Location: Calcium Dynamics Annotations @ 110f9ba31e34 / michailova_2005 / model / michailova_2005.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-24 21:37:35+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/michailova_2005/model/michailova_2005.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.K_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_4">
        <bqbiol:isPartOf>
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            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.C_sc">
    <dcterms:description>specific membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_Y_to1_gate.beta_Y_to1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.y">
    <dcterms:description>L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger_i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_CaADP">
    <dcterms:description>time constant for transfer of calcium-bound ADP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.ADP_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_12">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_2005.cellml#entity_3">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sarcolemmal_calcium_pump.MgATP_i0">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_8">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.Ca_NSR">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_13">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_2005.cellml#entity_14">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_MgATP">
    <dcterms:description>magnesium off-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.MgATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump_J_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.k_a_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PC1 - PO1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_MgADP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>magnesium-bound ADP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.k_MgATP_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_9">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_2005.cellml#entity_10">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62387"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for magnesium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_MgADP">
    <dcterms:description>magnesium off-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.g_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum time-independent potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current_i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_MgATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>magnesium-bound ATP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.Na_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_0">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.stim_amplitude">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.X_kr">
    <dcterms:description>rapid potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.k_a_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO1 - PC1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_CaATP">
    <dcterms:description>time constant for transfer of calcium-bound ATP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sarcolemmal_calcium_pump.I_pCa">
    <dcterms:description>maximum sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.P_Ca">
    <dcterms:description>calcium permeability of L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.MgADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.alpha">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_K1_gate.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.Ca_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_6">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.K_sat">
    <dcterms:description>saturation factor of sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.G_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum ATP-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.omega">
    <dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.k_htrpn_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium off-rate for troponin high affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.CaATP_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_20">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_10"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.tau_X_ks">
    <dcterms:description>activation time constant of slow potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_K1_gate.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.K_mNa">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>sodium half-saturation constant for sodium-calcium exchange</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_h_gate.h">
    <dcterms:description>sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.J_tr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.K_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_5">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_background_current.g_Nab">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum background sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_j_gate.alpha_j">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.K_rb">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>reverse half-saturation constant for calcium ATPase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.k_htrpn_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium on-rate for troponin high affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_K1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.CaADP_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_19">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_10"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.LTRPN_tot">
    <dcterms:description>total concentration of troponin low-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_m_gate.beta_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.Ca_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_7">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.k_minus_CaADP">
    <dcterms:description>calcium off-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.R_V">
    <dcterms:description>activation potential of rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#extracellular_ion_concentrations.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.K_NaCa">
    <dcterms:description>scale factor of sodium-calcium exchanger</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.k_c_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO1 - PC2 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.m">
    <dcterms:description>sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current.Kp_V">
    <dcterms:description>activation potential of plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.MgATP_i0">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_K1_gate.K1_infinity_V">
    <dcterms:description>steady-state function of time-independent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump_i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.I_NaK">
    <dcterms:description>maximum sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.g_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum slow potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.k_minus_CaATP">
    <dcterms:description>calcium off-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.V_NSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_14"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.J_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>ATP-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_CaATP">
    <dcterms:description>calcium on-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_j_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.K_mCa">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for sodium-calcium exchange</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.ATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Ca_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_CaADP">
    <dcterms:description>calcium on-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.HTRPNCa">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_15">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound troponin high-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.stim_duration">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.X_ks_infinity">
    <dcterms:description>steady state function of slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.K_mK1">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_Y_to1_gate.alpha_Y_to1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.HTRPN_tot">
    <dcterms:description>total concentration of troponin high-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.ATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sarcolemmal_calcium_pump_i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_h_gate.beta_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.X_kr_inf">
    <dcterms:description>steady state function of rapid potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.Vmaxf">
    <dcterms:description>maximum SERCA forward pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_Y_to1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current_i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_Y_to1_gate.Y_to1">
    <dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.K_o_normal">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.MgADP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_19"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#environment_time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.V_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of subspace</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current_Kp_gate.Kp_V">
    <dcterms:description>activation potential of plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current.Y_to1">
    <dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.Ca_JSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.MgADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.K1_infinity_V">
    <dcterms:description>steady-state function of time-independent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.P_O2">
    <dcterms:description>fraction of ryanodine receptor channels in state PO2</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_background_current_i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.n">
    <dcterms:description>ryanodine receptor calcium cooperativity parameter PC1 - PO1</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.K_fb">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>forward half-saturation constant for calcium ATPase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.CaADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current_y_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.m">
    <dcterms:description>ryanodine receptor calcium cooperativity parameter PO1 - PO2</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.X_kr">
    <dcterms:description>rapid potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.A_cap">
    <dcterms:description>capacitive membrane area</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current_i_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>ATP-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.J_LTRPNCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux to low-affinity troponin sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.P_O1">
    <dcterms:description>fraction of ryanodine receptor channels in state PO1</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.MgATP_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_11">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_10"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:18420"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.ADP_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_24">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_2005.cellml#entity_23">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67196"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total ADP concentration</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_CaADP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium-bound ADP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.CMDN_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_16">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62343"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total concentration of myoplasmic calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_j_gate.beta_j">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.ATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_20"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_CaATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium-bound ATP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.CaATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#extracellular_ion_concentrations.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.MgATP_i0">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.Ca_JSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current_Kp_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_Y_to1_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_Mg">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>free magnesium flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.g_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum rapid potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.V_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of subspace</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.EGTA_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_17">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30741"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total concentration of EGTA</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.alpha_prime">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.tau_tr">
    <dcterms:description>transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.N_rb">
    <dcterms:description>reverse cooperativity constant for SERCA pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_CaADP">
    <dcterms:description>calcium off-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current_i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_MgATP">
    <dcterms:description>time constant for transfer of magnesium-bound ATP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.Ca_JSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.beta_prime">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_CaATP">
    <dcterms:description>calcium off-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_m_gate.alpha_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.stim_end">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_MgADP">
    <dcterms:description>time constant for transfer of magnesium-bound ADP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.J_xfer">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>free calcium flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#plateau_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.k_c_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PC2 - PO1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current.X_to1">
    <dcterms:description>transient outward potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.J_trpn">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>buffering of calcium by troponin C</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.v1">
    <dcterms:description>maximum ryanodine receptor channel calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_Mg">
    <dcterms:description>time constant for transfer of free magnesium from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.K_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.J_xfer">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>free calcium flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.g">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>transition rate out of open state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.ADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Mg_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_21">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:18420"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic magnesium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sarcolemmal_calcium_pump.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.K21">
    <dcterms:description>activation curve of reverse rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.tau_X_kr">
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    <dcterms:description>fraction of ryanodine receptor channels in state PC2</dcterms:description>
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  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.ADP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_19"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
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    <dcterms:description>fraction of ryanodine receptor channels in state PC1</dcterms:description>
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    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This CellML model runs in both COR and OpenCell to recreate the published results.  The units have been checked and they are consistent. We thank the original model author Anushka Michailova for providing us with the MATLAB code for the 2001 model on which this 2005 model is based. Please note when running a simultaion the step size has to be smaller than 0.005 seconds.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: Changes in cytosolic free Mg(2+) and adenosine nucleotide phosphates affect cardiac excitability and contractility. To investigate how modulation by Mg(2+), ATP, and ADP of K(ATP) and L-type Ca(2+) channels influences excitation-contraction coupling, we incorporated equations for intracellular ATP and MgADP regulation of the K(ATP) current and MgATP regulation of the L-type Ca(2+) current in an ionic-metabolic model of the canine ventricular myocyte. The new model: 1), quantitatively reproduces a dose-response relationship for the effects of changes in ATP on K(ATP) current, 2), simulates effects of ADP in modulating ATP sensitivity of K(ATP) channel, 3), predicts activation of Ca(2+) current during rapid increase in MgATP, and 4), demonstrates that decreased ATP/ADP ratio with normal total Mg(2+) or increased free Mg(2+) with normal ATP and ADP activate K(ATP) current, shorten action potential, and alter ionic currents and intracellular Ca(2+) signals. The model predictions are in agreement with experimental data measured under normal and a variety of pathological conditions.&lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="katp_channel_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;imagedata fileref="michailova_2005_katp.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;Schematic representation of Kir6.2 and SUR2A subunit stoichiometry in cardiac octameric KATP channel. It is assumed that the single ATP molecule is sufficient to close the channel and that the binding of 2MgADP molecules to one SUR2A subunit increases the channel open probability.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
      &lt;informalfigure float="0" id="cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;imagedata fileref="michailova_2005_fullcell.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;Schematic diagram of the full cell model illustrating Ca2+ and Mg2+ buffering and transport by ATP and ADP, adenine nucleotides regulation of ionic channels and pumps, and electrophysiology in a ventricular myocyte.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Modeling Regulation of Cardiac KATP and L-type Ca2+ Currents by ATP, ADP, and Mg2+, Anushka Michailova, Jeffrey Saucerman, Mary Ellen Belik, and Andrew D. McCulloch, 2005,&#xD;
        &lt;emphasis&gt;Biophysical Journal&lt;/emphasis&gt;&#xD;
        .&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15738467"&gt;PubMed ID: 18339738&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
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    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.a">
    <dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current_y_gate.y">
    <dcterms:description>L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.K_mNa_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_K1_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.K_mEGTA">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for EGTA</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.N_fb">
    <dcterms:description>forward cooperativity constant for SERCA pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.k_ltrpn_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium on-rate for troponin low affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_i_to1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.K_mK_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.J_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>ryanodine receptor channel calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_MgATP">
    <dcterms:description>magnesium on-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_j_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.stim_start">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.CSQN_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_18">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_14"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total concentration of EGTA</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_K1_gate.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.K_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current_i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.X_ks">
    <dcterms:description>slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_X_to1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current_y_gate.tau_y">
    <dcterms:description>activation time constant of L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current_y_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.ATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.Ca_NSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_13"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.V_myo">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_potassium_pump.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.k_ATP">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane_V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.k_MgADP">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for magnesium-bound ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.j">
    <dcterms:description>sodium current slow inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel.k_b_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO2 - PO1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.i_Ca_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#ATP_sensitive_potassium_current.g_K_ATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>ATP-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Na_Ca_exchanger.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_Ca_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.beta">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_m_gate.E0_m">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_h_gate.alpha_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current_i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.ATP_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_2005.cellml#entity_22">
        <bqbiol:isPartOf rdf:resource="./michailova_2005.cellml#entity_23"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total ATP concentration</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#RyR_channel_J_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>ryanodine receptor channel calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.ATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_20"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.h">
    <dcterms:description>sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.Mg_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace magnesium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#Ca_and_Mg_buffering_by_ATP.MgATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.f">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>transition rate into open state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.b">
    <dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#SERCA2a_pump.Vmaxr">
    <dcterms:description>maximum SERCA reverse pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.K12">
    <dcterms:description>activation curve of forward rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_background_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#L_type_Ca_current.C_sc">
    <dcterms:description>specific membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current_i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_to1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sodium_background_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.X_ks">
    <dcterms:description>slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#time_independent_potassium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.K_mCMDN">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sarcolemmal_calcium_pump.K_mpCa">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-saturation constant for sarcolemmal calcium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_Ca_fluxes.Ca_NSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_13"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#fast_sodium_current.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#extracellular_ion_concentrations.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#membrane.i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#slow_activating_delayed_rectifiyer_K_current.E_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>slow delayed rectifier current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#sarcolemmal_calcium_pump.MgATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_2005.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#transient_outward_potassium_current_X_to1_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#intracellular_ion_concentrations.i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_2005.cellml#calcium_background_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
</rdf:RDF>