- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 20:14:52+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/28c2ad84a0934867149129508999a36c9d0fa1cf/colegrove_albrecht_friel_2000/model/colegrove_albrecht_friel_2000.rdf
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bqmodel:isDescribedBy="10694264"
semsim:modelName="colegrove_albrecht_friel_2000">
<semsim:unknown>Quantitative analysis of mitochondrial Ca2+ uptake and release.</semsim:unknown>
<semsim:unknown>sympathetic neuron</semsim:unknown>
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<article>
<articleinfo>
<title>Quantitative Analysis Of Mitochondrial Ca2+ Uptake And Release Pathways In Sympathetic Neurons</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model can not be solved as it is unsuitably constrained.</para>
<para>ValidateCellML verifies this model as valid CellML with consistent units.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
One of the central goals in the study of calcium signalling is to understand the basis of [Ca
<superscript>2+</superscript>
] dynamics. This is complicated by the fact that Ca
<superscript>2+</superscript>
is present in several membrane-bound intracellular compartments, each of which uses a distinct Ca
<superscript>2+</superscript>
transport system and the rate of Ca
<superscript>2+</superscript>
transport between these compartments can exhibit a complex non-linear dependence on free [Ca
<superscript>2+</superscript>
].
</para>
<para>
In their 2000 model, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel have studied how mitochondrial Ca
<superscript>2+</superscript>
transport contributes to the redistribution of intracellular Ca
<superscript>2+</superscript>
during and after depolarisation-evoked Ca
<superscript>2+</superscript>
entry in sympathetic neurons. The total Ca
<superscript>2+</superscript>
flux during the recovery phase following membrane depolarisation was divided into three components (see
<xref linkend="fig_cell_diagram" />
below): one representing net Ca
<superscript>2+</superscript>
extrusion across the plasma membrane (J
<subscript>extru</subscript>
), one representing mitochondrial Ca
<superscript>2+</superscript>
uptake via the uniporter (J
<subscript>uni</subscript>
) and one representing mitochondrial Ca
<superscript>2+</superscript>
release via the Na
<superscript>+</superscript>
/Ca
<superscript>2+</superscript>
exchanger (J
<subscript>NaCa</subscript>
). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in
<xref linkend="sec_download_this_model" />
.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
Quantitative Analysis of Mitochondrial Ca
<superscript>2+</superscript>
Uptake and Release Pathways in Sympathetic Neurons
<emphasis>
Reconstruction of the Recovery after Depolarisation-evoked [Ca
<superscript>2+</superscript>
] Elevations
</emphasis>
, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel, 2000,
<emphasis>The Journal Of General Physiology</emphasis>
, 115, 371-388.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10694264&amp;dopt=Abstract">PubMed ID: 10694264</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
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<objectinfo>
<title>cell schematic for the model</title>
</objectinfo>
<imagedata fileref="colegrove_2000.png" />
</imageobject>
</mediaobject>
<caption>
Schematic of the model indicating Ca
<superscript>2+</superscript>
compartmentalization in the extracellular matrix, cytosol and the mitochondrial matrix and pathways for Ca
<superscript>2+</superscript>
ion movement between the compartments.
</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
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