- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-24 21:37:35+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/rice_winslow_jafri_1999/model/rice_winslow_jafri_1999.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="rice_winslow_jafri_1999" cmeta:id="RJW_model_1999">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Functional Ca2+ Release Unit</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Calcium-induced calcium release (CICR) in cardiac muscle displays both gradedness and high gain. It is graded because release of Ca
<superscript>2+</superscript>
from the sarcoplasmic reticulum (SR) is proportional to the influx of trigger Ca
<superscript>2+</superscript>
, and high gain refers to the observation that Ca
<superscript>2+</superscript>
release from the SR is much greater than the trigger influx. Inherent to such high-gain systems is positive feedback, which causes an all-or-nothing response rather than graded Ca
<superscript>2+</superscript>
release. Such behaviour is predicted by all mathematical models in which sarcolemmal Ca
<superscript>2+</superscript>
influx and SR Ca
<superscript>2+</superscript>
release are directed into a single compartment, or common pool model.
</para>
<para>
The previous (1998) model of cardiac calcium handling, (see
<ulink url="${HTML_EXMPL_JRW_MODEL}">Jafri-Rice-Winslow Ventricular Model, 1998</ulink>
) by the authors was an example of a common pool model. While it was able to simulate frequency-dependent aspects of cardiac Ca
<superscript>2+</superscript>
cycling and high gain, it also displayed an all-or-none rather than a graded Ca
<superscript>2+</superscript>
release. By contrast, their 1999 model (see the figure below) is based on functional release units (FRUs) formulated from one sarcolemmal dihydropyridine receptor (DHPR), eight ryanodine receptor (RyR) channels, and the volume (subspace) surrounding them. It is assumed that a variable number of independent FRUs can be recruited to produce graded Ca
<superscript>2+</superscript>
release. Voltage-gated DHPR channels open adjacent RyRs via a localised increase in [Ca
<superscript>2+</superscript>
].
</para>
<para>
Results obtained with the stochastic model suggest that high gain and gradedness can occur by the recruitment of independent FRUs without requiring spatial [Ca
<superscript>2+</superscript>
] gradients within a functional unit, or coupling between adjacent units.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/77/4/1871">
Modeling Gain and Gradedness of Ca
<superscript>2+</superscript>
Release in the Functional Unit of the Cardiac Diadic Space
</ulink>
John J. Rice, Saleet Jafri and Raimond L. Winslow, 1999,
<ulink url="http://www.biophysj.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>
, 77, 1871-1884. (
<ulink url="http://www.biophysj.org/cgi/content/full/77/4/1871">Full text</ulink>
and
<ulink url="http://www.biophysj.org/cgi/reprint/77/4/1871.pdf">PDF</ulink>
versions of the article are available for Journal Members on the Biophysical Journal website.)
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10512809&dopt=Abstract">PubMed ID: 10512809</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell_diagram</title>
</objectinfo>
<imagedata fileref="rice_1999.png" />
</imageobject>
</mediaobject>
<caption>A) Schematic diagram of the functional release unit model. B) State diagram of the DHPR Channel. C) State diagram of the RyR channel.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="micromolar">
<unit prefix="micro" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="second_order_rate_constant">
<unit exponent="-1.0" units="micromolar" />
<unit exponent="-1.0" units="second" />
</units>
<units name="per_micromolar">
<unit exponent="-1.0" units="micromolar" />
</units>
<units name="flux">
<unit exponent="-1.0" units="second" />
<unit units="micromolar" />
</units>
<units name="microA_per_microF">
<unit exponent="-1.0" prefix="micro" units="farad" />
<unit prefix="micro" units="ampere" />
</units>
<units name="first_order_rate_constant">
<unit exponent="-1.0" units="second" />
</units>
<units name="millivolt">
<unit prefix="milli" units="volt" />
</units>
<units name="coulomb_per_mole">
<unit units="coulomb" />
<unit exponent="-1.0" units="mole" />
</units>
<units name="micro_litre">
<unit prefix="micro" units="litre" />
</units>
<units name="cm_per_millisecond">
<unit exponent="-1.0" units="millisecond" />
<unit prefix="centi" units="metre" />
</units>
<units name="millimolar">
<unit exponent="-1.0" units="litre" />
<unit prefix="milli" units="mole" />
</units>
<units name="micrometre">
<unit prefix="micro" units="metre" />
</units>
<units name="joule_per_mole_kelvin">
<unit exponent="-1.0" units="mole" />
<unit units="joule" />
<unit exponent="-1.0" units="kelvin" />
</units>
<units name="millisecond">
<unit prefix="milli" units="second" />
</units>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="second" />
</component>
<component name="sarcolemma">
<variable cmeta:id="sarcolemma.V" initial_value="-84.624" name="V" public_interface="out" units="millivolt" />
<variable cmeta:id="sarcolemma.R" initial_value="8.314" name="R" public_interface="out" units="joule_per_mole_kelvin" />
<variable cmeta:id="sarcolemma.T" initial_value="310.0" name="T" public_interface="out" units="kelvin" />
<variable cmeta:id="sarcolemma.F" initial_value="96500.0" name="F" public_interface="out" units="coulomb_per_mole" />
<variable cmeta:id="sarcolemma.Ca_o" initial_value="1.8" name="Ca_o" public_interface="out" units="millimolar" />
</component>
<component name="subspace">
<variable cmeta:id="subspace.V_SS" initial_value="2.03E-12" name="V_SS" public_interface="out" units="micro_litre" />
<variable cmeta:id="subspace.J_RyR" name="J_RyR" public_interface="out" units="flux" />
<variable cmeta:id="subspace.Ca_SS" name="Ca_SS" public_interface="out" units="micromolar" />
<variable cmeta:id="subspace.J_DHPR" name="J_DHPR" units="flux" />
<variable cmeta:id="subspace.DHPR_open" name="DHPR_open" units="dimensionless" />
<variable cmeta:id="subspace.RyR_open" name="RyR_open" units="dimensionless" />
<variable cmeta:id="subspace.I_DHPR" name="I_DHPR" units="microA_per_microF" />
<variable cmeta:id="subspace.J_RyR_perm" initial_value="3960.0" name="J_RyR_perm" units="first_order_rate_constant" />
<variable cmeta:id="subspace.beta_SS" name="beta_SS" units="micromolar" />
<variable cmeta:id="subspace.B_SR" initial_value="47.0" name="B_SR" units="micromolar" />
<variable cmeta:id="subspace.K_BSR" initial_value="0.87" name="K_BSR" units="micromolar" />
<variable cmeta:id="subspace.B_SL" initial_value="1124.0" name="B_SL" units="micromolar" />
<variable cmeta:id="subspace.K_BSL" initial_value="8.7" name="K_BSL" units="micromolar" />
<variable cmeta:id="subspace.P_Ca" initial_value="1.51E-11" name="P_Ca" units="cm_per_millisecond" />
<variable cmeta:id="subspace.J_xfer" name="J_xfer" units="flux" />
<variable cmeta:id="subspace.tau_xfer" initial_value="0.0007" name="tau_xfer" units="millisecond" />
<variable cmeta:id="subspace.Ca_myo" initial_value="0.1" name="Ca_myo" units="micromolar" />
<variable cmeta:id="subspace.i" initial_value="0.0" name="i" units="dimensionless" />
<variable cmeta:id="subspace.V_myo" initial_value="0.1" name="V_myo" units="micro_litre" />
<variable cmeta:id="subspace.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="subspace.time" name="time" public_interface="in" units="millisecond" />
<variable cmeta:id="subspace.R" name="R" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="subspace.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="subspace.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="subspace.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="subspace.O" name="O" public_interface="in" units="millimolar" />
<variable cmeta:id="subspace.O_Ca" name="O_Ca" public_interface="in" units="millimolar" />
<variable cmeta:id="subspace.P_O3" name="P_O3" public_interface="in" units="millimolar" />
<variable cmeta:id="subspace.P_O4" name="P_O4" public_interface="in" units="millimolar" />
<variable cmeta:id="subspace.Ca_JSR" name="Ca_JSR" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1" cmeta:id="1">
<apply id="J_xfer_calculation">
<eq />
<ci>J_xfer</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>tau_xfer</ci>
</apply>
<apply>
<minus />
<ci>Ca_SS</ci>
<ci>Ca_myo</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1a" cmeta:id="1a">
<apply id="J_DHPR_calculation">
<eq />
<ci>J_DHPR</ci>
<apply>
<divide />
<apply>
<times />
<ci>I_DHPR</ci>
<ci>DHPR_open</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>F</ci>
<ci>V_SS</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1b" cmeta:id="1b">
<apply id="I_DHPR_calculation">
<eq />
<ci>I_DHPR</ci>
<apply>
<times />
<ci>P_Ca</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<apply>
<divide />
<apply>
<times />
<ci>V</ci>
<apply>
<power />
<ci>F</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1c" cmeta:id="1c">
<apply id="DHPR_open_calculation">
<eq />
<ci>DHPR_open</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<or />
<apply>
<eq />
<ci>i</ci>
<ci>O</ci>
</apply>
<apply>
<eq />
<ci>i</ci>
<ci>O_Ca</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1d" cmeta:id="1d">
<apply id="J_RyR_calculation">
<eq />
<ci>J_RyR</ci>
<apply>
<sum />
<bvar>
<ci>i</ci>
</bvar>
<lowlimit>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
</lowlimit>
<uplimit>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8.0</cn>
</uplimit>
<apply>
<times />
<ci>J_RyR_perm</ci>
<ci>RyR_open</ci>
<apply>
<minus />
<ci>Ca_JSR</ci>
<ci>Ca_SS</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1e" cmeta:id="1e">
<apply id="RyR_open_calculation">
<eq />
<ci>RyR_open</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<or />
<apply>
<eq />
<ci>i</ci>
<ci>P_O3</ci>
</apply>
<apply>
<eq />
<ci>i</ci>
<ci>P_O4</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1f" cmeta:id="1f">
<apply id="calcium_subspace_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SS</ci>
</apply>
<apply>
<times />
<ci>beta_SS</ci>
<apply>
<plus />
<ci>J_DHPR</ci>
<ci>J_RyR</ci>
<apply>
<times />
<apply>
<divide />
<ci>V_myo</ci>
<ci>V_SS</ci>
</apply>
<ci>J_xfer</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1g" cmeta:id="1g">
<apply id="beta_SS_calculation">
<eq />
<ci>beta_SS</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<apply>
<times />
<ci>B_SR</ci>
<ci>K_BSR</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_BSR</ci>
<ci>Ca_SS</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>B_SL</ci>
<ci>K_BSL</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_BSL</ci>
<ci>Ca_SS</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-1.0</cn>
</apply>
</apply>
</math>
</component>
<component name="sarcoplasmic_reticulum">
<variable cmeta:id="sarcoplasmic_reticulum.Ca_JSR" name="Ca_JSR" public_interface="out" units="micromolar" />
<variable cmeta:id="sarcoplasmic_reticulum.V_JSR" initial_value="2.03E-12" name="V_JSR" units="micro_litre" />
<variable cmeta:id="sarcoplasmic_reticulum.beta_JSR" name="beta_JSR" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum.CSQN_tot" initial_value="15.0" name="CSQN_tot" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum.K_CSQN" initial_value="0.8" name="K_CSQN" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum.J_tr" name="J_tr" units="flux" />
<variable cmeta:id="sarcoplasmic_reticulum.tau_tr" initial_value="0.005" name="tau_tr" units="millisecond" />
<variable cmeta:id="sarcoplasmic_reticulum.Ca_NSR" initial_value="800.0" name="Ca_NSR" units="micromolar" />
<variable cmeta:id="sarcoplasmic_reticulum.J_RyR" name="J_RyR" public_interface="in" units="flux" />
<variable cmeta:id="sarcoplasmic_reticulum.V_SS" name="V_SS" public_interface="in" units="micro_litre" />
<variable cmeta:id="sarcoplasmic_reticulum.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="2" cmeta:id="2">
<apply id="calcium_JSR_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_JSR</ci>
</apply>
<apply>
<times />
<ci>beta_JSR</ci>
<apply>
<minus />
<ci>J_tr</ci>
<apply>
<times />
<apply>
<divide />
<ci>V_SS</ci>
<ci>V_JSR</ci>
</apply>
<ci>J_RyR</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="2a" cmeta:id="2a">
<apply id="beta_JSR_calculation">
<eq />
<ci>beta_JSR</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<apply>
<times />
<ci>CSQN_tot</ci>
<ci>K_CSQN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_CSQN</ci>
<ci>Ca_JSR</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">-1.0</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="2b" cmeta:id="2b">
<apply id="J_tr_calculation">
<eq />
<ci>J_tr</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<ci>tau_tr</ci>
</apply>
<apply>
<minus />
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C0" cmeta:id="C0">
<variable cmeta:id="C0.C0" name="C0" public_interface="out" units="dimensionless" />
<variable cmeta:id="C0.C1" name="C1" public_interface="in" units="dimensionless" />
<variable cmeta:id="C0.C_Ca0" name="C_Ca0" public_interface="in" units="dimensionless" />
<variable cmeta:id="C0.alpha" name="alpha" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C0.beta" name="beta" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C0.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C0.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="3">
<apply>
<eq />
<ci>C0</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C1</ci>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C_Ca0</ci>
<ci>omega</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C0</ci>
<ci>gamma</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C1" cmeta:id="C1">
<variable cmeta:id="C1.C1" name="C1" public_interface="out" units="dimensionless" />
<variable cmeta:id="C1.C0" name="C0" public_interface="in" units="dimensionless" />
<variable cmeta:id="C1.C2" name="C2" public_interface="in" units="dimensionless" />
<variable cmeta:id="C1.C_Ca1" name="C_Ca1" public_interface="in" units="micromolar" />
<variable cmeta:id="C1.alpha" name="alpha" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C1.beta" name="beta" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C1.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C1.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C1.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C1.b" name="b" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="4">
<apply>
<eq />
<ci>C1</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C_Ca1</ci>
<apply>
<divide />
<ci>omega</ci>
<ci>b</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C1</ci>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C1</ci>
<ci>gamma</ci>
<ci>a</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C2" cmeta:id="C2">
<variable cmeta:id="C2.C2" name="C2" public_interface="out" units="dimensionless" />
<variable cmeta:id="C2.C1" name="C1" public_interface="in" units="dimensionless" />
<variable cmeta:id="C2.C3" name="C3" public_interface="in" units="dimensionless" />
<variable cmeta:id="C2.C_Ca2" name="C_Ca2" public_interface="in" units="dimensionless" />
<variable cmeta:id="C2.alpha" name="alpha" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C2.beta" name="beta" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C2.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C2.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C2.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C2.b" name="b" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="5">
<apply>
<eq />
<ci>C2</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C_Ca2</ci>
<apply>
<divide />
<ci>omega</ci>
<apply>
<power />
<ci>b</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C2</ci>
<ci>gamma</ci>
<apply>
<power />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C3" cmeta:id="C3">
<variable cmeta:id="C3.C3" name="C3" public_interface="out" units="dimensionless" />
<variable cmeta:id="C3.C2" name="C2" public_interface="in" units="dimensionless" />
<variable cmeta:id="C3.C4" name="C4" public_interface="in" units="dimensionless" />
<variable cmeta:id="C3.C_Ca3" name="C_Ca3" public_interface="in" units="dimensionless" />
<variable cmeta:id="C3.alpha" name="alpha" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C3.beta" name="beta" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C3.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C3.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C3.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C3.b" name="b" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="6">
<apply>
<eq />
<ci>C3</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C4</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C_Ca3</ci>
<apply>
<divide />
<ci>omega</ci>
<apply>
<power />
<ci>b</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C3</ci>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>C3</ci>
<ci>gamma</ci>
<apply>
<power />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C4" cmeta:id="C4">
<variable cmeta:id="C4.C4" name="C4" public_interface="out" units="dimensionless" />
<variable cmeta:id="C4.C3" name="C3" public_interface="in" units="dimensionless" />
<variable cmeta:id="C4.O" name="O" public_interface="in" units="dimensionless" />
<variable cmeta:id="C4.C_Ca4" name="C_Ca4" public_interface="in" units="dimensionless" />
<variable cmeta:id="C4.alpha" name="alpha" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.beta" name="beta" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.b" name="b" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.f" name="f" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C4.g" name="g" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="7">
<apply>
<eq />
<ci>C4</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C3</ci>
<ci>alpha</ci>
</apply>
<apply>
<times />
<ci>O</ci>
<ci>g</ci>
</apply>
<apply>
<times />
<ci>C_Ca4</ci>
<apply>
<divide />
<ci>omega</ci>
<apply>
<power />
<ci>b</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C4</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>beta</ci>
</apply>
<apply>
<times />
<ci>C4</ci>
<ci>f</ci>
</apply>
<apply>
<times />
<ci>C4</ci>
<ci>gamma</ci>
<apply>
<power />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="O" cmeta:id="O">
<variable cmeta:id="O.O" name="O" public_interface="out" units="dimensionless" />
<variable cmeta:id="O.C4" name="C4" public_interface="in" units="dimensionless" />
<variable cmeta:id="O.f" name="f" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="O.g" name="g" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="8">
<apply>
<eq />
<ci>O</ci>
<apply>
<minus />
<apply>
<times />
<ci>C4</ci>
<ci>f</ci>
</apply>
<apply>
<times />
<ci>O</ci>
<ci>g</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_Ca0" cmeta:id="C_Ca0">
<variable cmeta:id="C_Ca0.C_Ca0" name="C_Ca0" public_interface="out" units="dimensionless" />
<variable cmeta:id="C_Ca0.C0" name="C0" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca0.C_Ca1" name="C_Ca1" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca0.alpha_" name="alpha_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca0.beta_" name="beta_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca0.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca0.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="9">
<apply>
<eq />
<ci>C_Ca0</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C0</ci>
<ci>gamma</ci>
</apply>
<apply>
<times />
<ci>C_Ca1</ci>
<ci>beta_</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C_Ca0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca0</ci>
<ci>omega</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_Ca1" cmeta:id="C_Ca1">
<variable cmeta:id="C_Ca1.C_Ca1" name="C_Ca1" public_interface="out" units="dimensionless" />
<variable cmeta:id="C_Ca1.C_Ca0" name="C_Ca0" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca1.C_Ca2" name="C_Ca2" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca1.C1" name="C1" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca1.alpha_" name="alpha_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca1.beta_" name="beta_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca1.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca1.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca1.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca1.b" name="b" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="10">
<apply>
<eq />
<ci>C_Ca1</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C_Ca0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C1</ci>
<ci>gamma</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C_Ca1</ci>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C_Ca1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca1</ci>
<apply>
<divide />
<ci>omega</ci>
<ci>b</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_Ca2" cmeta:id="C_Ca2">
<variable cmeta:id="C_Ca2.C_Ca2" name="C_Ca2" public_interface="out" units="dimensionless" />
<variable cmeta:id="C_Ca2.C_Ca1" name="C_Ca1" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca2.C_Ca3" name="C_Ca3" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca2.C2" name="C2" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca2.alpha_" name="alpha_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca2.beta_" name="beta_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca2.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca2.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca2.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca2.b" name="b" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="11">
<apply>
<eq />
<ci>C_Ca2</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C_Ca1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C2</ci>
<ci>gamma</ci>
<apply>
<power />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C_Ca2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C_Ca2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca2</ci>
<apply>
<divide />
<ci>omega</ci>
<apply>
<power />
<ci>b</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_Ca3" cmeta:id="C_Ca3">
<variable cmeta:id="C_Ca3.C_Ca3" name="C_Ca3" public_interface="out" units="dimensionless" />
<variable cmeta:id="C_Ca3.C_Ca2" name="C_Ca2" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca3.C_Ca4" name="C_Ca4" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca3.C3" name="C3" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca3.alpha_" name="alpha_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca3.beta_" name="beta_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca3.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca3.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca3.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca3.b" name="b" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="12">
<apply>
<eq />
<ci>C_Ca3</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C_Ca2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca4</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C3</ci>
<ci>gamma</ci>
<apply>
<power />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C_Ca3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C_Ca3</ci>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>C_Ca3</ci>
<apply>
<divide />
<ci>omega</ci>
<apply>
<power />
<ci>b</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_Ca4" cmeta:id="C_Ca4">
<variable cmeta:id="C_Ca4.C_Ca4" name="C_Ca4" public_interface="out" units="dimensionless" />
<variable cmeta:id="C_Ca4.C_Ca3" name="C_Ca3" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca4.O_Ca" name="O_Ca" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca4.C4" name="C4" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_Ca4.alpha_" name="alpha_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.beta_" name="beta_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.omega" name="omega" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.gamma" name="gamma" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.a" name="a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.b" name="b" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.f_" name="f_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="C_Ca4.g_" name="g_" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="13">
<apply>
<eq />
<ci>C_Ca4</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>C_Ca3</ci>
<ci>alpha_</ci>
</apply>
<apply>
<times />
<ci>O_Ca</ci>
<ci>g_</ci>
</apply>
<apply>
<times />
<ci>C4</ci>
<ci>gamma</ci>
<apply>
<power />
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>C_Ca4</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
<ci>beta_</ci>
</apply>
<apply>
<times />
<ci>C_Ca4</ci>
<ci>f_</ci>
</apply>
<apply>
<times />
<ci>C_Ca4</ci>
<apply>
<divide />
<ci>omega</ci>
<apply>
<power />
<ci>b</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="O_Ca" cmeta:id="O_Ca">
<variable cmeta:id="O_Ca.O_Ca" name="O_Ca" public_interface="out" units="dimensionless" />
<variable cmeta:id="O_Ca.C_Ca4" name="C_Ca4" public_interface="in" units="dimensionless" />
<variable cmeta:id="O_Ca.f_" name="f_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="O_Ca.g_" name="g_" public_interface="in" units="first_order_rate_constant" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="14">
<apply>
<eq />
<ci>O_Ca</ci>
<apply>
<minus />
<apply>
<times />
<ci>C_Ca4</ci>
<ci>f_</ci>
</apply>
<apply>
<times />
<ci>O_Ca</ci>
<ci>g_</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_C1" cmeta:id="P_C1">
<variable cmeta:id="P_C1.P_C1" name="P_C1" public_interface="out" units="dimensionless" />
<variable cmeta:id="P_C1.k12" name="k12" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C1.k21" name="k21" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C1.P_C2" name="P_C2" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="15">
<apply>
<eq />
<ci>P_C1</ci>
<apply>
<minus />
<apply>
<times />
<ci>P_C2</ci>
<ci>k21</ci>
</apply>
<apply>
<times />
<ci>P_C1</ci>
<ci>k12</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_C2" cmeta:id="P_C2">
<variable cmeta:id="P_C2.P_C2" name="P_C2" public_interface="out" units="dimensionless" />
<variable cmeta:id="P_C2.k12" name="k12" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C2.k21" name="k21" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C2.k23" name="k23" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C2.k32" name="k32" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C2.k25" name="k25" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C2.k52" name="k52" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C2.P_C1" name="P_C1" public_interface="in" units="dimensionless" />
<variable cmeta:id="P_C2.P_O3" name="P_O3" public_interface="in" units="dimensionless" />
<variable cmeta:id="P_C2.P_C5" name="P_C5" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="16">
<apply>
<eq />
<ci>P_C2</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>P_C1</ci>
<ci>k12</ci>
</apply>
<apply>
<times />
<ci>P_O3</ci>
<ci>k32</ci>
</apply>
<apply>
<times />
<ci>P_C5</ci>
<ci>k52</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>P_C2</ci>
<ci>k21</ci>
</apply>
<apply>
<times />
<ci>P_C2</ci>
<ci>k23</ci>
</apply>
<apply>
<times />
<ci>P_C2</ci>
<ci>k25</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_O3" cmeta:id="P_O3">
<variable cmeta:id="P_O3.P_O3" name="P_O3" public_interface="out" units="dimensionless" />
<variable cmeta:id="P_O3.k23" name="k23" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O3.k32" name="k32" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O3.k34" name="k34" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O3.k43" name="k43" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O3.P_C2" name="P_C2" public_interface="in" units="dimensionless" />
<variable cmeta:id="P_O3.P_O4" name="P_O4" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="17">
<apply>
<eq />
<ci>P_O3</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>P_C2</ci>
<ci>k23</ci>
</apply>
<apply>
<times />
<ci>P_O4</ci>
<ci>k43</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>P_O3</ci>
<ci>k32</ci>
</apply>
<apply>
<times />
<ci>P_O3</ci>
<ci>k34</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_O4" cmeta:id="P_O4">
<variable cmeta:id="P_O4.P_O4" name="P_O4" public_interface="out" units="dimensionless" />
<variable cmeta:id="P_O4.k45" name="k45" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O4.k54" name="k54" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O4.k34" name="k34" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O4.k43" name="k43" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_O4.P_C5" name="P_C5" public_interface="in" units="dimensionless" />
<variable cmeta:id="P_O4.P_O3" name="P_O3" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="18">
<apply>
<eq />
<ci>P_O4</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>P_O3</ci>
<ci>k34</ci>
</apply>
<apply>
<times />
<ci>P_C5</ci>
<ci>k54</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>P_O4</ci>
<ci>k43</ci>
</apply>
<apply>
<times />
<ci>P_O4</ci>
<ci>k45</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_C5" cmeta:id="P_C5">
<variable cmeta:id="P_C5.P_C5" name="P_C5" public_interface="out" units="dimensionless" />
<variable cmeta:id="P_C5.k45" name="k45" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C5.k54" name="k54" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C5.k56" name="k56" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C5.k65" name="k65" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C5.k25" name="k25" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C5.k52" name="k52" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C5.P_C2" name="P_C2" public_interface="in" units="dimensionless" />
<variable cmeta:id="P_C5.P_O4" name="P_O4" public_interface="in" units="dimensionless" />
<variable cmeta:id="P_C5.P_C6" name="P_C6" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="19">
<apply>
<eq />
<ci>P_C5</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>P_C2</ci>
<ci>k25</ci>
</apply>
<apply>
<times />
<ci>P_O4</ci>
<ci>k45</ci>
</apply>
<apply>
<times />
<ci>P_C6</ci>
<ci>k65</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>P_C5</ci>
<ci>k52</ci>
</apply>
<apply>
<times />
<ci>P_C5</ci>
<ci>k54</ci>
</apply>
<apply>
<times />
<ci>P_C5</ci>
<ci>k56</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_C6" cmeta:id="P_C6">
<variable cmeta:id="P_C6.P_C6" name="P_C6" public_interface="out" units="dimensionless" />
<variable cmeta:id="P_C6.k56" name="k56" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C6.k65" name="k65" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="P_C6.P_C5" name="P_C5" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="20">
<apply>
<eq />
<ci>P_C6</ci>
<apply>
<minus />
<apply>
<times />
<ci>P_C6</ci>
<ci>k65</ci>
</apply>
<apply>
<times />
<ci>P_C5</ci>
<ci>k56</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="DHPR_transition_probabilities">
<variable cmeta:id="DHPR_transition_probabilities.alpha" name="alpha" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.gamma" name="gamma" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.beta" name="beta" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.alpha_" name="alpha_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.beta_" name="beta_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.omega" initial_value="10.0" name="omega" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.a" initial_value="2.0" name="a" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.b" initial_value="2.0" name="b" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.f" initial_value="300.0" name="f" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.g" initial_value="2000.0" name="g" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.f_" initial_value="5.0" name="f_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.g_" initial_value="7000.0" name="g_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="DHPR_transition_probabilities.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="DHPR_transition_probabilities.Ca_SS" name="Ca_SS" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="21" cmeta:id="21">
<apply id="gamma_calculation">
<eq />
<ci>gamma</ci>
<apply>
<times />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second_order_rate_constant">0.1875</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="21a" cmeta:id="21a">
<apply id="alpha_calculation">
<eq />
<ci>alpha</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="first_order_rate_constant">0.4</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.0</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="21b" cmeta:id="21b">
<apply id="beta_calculation">
<eq />
<ci>beta</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="first_order_rate_constant">0.05</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.0</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">29.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="21c" cmeta:id="21c">
<apply id="alpha__calculation">
<eq />
<ci>alpha_</ci>
<apply>
<times />
<ci>alpha</ci>
<ci>a</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="21d" cmeta:id="21d">
<apply id="beta__calculation">
<eq />
<ci>beta_</ci>
<apply>
<divide />
<ci>beta</ci>
<ci>b</ci>
</apply>
</apply>
</math>
</component>
<component name="RyR_transition_probabilities">
<variable cmeta:id="RyR_transition_probabilities.k12" name="k12" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k21" initial_value="2.5E5" name="k21" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k23" name="k23" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k32" initial_value="9.6E3" name="k32" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k34" name="k34" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k43" initial_value="1.3E4" name="k43" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k54" name="k54" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k45" initial_value="66.67" name="k45" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k25" name="k25" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k52" initial_value="1.235" name="k52" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k56" name="k56" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.k65" initial_value="3.0E6" name="k65" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="RyR_transition_probabilities.Ca_SS" name="Ca_SS" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22" cmeta:id="22">
<apply>
<eq />
<ci>k12</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0E6</cn>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">2.68</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22a" cmeta:id="22a">
<apply>
<eq />
<ci>k23</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0E7</cn>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">2.68</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22b" cmeta:id="22b">
<apply>
<eq />
<ci>k34</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0E6</cn>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">2.68</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22c" cmeta:id="22c">
<apply>
<eq />
<ci>k54</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">198.0</cn>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">2.68</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22d" cmeta:id="22d">
<apply>
<eq />
<ci>k25</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0E5</cn>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">2.68</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22e" cmeta:id="22e">
<apply>
<eq />
<ci>k56</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0E6</cn>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">2.68</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>Ca_SS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="C_Ca2" component_2="C_Ca3" />
<map_variables variable_1="C_Ca2" variable_2="C_Ca2" />
</connection>
<connection>
<map_components component_1="C_Ca3" component_2="C_Ca4" />
<map_variables variable_1="C_Ca3" variable_2="C_Ca3" />
</connection>
<connection>
<map_components component_1="C_Ca0" component_2="C0" />
<map_variables variable_1="C_Ca0" variable_2="C_Ca0" />
</connection>
<connection>
<map_components component_1="RyR_transition_probabilities" component_2="P_O3" />
<map_variables variable_1="k32" variable_2="k32" />
<map_variables variable_1="k43" variable_2="k43" />
<map_variables variable_1="k23" variable_2="k23" />
<map_variables variable_1="k34" variable_2="k34" />
</connection>
<connection>
<map_components component_1="P_O4" component_2="P_O3" />
<map_variables variable_1="P_O4" variable_2="P_O4" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C_Ca0" />
<map_variables variable_1="beta_" variable_2="beta_" />
<map_variables variable_1="alpha_" variable_2="alpha_" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="omega" variable_2="omega" />
</connection>
<connection>
<map_components component_1="sarcoplasmic_reticulum" component_2="subspace" />
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C_Ca3" />
<map_variables variable_1="beta_" variable_2="beta_" />
<map_variables variable_1="alpha_" variable_2="alpha_" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="a" variable_2="a" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C_Ca2" />
<map_variables variable_1="beta_" variable_2="beta_" />
<map_variables variable_1="alpha_" variable_2="alpha_" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="a" variable_2="a" />
</connection>
<connection>
<map_components component_1="C0" component_2="C_Ca0" />
<map_variables variable_1="C0" variable_2="C0" />
</connection>
<connection>
<map_components component_1="C2" component_2="C3" />
<map_variables variable_1="C2" variable_2="C2" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C_Ca1" />
<map_variables variable_1="beta_" variable_2="beta_" />
<map_variables variable_1="alpha_" variable_2="alpha_" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="a" variable_2="a" />
</connection>
<connection>
<map_components component_1="environment" component_2="sarcoplasmic_reticulum" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="C1" component_2="C2" />
<map_variables variable_1="C1" variable_2="C1" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="O_Ca" />
<map_variables variable_1="g_" variable_2="g_" />
<map_variables variable_1="f_" variable_2="f_" />
</connection>
<connection>
<map_components component_1="C_Ca4" component_2="O_Ca" />
<map_variables variable_1="C_Ca4" variable_2="C_Ca4" />
</connection>
<connection>
<map_components component_1="RyR_transition_probabilities" component_2="P_C2" />
<map_variables variable_1="k21" variable_2="k21" />
<map_variables variable_1="k32" variable_2="k32" />
<map_variables variable_1="k23" variable_2="k23" />
<map_variables variable_1="k12" variable_2="k12" />
<map_variables variable_1="k52" variable_2="k52" />
<map_variables variable_1="k25" variable_2="k25" />
</connection>
<connection>
<map_components component_1="C1" component_2="C_Ca1" />
<map_variables variable_1="C1" variable_2="C1" />
</connection>
<connection>
<map_components component_1="C4" component_2="C3" />
<map_variables variable_1="C4" variable_2="C4" />
</connection>
<connection>
<map_components component_1="P_O4" component_2="subspace" />
<map_variables variable_1="P_O4" variable_2="P_O4" />
</connection>
<connection>
<map_components component_1="sarcolemma" component_2="DHPR_transition_probabilities" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="P_O3" component_2="P_C2" />
<map_variables variable_1="P_O3" variable_2="P_O3" />
</connection>
<connection>
<map_components component_1="P_C2" component_2="P_C1" />
<map_variables variable_1="P_C2" variable_2="P_C2" />
</connection>
<connection>
<map_components component_1="C2" component_2="C_Ca2" />
<map_variables variable_1="C2" variable_2="C2" />
</connection>
<connection>
<map_components component_1="O_Ca" component_2="subspace" />
<map_variables variable_1="O_Ca" variable_2="O_Ca" />
</connection>
<connection>
<map_components component_1="C3" component_2="C2" />
<map_variables variable_1="C3" variable_2="C3" />
</connection>
<connection>
<map_components component_1="sarcolemma" component_2="subspace" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="C3" component_2="C_Ca3" />
<map_variables variable_1="C3" variable_2="C3" />
</connection>
<connection>
<map_components component_1="C_Ca3" component_2="C_Ca2" />
<map_variables variable_1="C_Ca3" variable_2="C_Ca3" />
</connection>
<connection>
<map_components component_1="subspace" component_2="RyR_transition_probabilities" />
<map_variables variable_1="Ca_SS" variable_2="Ca_SS" />
</connection>
<connection>
<map_components component_1="O" component_2="subspace" />
<map_variables variable_1="O" variable_2="O" />
</connection>
<connection>
<map_components component_1="P_C6" component_2="P_C5" />
<map_variables variable_1="P_C6" variable_2="P_C6" />
</connection>
<connection>
<map_components component_1="C_Ca1" component_2="C_Ca0" />
<map_variables variable_1="C_Ca1" variable_2="C_Ca1" />
</connection>
<connection>
<map_components component_1="C4" component_2="C_Ca4" />
<map_variables variable_1="C4" variable_2="C4" />
</connection>
<connection>
<map_components component_1="C_Ca1" component_2="C_Ca2" />
<map_variables variable_1="C_Ca1" variable_2="C_Ca1" />
</connection>
<connection>
<map_components component_1="P_C2" component_2="P_O3" />
<map_variables variable_1="P_C2" variable_2="P_C2" />
</connection>
<connection>
<map_components component_1="RyR_transition_probabilities" component_2="P_C6" />
<map_variables variable_1="k56" variable_2="k56" />
<map_variables variable_1="k65" variable_2="k65" />
</connection>
<connection>
<map_components component_1="C_Ca4" component_2="C_Ca3" />
<map_variables variable_1="C_Ca4" variable_2="C_Ca4" />
</connection>
<connection>
<map_components component_1="O" component_2="C4" />
<map_variables variable_1="O" variable_2="O" />
</connection>
<connection>
<map_components component_1="RyR_transition_probabilities" component_2="P_C5" />
<map_variables variable_1="k56" variable_2="k56" />
<map_variables variable_1="k65" variable_2="k65" />
<map_variables variable_1="k52" variable_2="k52" />
<map_variables variable_1="k54" variable_2="k54" />
<map_variables variable_1="k45" variable_2="k45" />
<map_variables variable_1="k25" variable_2="k25" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C3" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="beta" variable_2="beta" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="alpha" variable_2="alpha" />
<map_variables variable_1="a" variable_2="a" />
</connection>
<connection>
<map_components component_1="subspace" component_2="DHPR_transition_probabilities" />
<map_variables variable_1="Ca_SS" variable_2="Ca_SS" />
</connection>
<connection>
<map_components component_1="C_Ca0" component_2="C_Ca1" />
<map_variables variable_1="C_Ca0" variable_2="C_Ca0" />
</connection>
<connection>
<map_components component_1="P_C1" component_2="P_C2" />
<map_variables variable_1="P_C1" variable_2="P_C1" />
</connection>
<connection>
<map_components component_1="C_Ca2" component_2="C2" />
<map_variables variable_1="C_Ca2" variable_2="C_Ca2" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C_Ca4" />
<map_variables variable_1="beta_" variable_2="beta_" />
<map_variables variable_1="g_" variable_2="g_" />
<map_variables variable_1="alpha_" variable_2="alpha_" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="a" variable_2="a" />
<map_variables variable_1="f_" variable_2="f_" />
</connection>
<connection>
<map_components component_1="P_O3" component_2="P_O4" />
<map_variables variable_1="P_O3" variable_2="P_O3" />
</connection>
<connection>
<map_components component_1="C3" component_2="C4" />
<map_variables variable_1="C3" variable_2="C3" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="O" />
<map_variables variable_1="f" variable_2="f" />
<map_variables variable_1="g" variable_2="g" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C4" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="beta" variable_2="beta" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="f" variable_2="f" />
<map_variables variable_1="alpha" variable_2="alpha" />
<map_variables variable_1="a" variable_2="a" />
<map_variables variable_1="g" variable_2="g" />
</connection>
<connection>
<map_components component_1="P_C2" component_2="P_C5" />
<map_variables variable_1="P_C2" variable_2="P_C2" />
</connection>
<connection>
<map_components component_1="P_O3" component_2="subspace" />
<map_variables variable_1="P_O3" variable_2="P_O3" />
</connection>
<connection>
<map_components component_1="P_C5" component_2="P_C6" />
<map_variables variable_1="P_C5" variable_2="P_C5" />
</connection>
<connection>
<map_components component_1="C2" component_2="C1" />
<map_variables variable_1="C2" variable_2="C2" />
</connection>
<connection>
<map_components component_1="C4" component_2="O" />
<map_variables variable_1="C4" variable_2="C4" />
</connection>
<connection>
<map_components component_1="P_O4" component_2="P_C5" />
<map_variables variable_1="P_O4" variable_2="P_O4" />
</connection>
<connection>
<map_components component_1="P_C5" component_2="P_O4" />
<map_variables variable_1="P_C5" variable_2="P_C5" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C0" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="beta" variable_2="beta" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="alpha" variable_2="alpha" />
</connection>
<connection>
<map_components component_1="C1" component_2="C0" />
<map_variables variable_1="C1" variable_2="C1" />
</connection>
<connection>
<map_components component_1="RyR_transition_probabilities" component_2="P_C1" />
<map_variables variable_1="k21" variable_2="k21" />
<map_variables variable_1="k12" variable_2="k12" />
</connection>
<connection>
<map_components component_1="P_C5" component_2="P_C2" />
<map_variables variable_1="P_C5" variable_2="P_C5" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C1" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="beta" variable_2="beta" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="alpha" variable_2="alpha" />
<map_variables variable_1="a" variable_2="a" />
</connection>
<connection>
<map_components component_1="RyR_transition_probabilities" component_2="P_O4" />
<map_variables variable_1="k43" variable_2="k43" />
<map_variables variable_1="k34" variable_2="k34" />
<map_variables variable_1="k54" variable_2="k54" />
<map_variables variable_1="k45" variable_2="k45" />
</connection>
<connection>
<map_components component_1="subspace" component_2="sarcoplasmic_reticulum" />
<map_variables variable_1="J_RyR" variable_2="J_RyR" />
<map_variables variable_1="V_SS" variable_2="V_SS" />
</connection>
<connection>
<map_components component_1="O_Ca" component_2="C_Ca4" />
<map_variables variable_1="O_Ca" variable_2="O_Ca" />
</connection>
<connection>
<map_components component_1="C_Ca1" component_2="C1" />
<map_variables variable_1="C_Ca1" variable_2="C_Ca1" />
</connection>
<connection>
<map_components component_1="C_Ca3" component_2="C3" />
<map_variables variable_1="C_Ca3" variable_2="C_Ca3" />
</connection>
<connection>
<map_components component_1="environment" component_2="subspace" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="C_Ca2" component_2="C_Ca1" />
<map_variables variable_1="C_Ca2" variable_2="C_Ca2" />
</connection>
<connection>
<map_components component_1="DHPR_transition_probabilities" component_2="C2" />
<map_variables variable_1="gamma" variable_2="gamma" />
<map_variables variable_1="beta" variable_2="beta" />
<map_variables variable_1="b" variable_2="b" />
<map_variables variable_1="omega" variable_2="omega" />
<map_variables variable_1="alpha" variable_2="alpha" />
<map_variables variable_1="a" variable_2="a" />
</connection>
<connection>
<map_components component_1="C0" component_2="C1" />
<map_variables variable_1="C0" variable_2="C0" />
</connection>
<connection>
<map_components component_1="C_Ca4" component_2="C4" />
<map_variables variable_1="C_Ca4" variable_2="C_Ca4" />
</connection>
<rdf:RDF xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:about="#C_Ca2.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.Ca_myo">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_10">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:226050" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.tau_xfer">
<dcterms:description>transfer time constant from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k43">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.J_tr">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.I_DHPR">
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#O.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.tau_tr">
<dcterms:description>transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcolemma.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#C1.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k32">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k56">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.CSQN_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_13">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>total concentration of sarcoplasmic reticulum calsequesterin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O_Ca.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.DHPR_open">
<dcterms:description>L-type calcium channel open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.P_Ca">
<dcterms:description>subspace permeability to calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O4.k34">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.C0">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.B_SR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_4">
<ro:part_of>
<rdf:Description rdf:about="#entity_5">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:80351" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:35225" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sarcoplasmic reticulum membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k21">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.P_C6">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k45">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.f">
<dcterms:description>L-type calcium channel transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C6.k65">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC6 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O4.k45">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C1.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.k32">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C3.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k34">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.J_xfer">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.g">
<dcterms:description>L-type calcium channel transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_O4.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C1.P_C1">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.Ca_JSR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_11">
<ro:part_of>
<rdf:Description rdf:about="#entity_12">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:62387" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.k43">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.f">
<dcterms:description>L-type calcium channel transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.B_SL">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_7">
<ro:part_of>
<rdf:Description rdf:about="#entity_8">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:67964" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:35225" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sarcolemmal membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.J_RyR_perm">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.RyR_open">
<dcterms:description>ryanodine receptor channel open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C4.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O.g">
<dcterms:description>L-type calcium channel transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C1.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.V_JSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_12">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62387" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C6.P_C6">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.g">
<dcterms:description>L-type calcium channel transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O_Ca.f_">
<dcterms:description>L-type calcium channel transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.P_C1">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k52">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.beta_JSR">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_12" />
<dcterms:description>junctional sarcoplasmic reticulum buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C6.k56">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcolemma.Ca_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C6.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.K_BSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_6">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>calcium dissociation constant of sarcoplasmic reticulum membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C6.k65">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC6 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_16">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67225" />
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k65">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC6 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C0.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.K_BSL">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_9">
<ro:part_of rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium dissociation constant of sarcolemmal membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k54">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.J_DHPR">
<dcterms:description>calcium flux through L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O.f">
<dcterms:description>L-type calcium channel transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.k52">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.V_SS">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_2">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62358" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O_Ca.f_">
<dcterms:description>L-type calcium channel transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.C0">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.k43">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.k23">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.K_BSL">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_9">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>calcium dissociation constant of sarcolemmal membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.I_DHPR">
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_C2.k52">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcolemma.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.C0">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.K_CSQN">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_14">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>calcium half-saturation constant of calsequestrin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.Ca_myo">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_10">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.k54">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_5">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:80351" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.Ca_SS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_3">
<ro:part_of>
<rdf:Description rdf:about="#entity_2">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:62358" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in subspace</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.Ca_JSR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C1.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.g_">
<dcterms:description>L-type calcium channel transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.V_SS">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_2" />
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcolemma.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.V_SS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.k25">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcolemma.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O_Ca.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C0.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022" />
</rdf:Description>
<rdf:Description rdf:about="#C1.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.C0">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C6.P_C6">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.k34">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.beta_SS">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_2" />
<dcterms:description>subspace buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcolemma.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.B_SL">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_7">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:35225" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of sarcolemmal membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.Ca_NSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_15">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.f_">
<dcterms:description>L-type calcium channel transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_C2.P_C1">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C6.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.k43">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.J_RyR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux out of the sarcoplasmic reticulum via ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.k32">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.J_xfer">
<dcterms:description>calcium flux from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.k54">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.J_DHPR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux through L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.V_myo">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C1.k12">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC1 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C0.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.K_BSR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium dissociation constant of sarcoplasmic reticulum membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.k32">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.k21">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.k34">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.C0">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O_Ca.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.K_CSQN">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:62353" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium half-saturation constant of calsequestrin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.k45">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.k52">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C0.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.k65">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC6 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.Ca_SS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in subspace</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k52">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.J_RyR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium flux out of the sarcoplasmic reticulum via ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_C5.k54">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.k12">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC1 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.f_">
<dcterms:description>L-type calcium channel transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.k25">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k65">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC6 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.B_SR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_4">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:35225" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of sarcoplasmic reticulum membrane buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_C5.k65">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC6 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.Ca_SS">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_3">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of calcium in subspace</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.V_myo">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_10" />
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.f">
<dcterms:description>L-type calcium channel transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C1.k21">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.P_C6">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O3.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_C5.k52">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.CSQN_tot">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_13">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:62353" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>total concentration of sarcoplasmic reticulum calsequesterin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.k56">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.Ca_JSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_11">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.g">
<dcterms:description>L-type calcium channel transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k43">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.DHPR_open">
<dcterms:description>L-type calcium channel open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C2.k23">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.V_SS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.k45">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C0.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.C2">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k54">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_8">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67964" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca0.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcolemma.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.beta_JSR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>junctional sarcoplasmic reticulum buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C0.C0">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C1.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcolemma.Ca_o">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#entity_0">
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.J_RyR">
<dcterms:description>calcium flux out of the sarcoplasmic reticulum via ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C0.C1">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O_Ca.g_">
<dcterms:description>L-type calcium channel transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.P_Ca">
<dcterms:description>subspace permeability to calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C1.P_C1">
<dcterms:description>fraction of ryanodine receptor channels in resting state PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.tau_tr">
<dcterms:description>transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcolemma.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RJW_model_1999" bqmodel:isDescribedBy="10512809" />
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.P_C5">
<dcterms:description>fraction of ryanodine receptor channels in refractory state PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.k45">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C4.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.k25">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.Ca_o">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_0" />
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C2.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.Ca_JSR">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_11" />
<dcterms:description>concentration of calcium in junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O.f">
<dcterms:description>L-type calcium channel transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.J_RyR">
<dcterms:description>calcium flux out of the sarcoplasmic reticulum via ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.k56">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.Ca_NSR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_15">
<ro:part_of>
<rdf:Description rdf:about="#entity_16">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:67225" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in network sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C1.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca1.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.k32">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C5.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O.g">
<dcterms:description>L-type calcium channel transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k25">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.Ca_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C6.k56">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#O_Ca.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.f_">
<dcterms:description>L-type calcium channel transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C0.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C5.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#P_C1.k12">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC1 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k12">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC1 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.tau_xfer">
<dcterms:description>transfer time constant from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#sarcoplasmic_reticulum.J_tr">
<dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.Ca_SS">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_3" />
<dcterms:description>concentration of calcium in subspace</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.beta_SS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>subspace buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.f">
<dcterms:description>L-type calcium channel transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca2.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.J_RyR_perm">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca0.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.k21">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.g_">
<dcterms:description>L-type calcium channel transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.g">
<dcterms:description>L-type calcium channel transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O_Ca.g_">
<dcterms:description>L-type calcium channel transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#subspace.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.Ca_SS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in subspace</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O4.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#O.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.k12">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC1 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k23">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.k34">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.Ca_SS">
<bqbiol:isPropertyOf rdf:resource="rice_winslow_jafri_1999.cellml#entity_3" />
<dcterms:description>concentration of calcium in subspace</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O4.k43">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k21">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k45">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO4 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.C4">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca1.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O4.P_O3">
<dcterms:description>fraction of ryanodine receptor channels in open state PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.k23">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k12">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC1 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C3.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_O4.k54">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C3.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca3.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k32">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k56">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC5 to PC6</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.f_">
<dcterms:description>L-type calcium channel transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#subspace.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410" />
</rdf:Description>
<rdf:Description rdf:about="#C_Ca2.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.g_">
<dcterms:description>L-type calcium channel transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#DHPR_transition_probabilities.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RyR_transition_probabilities.k25">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_C1.k21">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.C3">
<dcterms:description>fraction of closed L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C2.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k23">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca4.alpha_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O4.P_O4">
<dcterms:description>fraction of ryanodine receptor channels in open state PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RJW_model_1999" semsim:modelName="rice_winslow_jafri_1999_version01" bqmodel:isDescribedBy="10512809">
<semsim:unknown>Cardiac Myocyte</semsim:unknown>
<semsim:modelName>rice_winslow_jafri_1999</semsim:modelName>
<semsim:unknown>The Rice et al. 1999 model of the functional Ca2+ release unit.</semsim:unknown>
</rdf:Description>
<rdf:Description rdf:about="#sarcolemma.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C1.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum.V_JSR">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_Ca3.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.beta_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_C2.k25">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PC5</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#P_O3.k23">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PC2 to PO3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#C_Ca4.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#subspace.RyR_open">
<dcterms:description>ryanodine receptor channel open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C4.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="rice_winslow_jafri_1999.cellml#RyR_transition_probabilities.k34">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>ryanodine receptor transition rate from state PO3 to PO4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DHPR_transition_probabilities.g_">
<dcterms:description>L-type calcium channel transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
