless"/>
<variable name="OR_ICa_PP2A_PP1" units="dimensionless"/>
<variable name="OR_ICa_PKAC_OR_ICa_PP2A_PP1" units="dimensionless"/>
<variable name="OR_RyR_PP2A_PP1" units="dimensionless"/>
<variable name="OR_RyR_PKAC_OR_RyR_PP2A_PP1" units="dimensionless"/>
<variable name="OR_Inhib1_PKAC_PP2A" units="dimensionless"/>
<variable name="OR_TnI_PKAC_PP2A" units="dimensionless"/>
<variable name="OR_PLB_PKAC_PP1" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>OR_AC_GSA_FSK</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_Gsa_AC</ci>
<ci>f_act_FSK_AC</ci>
</apply>
<apply>
<times/>
<ci>f_act_Gsa_AC</ci>
<ci>f_act_FSK_AC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_cAMP_AC_PDE</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_AC_cAMP</ci>
<ci>f_inh_PDE_cAMP</ci>
</apply>
<apply>
<times/>
<ci>f_act_AC_cAMP</ci>
<ci>f_inh_PDE_cAMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_PKAC_PKA_PKI</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKA_PKAC</ci>
<ci>f_inh_PKI_PKAC</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKA_PKAC</ci>
<ci>f_inh_PKI_PKAC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_IKs_PKAC_PP1</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKAC_IKs</ci>
<ci>f_inh_PP1_IKs</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKAC_IKs</ci>
<ci>f_inh_PP1_IKs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_ICa_PP2A_PP1</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_inh_PP2A_ICa</ci>
<ci>f_inh_PP1_ICa</ci>
</apply>
<apply>
<times/>
<ci>f_inh_PP2A_ICa</ci>
<ci>f_inh_PP1_ICa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_ICa_PKAC_OR_ICa_PP2A_PP1</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKAC_ICa</ci>
<ci>OR_ICa_PP2A_PP1</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKAC_ICa</ci>
<ci>OR_ICa_PP2A_PP1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_RyR_PP2A_PP1</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_inh_PP2A_RyR</ci>
<ci>f_inh_PP1_RyR</ci>
</apply>
<apply>
<times/>
<ci>f_inh_PP2A_RyR</ci>
<ci>f_inh_PP1_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_RyR_PKAC_OR_RyR_PP2A_PP1</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKAC_RyR</ci>
<ci>OR_RyR_PP2A_PP1</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKAC_RyR</ci>
<ci>OR_RyR_PP2A_PP1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_Inhib1_PKAC_PP2A</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKAC_Inhib1</ci>
<ci>f_inh_PP2A_Inhib1</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKAC_Inhib1</ci>
<ci>f_inh_PP2A_Inhib1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_TnI_PKAC_PP2A</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKAC_TnI</ci>
<ci>f_inh_PP2A_TnI</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKAC_TnI</ci>
<ci>f_inh_PP2A_TnI</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OR_PLB_PKAC_PP1</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>f_act_PKAC_PLB</ci>
<ci>f_inh_PP1_PLB</ci>
</apply>
<apply>
<times/>
<ci>f_act_PKAC_PLB</ci>
<ci>f_inh_PP1_PLB</ci>
</apply>
</apply>
</apply>
<!-- ode(NE, time) = (W_NE_B1AR*Ymax-NE)/tau_NE;-->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B1AR</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_NE_B1AR</ci>
<ci>f_inh_B1ARPG_B1AR</ci>
<ci>f_inh_B1ARPA_B1AR</ci>
<ci>Ymax</ci>
</apply>
<ci>B1AR</ci>
</apply>
<ci>tau_B1AR</ci>
</apply>
</apply>
<!-- -->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GRK</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_B1AR_GRK</ci>
<ci>Ymax</ci>
</apply>
<ci>GRK</ci>
</apply>
<ci>tau_GRK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B1ARPG</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_GRK_B1ARPG</ci>
<ci>Ymax</ci>
</apply>
<ci>B1ARPG</ci>
</apply>
<ci>tau_B1ARPG</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>B1ARPA</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_PKAC_B1ARPA</ci>
<ci>Ymax</ci>
</apply>
<ci>B1ARPA</ci>
</apply>
<ci>tau_B1ARPA</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gsabg</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_B1AR_Gsabg</ci>
<ci>Ymax</ci>
</apply>
<ci>Gsabg</ci>
</apply>
<ci>tau_Gsabg</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gsa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_Gsabg_Gsa</ci>
<ci>Ymax</ci>
</apply>
<ci>Gsa</ci>
</apply>
<ci>tau_Gsa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gsbg</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_Gsabg_Gsbg</ci>
<ci>Ymax</ci>
</apply>
<ci>Gsbg</ci>
</apply>
<ci>tau_Gsbg</ci>
</apply>
</apply>
<!-- ode(FSK, time) = (W_FSK_AC*Ymax-FSK)/tau_FSK;-->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AC</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_AC_GSA_FSK</ci>
<ci>Ymax</ci>
</apply>
<ci>AC</ci>
</apply>
<ci>tau_AC</ci>
</apply>
</apply>
<!-- ode(IBMX, time) = (W_IBMX_PDE*Ymax-IBMX)/tau_IBMX;-->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PDE</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_inh_IBMX_PDE</ci>
<ci>Ymax</ci>
</apply>
<ci>PDE</ci>
</apply>
<ci>tau_PDE</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cAMP</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_cAMP_AC_PDE</ci>
<ci>Ymax</ci>
</apply>
<ci>cAMP</ci>
</apply>
<ci>tau_cAMP</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PKA</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_cAMP_PKA</ci>
<ci>Ymax</ci>
</apply>
<ci>PKA</ci>
</apply>
<ci>tau_PKA</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PKAR</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_act_PKA_PKAR</ci>
<ci>Ymax</ci>
</apply>
<ci>PKAR</ci>
</apply>
<ci>tau_PKAR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PKI</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>W_PKI_PKAC</ci>
<ci>Ymax</ci>
</apply>
<ci>PKI</ci>
</apply>
<ci>tau_PKI</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PKAC</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_PKAC_PKA_PKI</ci>
<ci>Ymax</ci>
</apply>
<ci>PKAC</ci>
</apply>
<ci>tau_PKAC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PP2A</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>W_PP2A_TnI</ci>
<ci>Ymax</ci>
</apply>
<ci>PP2A</ci>
</apply>
<ci>tau_PP2A</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IKs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_IKs_PKAC_PP1</ci>
<ci>Ymax</ci>
</apply>
<ci>IKs</ci>
</apply>
<ci>tau_IKs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ICa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_ICa_PKAC_OR_ICa_PP2A_PP1</ci>
<ci>Ymax</ci>
</apply>
<ci>ICa</ci>
</apply>
<ci>tau_ICa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RyR</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_RyR_PKAC_OR_RyR_PP2A_PP1</ci>
<ci>Ymax</ci>
</apply>
<ci>RyR</ci>
</apply>
<ci>tau_RyR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Inhib1</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_Inhib1_PKAC_PP2A</ci>
<ci>Ymax</ci>
</apply>
<ci>Inhib1</ci>
</apply>
<ci>tau_Inhib1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>TnI</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_TnI_PKAC_PP2A</ci>
<ci>Ymax</ci>
</apply>
<ci>TnI</ci>
</apply>
<ci>tau_TnI</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PLB</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>OR_PLB_PKAC_PP1</ci>
<ci>Ymax</ci>
</apply>
<ci>PLB</ci>
</apply>
<ci>tau_PLB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PP1</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>f_inh_Inhib1_PP1</ci>
<ci>Ymax</ci>
</apply>
<ci>PP1</ci>
</apply>
<ci>tau_PP1</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="env" component_2="f_NE_B1AR_module"/>
<map_variables variable_1="W_NE_B1AR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_NE_B1AR" variable_2="EC50"/>
<map_variables variable_1="NE" variable_2="X"/>
<map_variables variable_1="f_act_NE_B1AR" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_B1AR_GRK_module"/>
<map_variables variable_1="W_B1AR_GRK" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_B1AR_GRK" variable_2="EC50"/>
<map_variables variable_1="B1AR" variable_2="X"/>
<map_variables variable_1="f_act_B1AR_GRK" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_B1AR_Gsabg_module"/>
<map_variables variable_1="W_B1AR_Gsabg" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_B1AR_Gsabg" variable_2="EC50"/>
<map_variables variable_1="B1AR" variable_2="X"/>
<map_variables variable_1="f_act_B1AR_Gsabg" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_GRK_B1ARPG_module"/>
<map_variables variable_1="W_GRK_B1ARPG" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_GRK_B1ARPG" variable_2="EC50"/>
<map_variables variable_1="GRK" variable_2="X"/>
<map_variables variable_1="f_act_GRK_B1ARPG" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_Gsabg_Gsbg_module"/>
<map_variables variable_1="W_Gsabg_Gsbg" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_Gsabg_Gsbg" variable_2="EC50"/>
<map_variables variable_1="Gsabg" variable_2="X"/>
<map_variables variable_1="f_act_Gsabg_Gsbg" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_Gsabg_Gsa_module"/>
<map_variables variable_1="W_Gsabg_Gsa" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_Gsabg_Gsa" variable_2="EC50"/>
<map_variables variable_1="Gsabg" variable_2="X"/>
<map_variables variable_1="f_act_Gsabg_Gsa" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_Gsa_AC_module"/>
<map_variables variable_1="W_Gsa_AC" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_Gsa_AC" variable_2="EC50"/>
<map_variables variable_1="Gsa" variable_2="X"/>
<map_variables variable_1="f_act_Gsa_AC" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_AC_cAMP_module"/>
<map_variables variable_1="W_AC_cAMP" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_AC_cAMP" variable_2="EC50"/>
<map_variables variable_1="AC" variable_2="X"/>
<map_variables variable_1="f_act_AC_cAMP" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_FSK_AC_module"/>
<map_variables variable_1="W_FSK_AC" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_FSK_AC" variable_2="EC50"/>
<map_variables variable_1="FSK" variable_2="X"/>
<map_variables variable_1="f_act_FSK_AC" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_cAMP_PKA_module"/>
<map_variables variable_1="W_cAMP_PKA" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_cAMP_PKA" variable_2="EC50"/>
<map_variables variable_1="cAMP" variable_2="X"/>
<map_variables variable_1="f_act_cAMP_PKA" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKA_PKAR_module"/>
<map_variables variable_1="W_PKA_PKAR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKA_PKAR" variable_2="EC50"/>
<map_variables variable_1="PKA" variable_2="X"/>
<map_variables variable_1="f_act_PKA_PKAR" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKA_PKAC_module"/>
<map_variables variable_1="W_PKA_PKAC" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKA_PKAC" variable_2="EC50"/>
<map_variables variable_1="PKA" variable_2="X"/>
<map_variables variable_1="f_act_PKA_PKAC" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_B1ARPA_module"/>
<map_variables variable_1="W_PKAC_B1ARPA" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_B1ARPA" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_B1ARPA" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_PLB_module"/>
<map_variables variable_1="W_PKAC_PLB" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_PLB" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_PLB" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_IKs_module"/>
<map_variables variable_1="W_PKAC_IKs" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_IKs" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_IKs" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_ICa_module"/>
<map_variables variable_1="W_PKAC_ICa" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_ICa" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_ICa" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_RyR_module"/>
<map_variables variable_1="W_PKAC_RyR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_RyR" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_RyR" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_TnI_module"/>
<map_variables variable_1="W_PKAC_TnI" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_TnI" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_TnI" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKAC_Inhib1_module"/>
<map_variables variable_1="W_PKAC_Inhib1" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKAC_Inhib1" variable_2="EC50"/>
<map_variables variable_1="PKAC" variable_2="X"/>
<map_variables variable_1="f_act_PKAC_Inhib1" variable_2="f_act"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_B1ARPA_B1AR_module"/>
<map_variables variable_1="W_B1ARPA_B1AR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_B1ARPA_B1AR" variable_2="EC50"/>
<map_variables variable_1="B1ARPA" variable_2="X"/>
<map_variables variable_1="f_inh_B1ARPA_B1AR" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_B1ARPG_B1AR_module"/>
<map_variables variable_1="W_B1ARPG_B1AR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_B1ARPG_B1AR" variable_2="EC50"/>
<map_variables variable_1="B1ARPG" variable_2="X"/>
<map_variables variable_1="f_inh_B1ARPG_B1AR" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_IBMX_PDE_module"/>
<map_variables variable_1="W_IBMX_PDE" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_IBMX_PDE" variable_2="EC50"/>
<map_variables variable_1="IBMX" variable_2="X"/>
<map_variables variable_1="f_inh_IBMX_PDE" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PDE_cAMP_module"/>
<map_variables variable_1="W_PDE_cAMP" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PDE_cAMP" variable_2="EC50"/>
<map_variables variable_1="PDE" variable_2="X"/>
<map_variables variable_1="f_inh_PDE_cAMP" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PKI_PKAC_module"/>
<map_variables variable_1="W_PKI_PKAC" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PKI_PKAC" variable_2="EC50"/>
<map_variables variable_1="PKI" variable_2="X"/>
<map_variables variable_1="f_inh_PKI_PKAC" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP2A_TnI_module"/>
<map_variables variable_1="W_PP2A_TnI" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP2A_TnI" variable_2="EC50"/>
<map_variables variable_1="PP2A" variable_2="X"/>
<map_variables variable_1="f_inh_PP2A_TnI" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP2A_Inhib1_module"/>
<map_variables variable_1="W_PP2A_Inhib1" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP2A_Inhib1" variable_2="EC50"/>
<map_variables variable_1="PP2A" variable_2="X"/>
<map_variables variable_1="f_inh_PP2A_Inhib1" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP2A_ICa_module"/>
<map_variables variable_1="W_PP2A_ICa" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP2A_ICa" variable_2="EC50"/>
<map_variables variable_1="PP2A" variable_2="X"/>
<map_variables variable_1="f_inh_PP2A_ICa" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP2A_RyR_module"/>
<map_variables variable_1="W_PP2A_RyR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP2A_RyR" variable_2="EC50"/>
<map_variables variable_1="PP2A" variable_2="X"/>
<map_variables variable_1="f_inh_PP2A_RyR" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_Inhib1_PP1_module"/>
<map_variables variable_1="W_Inhib1_PP1" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_Inhib1_PP1" variable_2="EC50"/>
<map_variables variable_1="Inhib1" variable_2="X"/>
<map_variables variable_1="f_inh_Inhib1_PP1" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP1_RyR_module"/>
<map_variables variable_1="W_PP1_RyR" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP1_RyR" variable_2="EC50"/>
<map_variables variable_1="PP1" variable_2="X"/>
<map_variables variable_1="f_inh_PP1_RyR" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP1_ICa_module"/>
<map_variables variable_1="W_PP1_ICa" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP1_ICa" variable_2="EC50"/>
<map_variables variable_1="PP1" variable_2="X"/>
<map_variables variable_1="f_inh_PP1_ICa" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP1_IKs_module"/>
<map_variables variable_1="W_PP1_IKs" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP1_IKs" variable_2="EC50"/>
<map_variables variable_1="PP1" variable_2="X"/>
<map_variables variable_1="f_inh_PP1_IKs" variable_2="f_inhib"/>
</connection>
<connection>
<map_components component_1="env" component_2="f_PP1_PLB_module"/>
<map_variables variable_1="W_PP1_PLB" variable_2="W"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="EC50_PP1_PLB" variable_2="EC50"/>
<map_variables variable_1="PP1" variable_2="X"/>
<map_variables variable_1="f_inh_PP1_PLB" variable_2="f_inhib"/>
</connection>
</model>
