Location: Calcium Dynamics Annotations @ 110f9ba31e34 / iribe_kohl_noble_2006 / model / iribe_kohl_noble_2006.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-24 21:37:35+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/iribe_kohl_noble_2006/model/iribe_kohl_noble_2006.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SR_calcium_concentration.j_up">
    <dcterms:description>SERCA pump uptake calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.F_SRCa_RyR">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_10">
        <bqbiol:isPartOf>
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            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>effect factor of sarcoplasmic reticulum calcium on ryanodine receptors</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.g_12">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.i_Ca_L_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#potassium_background_current.g_b_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>potassium background current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current_r_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SR_calcium_concentration.v_SR">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_1"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>sarcoplasmic reticulum volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_f_gate.alpha_f">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.Ca_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_5">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_3">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#troponin_Trpn_Ca">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_11">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_0">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.i_b_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SR_calcium_concentration.j_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium release flux of ryanodine receptor channels</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration.i_Ca_L_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.g_23">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.P_Ca_L_Ca">
    <dcterms:description>maximum L-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration.Trpn_Ca">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.Force"
     dcterms:description="force"/>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.Na_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#cell_parameters.Cm">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.k_1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium-induced ryanodine receptor activation rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_m_gate.beta_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#cell_parameters.v_SR">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_1"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>sarcoplasmic reticulum volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#potassium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.Trpn_Ca">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SERCA.V_max_r">
    <dcterms:description>SERCA pump reverse rate parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.beta_tm">
    <dcterms:description>reverse rate of tropomyosin shifting</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration.i_Ca_L_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR_j_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium release flux of ryanodine receptor channels</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current_x_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.P_2">
    <dcterms:description>fraction of permissive tropomyosin with 2 crossbridges</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#troponin.beta_trpn">
    <dcterms:description>maximum calcium off-rate for troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.Ca_SR">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.gain_k2">
    <dcterms:description>calcium-induced ryanodine receptor inactivation rate gain</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.k_2">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium-induced ryanodine receptor inactivation rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_m_gate.alpha_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_b_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_to">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.g_01">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current.m">
    <dcterms:description>fast sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.Na_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_7">
        <bqbiol:isPartOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_0"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_d_gate.E0_d">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>L-type calcium chanel D-gate reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current_x_gate.beta_x">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.P_3">
    <dcterms:description>fraction of permissive tropomyosin with 3 crossbridges</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_d_gate.beta_d">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.P_2_max">
    <dcterms:description>maximum fraction of permissive tropomyosin with 2 crossbridges</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.k_3">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>recovery rate constant of ryanodine receptor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.gain_k1">
    <dcterms:description>calcium-induced ryanodine receptor activation rate gain</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#potassium_background_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.K_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#entity_6">
        <bqbiol:isPartOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_0"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calmodulin.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#iribe_model_2006"
     semsim:modelName="iribe_kohl_noble_2006"
     bqmodel:isDescribedBy="16608699">
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This model was created by Penny Noble of Oxford University. This file is known to run COR and OpenCell to reproduce the published results. The units have been checked and they are consistent.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: We hypothesize that slow inactivation of Ca2+/calmodulin-dependent kinase II (CaMKII) and its modulatory effect on sarcoplasmic reticulum (SR) Ca2+ handling are important for various interval-force (I-F) relations, in particular for the beat interval dependency in transient alternans during the decay of post-extrasystolic potentiation. We have developed a mathematical model of a single cardiomyocyte to integrate various I-F relations, including alternans, by incorporating a conceptual CaMKII kinetics model into the SR Ca2+ handling model. Our model integrates I-F relations, such as the beat interval-dependent twitch force duration, restitution and potentiation, positive staircase phenomenon and alternans. We found that CaMKII affects more or less all I-F relations, and it is a key factor for integration of the various I-F relations in our model. Alternans arises, in the model, out of a steep relation between SR Ca2+ load and release, owing to SR load-dependent changes in the releasability of Ca2+ via the ryanodine receptor. Beat interval-dependent CaMKII activity, owing to its kinetic properties and amplifying effect on SR Ca2+ load dependency of Ca2+ release, replicated the beat interval dependency of alternans, as observed experimentally. Additionally, our model enabled reproduction of the effects of various interventions on alternans, such as the slowing or accelerating of Ca2+ release and/or uptake. We conclude that a slow time-dependent factor, represented in the model by CaMKII, is important for the integration of I-F relations, including alternans, and that our model offers a useful tool for further analysis of the roles of integrative Ca2+ handling in myocardial I-F relations.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval-force relations: a modelling study, Gentaro Iribe, Peter Kohl and Denis Noble, 2006,&#xD;
        &lt;emphasis&gt;Philosophical Transactions of the Royal Society A&lt;/emphasis&gt;&#xD;
        , 364, (1842), 1107-1133.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;amp;cmd=Retrieve&amp;amp;dopt=AbstractPlus&amp;amp;list_uids=16608699&amp;amp;query_hl=1&amp;amp;itool=pubmed_docsum"&gt;PubMed ID: 16608699&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_reaction_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;model diagram&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="iribe_2006.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;Schematic diagram of the Iribe et al. cell model.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
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  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SERCA.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#cell_parameters.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#CaMKII_factor.Cmdn_Ca">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.F_CaMK">
    <dcterms:description>calmodulin-dependent kinase II activity factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#troponin.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#potassium_background_current_i_b_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current_i_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-dependent rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.K_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SERCA.F_CaMK">
    <dcterms:description>calmodulin-dependent kinase II activity factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.F_3">
    <dcterms:description>product fraction of ryanodine receptors</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.x">
    <dcterms:description>time-dependent rectifier potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.g_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>time-independent potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_h_gate.alpha_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calcium_background_current.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.K_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_h_gate.beta_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.i_Ca_L_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.d">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current_s_gate.alpha_s">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calmodulin_Cmdn_Ca">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current_s_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.v_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>myoplasmic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_f_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.i_NaK_max">
    <dcterms:description>maximum sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calcium_background_current.g_b_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>calcium background current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.F_2">
    <dcterms:description>activator fraction of ryanodine receptors</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.gamma">
    <dcterms:description>voltage dependence parameter of sodium-calcium exchanger</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_f_gate.f">
    <dcterms:description>L-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SR_calcium_concentration.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.N_0">
    <dcterms:description>fraction of non-permissive tropomyosin with 0 crossbridges</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_d_gate.alpha_d">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#environment_time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration.v_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>myoplasmic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SERCA.Ca_SR">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.F_1">
    <dcterms:description>precursor fraction of ryanodine receptors</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current_r_gate.r">
    <dcterms:description>transient outward current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calmodulin.beta_cmdn">
    <dcterms:description>calcium off-rate for calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current.g_to">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>transient outward current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.N_1">
    <dcterms:description>fraction of non-permissive tropomyosin with 1 crossbridge</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#CaMKII_factor.Tau_CaMK">
    <dcterms:description>time constant for calmodulin-dependent kinase II kinetics</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.stim_duration">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current.E_mh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>fast sodium current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.Tau_SRCa_RyR">
    <dcterms:description>time constant factor of effect of sarcoplasmic reticulum calcium on ryanodine receptor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current_r_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.beta_trpn">
    <dcterms:description>maximum calcium off-rate for troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration.i_b_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calcium_background_current_i_b_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_b_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_Stim">
    <dcterms:description>externally applied stimulus current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current_x_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_d_gate.d">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump_i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current_i_to">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.f_23">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.k_4">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor transition rate from precursor to product</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.P_0">
    <dcterms:description>fraction of permissive tropomyosin with 0 crossbridges</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SR_calcium_concentration.Ca_SR">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.stim_start">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.K_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.Force_max">
    <dcterms:description>maximum force</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_d_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.i_Ca_L_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.P_3_max">
    <dcterms:description>maximum fraction of permissive tropomyosin with 3 crossbridges</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-dependent rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.g_XB">
    <dcterms:description>minimum transition rate from strong to weak crossbridge</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_f_gate.beta_f">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#CaMKII_factor.F_CaMK">
    <dcterms:description>calmodulin-dependent kinase II activity factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current_x_gate.x">
    <dcterms:description>time-dependent rectifier potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.f_12">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_background_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration.dTrpn_Ca_dtime">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>rate of change of troponin buffer concentration</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.P_1">
    <dcterms:description>fraction of permissive tropomyosin with 1 crossbridge</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calmodulin.alpha_cmdn">
    <dcterms:description>calcium on-rate for calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.alpha_tm">
    <dcterms:description>forward rate of tropomyosin shifting</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_f_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#cell_parameters.K_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current.h">
    <dcterms:description>fast sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_h_gate.shift_h">
    <dcterms:description>saturation potential of fast sodium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#RyR.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#calmodulin.dCmdn_Ca_dtime">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>rate of change of calmodulin buffer concentration</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.Cm">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#cell_parameters.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_dependent_rectifier_potassium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_background_current_i_b_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.K_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger_i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#membrane_potential.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.f_01">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SR_calcium_concentration.v_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>myoplasmic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current.r">
    <dcterms:description>transient outward current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.E_mh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>fast sodium current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration_Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel_d_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration.i_b_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>background calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_m_gate.m">
    <dcterms:description>fast sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_potassium_pump.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#fast_sodium_current_m_gate.E0_m">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#reversal_potentials.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#Force.alpha_trpn">
    <dcterms:description>calcium on-rate for troponin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_potassium_concentration.i_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-dependent rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#sodium_calcium_exchanger.T">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00293"/>
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#transient_outward_current.s">
    <dcterms:description>transient outward current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#time_independent_potassium_current.K_mk1">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>extracellular potassium half-saturation constant of time-independent rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_sodium_concentration_Na_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#SERCA.V_max_f">
    <dcterms:description>SERCA pump forward rate parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#intracellular_calcium_concentration.v_i">
    <bqbiol:isPropertyOf rdf:resource="./iribe_kohl_noble_2006.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>myoplasmic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./iribe_kohl_noble_2006.cellml#L_type_Ca_channel.i_Ca_L_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
</rdf:RDF>