Location: Calcium Dynamics Annotations @ 110f9ba31e34 / michailova_mcculloch_2001 / model / michailova_mcculloch_2001.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-24 21:37:35+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/michailova_mcculloch_2001/model/michailova_mcculloch_2001.rdf
Compare... Download Source 

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.I_NaK">
    <dcterms:description>maximum sodium-potassium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.Ca_JSR">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_9">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_10">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62387"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.K_rb">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_6">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_3">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>reverse half-saturation constant for calcium ATPase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.stim_amplitude">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_X_to1_gate.beta_X_to1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.P_K">
    <dcterms:description>potassium permeability of L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.omega">
    <dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.i_Ca_max">
    <dcterms:description>calcium current at maximum potassium permeability of L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_j_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.Na_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_j_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.O">
    <dcterms:description>fraction of open L-type calcium channels</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_Y_to1_gate.alpha_Y_to1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.C_sc">
    <dcterms:description>specific membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.P_O2">
    <dcterms:description>fraction of ryanodine receptor channels in state PO2</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.g_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum rapid potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#model_parameters.V_myo">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current_i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current_i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_MgATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>magnesium-bound ATP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_CaADP">
    <dcterms:description>calcium off-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.MgATP_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_8">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.tau_xfer">
    <dcterms:description>transfer time constant from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.CaADP_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_17">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.alpha">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.g_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum time-independent potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_CaATP">
    <dcterms:description>calcium off-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.gprime">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>transition rate out of open state for calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.K21">
    <dcterms:description>activation curve of reverse rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.k_c_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PC2 - PO1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.k_b_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO2 - PO1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.Ca_JSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Mg_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_21">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:18420"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic magnesium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.J_trpn">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>buffering of calcium by troponin C</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_y_gate.y">
    <dcterms:description>L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C1">
    <dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.Na_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_0">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_1">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_h_gate.alpha_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.tau_X_kr">
    <dcterms:description>activation time constant of rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.V_NSR">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_12">
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.K_mK_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_4">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.beta_b">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.J_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>ryanodine receptor channel calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_h_gate.h">
    <dcterms:description>sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current_Kp_gate.Kp_V">
    <dcterms:description>activation potential of plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP_MgATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump.MgATP_i0">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_background_current_i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C0">
    <dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.k_ltrpn_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium off-rate for troponin low affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.K_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_5">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.k_ltrpn_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium on-rate for troponin low affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.R_V">
    <dcterms:description>activation potential of rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Ca_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.ATP_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_19">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_Y_to1_gate.Y_to1">
    <dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_background_current.g_Nab">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum background sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.LTRPNCa">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_13">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound troponin low-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#extracellular_ion_concentrations.Ca_o">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_7">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_1"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.V_myo">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#model_parameters.V_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of subspace</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current.Kp_V">
    <dcterms:description>activation potential of plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.ADP_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_24">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_23">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67196"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total ADP concentration</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.MgATP_i0">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.K1_infinity_V">
    <dcterms:description>steady-state function of time-independent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.ADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_17"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.f">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>transition rate into open state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.O_Ca">
    <dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_m_gate.alpha_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.CaATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_19"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_X_to1_gate.X_to1">
    <dcterms:description>transient outward potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C_Ca4">
    <dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_y_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.alpha_a">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.CMDN_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_14">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62343"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total concentration of myoplasmic calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.V_myo">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.ATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.g">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>transition rate out of open state</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.V_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of subspace</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_i_to1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.X_ks_infinity">
    <dcterms:description>steady state function of slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_X_to1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C_Ca3">
    <dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.K_mCSQN">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_11">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_12"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calsequestrin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_CaADP">
    <dcterms:description>calcium on-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.HTRPN_tot">
    <dcterms:description>total concentration of troponin high-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current_Kp_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_m_gate.m">
    <dcterms:description>sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_y_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_CaATP">
    <dcterms:description>calcium on-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.K_mNa">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>sodium half-saturation constant for sodium-calcium exchange</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C_Ca2">
    <dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.MgATP_i0">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP_Jxfer_CaADP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium-bound ADP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump_i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.K_sat">
    <dcterms:description>saturation factor of sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C_Ca1">
    <dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump.K_mpCa">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-saturation constant for sarcolemmal calcium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.Ca_NSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.C_sc">
    <dcterms:description>specific membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Ca_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_m_gate.E0_m">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump.I_pCa">
    <dcterms:description>maximum sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump.MgATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.K_mEGTA">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for EGTA</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.m">
    <dcterms:description>ryanodine receptor calcium cooperativity parameter PO1 - PO2</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.K12">
    <dcterms:description>activation curve of forward rapid potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C_Ca0">
    <dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_j_gate.alpha_j">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.stim_period">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Ca_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.K_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current_i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.n">
    <dcterms:description>ryanodine receptor calcium cooperativity parameter PC1 - PO1</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.N_fb">
    <dcterms:description>forward cooperativity constant for SERCA pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.MgADP_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_18">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.v1">
    <dcterms:description>maximum ryanodine receptor channel calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.X_ks">
    <dcterms:description>slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.X_kr">
    <dcterms:description>rapid potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.k_htrpn_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium on-rate for troponin high affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_m_gate.beta_m">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.Ca_NSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.Ca_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.Vmaxf">
    <dcterms:description>maximum SERCA forward pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.k_minus_CaADP">
    <dcterms:description>calcium off-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_MgATP">
    <dcterms:description>magnesium on-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_i_Ca_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>potassium current through L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current.Y_to1">
    <dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes_J_tr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.k_minus_CaATP">
    <dcterms:description>calcium off-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_plus_MgADP">
    <dcterms:description>magnesium on-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C_sc">
    <dcterms:description>specific membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.CaADP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.tau_X_ks">
    <dcterms:description>activation time constant of slow potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.fprime">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>transition rate into open state for calcium mode</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.V_JSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_to1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#michailova_2001"
     semsim:modelName="michailova_2001"
     bqmodel:isDescribedBy="11463611">
    <semsim:unknown>ventricular myocyte@en</semsim:unknown>
    <semsim:unknown>Michailova and McCulloch's mathematical model of ATP and ADP buffering, transport of Ca and Mg, and regulation of ion pumps in ventricular myocytes.@en</semsim:unknown>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This CellML model runs in both COR and OpenCell to recreate the published results.  The units have been checked and they are consistent. We thank the original model author Anushka Michailova for providing us with the MATLAB code for this model. Please note when running a simultaion the step size has to be smaller than 0.005 seconds.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: We extended the model of the ventricular myocyte by Winslow et al. (Circ. Res 1999, 84:571-586) by incorporating equations for Ca(2+) and Mg(2+) buffering and transport by ATP and ADP and equations for MgATP regulation of ion transporters (Na(+)-K(+) pump, sarcolemmal and sarcoplasmic Ca(2+) pumps). The results indicate that, under normal conditions, Ca(2+) binding by low-affinity ATP and diffusion of CaATP may affect the amplitude and time course of intracellular Ca(2+) signals. The model also suggests that a fall in ATP/ADP ratio significantly reduces sarcoplasmic Ca(2+) content, increases diastolic Ca(2+), lowers systolic Ca(2+), increases Ca(2+) influx through L-type channels, and decreases the efficiency of the Na(+)/Ca(2+) exchanger in extruding Ca(2+) during periodic voltage-clamp stimulation. The analysis suggests that the most important reason for these changes during metabolic inhibition is the down-regulation of the sarcoplasmic Ca(2+)-ATPase pump by reduced diastolic MgATP levels. High Ca(2+) concentrations developed near the membrane might have a greater influence on Mg(2+), ATP, and ADP concentrations than that of the lower Ca(2+) concentrations in the bulk myoplasm. The model predictions are in general agreement with experimental observations measured under normal and pathological conditions.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte, Anushka Michailova and Andrew McCulloch, 2001,&#xD;
        &lt;emphasis&gt;Biophysical Journal&lt;/emphasis&gt;&#xD;
        , 81, 614-629.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/pubmed/11463611"&gt;PubMed ID: 11463611&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;cell diagram&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="michailova_mcculloch_2001.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;Schematic diagram of the mechanisms involved in the model.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
    <semsim:modelName>michailova_mcculloch_2001</semsim:modelName>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.ADP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_to1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>transient outward potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.J_trpn">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>buffering of calcium by troponin C</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.A_cap">
    <dcterms:description>capacitive membrane area</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_MgADP">
    <dcterms:description>time constant for transfer of magnesium-bound ADP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_CaATP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium-bound ATP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_MgATP">
    <dcterms:description>time constant for transfer of magnesium-bound ATP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.stim_start">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.k_htrpn_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>calcium off-rate for troponin high affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.K_mCMDN">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for calmodulin</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.ATP_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_22">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_23"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total ATP concentration</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.i_Ca_half">
    <dcterms:description>calcium current at half potassium permeability of L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.X_kr_inf">
    <dcterms:description>steady state function of rapid potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current.X_to1">
    <dcterms:description>transient outward potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.K_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current.g_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum plateau potassium channel conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.Ca_JSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger_i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_y_gate.tau_y">
    <dcterms:description>activation time constant of L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.K1_infinity_V">
    <dcterms:description>steady-state function of time-independent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.CaADP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_X_to1_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes_J_xfer">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>free calcium flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.a">
    <dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.stim_end">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current.g_to1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum transient outward potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Mg_ss">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_20">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:18420"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace magnesium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.K_mCa">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for sodium-calcium exchange</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.b">
    <dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.P_C1">
    <dcterms:description>fraction of ryanodine receptor channels in state PC1</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.ATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_19"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.P_Ca">
    <dcterms:description>calcium permeability of L-type calcium channel</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.K_mK1">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>calcium half-saturation constant for time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.beta">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>fast sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.g_Cab">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum background calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.X_kr">
    <dcterms:description>rapid potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.P_C2">
    <dcterms:description>fraction of ryanodine receptor channels in state PC2</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.m">
    <dcterms:description>sodium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_X_to1_gate.alpha_X_to1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.Na_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.N_rb">
    <dcterms:description>reverse cooperativity constant for SERCA pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.g_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum slow potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP_Jxfer_Mg">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>free magnesium flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_Y_to1_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current_Kp_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.K_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.MgATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_19"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel_J_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>ryanodine receptor channel calcium flux</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane_V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_Mg">
    <dcterms:description>time constant for transfer of free magnesium from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#plateau_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.k_plus_CaATP">
    <dcterms:description>calcium on-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Kr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>rapid-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.V_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of subspace</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.J_LTRPNCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux to low-affinity troponin sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.K_fb">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>forward half-saturation constant for calcium ATPase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_Y_to1_gate.beta_Y_to1">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#extracellular_ion_concentrations.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.ADP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_background_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.J_HTRPNCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux to high-affinity troponin sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.k_b_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO1 - PO2 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.MgATP_i0">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>resting myoplasmic magnesium-bound ATP concentration in normal conditions</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.h">
    <dcterms:description>sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.tau_tr">
    <dcterms:description>transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current_Y_to1_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_K1">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>time-independent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>slow-activating delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_j_gate.beta_j">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_y_gate.y_infinity">
    <dcterms:description>steady state function of L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.k_plus_CaADP">
    <dcterms:description>calcium on-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#calcium_background_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.J_tr">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C4">
    <dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current_K1_gate.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.y">
    <dcterms:description>L-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.j">
    <dcterms:description>sodium current slow inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.CaATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#rapid_activating_delayed_rectifiyer_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP_CaADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_17"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.Vmaxr">
    <dcterms:description>maximum SERCA reverse pumping rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C3">
    <dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.MgADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.C2">
    <dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.Ca_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free subspace calcium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.MgATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of magnesium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.K_mNa_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.CaATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.k_a_minus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO1 - PC1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.CSQN_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_16">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_12"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total concentration of EGTA</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.E_Ks">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>slow delayed rectifier current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.Jxfer_MgADP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>magnesium-bound ADP flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current.K_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.eta">
    <dcterms:description>voltage dependence factor of sodium-calcium exchange</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#L_type_Ca_current_i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.CaATP_ss">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_19"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound subspace ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.P_O1">
    <dcterms:description>fraction of ryanodine receptor channels in state PO1</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.k_c_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PO1 - PC2 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Na_b">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium background current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_potassium_pump.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.ADP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_17"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#transient_outward_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#environment_time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_MgATP">
    <dcterms:description>magnesium off-rate constant for ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.EGTA_tot">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#entity_15">
        <bqbiol:isPartOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_3"/>
        <bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30741"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>total concentration of EGTA</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#time_independent_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_NaCa">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium-calcium exchanger current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#slow_activating_delayed_rectifiyer_K_current.X_ks">
    <dcterms:description>slow potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.J_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_CaADP">
    <dcterms:description>time constant for transfer of calcium-bound ADP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Kp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>plateau potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.k_minus_MgADP">
    <dcterms:description>magnesium off-rate constant for ADP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.HTRPNCa">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_13"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium-bound troponin high-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_j_gate.j">
    <dcterms:description>sodium current slow inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#SERCA2a_pump_J_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#extracellular_ion_concentrations.Na_o">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular sodium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_NaK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sodium-potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.stim_duration">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.tau_xfer_CaATP">
    <dcterms:description>time constant for transfer of calcium-bound ATP from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.Ca_NSR">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sarcolemmal_calcium_pump_i_p_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>modified sarcolemmal calcium pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_ion_concentrations.J_xfer">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>free calcium flux from subspace to myoplasm</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#membrane.i_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#intracellular_Ca_fluxes.LTRPN_tot">
    <dcterms:description>total concentration of troponin low-affinity sites</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#RyR_channel.k_a_plus">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
    <dcterms:description>ryanodine receptor PC1 - PO1 rate constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Ca_and_Mg_buffering_by_ATP.ATP_i">
    <bqbiol:isPropertyOf rdf:resource="./michailova_mcculloch_2001.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of free myoplasmic ATP</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current_h_gate.beta_h">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#sodium_background_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#Na_Ca_exchanger.K_NaCa">
    <dcterms:description>scale factor of sodium-calcium exchanger</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./michailova_mcculloch_2001.cellml#fast_sodium_current.g_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
    <dcterms:description>maximum sodium channel conductance</dcterms:description>
  </rdf:Description>
</rdf:RDF>