- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-24 21:37:35+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/magnus_keizer_1997/model/magnus_keizer_1997.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="magnus_keizer_1997" cmeta:id="magnus_keizer_1997_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Mitochondrial Ca2+ Handling</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In 1997 Gerhard Magnus and Joel Keizer published a minimal mathematical model to describe Ca
<superscript>2+</superscript>
handling by mitochondria in the pancreatic beta-cell. Their kinetic model includes six transport mechanisms in the inner mitochondrial membrane, including proton pumping via respiration and proton pumping by the F0F1-ATPase, a proton leak, adenine nucleotide exchange, the Ca
<superscript>2+</superscript>
uniporter and Na
<superscript>+</superscript>
/Ca
<superscript>2+</superscript>
exchange (see
<xref linkend="fig_cell_diagram" />
below).
</para>
<para>The complete original paper reference is cited below:</para>
<para>
Minimal model of beta-cell mitochondrial Ca
<superscript>2+</superscript>
handling, Gerhard Magnus and Joel Keizer, 1997,
<ulink url="http://ajpcell.physiology.org/">
<emphasis>American Journal of Physiology</emphasis>
</ulink>
, 273, C717-C733.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9277370&dopt=Abstract">PubMed ID: 9277370</ulink>
</para>
<para>
The raw CellML description of the mitochondrial Ca
<superscript>2+</superscript>
handling model can be downloaded in various formats as described in
<xref linkend="sec_download_this_model" />
. For an example of a more complete documentation for an electrophysiological model, see
<ulink url="${HTML_EXMPL_HHSA_INTRO}">The Hodgkin-Huxley Squid Axon Model, 1952</ulink>
.
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>diagram of the mitochondrial Ca2+ handling model showing ionic currents across the mitochondrial membrane</title>
</objectinfo>
<imagedata fileref="magnus_1997.png" />
</imageobject>
</mediaobject>
<caption>A schematic representation of the ion fluxes through the mitochondrial inner membrane that are included in the Magnus-Keizer minimal model.</caption>
</informalfigure>
<informalfigure float="0" id="fig_cellml_rendering">
<mediaobject>
<imageobject>
<objectinfo>
<title>the cellml rendering of the mitochondrial Ca2+ handling model</title>
</objectinfo>
<imagedata fileref="cellml_rendering.gif" />
</imageobject>
</mediaobject>
<caption>
The network defined in the CellML description of the mitochondrial Ca
<superscript>2+</superscript>
handling model.
</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<variable cmeta:id="membrane.F" initial_value="96845.0" name="F" public_interface="out" units="coulomb_per_mole" />
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<variable cmeta:id="membrane.pH_m" name="pH_m" units="dimensionless" />
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<variable cmeta:id="F0_F1_ATPase.A_F1" name="A_F1" units="dimensionless" />
<variable cmeta:id="F0_F1_ATPase.total_mitochondrial_adenosine_phosphate" initial_value="12.0" name="total_mitochondrial_adenosine_phosphate" units="nanomolar" />
<variable cmeta:id="F0_F1_ATPase.ATP_m" name="ATP_m" units="nanomolar" />
<variable cmeta:id="F0_F1_ATPase.ADP_m_free" name="ADP_m_free" units="nanomolar" />
<variable cmeta:id="F0_F1_ATPase.Pi_m" initial_value="20.0" name="Pi_m" units="millimolar" />
<variable cmeta:id="F0_F1_ATPase.p1" initial_value="0.00000001346" name="p1" units="dimensionless" />
<variable cmeta:id="F0_F1_ATPase.p2" initial_value="0.0000007739" name="p2" units="dimensionless" />
<variable cmeta:id="F0_F1_ATPase.p3" initial_value="0.00000000000000665" name="p3" units="dimensionless" />
<variable cmeta:id="F0_F1_ATPase.pa" initial_value="0.00001656" name="pa" units="per_second" />
<variable cmeta:id="F0_F1_ATPase.pb" initial_value="0.0000003373" name="pb" units="per_second" />
<variable cmeta:id="F0_F1_ATPase.pc1" initial_value="0.00000000000009651" name="pc1" units="per_second" />
<variable cmeta:id="F0_F1_ATPase.pc2" initial_value="0.0000000000000000004845" name="pc2" units="per_second" />
<variable cmeta:id="F0_F1_ATPase.ADP_m" name="ADP_m" public_interface="in" units="nanomolar" />
<variable cmeta:id="F0_F1_ATPase.delta_pH" name="delta_pH" public_interface="in" units="dimensionless" />
<variable cmeta:id="F0_F1_ATPase.R" name="R" public_interface="in" units="millijoule_per_mole_kelvin" />
<variable cmeta:id="F0_F1_ATPase.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="F0_F1_ATPase.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="F0_F1_ATPase.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="F0_F1_ATPase.V_B" name="V_B" public_interface="in" units="millivolt" />
<variable cmeta:id="F0_F1_ATPase.time" name="time" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="JH_F1_calculation">
<eq />
<ci>JH_F1</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-180.0</cn>
<ci>rho_F1</ci>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>pa</ci>
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10.0</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>delta_pH</ci>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>pb</ci>
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10.0</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>delta_pH</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>pa</ci>
<ci>pb</ci>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<times />
<ci>p1</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V_B</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>p2</ci>
<apply>
<times />
<ci>p3</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="Jp_F1_calculation">
<eq />
<ci>Jp_F1</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-60.0</cn>
<ci>rho_F1</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<ci>pa</ci>
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10.0</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>delta_pH</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>pc1</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V_B</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>pa</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>pc2</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<times />
<ci>p1</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V_B</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>p2</ci>
<apply>
<times />
<ci>p3</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>A_F1</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="A_F1_calculation">
<eq />
<ci>A_F1</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<apply>
<times />
<ci>K_F1</ci>
<ci>ATP_m</ci>
</apply>
<apply>
<times />
<ci>ADP_m_free</ci>
<ci>Pi_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="total_mitochondrial_adenosine_phosphate_calculation">
<eq />
<ci>total_mitochondrial_adenosine_phosphate</ci>
<apply>
<plus />
<ci>ATP_m</ci>
<ci>ADP_m</ci>
</apply>
</apply>
<apply id="ADP_m_free_calculation">
<eq />
<ci>ADP_m_free</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
<ci>ADP_m</ci>
</apply>
</apply>
</math>
</component>
<component name="ATP_ADP_exchange">
<variable cmeta:id="ATP_ADP_exchange.J_ant" name="J_ant" public_interface="out" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="ATP_ADP_exchange.ADP_m" name="ADP_m" public_interface="out" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.Jmax_ant" initial_value="1000.0" name="Jmax_ant" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="ATP_ADP_exchange.ATP_i" name="ATP_i" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.ATP_m" name="ATP_m" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.ADP_i" name="ADP_i" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.ATP4_i" name="ATP4_i" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.ATP4_m" name="ATP4_m" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.ADP3_i" name="ADP3_i" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.ADP3_m" name="ADP3_m" units="nanomolar" />
<variable cmeta:id="ATP_ADP_exchange.f" initial_value="0.5" name="f" units="dimensionless" />
<variable cmeta:id="ATP_ADP_exchange.Jp_F1" name="Jp_F1" public_interface="in" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="ATP_ADP_exchange.R" name="R" public_interface="in" units="millijoule_per_mole_kelvin" />
<variable cmeta:id="ATP_ADP_exchange.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="ATP_ADP_exchange.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="ATP_ADP_exchange.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="ATP_ADP_exchange.time" name="time" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="J_ant_calculation">
<eq />
<ci>J_ant</ci>
<apply>
<times />
<ci>Jmax_ant</ci>
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>ATP4_i</ci>
<ci>ADP3_m</ci>
</apply>
<apply>
<times />
<ci>ADP3_i</ci>
<ci>ATP4_m</ci>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>F</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<times />
<apply>
<divide />
<ci>ATP4_i</ci>
<ci>ADP3_i</ci>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>f</ci>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<ci>ADP3_m</ci>
<ci>ATP4_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="ADP_m_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP_m</ci>
</apply>
<apply>
<minus />
<ci>J_ant</ci>
<ci>Jp_F1</ci>
</apply>
</apply>
<apply id="ADP3_m_calculation">
<eq />
<ci>ADP3_m</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.45</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
<ci>ADP_m</ci>
</apply>
</apply>
<apply id="ADP3_i_calculation">
<eq />
<ci>ADP3_i</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.45</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>ADP_i</ci>
</apply>
</apply>
<apply id="ATP4_m_calculation">
<eq />
<ci>ATP4_m</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.05</cn>
<ci>ATP_m</ci>
</apply>
</apply>
<apply id="ATP4_i_calculation">
<eq />
<ci>ATP4_i</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.05</cn>
<ci>ATP_i</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_uniporter">
<variable cmeta:id="Ca_uniporter.J_uni" name="J_uni" public_interface="out" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="Ca_uniporter.V_offset" initial_value="91.0" name="V_offset" public_interface="out" units="millivolt" />
<variable cmeta:id="Ca_uniporter.Jmax_uni" initial_value="300.0" name="Jmax_uni" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="Ca_uniporter.Ca_i" name="Ca_i" units="nanomolar" />
<variable cmeta:id="Ca_uniporter.K_trans" initial_value="19.0" name="K_trans" units="micromolar" />
<variable cmeta:id="Ca_uniporter.K_act" initial_value="0.38" name="K_act" units="micromolar" />
<variable cmeta:id="Ca_uniporter.L" initial_value="110.0" name="L" units="dimensionless" />
<variable cmeta:id="Ca_uniporter.na" initial_value="2.8" name="na" units="dimensionless" />
<variable cmeta:id="Ca_uniporter.R" name="R" public_interface="in" units="millijoule_per_mole_kelvin" />
<variable cmeta:id="Ca_uniporter.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="Ca_uniporter.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="Ca_uniporter.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="Ca_uniporter.time" name="time" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="J_uni_calculation">
<eq />
<ci>J_uni</ci>
<apply>
<times />
<ci>Jmax_uni</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_trans</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_trans</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_trans</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<divide />
<ci>L</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_act</ci>
</apply>
</apply>
<ci>na</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>F</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_offset</ci>
</apply>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-2.0</cn>
<ci>F</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_offset</ci>
</apply>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_exchanger">
<variable cmeta:id="Na_Ca_exchanger.J_Na_Ca" name="J_Na_Ca" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="Na_Ca_exchanger.Jmax_Na_Ca" initial_value="25.0" name="Jmax_Na_Ca" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="Na_Ca_exchanger.Ca_m" name="Ca_m" units="nanomolar" />
<variable cmeta:id="Na_Ca_exchanger.Na_i" initial_value="30.0" name="Na_i" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.K_Na" initial_value="9.4" name="K_Na" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.K_Ca" initial_value="0.003" name="K_Ca" units="nanomole_per_mg" />
<variable cmeta:id="Na_Ca_exchanger.b" initial_value="0.0" name="b" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.n" initial_value="2.0" name="n" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.fm" initial_value="0.0003" name="fm" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.J_uni" name="J_uni" public_interface="in" units="nanomole_per_minute_per_mg" />
<variable cmeta:id="Na_Ca_exchanger.V_offset" name="V_offset" public_interface="in" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger.R" name="R" public_interface="in" units="millijoule_per_mole_kelvin" />
<variable cmeta:id="Na_Ca_exchanger.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="Na_Ca_exchanger.T" name="T" public_interface="in" units="kelvin" />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="J_Na_Ca_calculation">
<eq />
<ci>J_Na_Ca</ci>
<apply>
<times />
<ci>Jmax_Na_Ca</ci>
<apply>
<divide />
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
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<apply>
<minus />
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</apply>
</apply>
<apply>
<times />
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</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<power />
<apply>
<plus />
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<apply>
<divide />
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</apply>
</apply>
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</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
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<ci>Ca_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="Ca_m_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_m</ci>
</apply>
<apply>
<times />
<ci>fm</ci>
<apply>
<minus />
<ci>J_uni</ci>
<ci>J_Na_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
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<component_ref component="F0_F1_ATPase" />
</component_ref>
</group>
<connection>
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</connection>
<connection>
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</connection>
<connection>
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</connection>
<connection>
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</connection>
<connection>
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</connection>
<connection>
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<map_variables variable_1="R" variable_2="R" />
</connection>
<connection>
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</connection>
<connection>
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<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
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<map_variables variable_1="J_ant" variable_2="J_ant" />
</connection>
<connection>
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<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
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<map_variables variable_1="F" variable_2="F" />
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<map_variables variable_1="R" variable_2="R" />
</connection>
<connection>
<map_components component_1="environment" component_2="proton_leak" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="F0_F1_ATPase" component_2="membrane" />
<map_variables variable_1="JH_F1" variable_2="JH_F1" />
</connection>
<connection>
<map_components component_1="membrane" component_2="proton_pump" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="V_B" variable_2="V_B" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="delta_pH" variable_2="delta_pH" />
<map_variables variable_1="R" variable_2="R" />
</connection>
<connection>
<map_components component_1="proton_leak" component_2="membrane" />
<map_variables variable_1="JH_leak" variable_2="JH_leak" />
</connection>
<connection>
<map_components component_1="environment" component_2="Na_Ca_exchanger" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="Ca_uniporter" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="F0_F1_ATPase" />
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<map_variables variable_1="V_B" variable_2="V_B" />
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<map_variables variable_1="delta_pH" variable_2="delta_pH" />
<map_variables variable_1="R" variable_2="R" />
</connection>
<connection>
<map_components component_1="membrane" component_2="proton_leak" />
<map_variables variable_1="g_H" variable_2="g_H" />
<map_variables variable_1="proton_motive_force" variable_2="proton_motive_force" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="F0_F1_ATPase" component_2="ATP_ADP_exchange" />
<map_variables variable_1="Jp_F1" variable_2="Jp_F1" />
</connection>
<rdf:RDF xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:about="#Na_Ca_exchanger.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_17">
<ro:part_of>
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</ro:part_of>
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</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.Jmax_ant">
<dcterms:description>maximum adenine nucleotide translocator flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.V_offset">
<dcterms:description>calcium uniporter voltage offset for calcium transport</dcterms:description>
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.total_NAD_m">
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_2">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:13389" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of total mitochondrial NAD</dcterms:description>
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.K_F1">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_0">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>calcium equilibrium constant of F1F0-ATPase</dcterms:description>
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.total_mitochondrial_adenosine_phosphate">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_6">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:22256" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of total mitochondrial adenosine phosphate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.rb">
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<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
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<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_17">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchanger flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.V">
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<rdf:Description rdf:about="#property_0">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
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<rdf:Description rdf:about="#ATP_ADP_exchange.Jp_F1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
<dcterms:description>phosphate flux through F1F0-ATPase driven proton pumps</dcterms:description>
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<dcterms:description>phosphate flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_leak.proton_motive_force">
<dcterms:description>proton motive force</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.Cmito">
<dcterms:description>inner mitochondrial membrane capacitance</dcterms:description>
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<rdf:Description rdf:about="#ATP_ADP_exchange.ATP_i">
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<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_10">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:15422" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
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<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
<dcterms:description>proton flux through F1F0-ATPase driven proton pumps</dcterms:description>
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<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_9">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:24838" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial inorganic phosphate</dcterms:description>
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</rdf:Description>
<rdf:Description rdf:about="#membrane.F">
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.ra">
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<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.V">
<dcterms:description>membrane potential</dcterms:description>
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<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_36">
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<rdf:Description rdf:about="#entity_0">
<ro:part_of rdf:resource="#entity_1" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.K_res">
<bqbiol:isPropertyOf rdf:resource="magnus_keizer_1997.cellml#entity_0" />
<dcterms:description>calcium equilibrium constant of respiration driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
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<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_14">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:456216" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of cytosolic ADP(3-)</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.L">
<dcterms:description>equilibrium constant for calcium uniporter conformations</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.na">
<dcterms:description>calcium uniporter activation cooperativity</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.rho_res">
<dcterms:description>proton pump density</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.g_H">
<dcterms:description>proton leakage conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.K_Na">
<bqbiol:isPropertyOf rdf:resource="magnus_keizer_1997.cellml#entity_17" />
<dcterms:description>sodium half-saturation constant of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#membrane.pH_m">
<dcterms:description>pH of mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.pa">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.ra">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.pH_i">
<dcterms:description>pH of cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.JH_res">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_leak.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.ADP_m">
<bqbiol:isPropertyOf>
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<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial ADP</dcterms:description>
</rdf:Description>
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<semsim:isComputationalComponentFor>
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</semsim:isComputationalComponentFor>
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<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.r1">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
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<ro:part_of>
<rdf:Description rdf:about="#entity_3">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:66864" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:30616" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial ATP(4-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.Jp_F1">
<dcterms:description>phosphate flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.JH_res">
<dcterms:description>proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.pb">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.ADP_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_8">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:16761" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.rb">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.pc1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.g">
<dcterms:description>voltage fitting factor for respiratory driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.p2">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.J_ant">
<dcterms:description>adenine nucleotide translocator flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.A_F1">
<dcterms:description>driving reaction affinity of F1F0-ATPase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.L">
<dcterms:description>equilibrium constant for calcium uniporter conformations</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.rho_F1">
<dcterms:description>F1F0-ATPase pump concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.r2">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP4_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_13">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30616" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial ATP(4-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.Jmax_Na_Ca">
<dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.f">
<dcterms:description>fraction of effective voltage difference</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.JH_F1">
<dcterms:description>proton flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_10">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.V_offset">
<dcterms:description>calcium uniporter voltage offset for calcium transport</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.K_trans">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium dissociation constant of uniporter transportation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.K_act">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium dissociation constant of uniporter activation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.K_res">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium equilibrium constant of respiration driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.p3">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_3">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:66864" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.K_act">
<bqbiol:isPropertyOf rdf:resource="magnus_keizer_1997.cellml#entity_0" />
<dcterms:description>calcium dissociation constant of uniporter activation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.r3">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.ADP3_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_15">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:456216" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial ADP(3-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Jmax_Na_Ca">
<dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.Jo">
<dcterms:description>half proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.proton_motive_force">
<dcterms:description>proton motive force</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.b">
<dcterms:description>sodium-calcium exchanger voltage dependence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.ADP_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.rc1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.rc1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.rho_res">
<dcterms:description>proton pump density</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.ADP3_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_15">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:456216" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial ADP(3-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.f">
<dcterms:description>fraction of effective voltage difference</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.JH_res">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_leak.JH_leak">
<dcterms:description>proton leakage flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.JH_F1">
<dcterms:description>proton flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.K_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:physicalPropertyOf rdf:resource="#entity_17" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium half-saturation constant of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_7">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.rc2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.g_H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>proton leakage conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.JH_res">
<dcterms:description>proton flux via respiration driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.NAD_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_4">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:15846" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial NAD</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.Ca_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_16">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.rc2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.J_uni">
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.b">
<dcterms:description>sodium-calcium exchanger voltage dependence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.Jmax_uni">
<dcterms:description>maximum calcium flux through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.pc2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.n">
<dcterms:description>sodium-calcium exchanger cooperativity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.J_uni">
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.g">
<dcterms:description>voltage fitting factor for respiratory driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.p2">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.K_Ca">
<dcterms:description>sodium half-saturation constant of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.ATP_m">
<bqbiol:isPropertyOf rdf:resource="magnus_keizer_1997.cellml#entity_7" />
<dcterms:description>concentration of mitochondrial ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#ATP_ADP_exchange.ATP4_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_12">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30616" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of cytosolic ATP(4-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.J_Na_Ca">
<dcterms:description>sodium-calcium exchanger flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.pc1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_leak.JH_leak">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
<dcterms:description>proton leakage flux</dcterms:description>
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.J_ant">
<dcterms:description>adenine nucleotide translocator flux</dcterms:description>
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<rdf:Description rdf:about="#Na_Ca_exchanger.R">
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<rdf:Description rdf:about="#ATP_ADP_exchange.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#magnus_keizer_1997_version01" semsim:modelName="magnus_keizer_1997" bqmodel:isDescribedBy="9277370">
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<semsim:unknown>Pancreatic Beta-cell</semsim:unknown>
<semsim:unknown>Minimal model of beta-cell mitochondrial Ca2+ handling</semsim:unknown>
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<rdf:Description rdf:about="#ATP_ADP_exchange.ADP_i">
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<rdf:Description rdf:about="#property_28">
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</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.p3">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.pb">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
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<rdf:Description rdf:about="#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.A_res">
<dcterms:description>driving reaction affinity of respiratory driven proton pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.J_uni">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.total_NAD_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:13389" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of total mitochondrial NAD</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Na_Ca_exchanger.fm">
<dcterms:description>fraction of free mitochondrial matrix calcium</dcterms:description>
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<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:22256" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of total mitochondrial adenosine phosphate</dcterms:description>
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<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_11">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761" />
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.ADP3_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_31">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:456216" />
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</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ADP(3-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.J_uni">
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<rdf:Description rdf:about="#property_35">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux into mitochondrial matrix through uniporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.K_Ca">
<dcterms:description>sodium half-saturation constant of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.JH_leak">
<dcterms:description>proton leakage flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.proton_motive_force">
<dcterms:description>proton motive force</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#F0_F1_ATPase.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.V_B">
<dcterms:description>total phase boundary potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.ATP_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_7">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:15422" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.J_ant">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>adenine nucleotide translocator flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.ADP_m_free">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free mitochondrial matrix ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.p1">
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:260691" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.NAD_m">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_4">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15846" />
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</bqbiol:isPropertyOf>
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</rdf:Description>
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<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00592" />
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</semsim:isComputationalComponentFor>
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</rdf:Description>
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<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.JH_F1">
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>proton flux through F1F0-ATPase driven proton pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.fm">
<dcterms:description>fraction of free mitochondrial matrix calcium</dcterms:description>
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<rdf:Description rdf:about="#property_17">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium equilibrium constant of F1F0-ATPase</dcterms:description>
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<rdf:Description rdf:about="#F0_F1_ATPase.rho_F1">
<dcterms:description>F1F0-ATPase pump concentration</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Ca_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_16">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
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</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.Ca_i">
<bqbiol:isPropertyOf rdf:resource="magnus_keizer_1997.cellml#entity_0" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.V_offset">
<dcterms:description>calcium uniporter voltage offset for calcium transport</dcterms:description>
</rdf:Description>
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<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.n">
<dcterms:description>sodium-calcium exchanger cooperativity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.pa">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>sum of F1F0-ATPase products</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#proton_pump.r3">
<dcterms:description>sum of respiration driven proton pump products</dcterms:description>
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<rdf:Description rdf:about="#ATP_ADP_exchange.ATP_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_leak.proton_motive_force">
<dcterms:description>proton motive force</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.Cmito">
<dcterms:description>inner mitochondrial membrane capacitance</dcterms:description>
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<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="magnus_keizer_1997.cellml#Ca_uniporter.na">
<dcterms:description>calcium uniporter activation cooperativity</dcterms:description>
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<bqbiol:isPropertyOf>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#entity_5">
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</bqbiol:isPropertyOf>
<dcterms:description>concentration of mitochondrial NADH</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.Pi_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_9">
<ro:part_of rdf:resource="#entity_3" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of mitochondrial inorganic phosphate</dcterms:description>
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<dcterms:description>pH of mitochondrial matrix</dcterms:description>
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<rdf:Description rdf:about="#ATP_ADP_exchange.Jmax_ant">
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<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
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<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.delta_pH">
<dcterms:description>pH difference between cytosol and mitochondrial matrix</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#proton_leak.g_H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00041" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>proton leakage conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_uniporter.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#ATP_ADP_exchange.ATP4_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_12">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:30616" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ATP(4-)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="magnus_keizer_1997.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#F0_F1_ATPase.A_F1">
<dcterms:description>driving reaction affinity of F1F0-ATPase</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
