- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-26 14:35:03+13:00
- Desc:
- modifying rdf files
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/4d6408caaf3e7b1b86d33d53d26105360ef95347/winslow_rice_jafri_marban_ororke_1999/model/winslow_rice_jafri_marban_ororke_1999.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_m_gate.E0_m">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Na_b">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.J_rel">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sarcolemmal_calcium_pump.K_mpCa">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6">
<bqbiol:isPartOf>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-saturation constant for sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.HTRPN_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_14">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_3"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total concentration of troponin high-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.J_tr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.beta_i">
<dcterms:description>cytosol buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.J_xfer">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.omega">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.i_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_background_current.E_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.tau_X_ks">
<dcterms:description>activation time constant of slow potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Ca_b">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>background calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.n">
<dcterms:description>ryanodine receptor calcium cooperativity parameter PC1 - PO1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.A_cap">
<dcterms:description>capacitive membrane area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.k_ltrpn_plus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>calcium on-rate for troponin low affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.tau_xfer">
<dcterms:description>transfer time constant from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.stim_amplitude">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.Nai">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_2">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_3"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.gprime">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>transition rate out of open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_j_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_X_to1_gate.alpha_X_to1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.P_K">
<dcterms:description>potassium permeability of L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_j_gate.beta_j">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current.i_Kp">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plateau potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.g_to1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum transient outward potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.i_to1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.Ki">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_5">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_3"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current_Kp_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.Nao">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_0">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.i_Ca_half">
<dcterms:description>calcium current at half potassium permeability of L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_X_to1_gate.beta_X_to1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C4">
<dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C_sc">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.E_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>slow potassium current reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.b">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.i_Ca_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium channel potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.X_ks">
<dcterms:description>slow potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_h_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.beta_SS">
<dcterms:description>subspace buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.Nai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.K_mCa">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for sodium-calcium exchange</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.tau_X_kr">
<dcterms:description>activation time constant of rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.tau_tr">
<dcterms:description>transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C3">
<dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_X_to1_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.C_sc">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.Ki">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.a">
<dcterms:description>L-type calcium channel mode transition parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_j_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.K_mNai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_h_gate.alpha_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_h_gate.beta_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.Cai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.K_mCMDN">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.X_ks">
<dcterms:description>slow potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.Nao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.Nai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C2">
<dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.J_up">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.Nai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.I_NaK">
<dcterms:description>maximum sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.Ca_NSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_12">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_13">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62390"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of network sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.Cao">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_7">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.j">
<dcterms:description>sodium current slow inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C_Ca0">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.Ca_JSR">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_10">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_11">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62387"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of junctional sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.Cao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_j_gate.j">
<dcterms:description>sodium current slow inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.Vmaxr">
<dcterms:description>maximum SERCA reverse pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.stim_end">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.O">
<dcterms:description>fraction of open L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.g_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum sodium channel conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.C_sc">
<dcterms:description>specific membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.stim_duration">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C1">
<dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.K_mKo">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.P_Ca">
<dcterms:description>calcium permeability of L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.J_trpn">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux to troponin buffers</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_Y_to1_gate.Y_to1">
<dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.HTRPNCa">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_14"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium-bound troponin high-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C_Ca1">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.k_b_minus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO2 - PO1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#standard_ionic_concentrations.Nao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.K_rb">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>reverse half-saturation constant for calcium ATPase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Ca_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium channel potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_p_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.i_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.Cai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.i_Ca_b">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>background calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C0">
<dcterms:description>fraction of closed L-type calcium channels </dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C_Ca2">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_j_gate.alpha_j">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.P_O1">
<dcterms:description>fraction of ryanodine receptor channels in state PO1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.X_kr">
<dcterms:description>steady state function of rapid potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.J_LTRPNCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux to low-affinity troponin sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.Ca_ss">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_8">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_9">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62358"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_Y_to1_gate.beta_Y_to1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.N_fb">
<dcterms:description>forward cooperativity constant for SERCA pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current_y_gate.y_infinity">
<dcterms:description>steady state function of L-type calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.g_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum time-independent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.K12">
<dcterms:description>activation curve of forward rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.eta">
<dcterms:description>voltage dependence factor of sodium-calcium exchange</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_to1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sarcolemmal_calcium_pump.Cai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C_Ca3">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.m">
<dcterms:description>sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.K1_infinity_V">
<dcterms:description>steady-state function of time-independent potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.P_O2">
<dcterms:description>fraction of ryanodine receptor channels in state PO2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.V_SS">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>subspace volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_to1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>transient outward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.Vmaxf">
<dcterms:description>maximum SERCA forward pumping rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.K_mNa">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>sodium half-saturation constant for sodium-calcium exchange</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.Ki">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.V_myo">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>myoplasmic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.C_Ca4">
<dcterms:description>fraction of closed L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.CMDN_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_15">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_3"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62343"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total concentration of myoplasmic calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.J_up">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.K1_infinity_V">
<dcterms:description>steady-state function of time-independent potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sarcolemmal_calcium_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.alpha_a">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.K_mEGTA">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for EGTA</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_m_gate.m">
<dcterms:description>sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Kp">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plateau potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.Y_to1">
<dcterms:description>transient outward potassium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.E_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#standard_ionic_concentrations.Ko">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_X_to1_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.beta_b">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current_K1_gate.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.g_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum rapid potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_background_current.g_Nab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum background sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_Y_to1_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current.Kp_V">
<dcterms:description>activation potential of plateau potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_background_current.i_Na_b">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Na_b">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.Ko">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.J_xfer">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux from subspace to myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.i_Ca_max">
<dcterms:description>calcium current at maximum potassium permeability of L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.Cao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.h">
<dcterms:description>sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.K21">
<dcterms:description>activation curve of reverse rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_m_gate.alpha_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.Nao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.Cai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.stim_start">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Ca_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium channel potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_potassium_pump.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.X_ks_infinity">
<dcterms:description>steady state function of slow potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.O_Ca">
<dcterms:description>fraction of open L-type calcium channels in calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.Ca_NSR">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of network sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#standard_ionic_concentrations.Cao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.LTRPN_tot">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_14"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total concentration of troponin low-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.Nao">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Ca_b">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>background calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.V_NSR">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_13"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.K_NaCa">
<dcterms:description>scale factor of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.beta">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.k_c_minus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PC2 - PO1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.Ca_ss">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.K_mCSQN">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for calsequestrin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.K_sat">
<dcterms:description>saturation factor of sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.X_kr_inf">
<dcterms:description>steady state function of rapid potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.v1">
<dcterms:description>maximum ryanodine receptor channel calcium flux</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.stim_period">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.Ca_JSR">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of junctional sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.X_kr">
<dcterms:description>steady state function of rapid potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.k_a_plus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PC1 - PO1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.J_trpn">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux to troponin buffers</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.y">
<dcterms:description>L-type calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.CSQN_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_17">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_13"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62353"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total concentration of network sarcoplasmic reticulum calsequestrin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_m_gate.beta_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sarcolemmal_calcium_pump.I_pCa">
<dcterms:description>maximum sarcolemmal calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.Cai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.g_Ks">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum slow potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.fprime">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>transition rate into open state for calcium mode</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current_X_ks_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.k_htrpn_minus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>calcium off-rate for troponin high affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.R_V">
<dcterms:description>activation potential of rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.g_Cab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum background calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.J_tr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.Ca_JSR">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of junctional sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.K_fb">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>forward half-saturation constant for calcium ATPase</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_h_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current_y_gate.tau_y">
<dcterms:description>activation time constant of L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#slow_activating_delayed_rectifiyer_K_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.J_rel">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.P_C1">
<dcterms:description>fraction of ryanodine receptor channels in state PC1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#winslow_model_1999"
semsim:modelName="winslow_rice_jafri_marban_ororke_1999"
bqmodel:isDescribedBy="10082479">
<semsim:modelName>winslow_model_1999</semsim:modelName>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Canine Ventricular Cell Model, 1999</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model has been curated and unit-checked by Penny Noble and is known to run in PCEnv and COR to replicate the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In 1999 Raimond Winslow, Jeremy Rice, Saleet Jafri, Eduardo Marban and Brian O'Rourke published a computational model of the action potential and of intracellular Ca
<superscript>2+</superscript>
handling in normal and failing canine ventricular myocytes. Using the experimental data of O'Rourke
<emphasis>et al</emphasis>
(1999) they modified Jafri
<emphasis>et al's</emphasis>
guinea pig ventricular cell model (1999) to make it appropriate for canine midmyocardial cells (see the figure below). The CellML description here is of the normal canine ventricular myocyte model. In failing myocytes i_to1 and i_K1 are down regulated on average by 66 percent and 32 percent respectively. The kinetic properties of i_to1 and the gating behaviour if i_K1 remain unaltered. Only the number of expressed channels is reduced (the control may be pre- or post-transcriptional but it is not post-translational). On the basis of these data, the effects of terminal heart failure are modelled by reducing the peak conductance of i_to1 and i_K1. Downregulation of the sarcoplasmic reticulum Ca
<superscript>2+</superscript>
pump is modelled by simultaneous scaling of both the forward and reverse maximum pump rates V
<subscript>maxf</subscript>
and V
<subscript>maxr</subscript>
by a scale factor K
<subscript>SR</subscript>
. Upregulation of the Na-Ca exchanger is modelled by increasing a scale factor K
<subscript>NaCa</subscript>
.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://circres.ahajournals.org/cgi/content/full/84/5/571">Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II Model Studies</ulink>
, Raimond L. Winslow, Jeremy Rice, Saleet Jafri, Eduardo Marban and Brian O'Rourke, 1999,
<ulink url="http://circres.ahajournals.org/">
<emphasis>Circulation Research</emphasis>
</ulink>
, 84, 571-586.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10082479&amp;dopt=Abstract">PubMed ID: 10082479</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram of the Winslow et al ventricular cell model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
</objectinfo>
<imagedata fileref="winslow_1999.png" />
</imageobject>
</mediaobject>
<caption>
A schematic diagram describing the current flows across the cell membrane that are captured in the Winslow
<emphasis>et al</emphasis>
canine ventricular cell model.
</caption>
</informalfigure>
<informalfigure float="0" id="fig_cellml_rendering">
<mediaobject>
<imageobject>
<objectinfo>
<title>the cellml rendering of the Winslow et al model</title>
</objectinfo>
<imagedata fileref="cellml_rendering.gif" />
</imageobject>
</mediaobject>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_X_to1_gate.X_to1">
<dcterms:description>transient outward potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.LTRPNCa">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_14"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium-bound troponin low-affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current_y_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sarcolemmal_calcium_pump.i_p_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_p_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sarcolemmal calcium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.g">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>transition rate out of open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.alpha">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#calcium_background_current.E_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.Ca_ss">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#sodium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current_X_kr_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.Nai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.beta_JSR">
<dcterms:description>junctional sarcoplasmic reticulum buffering</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#SERCA2a_pump.N_rb">
<dcterms:description>reverse cooperativity constant for SERCA pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.EGTA_tot">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_16">
<bqbiol:isPartOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_3"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:30741"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>total concentration of EGTA</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.J_HTRPNCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux to high-affinity troponin sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#Na_Ca_exchanger.Cai">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.P_C2">
<dcterms:description>fraction of ryanodine receptor channels in state PC2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current.X_to1">
<dcterms:description>transient outward potassium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_h_gate.h">
<dcterms:description>sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#rapid_activating_delayed_rectifiyer_K_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.k_htrpn_plus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>calcium on-rate for troponin high affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_Ca_fluxes.k_ltrpn_minus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>calcium off-rate for troponin low affinity sites</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.f">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>transition rate into open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.k_c_plus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO1 - PC2 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.i_Kp">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plateau potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current_Kp_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current.g_Kp">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01300"/>
<dcterms:description>maximum plateau potassium channel conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.k_b_plus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO1 - PO2 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#membrane.i_Kr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>rapid potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_Y_to1_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#time_independent_potassium_current.K_mK1">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current_y_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.Ca_ss">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of subspace calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.k_a_minus">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>ryanodine receptor PO1 - PC1 rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#plateau_potassium_current_Kp_gate.Kp_V">
<dcterms:description>activation potential of plateau potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current.Ki">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#RyR_channel.m">
<dcterms:description>ryanodine receptor calcium cooperativity parameter PO1 - PO2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.Ca_NSR">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of network sarcoplasmic reticulum calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#transient_outward_potassium_current_Y_to1_gate.alpha_Y_to1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#intracellular_ion_concentrations.V_JSR">
<bqbiol:isPropertyOf rdf:resource="./winslow_rice_jafri_marban_ororke_1999.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>junctional sarcoplasmic reticulum volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#L_type_Ca_current_y_gate.y">
<dcterms:description>L-type calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./winslow_rice_jafri_marban_ororke_1999.cellml#fast_sodium_current_m_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
</rdf:RDF>
