- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-24 20:36:00+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- http://models.cellml.org/workspace/7f1/rawfile/badd70406e83865d500190f4842e0cc057d82ae0/hilgemann_noble_1987/model/hilgemann_noble_1987.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.f_Ca">
<dcterms:description>second inward calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_si">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>total second inward current</dcterms:description>
</rdf:Description>
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<bqbiol:isPropertyOf>
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</bqbiol:isPartOf>
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</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium half-saturation constant for time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.alpha_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration_Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.ActFrac">
<dcterms:description>activator fraction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.i_siCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.CaChon">
<dcterms:description>fraction of channels inactivated by voltage-dependent process</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.i_siK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.alpha_Calmod">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_siNa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.dCaTropdt">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>rate of change of calcium-bound troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_rel">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current_i_b_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#time_independent_potassium_current.K_c">
<bqbiol:isPropertyOf>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_i_ratio">
<dcterms:description>volume ratio of cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.Ca_o">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#entity_7">
<bqbiol:isPartOf>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_e_ratio">
<dcterms:description>volume ratio of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.E_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.beta_Trop">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#potassium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.K_c">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#environment_time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.h">
<dcterms:description>fast sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.dCaCalmoddt">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>rate of change of calcium-bound calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_translocation.alpha_tr">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.V_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#entity_9">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226050"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.E0_f">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_siCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.delta_f">
<dcterms:description>saturation potential of second inward calcium current inactivation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.f_Ca">
<dcterms:description>second inward calcium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.InactRate">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.Na_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#entity_2">
<bqbiol:isPartOf rdf:resource="./hilgemann_noble_1987.cellml#entity_3"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.K_i">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#entity_6">
<bqbiol:isPartOf rdf:resource="./hilgemann_noble_1987.cellml#entity_3"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29103"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_translocation.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.K_i">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.beta_h">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.beta_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.K_mNa">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>sodium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.beta_up">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.alpha_Trop">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.d">
<dcterms:description>second inward calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.i_si">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>total second inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.K_m_rel">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ve">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#entity_10">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67196"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>volume of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#potassium_background_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.stim_start">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.g_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
<dcterms:description>fast sodium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_up_ratio">
<dcterms:description>volume ratio of uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.Na_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.beta_Calmod">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.Ca_i">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.stim_duration">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.Ca_i">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
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<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_potassium_concentration.K_c">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.Na_o">
<bqbiol:isPropertyOf>
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<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
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<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.i_siNa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current_i_b_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.K_c">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#time_independent_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_Stim">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
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<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.Ca_i">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.ActRate">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
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<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.E0_d">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
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<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.Na_o">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.Cab">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.g_b_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
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</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_h_gate.h">
<dcterms:description>fast sodium current inactivation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux out of sarcoplasmic reticulum through ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump_i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00410"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.VoltDep">
<dcterms:description>voltage dependence of calcium release</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
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</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.Na_o">
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<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.g_b_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
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<bqbiol:isPropertyOf>
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<bqbiol:isPartOf rdf:resource="./hilgemann_noble_1987.cellml#entity_3"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:62338"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.stim_period">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.length">
<dcterms:description>cell length</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_up">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium flux into sarcoplasmic reticulum through SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#time_independent_potassium_current.E_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.m">
<dcterms:description>fast sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#potassium_background_current.g_b_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
<dcterms:description>potassium background current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_translocation_i_trans">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium transfer flux from the network sarcoplasmic reticulum to the junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.i_up">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_Cell">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.radius">
<dcterms:description>cell radius</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.m">
<dcterms:description>fast sodium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.CaChon">
<dcterms:description>fraction of channels inactivated by voltage-dependent process</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#potassium_background_current.i_b_K">
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<dcterms:description>background potassium current</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>fast sodium current</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
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<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#hilgemann_noble_1987"
semsim:unknown="unknown"
semsim:modelName="hilgemann_noble_1987"
bqmodel:isDescribedBy="2884668">
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Hilemann-Noble Atrial Cell Model 1987</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model is known to run in OpenCell and COR and reproduce the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: Interactions of electrogenic sodium-calcium exchange, calcium channel and sarcoplasmic reticulum in the mammalian heart have been explored by simulation of extracellular calcium transients measured with tetramethylmurexide in rabbit atrium. The approach has been to use the simplest possible formulations of these mechanisms, which together with a minimum number of additional mechanisms allow reconstruction of action potentials, intracellular calcium transients and extracellular calcium transients. A 3:1 sodium-calcium exchange stoichiometry is assumed. Calcium-channel inactivation is assumed to take place by a voltage-dependent mechanism, which is accelerated by a rise in intracellular calcium; intracellular calcium release becomes a major physiological regulator of calcium influx via calcium channels. A calcium release mechanism is assumed, which is both calcium- and voltage-sensitive, and which undergoes prolonged inactivation. 200 microM cytosolic calcium buffer is assumed. For most simulations only instantaneous potassium conductances are simulated so as to study the other mechanisms independently of time- and calcium-dependent outward current. Thus, the model reconstructs extracellular calcium transients and typical action-potential configuration changes during steady-state and non-steady-state stimulation from the mechanisms directly involved in trans-sarcolemmal calcium movements. The model predicts relatively small trans-sarcolemmal calcium movements during regular stimulation (ca. 2 mumol kg-1 fresh mass per excitation); calcium current is fully activated within 2 ms of excitation, inactivation is substantially complete within 30 ms, and sodium-calcium exchange significantly resists repolarization from approximately -30 mV. Net calcium movements many times larger are possible during non-steady-state stimulation. Long action potentials at premature excitations or after inhibition of calcium release can be supported almost exclusively by calcium current (net calcium influx 5-30 mumol kg-1 fresh mass); action potentials during potentiated post-stimulatory contractions can be supported almost exclusively by sodium-calcium exchange (net calcium efflux 4-20 mumol kg-1 fresh mass). Large calcium movements between the extracellular space and the sarcoplasmic reticulum can take place through the cytosol with virtually no contractile activation. The simulations provide integrated explanations of electrical activity, contractile function and trans-sarcolemmal calcium movements, which were outside the explanatory range of previous models.</para>
<para>The original paper reference is cited below:</para>
<para>
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of the basic cellular mechanisms, Hilemann, D.W. and Noble, D. 1987,
<emphasis>Proc. R. Soc. Lond.</emphasis>
, B230, 163-205.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=2884668&amp;dopt=Abstract">PubMed ID: 2884668</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram of the Hilemann-Noble model showing ionic currents across the sarcolemma</title>
</objectinfo>
<imagedata fileref="hilgemann_noble_1987.png" />
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Hilemann-Noble model.</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.K_leak_rate">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#time_independent_potassium_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.E_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.delta_m">
<dcterms:description>saturation potential of fast sodium current activation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_rel">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in release site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#time_independent_potassium_current.g_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
<dcterms:description>time-independent potassium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_Calmod">
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</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium-bound calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.i_b_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Calmod">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calmodulin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_b_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.Na_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_translocation.Ca_rel">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in release site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.E0_m">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>fast sodium current M-gate reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.Na_o">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_b_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.k_NaCa">
<dcterms:description>maximum sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.V_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>cytosolic volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.C_m">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_Trop">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium-bound troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.alpha_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.i_b_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#time_independent_potassium_current_i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_b_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_siK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>second inward potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.K_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.Ca_up">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.Ca_up">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.Ca_rel">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_9"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in release site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.E_mh">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>fast sodium current H-gate reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.ProdFrac">
<dcterms:description>product fraction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.RegBindSite">
<dcterms:description>regulatory calcium binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.CaChoff">
<dcterms:description>fraction of channels with calcium-bound regulatory site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_cyca">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-saturation constant of calcium binding to cytosolic enzymes</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_K1">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>time-independent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_f_Ca_gate.beta_f_Ca">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.Ve">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_10"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>volume of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#potassium_background_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.K_c">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger.Na_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_sodium_concentration.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_calcium_concentration.K_diff">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.stim_end">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_trans">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
<dcterms:description>calcium transfer flux from the network sarcoplasmic reticulum to the junctional sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.d">
<dcterms:description>second inward calcium current activation variable</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#extracellular_sodium_concentration.Na_o">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_2">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.delta_d">
<dcterms:description>saturation potential of second inward calcium current activation gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.K_mK">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>potassium half-saturation constant for sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_b_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>background potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.P_si">
<dcterms:description>maximum second inward calcium current conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_background_current.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.RTONF">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.V_rel_ratio">
<dcterms:description>volume ratio of release site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current_m_gate.alpha_m">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_calcium_concentration.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#fast_sodium_current.Na_i">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#second_inward_calcium_current_d_gate.beta_d">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_translocation.Ca_up">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in uptake site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.stim_amplitude">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#membrane.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_b_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>background potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#intracellular_potassium_concentration.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#calcium_release.PrecFrac">
<dcterms:description>precursor fraction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#Na_Ca_exchanger_i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchanger current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_xcs">
<dcterms:description>rate of calcium transfer between cytosol and sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sarcoplasmic_reticulum_calcium_pump.K_srca">
<bqbiol:isPropertyOf rdf:resource="./hilgemann_noble_1987.cellml#entity_8"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-saturation constant of calcium binding to sarcoplasmic reticulum enzymes</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hilgemann_noble_1987.cellml#sodium_potassium_pump.i_NaK_max">
<dcterms:description>maximum sodium-potassium pump current</dcterms:description>
</rdf:Description>
</rdf:RDF>
