- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/devries_sherman_2000/model/devries_sherman_2000.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./devries_sherman_2000.cellml#ATP_sensitive_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#ATP_sensitive_potassium_current_i_K_ATP">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.theta_n">
<dcterms:description>saturation potential of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current_m_gate.V_m">
<dcterms:description>activation potential of calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.theta_s">
<dcterms:description>saturation potential of slow inhibitory potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#ATP_sensitive_potassium_current.p">
<dcterms:description>average fraction of open ATP-sensitive potassium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane.i_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane.i_K_ATP">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ATP-sensitive potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current.g_K">
<dcterms:description>delayed rectifier potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current.g_s">
<dcterms:description>slow inhibitory potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane.tau">
<dcterms:description>activation time constant for delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#ATP_sensitive_potassium_current.g_K_ATP">
<dcterms:description>ATP-sensitive potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#ATP_sensitive_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current.s">
<dcterms:description>slow inhibitory potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.n_infinity">
<dcterms:description>steady state function of delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current.g_Ca">
<dcterms:description>calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_i_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#ATP_sensitive_potassium_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#devries_2000"
bqmodel:isDescribedBy="11093836"
semsim:modelName="devries_sherman_2000">
<semsim:unknown>De Vries and Sherman's 2000 mathematical model of channel sharing in pancreatic beta cells.@en</semsim:unknown>
<semsim:unknown>Pancreatic Beta-Cell@en</semsim:unknown>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Enhancement Of Emergent Bursting In Pancreatic Beta-Cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model has been validated and is known to run in OpenCell and COR to recreate the published results (figure 1). The paper by Devries and Sherman describes several different parameter sets including single cell and two cell sets, and also describes a deterministic and a stochastic model. This CellML model uses equations 1-3 and the parameters given in table 1 for the single cell deterministic model. For this particular model lambda = 0.9. Note there is a unit inconsistency in the equation for V, but our attempts to balance the units for this equation resulted in a model which no longer worked.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: Secretion of insulin by electrically coupled populations of pancreatic beta -cells is governed by bursting electrical activity. Isolated beta -cells, however, exhibit atypical bursting or continuous spike activity. We study bursting as an emergent property of the population, focussing on interactions among the subclass of spiking cells. These are modelled by equipping the fast subsystem with a saddle-node-loop bifurcation, which makes it monostable. Such cells can only spike tonically or remain silent when isolated, but can be induced to burst with weak diffusive coupling. With stronger coupling, the cells revert to tonic spiking. We demonstrate that the addition of noise dramatically increases, via a phenomenon like stochastic resonance, the coupling range over which bursting is seen.</para>
<para>The original paper reference is cited below:</para>
<para>
Channel Sharing in Pancreatic Beta-Cells Revisited: Enhancement of Emergent Bursting by Noise, Gerda De Vries and Arthur Sherman, 2000,
<emphasis>The Journal Of Theoretical Biology</emphasis>
, 207, 513-530.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11093836&amp;dopt=Abstract">PubMed ID: 11093836</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>diagram of the model</title>
</objectinfo>
<imagedata fileref="devries_2000.png" />
</imageobject>
</mediaobject>
<caption>A schematic representation of the four transmembrane currents captured by the De Vries and Sherman 2000 pancreatic beta-cell model.</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
<semsim:modelName>devries_2000</semsim:modelName>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current_m_gate.m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current_m_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane.i_s">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow inhibitory potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#environment_time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.tau">
<dcterms:description>activation time constant for delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current_i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.tau_s">
<dcterms:description>activation time constant for slow inhibitory potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.V_s">
<dcterms:description>activation potential of slow inhibitory potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.V_n">
<dcterms:description>activation potential of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current_m_gate.theta_m">
<dcterms:description>saturation potential of calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#membrane_V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.s_infinity">
<dcterms:description>steady state function of slow inhibitory potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#calcium_current.m_infinity">
<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#potassium_current.tau">
<dcterms:description>activation time constant for delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_i_s">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow inhibitory potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.s">
<dcterms:description>slow inhibitory potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./devries_sherman_2000.cellml#slow_current_s_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
</rdf:RDF>
