Location: Calcium Dynamics Annotations @ 110f9ba31e34 / gall_susa_1999_a / model / gall_susa_1999_a.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-24 21:37:35+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/gall_susa_1999_a/model/gall_susa_1999_a.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.Ca_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./gall_susa_1999_a.cellml#entity_0">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./gall_susa_1999_a.cellml#entity_1">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:85704"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free cytosolic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.n_infinity">
    <dcterms:description>steady state function of delayed rectifier potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.g_Ca">
    <dcterms:description>calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.V_K">
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_h_gate.S_h">
    <dcterms:description>saturation potential of M-gate calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.g_Na_Ca">
    <dcterms:description>maximum sodium-calcium exchanger current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_m_gate.V_m">
    <dcterms:description>half-maximal activation potential of M-gate calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.K_d">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium dissociation constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.V_">
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.V_n">
    <dcterms:description>half-maximal activation potential of delayed rectifier potassium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free cytosolic sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.alpha">
    <dcterms:description>factor converting current into concentration changes</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.i_Na_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free cytosolic sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_m_gate.m_infinity">
    <dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_h_gate.V_h">
    <dcterms:description>half-maximal activation potential of H-gate calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.V_Ca">
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.k_Ca">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium removal rate in the endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current.i_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.g_K_Ca">
    <dcterms:description>calcium-activated potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.nH">
    <dcterms:description>Hill coefficient of sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free cytosolic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.tau_n">
    <dcterms:description>activation time constant of delayed rectifier potassium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#environment.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.Cm">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_h_gate.h">
    <dcterms:description>H-gate calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.Ca_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./gall_susa_1999_a.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./gall_susa_1999_a.cellml#entity_1"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.i_Na_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#gall_1999"
     semsim:modelName="gall_1999"
     bqmodel:isDescribedBy="10388739">
    <semsim:unknown>Pancreatic Beta-Cell</semsim:unknown>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Na/Ca Exchange in Models for Pancreatic Beta-Cells&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Bioengineering Institute, University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This CellML model represents Model I from the published paper. The CellML matches the published equations and the model runs in OpenCell and COR but it does not replicate the published results.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Effect of Na/Ca Exchange on Plateau Fraction and [Ca&#xD;
        &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
        ]&#xD;
        &lt;subscript&gt;i&lt;/subscript&gt;&#xD;
        in Models for Bursting in Pancreatic Beta-Cells, David Gall and Isabella Susa, 1999,&#xD;
        &lt;emphasis&gt;Biophysical Journal&lt;/emphasis&gt;&#xD;
        , 77, 45-53.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10388739"&gt;PubMed ID: 10388739&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
    <semsim:unknown>The Gall and Susa 1999 model of Na/Ca exchange in Model I for pancreatic         beta-cells.</semsim:unknown>
    <semsim:modelName>gall_susa_1999_a</semsim:modelName>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.i_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.i_Na_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.V_Na_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>reversal potential of sodium-calcium exchanger</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free cytosolic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.h">
    <dcterms:description>H-gate calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#membrane.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.f">
    <dcterms:description>fraction of free cytoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current.g_K">
    <dcterms:description>rapid potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.n">
    <dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#ionic_concentrations.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.K_1_2">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant of the sodium-calcium exchanger</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_m_gate.S_m">
    <dcterms:description>saturation potential of M-gate calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#Na_Ca_exchanger_current.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_a.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current.V_K">
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current_n_gate.S_n">
    <dcterms:description>saturation potential of delayed rectifier potassium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#rapidly_activating_K_current.n">
    <dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_current.m_infinity">
    <dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./gall_susa_1999_a.cellml#calcium_activated_K_current.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
</rdf:RDF>