Location: Calcium Dynamics Annotations @ 110f9ba31e34 / goldbeter_dupont_berridge_1990 / model / goldbeter_dupont_berridge_1990.cellml

Author:

neilstephen2001 <npar276@aucklanduni.ac.nz>

Date:

2021-01-24 21:37:35+13:00

Desc:

adding OMEX archives to workspace

Permanent Source URI:

http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/goldbeter_dupont_berridge_1990/model/goldbeter_dupont_berridge_1990.cellml

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    <article>
      <articleinfo>
        <title>Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation</title>
        <author>
          <firstname>Mark</firstname>
          <surname>Hanna</surname>
          <affiliation>
            <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
          </affiliation>
        </author>
      </articleinfo>
      <section id="sec_status">
        <title>Model Status</title>
        <para>Runs in PCEnv and COR.  Reproduces published output (figures 2a, 2b when the value of 'k' is changed to 6, 4a, 4b when the value of 'beta' is changed to 0.644)</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>
          ABSTRACT: In a variety of cells, hormonal or neurotransmitter signals elicit a train of intracellular Ca2+ spikes.  The analysis of a minimal model based on Ca2+-induced Ca2+ release from intracellular stores shows how sustained oscillations of cytosolic Ca2+ may develop as a result of a rise in inositol 1,4,5-trisphosphate (InsP3) triggered by external stimulation.  This rise elicits the release of a certain amount of Ca2+ from an InsP3-sensitive intracellular store.  The subsequent rise in cytosolic Ca2+ in turn triggers the release of Ca2+ from a second store insensitive to InsP3.  In contrast to the model proposed by Meyer and Stryer [Meyer, T. &amp; Stryer, L. (1988)
          <emphasis>Proc. Matl. Acad. Sci. USA 85, 5051-5055</emphasis>
          ], the present model, which contains only two variable, predicts the occurrence of periodic Ca2+ spikes in the absence of InsP3 oscillations.  Such results indicate that repetitive Ca2+ spikes evoked by external stimuli do not necessarily require the concomitant, periodic variation of InsP3.  The model is closely related to that proposed by Kuba and Takeshita [Kuba, K. &amp; Takeshita, S. (1981)
          <emphasis>J. Theor. Biol. 93, 1009-1031</emphasis>
          ] for Ca2+ oscillations in sympathetic neurones, based on Ca2+-induced Ca2+ release.  We extend their results by showing the minimal conditions in which the latter process gives rise to periodic behaviour and take into account the role of the rise in InsP3 caused by external stimulation.  The analysis further shows how signal-induced Ca2+ oscillations might be effectively encoded in terms of their frequency through the phospohorylation of a cellular substrate by a protein kinase activated by cytosolic Ca2+.
        </para>
        <para>
          Minimla model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation, Albert Goldbeter, Genevieve Dupont, Michael J. Berridge, 1990,
          <emphasis>Biophysics</emphasis>
          , 87, 1461-1465.
          <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=2304911&amp;dopt=Abstract">PubMed ID: 2304911</ulink>
        </para>
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          <caption>Schematic representation of the mechanism generating Ca2+ oscillations, based on the self-amplified release of Ca2+ from intracellular stores.</caption>
        </informalfigure>
      </sect1>
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      <bqbiol:isPropertyOf rdf:resource="goldbeter_dupont_berridge_1990.cellml#entity_0" />
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#beta">
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#entity_1">
      <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829" />
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#V_M3">
      <dcterms:description>maximal calcium flux out of the intracellular store</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#beta">
      <dcterms:description>stimulation factor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#environment_time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#W_star.Z">
      <bqbiol:isPropertyOf rdf:resource="goldbeter_dupont_berridge_1990.cellml#entity_0" />
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    </rdf:Description>
    <rdf:Description rdf:about="#W_star.Z">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_12">
          <semsim:physicalPropertyOf rdf:resource="#entity_0" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of cytosolic calcium</dcterms:description>
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    <rdf:Description rdf:about="#v_P">
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    </rdf:Description>
    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#v_3.m">
      <dcterms:description>Hill coefficient for calcium release from IP3-insensitive store</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#W_T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_13">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>total concentration of protein substrate</dcterms:description>
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      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_7">
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      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of cytosolic calcium</dcterms:description>
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#Y">
      <bqbiol:isPropertyOf rdf:resource="goldbeter_dupont_berridge_1990.cellml#entity_2" />
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    <rdf:Description rdf:about="#v_2.n">
      <dcterms:description>Hill coefficient for calcium pumping into IP3-insensitive store</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#entity_3">
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#v_P">
      <dcterms:description>effective maximal rate of phosphatase</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#K_a">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_17">
          <semsim:physicalPropertyOf rdf:resource="#entity_0" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>htreshold constant for activation of enzyme by cytosolic calcium</dcterms:description>
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      <dcterms:description>maximal calcium flux into the intracellular store</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#W_star.time">
      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#goldbeter_model_1990" bqmodel:isDescribedBy="2304911" semsim:modelName="goldbeter_dupont_berridge_1990">
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      <semsim:unknown>Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation</semsim:unknown>
    </rdf:Description>
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      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_3">
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>calcium flux from IP3-insensitive intracellular store into the cytosol</dcterms:description>
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    <rdf:Description rdf:about="#V_MK">
      <dcterms:description>effective maximal rate of kinase</dcterms:description>
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      <dcterms:description>total concentration of protein substrate</dcterms:description>
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      <dcterms:description>stimulated calcium influx from the extracellular medium</dcterms:description>
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      <dcterms:description>fraction of phosphorylated protein</dcterms:description>
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    <rdf:Description rdf:about="#K_A">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_11">
          <semsim:physicalPropertyOf rdf:resource="#entity_0" />
          <semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
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    <rdf:Description rdf:about="goldbeter_dupont_berridge_1990.cellml#v_2.Z">
      <bqbiol:isPropertyOf rdf:resource="goldbeter_dupont_berridge_1990.cellml#entity_0" />
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      <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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    <rdf:Description rdf:about="#v_3.m">
      <dcterms:description>Hill coefficient for calcium release from IP3-insensitive store</dcterms:description>
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    <rdf:Description rdf:about="#v_0">
      <dcterms:description>passive calcium influx from the extracellular medium</dcterms:description>
    </rdf:Description>
  </rdf:RDF>
</model>