- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 22:22:21+13:00
- Desc:
- modifying composite annotations
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/629d77f02876098d987c9f59e66a4b6a87bdff87/gall_susa_1999_b/model/gall_susa_1999_b.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.V_Na_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>reversal potential of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
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<dcterms:description>steady state function of slow inhibitory potassium channel activation variable</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
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<dcterms:description>slow inhibitory potassium channel activation variable</dcterms:description>
</rdf:Description>
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<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
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<dcterms:description>saturation potential of M-gate calcium channel</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.k_Ca">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>calcium removal rate in the endoplasmic reticulum</dcterms:description>
</rdf:Description>
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<dcterms:description>rate of calcium pumping into the endoplasmic reticulum</dcterms:description>
</rdf:Description>
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<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current_s_gate.tau_s">
<dcterms:description>activation time constant of slow inhibitory potassium channel</dcterms:description>
</rdf:Description>
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</rdf:Description>
</bqbiol:isPropertyOf>
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<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_2"/>
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</rdf:Description>
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<dcterms:description>steady state function of calcium channel activation variable</dcterms:description>
</rdf:Description>
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<dcterms:description>half-maximal activation potential of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
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</rdf:Description>
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<dcterms:description>slow inhibitory potassium channel activation variable</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
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</rdf:Description>
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<dcterms:description>maximum sodium-calcium exchanger current conductance</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current_s_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#gall_1999"
semsim:modelName="gall_1999"
bqmodel:isDescribedBy="10388739">
<semsim:unknown>Pancreatic Beta-Cell</semsim:unknown>
<semsim:unknown>The Gall and Susa 1999 model of Na/Ca exchange in Model II for pancreatic beta-cells.</semsim:unknown>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Na/Ca Exchange in Models for Pancreatic Beta-Cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model represents Model II from the published paper. The CellML matches the published equations and the model runs in OpenCell and COR but it does not replicate the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: In the presence of an insulinotropic glucose concentration, beta-cells, in intact pancreatic islets, exhibit periodic bursting electrical activity consisting of an alternation of active and silent phases. The fraction of time spent in the active phase over a period is called the plateau fraction and is correlated with the rate of insulin release. However, the mechanisms that regulate the plateau fraction remain unclear. In this paper we investigate the possible role of the plasma membrane Na+/Ca2+ exchange of the beta-cell in controlling the plateau fraction. We have extended different single-cell models to incorporate this Ca2+-activated electrogenic Ca2+ transporter. We find that the Na+/Ca2+ exchange can provide a physiological mechanism to increase the plateau fraction as the glucose concentration is raised. In addition, we show theoretically that the Na+/Ca2+ exchanger is a key regulator of the cytoplasmic calcium concentration in clusters of heterogeneous cells with gap-junctional electrical coupling.</para>
<para>The original paper reference is cited below:</para>
<para>
Effect of Na/Ca Exchange on Plateau Fraction and [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
in Models for Bursting in Pancreatic Beta-Cells, David Gall and Isabella Susa, 1999,
<emphasis>Biophysical Journal</emphasis>
, 77, 45-53.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10388739">PubMed ID: 10388739</ulink>
</para>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
<semsim:modelName>gall_susa_1999_b</semsim:modelName>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current_s_gate.V_s">
<dcterms:description>half-maximal activation potential of slow inhibitory potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#membrane.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current_n_gate.n_infinity">
<dcterms:description>steady state function of delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#calcium_current_m_gate.V_m">
<dcterms:description>half-maximal activation potential of M-gate calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#membrane.i_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.K_1_2">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant of the sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free cytosolic sodium</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.k_rel">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate of calcium release from the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current_n_gate.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current_s_gate.S_s">
<dcterms:description>saturation potential of slow inhibitory potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free cytosolic calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current.i_slow">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow inhibitory potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.nH">
<dcterms:description>Hill coefficient of sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.Ca_ret">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.f">
<dcterms:description>fraction of free cytoplasmic calcium</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current_s_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current.g_s">
<dcterms:description>slow inhibitory potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#calcium_current.i_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>L-type calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current_n_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#membrane.i_Na_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#membrane.i_slow">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>slow inhibitory potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current.g_K">
<dcterms:description>rapid potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current.n">
<dcterms:description>delayed rectifier potassium channel activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current_n_gate.tau_n">
<dcterms:description>activation time constant of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.Na_i">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free cytosolic sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.alpha">
<dcterms:description>factor converting current into concentration changes</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#calcium_current.g_Ca">
<dcterms:description>calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#Na_Ca_exchanger_current.Na_o">
<bqbiol:isPropertyOf rdf:resource="./gall_susa_1999_b.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#ionic_concentrations.i_Na_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#slow_K_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#calcium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#rapidly_activating_K_current_n_gate.S_n">
<dcterms:description>saturation potential of delayed rectifier potassium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./gall_susa_1999_b.cellml#calcium_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
</rdf:RDF>
