- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 20:14:52+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/28c2ad84a0934867149129508999a36c9d0fa1cf/lemon_2003/model/lemon_2003.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="lemon_2003" cmeta:id="lemon_2003">
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<article>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model is the model which was used to produce the original results in the paper. The units have been checked and are consistent and this model is known to be valid CellML.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: A mathematical account is given of the processes governing the time courses of calcium ions (Ca2+), inositol 1,4,5-trisphosphate (IP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)) in single cells following the application of external agonist to metabotropic receptors. A model is constructed that incorporates the regulation of metabotropic receptor activity, the G-protein cascade and the Ca2+ dynamics in the cytosol. It is subsequently used to reproduce observations on the extent of desensitization and sequestration of the P(2)Y(2) receptor following its activation by uridine triphosphate (UTP). The theory predicts the dependence on agonist concentration of the change in the number of receptors in the membrane as well as the time course of disappearance of receptors from the plasmalemma, upon exposure to agonist. In addition, the extent of activation and desensitization of the receptor, using the calcium transients in cells initiated by exposure to agonist, is also predicted. Model predictions show the significance of membrane PIP(2) depletion and resupply on the time course of IP(3) and Ca2+ levels. Results of the modelling also reveal the importance of receptor recycling and PIP(2) resupply for maintaining Ca2+ and IP(3) levels during sustained application of agonist.</para>
<para>The original paper is cited below:</para>
<para>
Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. G.Lemon, W.G. Gibson and M.R. Bennett, 2003, Journal of Theoretical Biology, 223, 93-111.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/12782119">PubMed ID: 12782119</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
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<title>Diagram of model</title>
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<imagedata fileref="lemon_2003.png" />
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<caption>A schematic diagram of the processes described by the mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<apply>
<eq />
<ci>h_infinit</ci>
<apply>
<divide />
<ci>zeta</ci>
<apply>
<plus />
<ci>zeta</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="zeta">
<variable cmeta:id="zeta.zeta" name="zeta" public_interface="out" units="micromolar" />
<variable cmeta:id="zeta.d_1" name="d_1" public_interface="in" units="micromolar" />
<variable cmeta:id="zeta.d_2" name="d_2" public_interface="in" units="micromolar" />
<variable cmeta:id="zeta.d_3" name="d_3" public_interface="in" units="micromolar" />
<variable cmeta:id="zeta.IP_3" name="IP_3" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>zeta</ci>
<apply>
<divide />
<apply>
<times />
<ci>d_2</ci>
<apply>
<plus />
<ci>IP_3</ci>
<ci>d_1</ci>
</apply>
</apply>
<apply>
<plus />
<ci>IP_3</ci>
<ci>d_3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="m_infinit">
<variable cmeta:id="m_infinit.m_infinit" name="m_infinit" public_interface="out" units="dimensionless" />
<variable cmeta:id="m_infinit.d_1" name="d_1" public_interface="in" units="micromolar" />
<variable cmeta:id="m_infinit.d_5" name="d_5" public_interface="in" units="micromolar" />
<variable cmeta:id="m_infinit.IP_3" name="IP_3" public_interface="in" units="micromolar" />
<variable cmeta:id="m_infinit.C" name="C" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>m_infinit</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>IP_3</ci>
<apply>
<plus />
<ci>d_1</ci>
<ci>IP_3</ci>
</apply>
</apply>
<ci>C</ci>
</apply>
<apply>
<plus />
<ci>d_5</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="beta">
<variable cmeta:id="beta.beta" name="beta" public_interface="out" units="dimensionless" />
<variable cmeta:id="beta.K_e" name="K_e" public_interface="in" units="micromolar" />
<variable cmeta:id="beta.B_e" name="B_e" public_interface="in" units="micromolar" />
<variable cmeta:id="beta.K_x" name="K_x" public_interface="in" units="micromolar" />
<variable cmeta:id="beta.B_x" name="B_x" public_interface="in" units="micromolar" />
<variable cmeta:id="beta.C" name="C" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>beta</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>K_e</ci>
<ci>B_e</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_e</ci>
<ci>C</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>K_x</ci>
<ci>B_x</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_x</ci>
<ci>C</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="gamma">
<variable cmeta:id="gamma.gamma" name="gamma" public_interface="out" units="dimensionless" />
<variable cmeta:id="gamma.K_e" name="K_e" public_interface="in" units="micromolar" />
<variable cmeta:id="gamma.B_e" name="B_e" public_interface="in" units="micromolar" />
<variable cmeta:id="gamma.K_x" name="K_x" public_interface="in" units="micromolar" />
<variable cmeta:id="gamma.B_x" name="B_x" public_interface="in" units="micromolar" />
<variable cmeta:id="gamma.C" name="C" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>gamma</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>B_e</ci>
<apply>
<plus />
<ci>K_e</ci>
<ci>C</ci>
</apply>
</apply>
<apply>
<divide />
<ci>B_x</ci>
<apply>
<plus />
<ci>K_x</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_ER">
<variable cmeta:id="C_ER.C_ER" name="C_ER" public_interface="out" units="micromolar" />
<variable cmeta:id="C_ER.K_ER" name="K_ER" public_interface="in" units="micromolar" />
<variable cmeta:id="C_ER.B_ER" name="B_ER" public_interface="in" units="micromolar" />
<variable cmeta:id="C_ER.epsilon_r" name="epsilon_r" public_interface="in" units="dimensionless" />
<variable cmeta:id="C_ER.C_T" name="C_T" public_interface="in" units="micromolar" />
<variable cmeta:id="C_ER.C" name="C" public_interface="in" units="micromolar" />
<variable cmeta:id="C_ER.gamma" name="gamma" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>C_ER</ci>
<apply>
<times />
<apply>
<divide />
<ci>K_ER</ci>
<apply>
<times />
<ci>B_ER</ci>
<ci>epsilon_r</ci>
</apply>
</apply>
<apply>
<minus />
<ci>C_T</ci>
<apply>
<divide />
<ci>C</ci>
<ci>gamma</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
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<variable cmeta:id="RS_E.RS_E" name="RS_E" public_interface="out" units="dimensionless" />
<variable cmeta:id="RS_E.R_T" name="R_T" public_interface="in" units="dimensionless" />
<variable cmeta:id="RS_E.L" name="L" public_interface="in" units="micromolar" />
<variable cmeta:id="RS_E.K_1" name="K_1" public_interface="in" units="micromolar" />
<variable cmeta:id="RS_E.K_2" name="K_2" public_interface="in" units="micromolar" />
<variable cmeta:id="RS_E.k_r" name="k_r" public_interface="in" units="per_second" />
<variable cmeta:id="RS_E.k_p" name="k_p" public_interface="in" units="per_second" />
<variable cmeta:id="RS_E.k_e" name="k_e" public_interface="in" units="per_second" />
<variable cmeta:id="RS_E.xi" name="xi" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>RS_E</ci>
<apply>
<plus />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>k_r</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<ci>k_p</ci>
<ci>k_e</ci>
</apply>
<apply>
<plus />
<ci>K_2</ci>
<ci>L</ci>
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</apply>
<apply>
<plus />
<ci>K_1</ci>
<ci>L</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<ci>k_r</ci>
<apply>
<divide />
<apply>
<times />
<ci>k_p</ci>
<ci>L</ci>
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<apply>
<plus />
<ci>K_1</ci>
<ci>L</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>k_r</ci>
<ci>k_p</ci>
</apply>
<ci>k_e</ci>
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<apply>
<plus />
<ci>K_2</ci>
<ci>L</ci>
</apply>
</apply>
<apply>
<plus />
<ci>K_1</ci>
<ci>L</ci>
</apply>
</apply>
</apply>
</apply>
<ci>xi</ci>
<ci>R_T</ci>
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<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>xi</ci>
</apply>
<ci>R_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
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<map_components component_1="Parameters" component_2="PIP_2" />
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<map_variables variable_1="N_a" variable_2="N_a" />
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<connection>
<map_components component_1="ligand" component_2="rho_r" />
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<connection>
<map_components component_1="Parameters" component_2="RS_E" />
<map_variables variable_1="xi" variable_2="xi" />
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<map_variables variable_1="R_T" variable_2="R_T" />
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<connection>
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<connection>
<map_components component_1="Parameters" component_2="zeta" />
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_1="Parameters" component_2="RS" />
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_1="Parameters" component_2="G_GTP" />
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_1="RS" component_2="rho_r" />
<map_variables variable_1="RS" variable_2="RS" />
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<connection>
<map_components component_1="rho_r" component_2="G_GTP" />
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<connection>
<map_components component_1="Parameters" component_2="IP_3" />
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<connection>
<map_components component_1="ligand" component_2="RS_E" />
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<connection>
<map_components component_1="environment" component_2="C" />
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<connection>
<map_components component_1="environment" component_2="G_GTP" />
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<connection>
<map_components component_1="r_h" component_2="IP_3" />
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<connection>
<map_components component_1="Parameters" component_2="C" />
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<map_variables variable_1="eta_2" variable_2="eta_2" />
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<connection>
<map_components component_1="Parameters" component_2="beta" />
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<map_variables variable_1="K_x" variable_2="K_x" />
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<connection>
<map_components component_1="environment" component_2="PIP_2" />
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<connection>
<map_components component_1="zeta" component_2="tau_h" />
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<connection>
<map_components component_1="Parameters" component_2="tau_h" />
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<connection>
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<connection>
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<connection>
<map_components component_1="environment" component_2="RS_p" />
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<connection>
<map_components component_1="environment" component_2="h" />
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<rdf:RDF xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:about="#Parameters.delta">
<dcterms:description>G-protein intrinsic activity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_h.G">
<dcterms:description>amount of active G-protein</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#zeta.d_1">
<bqbiol:isPropertyOf>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:66835" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.k_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein deactivation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#m_infinit.m_infinit">
<dcterms:description>steady state fraction of IP3 channels inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_h.zeta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/go/GO:0005829" />
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</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Michaelis-Menten constant of IP3 channel calcium-binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.K_x">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#rho_r.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#m_infinit.IP_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_7">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:16595" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.m_infinit">
<dcterms:description>steady state fraction of IP3 channels inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.eta_2">
<dcterms:description>effective endoplasmic reticulum leak permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.eta_2">
<dcterms:description>effective endoplasmic reticulum leak permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#zeta.zeta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Michaelis-Menten constant of IP3 channel calcium-binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h_infinit.h_infinit">
<dcterms:description>steady state fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#zeta.d_2">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#m_infinit.d_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.K_2">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>phosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#m_infinit.IP_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.v">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>volume of cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.xi">
<dcterms:description>fraction of mobile receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#m_infinit.d_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.k_deg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.k_e">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#beta.B_e">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#r_h.C">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="lemon_2003.cellml#entity_2">
<bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.G">
<dcterms:description>amount of active G-protein</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.alpha">
<dcterms:description>effective signal gain parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.eta_3">
<dcterms:description>effective calcium pump permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.eta_1">
<dcterms:description>effective IP3 channel permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.B_ER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_3">
<ro:part_of>
<rdf:Description rdf:about="#entity_4">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:63842" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:35225" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h.h_infinit">
<dcterms:description>steady state fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma.B_x">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_54">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h_infinit.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.N_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01622" />
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.k_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein activation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.k_deg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.N_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01622" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#zeta.d_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#r_h.alpha">
<dcterms:description>effective signal gain parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.m_infinit">
<dcterms:description>steady state fraction of IP3 channels inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_ER.B_ER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_58">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h.tau_h">
<dcterms:description>time constant of IP3 channel inactivation by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.v">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>volume of cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.RS_p">
<dcterms:description>number of phosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#r_h.r_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of PIP2 hydrolysis</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.RS_E">
<dcterms:description>equilibrium number of surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_deg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.k_deg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.K_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_63">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>phosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.epsilon_r">
<dcterms:description>ratio of endoplasmic reticulum to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ligand.L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:52214" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rho_r.xi">
<dcterms:description>fraction of mobile receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#beta.B_x">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_ER.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_60">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.epsilon_r">
<dcterms:description>ratio of endoplasmic reticulum to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.PIP_2_T">
<dcterms:description>total number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.C_ER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_31">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_5">
<ro:part_of rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.a_2">
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#tau_h.zeta">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>Michaelis-Menten constant of IP3 channel calcium-binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.k_e">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.r_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>PIP2 replenishment rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.r_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of PIP2 hydrolysis</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma.B_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_52">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:35225" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#zeta.IP_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.N_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01622" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#rho_r.rho_r">
<dcterms:description>ratio of number of ligand bound receptors to total number of receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.PIP_2_T">
<dcterms:description>total number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant for calcium binding to phospholipase C</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>pump dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rho_r.RS">
<dcterms:description>total number of unphosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.N_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01622" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.a_2">
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#zeta.zeta">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>Michaelis-Menten constant of IP3 channel calcium-binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rho_r.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.K_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.k_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein deactivation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_e">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.r_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of PIP2 hydrolysis</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.r_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of PIP2 hydrolysis</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.RS">
<dcterms:description>total number of unphosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.eta_2">
<dcterms:description>effective endoplasmic reticulum leak permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h.h">
<dcterms:description>fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.K_e">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma.K_x">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_53">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.K_2">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>phosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h.h_infinit">
<dcterms:description>steady state fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.PIP_2_T">
<dcterms:description>total number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#m_infinit.d_5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.rho_r">
<dcterms:description>ratio of number of ligand bound receptors to total number of receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#m_infinit.d_5">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.gamma">
<dcterms:description>ratio of free to total cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_ER.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_59">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>total concentration of calcium in terms of cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.B_ER">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="lemon_2003.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:63842" />
</rdf:Description>
</bqbiol:isPropertyOf>
<dcterms:description>concentration of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#gamma.gamma">
<dcterms:description>ratio of free to total cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein deactivation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#beta.B_x">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_49">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.K_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>phosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.K_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_62">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.K_ER">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_1" />
<dcterms:description>dissociation constant of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.B_e">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.eta_3">
<dcterms:description>effective calcium pump permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.IP_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_55">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.r_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>PIP2 replenishment rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.r_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>PIP2 replenishment rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.k_e">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#rho_r.rho_r">
<dcterms:description>ratio of number of ligand bound receptors to total number of receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.r_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of PIP2 hydrolysis</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Parameters.K_ER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.G_T">
<dcterms:description>total number of G-protein moleculues</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.K_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.K_ER">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_1" />
<dcterms:description>dissociation constant of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h_infinit.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_36">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.PIP_2">
<dcterms:description>number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.h">
<dcterms:description>fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#RS.RS_p">
<dcterms:description>number of phosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.RS_p">
<dcterms:description>number of phosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rho_r.L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_28">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.B_ER">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_1" />
<dcterms:description>concentration of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.PIP_2">
<dcterms:description>number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#rho_r.RS">
<dcterms:description>total number of unphosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.k_deg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#tau_h.tau_h">
<dcterms:description>time constant of IP3 channel inactivation by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.d_5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.epsilon_r">
<dcterms:description>ratio of endoplasmic reticulum to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.K_x">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.RS">
<dcterms:description>total number of unphosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.G_T">
<dcterms:description>total number of G-protein moleculues</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#rho_r.K_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_h.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant for calcium binding to phospholipase C</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Parameters.eta_3">
<dcterms:description>effective calcium pump permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.K_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#C_ER.C_ER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_56">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#gamma.B_x">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.C_ER">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_1" />
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.alpha">
<dcterms:description>effective signal gain parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.k_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>pump dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h_infinit.zeta">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>Michaelis-Menten constant of IP3 channel calcium-binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.k_e">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.K_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>phosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>volume of cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.delta">
<dcterms:description>G-protein intrinsic activity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_h.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein activation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein activation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.d_5">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#ligand.L">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h.tau_h">
<dcterms:description>time constant of IP3 channel inactivation by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#zeta.IP_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_51">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.K_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.L">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.delta">
<dcterms:description>G-protein intrinsic activity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.k_deg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.d_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.delta">
<dcterms:description>G-protein intrinsic activity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.K_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#gamma.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.PIP_2">
<dcterms:description>number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h_infinit.h_infinit">
<dcterms:description>steady state fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_ER.epsilon_r">
<dcterms:description>ratio of endoplasmic reticulum to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#zeta.d_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#h.h">
<dcterms:description>fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_ER.gamma">
<dcterms:description>ratio of free to total cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.eta_1">
<dcterms:description>effective IP3 channel permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#C.beta">
<dcterms:description>calcium buffering coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#m_infinit.m_infinit">
<dcterms:description>steady state fraction of IP3 channels inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>volume of cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#beta.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.C_ER">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_1" />
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_ER.K_ER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_57">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of endoplasmic reticulum endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.v">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>volume of cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.RS_E">
<dcterms:description>equilibrium number of surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.N_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01622" />
</rdf:Description>
<rdf:Description rdf:about="#beta.B_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.d_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.PIP_2_T">
<dcterms:description>total number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#gamma.B_e">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#beta.beta">
<dcterms:description>calcium buffering coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.L">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_h.a_2">
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein deactivation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.K_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#zeta.d_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Parameters.B_x">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.G">
<dcterms:description>amount of active G-protein</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.RS_p">
<dcterms:description>number of phosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.h">
<dcterms:description>fraction of IP3 channels not yet inactivated by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.L">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.eta_2">
<dcterms:description>effective endoplasmic reticulum leak permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>total concentration of calcium in terms of cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#gamma.K_x">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.K_c">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant for calcium binding to phospholipase C</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>pump dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#beta.K_e">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.d_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.C_T">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>total concentration of calcium in terms of cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.IP_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.B_x">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_h.tau_h">
<dcterms:description>time constant of IP3 channel inactivation by calcium binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.K_2">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>phosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma.gamma">
<dcterms:description>ratio of free to total cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.epsilon_r">
<dcterms:description>ratio of endoplasmic reticulum to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_e">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#tau_h.a_2">
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#zeta.d_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_40">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#lemon_2003" semsim:modelName="lemon_2003" bqmodel:isDescribedBy="12782119">
<semsim:unknown>The Lemon et al. 2003 model of calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation</semsim:unknown>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#r_h.K_c">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant for calcium binding to phospholipase C</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C_ER.C_T">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>total concentration of calcium in terms of cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.eta_1">
<dcterms:description>effective IP3 channel permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.PIP_2">
<dcterms:description>number of PIP2 molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.eta_3">
<dcterms:description>effective calcium pump permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.RS">
<dcterms:description>total number of unphosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h_infinit.zeta">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_35">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Michaelis-Menten constant of IP3 channel calcium-binding</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.epsilon_r">
<dcterms:description>ratio of endoplasmic reticulum to cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.xi">
<dcterms:description>fraction of mobile receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#beta.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_50">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.beta">
<dcterms:description>calcium buffering coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#gamma.K_e">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_p.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#m_infinit.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.d_1">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#rho_r.L">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.rho_r">
<dcterms:description>ratio of number of ligand bound receptors to total number of receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.v">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>volume of cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_h.r_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of PIP2 hydrolysis</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_h.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#m_infinit.C">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C.k_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>pump dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#r_h.G">
<dcterms:description>amount of active G-protein</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#rho_r.xi">
<dcterms:description>fraction of mobile receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#beta.K_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_46">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP_3.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.d_2">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.K_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_E.L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_61">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.G_T">
<dcterms:description>total number of G-protein moleculues</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rho_r.K_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>unphosphorylated receptor dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS_p.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.k_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.G_T">
<dcterms:description>total number of G-protein moleculues</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.xi">
<dcterms:description>fraction of mobile receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#beta.K_x">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>dissociation constant of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.d_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>IP3 channel kinetic parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS_E.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#lemon_2003" bqmodel:isDescribedBy="12782119" />
<rdf:Description rdf:about="#r_h.alpha">
<dcterms:description>effective signal gain parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RS.L">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#Parameters.k_p">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>receptor phosphorylation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.xi">
<dcterms:description>fraction of mobile receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#RS.RS">
<dcterms:description>total number of unphosphorylated surface receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#G_GTP.k_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>G-protein activation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.N_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01622" />
</rdf:Description>
<rdf:Description rdf:about="#RS_E.R_T">
<dcterms:description>total number of P2Y2 receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Parameters.B_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic endogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#beta.beta">
<dcterms:description>calcium buffering coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#beta.K_x">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_48">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant of cytosolic exogenous buffer</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#IP_3.IP_3">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_0" />
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#C.eta_1">
<dcterms:description>effective IP3 channel permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_GTP.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#PIP_2.r_r">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>PIP2 replenishment rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP_2.IP_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="lemon_2003.cellml#tau_h.C">
<bqbiol:isPropertyOf rdf:resource="lemon_2003.cellml#entity_2" />
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
