Location: Calcium Dynamics Annotations @ 110f9ba31e34 / albrecht_colegrove_friel_2002 / model / albrecht_colegrove_friel_2002.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-24 21:37:35+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/albrecht_colegrove_friel_2002/model/albrecht_colegrove_friel_2002.rdf

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    <semsim:modelName>albrecht_colegrove_friel_2002</semsim:modelName>
    <semsim:unknown>Differential regulation of ER Ca2+ uptake and release.</semsim:unknown>
    <semsim:unknown>sympathetic neuron</semsim:unknown>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Bioengineering Institute, University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This model is consistently represented within the CellML but contains sets of algebraic equations that prevent the model from being solved in currently available software - 03/08.&lt;/para&gt;&#xD;
      &lt;para&gt;ValidateCellML found unit inconsistencies in this model&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;&#xD;
        Calcium is an important signalling ion, and changes in Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        concentration ([Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        ]) regulate diverse processes in many cellular compartments.  In excitable cells, depolarisation-induced Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        entry increases [Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        ]&#xD;
        &lt;subscript&gt;i&lt;/subscript&gt;&#xD;
        , leading to secondary changes in [Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        ] within organelles such as mitochondria and ER that regulate specific Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        -sensitive targets within these organelles.  Although mitochondria accumulate Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        in response to depolarisation-evoked [Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        ]&#xD;
        &lt;subscript&gt;i&lt;/subscript&gt;&#xD;
        elevations (see&#xD;
        &lt;ulink url="${HTML_EXMPL_COLEGROVE_MODEL}"&gt;&#xD;
          The Colegrove&#xD;
          &lt;emphasis&gt;et al&lt;/emphasis&gt;&#xD;
          Model Of Mitochondrial Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          Uptake And Release, 2000&#xD;
        &lt;/ulink&gt;&#xD;
        ), the ER is also an important component in Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        signalling in virtually all non-muscle cells, and it has been described as either a Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        source or sink.  Different modes of net ER Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        transport are expected to have very different effects on cytoplasmic and intraluminal Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        signals and on the processes they regulate (see&#xD;
        &lt;ulink url="${HTML_EXMPL_ALBRECHT_MODEL1}"&gt;&#xD;
          The Albrecht&#xD;
          &lt;emphasis&gt;et al&lt;/emphasis&gt;&#xD;
          Model Of Multiple Modes of Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -induced Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          Release in Sympathetic Neurons, 2001&#xD;
        &lt;/ulink&gt;&#xD;
        ).&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        In a follow up study to their 2001 paper, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel have examined how differential regulation of ER Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        uptake and release rates accounts for multiple modes of Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        -induced Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        release.  Three different macroscopic Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        fluxes were modelled: J&#xD;
        &lt;subscript&gt;SERCA&lt;/subscript&gt;&#xD;
        , the rate of Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        uptake via SR Ca-ATPases; J&#xD;
        &lt;subscript&gt;ICa&lt;/subscript&gt;&#xD;
        , the total cytoplasmic Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        flux when SR Ca-ATPases are inhibited; and J&#xD;
        &lt;subscript&gt;pm&lt;/subscript&gt;&#xD;
        , the rate of Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        extrusion across the plasma membrane.  One additional flux J&#xD;
        &lt;subscript&gt;release&lt;/subscript&gt;&#xD;
        was calculated from the difference between J&#xD;
        &lt;subscript&gt;ICa&lt;/subscript&gt;&#xD;
        and J&#xD;
        &lt;subscript&gt;pm&lt;/subscript&gt;&#xD;
        (see&#xD;
        &lt;xref linkend="fig_cell_diagram" /&gt;&#xD;
        below).  This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in&#xD;
        &lt;xref linkend="sec_download_this_model" /&gt;&#xD;
        .&#xD;
      &lt;/para&gt;&#xD;
      &lt;para&gt;The complete original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        &lt;ulink url="http://www.jgp.org/cgi/content/abstract/119/3/211"&gt;&#xD;
          Differential Regulation of ER Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          Uptake and Release Rates Accounts for Multiple Modes of Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -induced Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          Release&#xD;
        &lt;/ulink&gt;&#xD;
        , Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel, 2002,&#xD;
        &lt;ulink url="http://www.jgp.org/"&gt;&#xD;
          &lt;emphasis&gt;The Journal Of General Physiology&lt;/emphasis&gt;&#xD;
        &lt;/ulink&gt;&#xD;
        , 119, 211-233.  (&#xD;
        &lt;ulink url="http://www.jgp.org/cgi/content/full/119/3/211"&gt;Full text&lt;/ulink&gt;&#xD;
        and&#xD;
        &lt;ulink url="http://www.jgp.org/cgi/reprint/119/3/211.pdf"&gt;PDF&lt;/ulink&gt;&#xD;
        versions of the article are available for Journal Members on the JGP website.)&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=11865019&amp;amp;dopt=Abstract"&gt;PubMed ID: 11865019&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;cell schematic for the model&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="albrecht_2002.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;&#xD;
          Schematic of the model indicating Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          compartmentation in the extracellular matrix, cytosol and the ER and pathways for Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          ion movement between the compartments.&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
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    <dcterms:description>rate of change in total cytoplasmic calcium concentration</dcterms:description>
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