- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-24 21:37:35+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/110f9ba31e34b7499c8d02e13a6b9984351c0e8f/wang_sobie_2008/model/wang_sobie_2008.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.P_O1">
<dcterms:description>fraction of ryanodine receptor channels in state PO1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.i_CaT">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.k_minus_b">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO2 - PO1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.BJSR">
<dcterms:description>total junctional sarcoplasmic reticulum calcium flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.C3">
<dcterms:description>L-type calcium channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current_i_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapidly delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Cass">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_11">
<bqbiol:isPartOf>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62358"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.tau_xfer">
<dcterms:description>time constant for transfer from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Vmyo">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_0">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#slow_delayed_rectifier_potassium_current.beta_n">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.j">
<dcterms:description>sodium current slow inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.J_xfer">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux from subspace volume to the bulk myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Acap">
<dcterms:description>capacitive membrane area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.g_CaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>specific maximum conductivity for L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#environment_time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.P_O2">
<dcterms:description>fraction of ryanodine receptor channels in state PO2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes_J_leak">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium leak flux from the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.C4">
<dcterms:description>L-type calcium channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.k_minus_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO1 - PC1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_pump_current.Km_pCa">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_10">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant of sarcolemmal calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.P_RyR">
<dcterms:description>ryanodine receptor modulation factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#time_independent_potassium_current.g_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum time-independent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_background_current.g_Nab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum background sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.k_sat">
<dcterms:description>sodium-calcium exchange saturation factor at very negative potentials</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#slow_delayed_rectifier_potassium_current.alpha_n">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes_J_rel">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium release flux from the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.CaJSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_12">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62387"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of junctional sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.gamma">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Nao">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_6">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_5">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.kf">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate constant for rapid delayed-rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current_i_ClCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium-activated chloride current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.C_K1">
<dcterms:description>mERG channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.Cai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_i_CaT">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_h_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.g_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum rapid delayed-rectifier potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.VJSR">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_1"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapidly delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Km_CMDN">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.C1">
<dcterms:description>L-type calcium channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.m">
<dcterms:description>sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.beta_a1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.iss">
<dcterms:description>steady state function of potassium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_m_gate.beta_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.g_Cab">
<dcterms:description>background calcium conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#slow_delayed_rectifier_potassium_current_i_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.alpha_i">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.i_CaL_max">
<dcterms:description>normalisation constant for L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.C_K0">
<dcterms:description>mERG channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current_i_Kss">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>non-inactivating steady-state potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.beta_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.C2">
<dcterms:description>L-type calcium channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.Nai">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_17">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#time_independent_potassium_current_i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.CaJSR">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of junctional sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.Cass">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.Acap">
<dcterms:description>capacitive membrane area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.Cli">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_9">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.beta_a0">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.Kpcb">
<dcterms:description>backward voltage-insensitive rate constant for inactivation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.LTRPN_Ca">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_16">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium bound low-affinity troponin-binding sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current_i_Kur">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ultrarapidly activating delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.J_leak">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium leak flux from the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.i_Cab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_pump_current_i_pCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sarcolemmal calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.i_pCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sarcolemmal calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.g_Na">
<dcterms:description>maximum fast sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.Ki">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_18">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.Cao">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_7">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_5"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.ato_f">
<dcterms:description>transient outward potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.stim_start">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.I3">
<dcterms:description>L-type calcium channel inactivated state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.VNSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_2">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>network sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes_J_tr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.Cai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_j_gate.beta_j">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.J_trpn">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux to troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.HTRPN_Ca">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium bound high-affinity troponin-binding sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.tau_aur">
<dcterms:description>time constant for ultrarapidly activating delayed-rectifier potassium current activation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.n_ClCa">
<dcterms:description>cooperativity parameter of calcium-activated chloride current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.C_K2">
<dcterms:description>mERG channel closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Kss">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>non-inactivating steady-state potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#time_independent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_h_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#slow_delayed_rectifier_potassium_current.g_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum slow delayed-rectifier potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.Acap">
<dcterms:description>capacitive membrane area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration_CMDN_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_14">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62343"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total myoplasmic calmodulin concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_pCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sarcolemmal calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current.E_CaT">
<dcterms:description>saturation potential of T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.alpha_a0">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.alpha_i">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.beta_i">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current_i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Km_CSQN">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_13">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_2"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for calsequestrin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.CaNSR">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_13"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of network sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Cao">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.Vmyo">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.ito_f_infinity">
<dcterms:description>steady state function of transient outward potassium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.Nao">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.Km_Nai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_17"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>sodium half-saturation constant for sodium-potassium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current_i_CaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current.aKss">
<dcterms:description>non-inactivating steady-state potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.Nai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_17"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.I1">
<dcterms:description>L-type calcium channel inactivated state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.Clo">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_8">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_5"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.stim_amplitude">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.i_CaL_max">
<dcterms:description>normalisation constant for L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.Km_up">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-saturation constant for sarcoplasmic reticulum calcium-ATPase pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_b_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_pump_current.i_pCa_max">
<dcterms:description>maximum calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.Kpc_max">
<dcterms:description>maximum time constant for calcium-induced inactivation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_CaT">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_pump_current.Cai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.iur">
<dcterms:description>ultrarapidly activating delayed-rectifier potassium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.k_minus_c">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PC2 - PO1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.I2">
<dcterms:description>L-type calcium channel inactivated state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_g_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.Kpcf">
<dcterms:description>forward voltage-insensitive rate constant for inactivation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.Cm">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.Vmyo">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_m_gate.alpha_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_h_gate.h">
<dcterms:description>sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.Cass">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.i_Nab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.i_CaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.Cao">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current_i_Cab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Clo">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_stim">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>externally applied stimulus current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.Cai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_g_gate.g">
<dcterms:description>T-type calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current_i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.J_rel">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium release flux from the sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.i_CaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.P_C1">
<dcterms:description>fraction of ryanodine receptor channels in state PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.VJSR">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes_J_up">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium extrusion flux from the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.Cass">
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</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.v3">
<dcterms:description>sarcoplasmic reticulum calcium ATPase maximum pump rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current.g_Kss">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum noninactivating steady-state potassium current conductance (apex)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.O_K">
<dcterms:description>mERG channel open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_Kss">
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<dcterms:description>non-inactivating steady-state potassium current</dcterms:description>
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<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.Km_Ko">
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</rdf:Description>
</bqbiol:isPropertyOf>
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<dcterms:description>potassium half-saturation constant for sodium-potassium exchange current</dcterms:description>
</rdf:Description>
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</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Cm">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
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</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Bss">
<dcterms:description>total subspace calcium flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_m_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.J_xfer">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux from subspace volume to the bulk myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.g_Kto_f">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum transient outward potassium current conductance (septum)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.k_plus_ltrpn">
<dcterms:description>calcium on rate constant for troponin low-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.Ki">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_18"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.Nao">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.J_tr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.alpha">
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</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.k_plus_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PC1 - PO1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.E_CaL">
<dcterms:description>reversal potential for L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_g_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.tau_ito_f">
<dcterms:description>inactivation constant of transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.tau_tr">
<dcterms:description>time constant for transfer from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.ass">
<dcterms:description>steady state function of potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Vss">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_Kto_f">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapid transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.Cm">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Kur">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ultrarapidly activating delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.ito_f">
<dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration_CSQN_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#entity_15">
<bqbiol:isPartOf rdf:resource="./wang_sobie_2008.cellml#entity_1"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total junctional sarcoplasmic reticulum calsequestrin concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_b_gate.b">
<dcterms:description>T-type calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.stim_duration">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.alpha_a1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Acap">
<dcterms:description>capacitive membrane area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Cab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.g_Kur">
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<dcterms:description>maximum ultrarapidly delayed-rectifier potassium current conductance (apex)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.v1">
<dcterms:description>maximum ryanodine receptor channel calcium permeability</dcterms:description>
</rdf:Description>
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<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.E_K">
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<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_h_gate.beta_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Bi">
<dcterms:description>total intracellular calcium flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#wang_model_2008"
semsim:modelName="wang_model_2008"
bqmodel:isDescribedBy="18408122">
<semsim:modelName>wang_sobie_2008</semsim:modelName>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Mathematical model of the neonatal mouse ventricular action potential</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>ABI</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model is known to run in OpenCell and COR to recreate the published results. The units have been checked and are consistent.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: Therapies for heart disease are based largely on our understanding of the adult myocardium. The dramatic differences in action potential (AP) shape between neonatal and adult cardiac myocytes, however, indicate that a different set of molecular interactions in neonatal myocytes necessitates different treatment for newborns. Computational modeling is useful for synthesizing data to determine how interactions between components lead to systems-level behavior, but this technique has not been used extensively to study neonatal heart cell function. We created a mathematical model of the neonatal (day 1) mouse myocyte by modifying, on the basis of experimental data, the densities and/or formulations of ion transport mechanisms in an adult cell model. The new model reproduces the characteristic AP shape of neonatal cells, with a brief plateau phase and longer duration than the adult (action potential duration at 80% repolarization = 60.1 vs. 12.6 ms). The simulation results are consistent with experimental data, including 1) decreased density and altered inactivation of transient outward K+ currents, 2) increased delayed rectifier K+ currents, 3) Ca2+ entry through T-type as well as L-type Ca2+ channels, 4) increased Ca2+ influx through Na+/Ca2+ exchange, and 5) Ca2+ transients resulting from transmembrane Ca2+ entry rather than release from the sarcoplasmic reticulum (SR). Simulations performed with the model generated novel predictions, including increased SR Ca2+ leak and elevated intracellular Na+ concentration in neonatal compared with adult myocytes. This new model can therefore be used for testing hypotheses and obtaining a better quantitative understanding of differences between neonatal and adult physiology.</para>
<para>The original paper reference is cited below:</para>
<para>
Mathematical model of the neonatal mouse ventricular action potential, Linda J. Wang and Eric A. Sobie, 2008,
<emphasis>American Journal of Physiology: Heart and Circulatory Physiology</emphasis>
, 294, H2565-H2575.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=18408122&amp;amp;dopt=Abstract">PubMed ID: 18408122</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="wang_2008.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the neonatal mouse model.</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
</rdf:Description>
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<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux to troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_j_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.eta">
<dcterms:description>voltage dependence of sodium-calcium exchange</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_activated_chloride_current.Km_Cl">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-saturation constant of calcium-activated chloride current</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.k_NaCa">
<dcterms:description>scaling factor of sodium-calcium exchange</dcterms:description>
</rdf:Description>
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<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.k_plus_htrpn">
<dcterms:description>calcium on rate constant for troponin high-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering_LTRPN_tot">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total myoplasmic troponin low-affinity site concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.k_minus_ltrpn">
<dcterms:description>calcium off rate constant for troponin low-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.beta_i">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.v2">
<dcterms:description>calcium leak rate constant from the network sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current_i_Kto_f">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapid transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current.g">
<dcterms:description>T-type calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#slow_delayed_rectifier_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.k_minus_ltrpn">
<dcterms:description>calcium off rate constant for troponin low-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.m">
<dcterms:description>ryanodine receptor calcium cooperativity parameter PO1 - PO2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#time_independent_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.LTRPN_Ca">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium bound low-affinity troponin-binding sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.tau_iur">
<dcterms:description>time constant for ultrarapidly activating delayed-rectifier potassium current inactivation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.Nai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_17"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.P_O1">
<dcterms:description>fraction of ryanodine receptor channels in state PO1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.HTRPN_Ca">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium bound high-affinity troponin-binding sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_calcium_exchange_current.K_mCa">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_background_current_i_Nab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.Nao">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.HTRPN_tot">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total myoplasmic troponin high-affinity site concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.Nai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_17"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current.g_CaT">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum T-type calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.i_NaK_max">
<dcterms:description>maximum sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.Kpc_half">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-saturation constant for calcium-induced inactivation of L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.k_plus_ltrpn">
<dcterms:description>calcium on rate constant for troponin low-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.n">
<dcterms:description>ryanodine receptor calcium cooperativity parameter PC1 - PO1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Cm">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_ClCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium-activated chloride current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_b_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.alpha_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_j_gate.j">
<dcterms:description>sodium current slow inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.k_minus_htrpn">
<dcterms:description>calcium off rate constant for troponin high-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#slow_delayed_rectifier_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_j_gate.alpha_j">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Vmyo">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.J_up">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium extrusion flux from the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Cai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_g_gate.g_infinity">
<dcterms:description>steady state function of T-type calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#time_independent_potassium_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#potassium_concentration.i_Kur">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ultrarapidly activating delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_g_gate.tau_g">
<dcterms:description>activation time constant of T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.E_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.k_plus_htrpn">
<dcterms:description>calcium on rate constant for troponin high-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_h_gate.alpha_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.kb">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate constant for rapid delayed-rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Kto_f">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapid transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.Cai">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.k_minus_htrpn">
<dcterms:description>calcium off rate constant for troponin high-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current.tau_Kss">
<dcterms:description>time constant for non-inactivating steady-state potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.VNSR">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>network sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Cli">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_background_current.E_CaN">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.h">
<dcterms:description>sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_potassium_pump_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.k_plus_b">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO1 - PO2 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_concentration.Vss">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current.b">
<dcterms:description>T-type calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapidly delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#rapid_delayed_rectifier_potassium_current.I_K">
<dcterms:description>mERG channel inactivated state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_buffering.HTRPN_tot">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total myoplasmic troponin high-affinity site concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current_m_gate.m">
<dcterms:description>sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.LTRPN_tot">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total myoplasmic troponin low-affinity site concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_transient_outward_potassium_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.aur">
<dcterms:description>ultrarapidly activating delayed-rectifier potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#non_inactivating_steady_state_potassium_current.ass">
<dcterms:description>steady state function of potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ultra_rapidly_activating_delayed_rectifier_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.O">
<dcterms:description>L-type calcium channel conducting state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_b_gate.tau_b">
<dcterms:description>inactivation time constant of T-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#L_type_calcium_current.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#fast_sodium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#T_type_calcium_current_b_gate.b_infinity">
<dcterms:description>steady state function of T-type calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.P_O2">
<dcterms:description>fraction of ryanodine receptor channels in state PO2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#calcium_fluxes.CaNSR">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_13"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of network sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.Ko">
<bqbiol:isPropertyOf rdf:resource="./wang_sobie_2008.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#sodium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#ryanodine_receptors.k_plus_c">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO1 - PC2 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#time_independent_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.i_CaL">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./wang_sobie_2008.cellml#membrane.stim_period">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
</rdf:RDF>