- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 20:14:52+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/28c2ad84a0934867149129508999a36c9d0fa1cf/gall_susa_1999_c/model/gall_susa_1999_c.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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</rdf:Description>
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<dcterms:description>fraction of free cytoplasmic calcium</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_current_m_gate.m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
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<dcterms:description>saturation potential of M-gate calcium channel</dcterms:description>
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<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
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<dcterms:description>L-type calcium current</dcterms:description>
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</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#gall_1999"
semsim:modelName="gall_susa_1999_c"
bqmodel:isDescribedBy="10388739">
<semsim:unknown>Pancreatic Beta-Cell</semsim:unknown>
<semsim:modelName>gall_1999</semsim:modelName>
<semsim:unknown>The Gall and Susa 1999 model of Na/Ca exchange in Model III for
pancreatic beta-cells.</semsim:unknown>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Na/Ca Exchange in Models for Pancreatic Beta-Cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model represents Model III from the published paper. The CellML matches the published equations and the model runs in OpenCell and COR but it does not replicate the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling.</para>
<para>The original paper reference is cited below:</para>
<para>
Effect of Na/Ca Exchange on Plateau Fraction and [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
in Models for Bursting in Pancreatic Beta-Cells, David Gall and Isabella Susa, 1999,
<emphasis>Biophysical Journal</emphasis>
, 77, 45-53.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10388739">PubMed ID: 10388739</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell schematic for the model</title>
</objectinfo>
<imagedata fileref="gall_1999.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the pancreatic beta-cell plasma membrane showing the ionic currents captured by the three single cell mathematical models.</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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</rdf:Description>
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<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#ionic_concentrations.k_pump">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate of calcium pumping into the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_activated_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_activated_K_current.g_K_Ca">
<dcterms:description>calcium-activated potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#Na_Ca_exchanger_current.g_Na_Ca">
<dcterms:description>maximum sodium-calcium exchanger current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#membrane.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#ionic_concentrations.Na_i">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_c.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free cytosolic sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_activated_K_current.K_d">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_c.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium dissociation constant</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#Na_Ca_exchanger_current.Ca_o">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
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</rdf:Description>
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<dcterms:description>half-maximal activation potential of M-gate calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#ionic_concentrations.alpha">
<dcterms:description>factor converting current into concentration changes</dcterms:description>
</rdf:Description>
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<dcterms:description>saturation potential of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
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<dcterms:description>potassium reversal potential</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate of calcium release from the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#rapidly_activating_K_current_n_gate.n_infinity">
<dcterms:description>steady state function of delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
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</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in the endoplasmic reticulum</dcterms:description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#rapidly_activating_K_current.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant of the sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#membrane.i_Na_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#Na_Ca_exchanger_current.nH">
<dcterms:description>Hill coefficient of sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_activated_K_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_c.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#rapidly_activating_K_current.g_K">
<dcterms:description>rapid potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#Na_Ca_exchanger_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
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<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_c.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_c.cellml#rapidly_activating_K_current_n_gate.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
</rdf:RDF>
