Location: Calcium Dynamics Annotations @ 28c2ad84a093 / shorten_wall_2000 / model / shorten_wall_2000.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-25 20:14:52+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/28c2ad84a0934867149129508999a36c9d0fa1cf/shorten_wall_2000/model/shorten_wall_2000.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.f_er">
    <dcterms:description>endoplasmic reticulum calcium buffering factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.Cm">
    <dcterms:description>membrane capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.n_infinity">
    <dcterms:description>steady state function of voltage-sensitive potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#leak_current.g_L">
    <dcterms:description>leakage current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.i_K_DR">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>voltage-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#shorten_2000"
     bqmodel:isDescribedBy="10938629"
     semsim:modelName="shorten_2000">
    <semsim:unknown>Pituitary Corticotrophs</semsim:unknown>
    <semsim:unknown>Shorten and Wall's 2000 Hodgkin-Huxley type mathematical model of 
         bursting oscillations in pituitary corticotrophs.</semsim:unknown>
    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;A Hodgkin-Huxley Model Exhibiting Bursting Oscillations&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This model runs in OpenCell and COR and the units are consistent throughout. It it an accurate reproduction of the paper equations but does not reproduce the published results for unknown reasons, possibly because initial conditions for state variables were guessed.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: We investigate bursting behaviour generated in an electrophysiological model of pituitary corticotrophs. The active and silent phases of this mode of bursting are generated by moving between two stable oscillatory solutions. The bursting is indirectly driven by slow modulation of the endoplasmic reticulum Ca2+ concentration. The model exhibits different modes of bursting, and we investigate mode transitions and similar modes of bursting in other Hodgkin-Huxley models. Bifurcation analysis and the use of null-surfaces facilitate a geometric interpretation of the model bursting modes and action potential generation, respectively.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        A Hodgkin-Huxley Model Exhibiting Bursting Oscillations, Paul R. Shorten and David J.N. Wall, 2000,&#xD;
        &lt;emphasis&gt;Bulletin of Mathematical Biology&lt;/emphasis&gt;&#xD;
        , 62, 695-715.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=10938629&amp;amp;dopt=Abstract"&gt;PubMed ID: 10938629&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;cell schematic for the model&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="shorten_wall_2000.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;&#xD;
          Schematic diagram of a pituitary corticotroph cell showing the transmembrane ionic currents and the intracellular Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          dynamics captured by the mathematical model.  Arrows indicate ionic channels and pumps.&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;Ca-L&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          represents an L-type Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          current responsible for most of the Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          influx during an action potential.&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;Ca-T&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          is a T-type voltage-sensitive Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          current.  A voltage-sensitive K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current,&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;K-DR&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          , is mainly responsible for action potential repolarisation.  A Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -activated K&#xD;
          &lt;superscript&gt;+&lt;/superscript&gt;&#xD;
          current,&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;K-Ca&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          , is essential for bursting behaviour.  The remaining leak current,&#xD;
          &lt;emphasis&gt;&#xD;
            I&#xD;
            &lt;subscript&gt;leak&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          , represents all other ionic fluxes across the plasma membrane which are not specifically described by the model.&#xD;
          &lt;emphasis&gt;&#xD;
            J&#xD;
            &lt;subscript&gt;eff&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          and&#xD;
          &lt;emphasis&gt;&#xD;
            J&#xD;
            &lt;subscript&gt;up&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          are the ER and plasma membrane Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          -ATPase pumps, and&#xD;
          &lt;emphasis&gt;&#xD;
            J&#xD;
            &lt;subscript&gt;rel&lt;/subscript&gt;&#xD;
          &lt;/emphasis&gt;&#xD;
          represents the ER Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          leakage term.  Within the ER and the cytosol, significant portions of Ca&#xD;
          &lt;superscript&gt;2+&lt;/superscript&gt;&#xD;
          are bound to buffers, denoted by B&#xD;
          &lt;subscript&gt;er&lt;/subscript&gt;&#xD;
          and B&#xD;
          &lt;subscript&gt;c&lt;/subscript&gt;&#xD;
          respectively.&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
&lt;/documentation&gt;</semsim:hasCellMLdocumentation>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.m_L">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.k_n">
    <dcterms:description>slope factor for voltage-sensitive potassium channel activation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.m_T_infinity">
    <dcterms:description>steady state function of T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.g_Ca_L">
    <dcterms:description>L-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.beta">
    <dcterms:description>ratio of cell surface area to cytosolic volume</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.alpha">
    <dcterms:description>calcium current to flux proportionality constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.V_m_T">
    <dcterms:description>T-type calcium channel half-activation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.V_er">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_wall_2000.cellml#entity_4">
        <bqbiol:isPartOf>
          <rdf:Description rdf:about="./shorten_wall_2000.cellml#entity_1">
            <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:83098"/>
          </rdf:Description>
        </bqbiol:isPartOf>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:63842"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.n">
    <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.K_p">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-maximal activity constant of SERCA pump</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.v_p">
    <dcterms:description>maximum plasma membrane pump rate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L">
    <dcterms:description>L-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.V_cell">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_wall_2000.cellml#entity_0">
        <bqbiol:isPartOf rdf:resource="./shorten_wall_2000.cellml#entity_1"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:66835"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.J_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>calcium uptake flux from the endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.tau_m_L_max">
    <dcterms:description>maximum L-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.K_i">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_wall_2000.cellml#entity_3">
        <bqbiol:isPartOf rdf:resource="./shorten_wall_2000.cellml#entity_1"/>
        <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.J_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>calcium release flux from the endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.k_m_T">
    <dcterms:description>slope factor for T-type calcium channel activation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.phi_Ca">
    <dcterms:description>calcium equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.phi_K">
    <dcterms:description>potassium equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#leak_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.V_cell">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.Ca_er">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.i_K_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.K_e">
    <bqbiol:isPropertyOf>
      <rdf:Description rdf:about="./shorten_wall_2000.cellml#entity_2">
        <bqbiol:isPartOf rdf:resource="./shorten_wall_2000.cellml#entity_1"/>
        <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
      </rdf:Description>
    </bqbiol:isPropertyOf>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.n">
    <dcterms:description>voltage-sensitive potassium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.J_up">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>calcium uptake flux from the endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#leak_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.V_n">
    <dcterms:description>voltage-sensitive potassium channel half-activation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.J_eff">
    <dcterms:description>calcium flux out of the cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.i_leak">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>leakage current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.k_h_T">
    <dcterms:description>slope factor for T-type calcium channel inactivation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.g_Ca_T">
    <dcterms:description>T-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.Ca_e">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.m_T">
    <dcterms:description>T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.i_K_DR">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>voltage-sensitive potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.tau_h_T">
    <dcterms:description>T-type calcium channel inactivation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.h_T_infinity">
    <dcterms:description>steady state function of T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.F">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.i_Ca_L">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>L-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.tau_m_T_max">
    <dcterms:description>maximum T-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.g_K_DR">
    <dcterms:description>voltage-sensitive potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.tau_m_T">
    <dcterms:description>T-type calcium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.phi_K">
    <dcterms:description>potassium equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.V_c">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of cytosol</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.k_m_L">
    <dcterms:description>slope factor for L-type calcium channel activation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.R">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.phi_Ca">
    <dcterms:description>calcium equilibrium potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.J_in">
    <dcterms:description>calcium flux into the cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.k_tau">
    <dcterms:description>slope factor for time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.i_Ca_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.K_e">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.h_T">
    <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.V_cell">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
    <dcterms:description>volume of cell</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.V_tau">
    <dcterms:description>midpoint potential of time factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.v_er">
    <dcterms:description>maximum SERCA pump current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#membrane.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current.T">
    <dcterms:description>absolute temperature</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.V_h_T">
    <dcterms:description>T-type calcium channel half-inactivation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.J_rel">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>calcium release flux from the endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#leak_current.V_L">
    <dcterms:description>leakage reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.V_m_L">
    <dcterms:description>L-type calcium channel half-activation potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.m_L_infinity">
    <dcterms:description>steady state function of L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.Kc">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>half-maximal activity constant of calcium-activated potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.tau_n">
    <dcterms:description>voltage-sensitive potassium channel activation time constant</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.K_er">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of potassium in endoplasmic reticulum</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#voltage_sensitive_K_current_n_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current_m_gate.m_T">
    <dcterms:description>T-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#ER_calcium.P">
    <dcterms:description>endoplasmic reticulum permeability</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.f_cyt">
    <dcterms:description>cytosolic calcium buffering factor</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#cytosolic_calcium.Ca_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular calcium </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.g_K_Ca">
    <dcterms:description>calcium-activated potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#Ca_activated_K_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.K_i">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of intracellular potassium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#leak_current.i_leak">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>leakage current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current_m_gate.m_L">
    <dcterms:description>L-type calcium channel activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#environment.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#L_type_calcium_current.Ca_e">
    <bqbiol:isPropertyOf rdf:resource="./shorten_wall_2000.cellml#entity_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>concentration of extracellular calcium </dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./shorten_wall_2000.cellml#T_type_calcium_current.h_T">
    <dcterms:description>T-type calcium channel inactivation variable</dcterms:description>
  </rdf:Description>
</rdf:RDF>