- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-24 22:01:22+13:00
- Desc:
- adding OMEX files to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/5b63d66fdea3ed543757ed06bf49e7b99e88c992/albrecht_colegrove_friel_2002/model/albrecht_colegrove_friel_2002.rdf
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semsim:modelName="albrecht_colegrove_friel_2002_version01"
bqmodel:isDescribedBy="11865019">
<semsim:modelName>albrecht_colegrove_friel_2002</semsim:modelName>
<semsim:unknown>Differential regulation of ER Ca2+ uptake and release.</semsim:unknown>
<semsim:unknown>sympathetic neuron</semsim:unknown>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model is consistently represented within the CellML but contains sets of algebraic equations that prevent the model from being solved in currently available software - 03/08.</para>
<para>ValidateCellML found unit inconsistencies in this model</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Calcium is an important signalling ion, and changes in Ca
<superscript>2+</superscript>
concentration ([Ca
<superscript>2+</superscript>
]) regulate diverse processes in many cellular compartments. In excitable cells, depolarisation-induced Ca
<superscript>2+</superscript>
entry increases [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
, leading to secondary changes in [Ca
<superscript>2+</superscript>
] within organelles such as mitochondria and ER that regulate specific Ca
<superscript>2+</superscript>
-sensitive targets within these organelles. Although mitochondria accumulate Ca
<superscript>2+</superscript>
in response to depolarisation-evoked [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
elevations (see
<ulink url="${HTML_EXMPL_COLEGROVE_MODEL}">
The Colegrove
<emphasis>et al</emphasis>
Model Of Mitochondrial Ca
<superscript>2+</superscript>
Uptake And Release, 2000
</ulink>
), the ER is also an important component in Ca
<superscript>2+</superscript>
signalling in virtually all non-muscle cells, and it has been described as either a Ca
<superscript>2+</superscript>
source or sink. Different modes of net ER Ca
<superscript>2+</superscript>
transport are expected to have very different effects on cytoplasmic and intraluminal Ca
<superscript>2+</superscript>
signals and on the processes they regulate (see
<ulink url="${HTML_EXMPL_ALBRECHT_MODEL1}">
The Albrecht
<emphasis>et al</emphasis>
Model Of Multiple Modes of Ca
<superscript>2+</superscript>
-induced Ca
<superscript>2+</superscript>
Release in Sympathetic Neurons, 2001
</ulink>
).
</para>
<para>
In a follow up study to their 2001 paper, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel have examined how differential regulation of ER Ca
<superscript>2+</superscript>
uptake and release rates accounts for multiple modes of Ca
<superscript>2+</superscript>
-induced Ca
<superscript>2+</superscript>
release. Three different macroscopic Ca
<superscript>2+</superscript>
fluxes were modelled: J
<subscript>SERCA</subscript>
, the rate of Ca
<superscript>2+</superscript>
uptake via SR Ca-ATPases; J
<subscript>ICa</subscript>
, the total cytoplasmic Ca
<superscript>2+</superscript>
flux when SR Ca-ATPases are inhibited; and J
<subscript>pm</subscript>
, the rate of Ca
<superscript>2+</superscript>
extrusion across the plasma membrane. One additional flux J
<subscript>release</subscript>
was calculated from the difference between J
<subscript>ICa</subscript>
and J
<subscript>pm</subscript>
(see
<xref linkend="fig_cell_diagram" />
below). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in
<xref linkend="sec_download_this_model" />
.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://www.jgp.org/cgi/content/abstract/119/3/211">
Differential Regulation of ER Ca
<superscript>2+</superscript>
Uptake and Release Rates Accounts for Multiple Modes of Ca
<superscript>2+</superscript>
-induced Ca
<superscript>2+</superscript>
Release
</ulink>
, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel, 2002,
<ulink url="http://www.jgp.org/">
<emphasis>The Journal Of General Physiology</emphasis>
</ulink>
, 119, 211-233. (
<ulink url="http://www.jgp.org/cgi/content/full/119/3/211">Full text</ulink>
and
<ulink url="http://www.jgp.org/cgi/reprint/119/3/211.pdf">PDF</ulink>
versions of the article are available for Journal Members on the JGP website.)
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11865019&amp;dopt=Abstract">PubMed ID: 11865019</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell schematic for the model</title>
</objectinfo>
<imagedata fileref="albrecht_2002.png" />
</imageobject>
</mediaobject>
<caption>
Schematic of the model indicating Ca
<superscript>2+</superscript>
compartmentation in the extracellular matrix, cytosol and the ER and pathways for Ca
<superscript>2+</superscript>
ion movement between the compartments.
</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
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