Location: Calcium Dynamics Annotations @ c5079f12eb1d / purvis_butera_2005 / model / purvis_butera_2005.rdf

Author:
neilstephen2001 <npar276@aucklanduni.ac.nz>
Date:
2021-01-25 18:50:11+13:00
Desc:
adding OMEX archives to workspace
Permanent Source URI:
http://models.cellml.org/workspace/7f1/rawfile/c5079f12eb1d8c164a111eea8277d5627c24a0b2/purvis_butera_2005/model/purvis_butera_2005.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.sigma_1">
    <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.sigma_2">
    <dcterms:description>half-maximal potential of fast transient potassium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current.g_A">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>fast transient potassium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.m_infinity">
    <dcterms:description>steady state function of P-type calcium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.tau_m">
    <dcterms:description>activation time constant of hyperpolarisation-activated current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_m_gate.tau_m">
    <dcterms:description>time constant of N-type calcium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#persistent_sodium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_N">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>N-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current.g_N">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>N-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#persistent_sodium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#persistent_sodium_current_h_gate.theta_h">
    <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.tau_m">
    <dcterms:description>time constant of fast transient potassium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.theta_h">
    <dcterms:description>saturation potential of N-type calcium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_NaP">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>persistent sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_m_gate.sigma_m">
    <dcterms:description>half-maximal potential of T-type calcium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current_i_H">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>hyperpolarisation-activated current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current.g_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>T-type calcium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.h">
    <dcterms:description>N-type calcium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_h_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_h_gate.theta_1">
    <dcterms:description>saturation potential of T-type calcium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#persistent_sodium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current.g_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>sodium current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#stimulus_protocol.i_app">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.theta_1">
    <dcterms:description>saturation potential of hyperpolarisation-activated current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#stimulus_protocol.i_stimAmplitude">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00318"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_h_gate.h_infinity">
    <dcterms:description>steady state function of T-type calcium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#persistent_sodium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#leak_current_i_leak">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>leak current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_m_gate.sigma_m">
    <dcterms:description>half-maximal potential of N-type calcium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.i_P">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>P-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.tau_m">
    <dcterms:description>activation time constant of P-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current.g_H">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00041"/>
    <dcterms:description>hyperpolarisation-activated current conductance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_i_N">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>N-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current.z">
    <dcterms:description>calcium-dependent potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current.i_N">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>N-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.sigma_2">
    <dcterms:description>half-maximal activation potential of delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current.h">
    <dcterms:description>T-type calcium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current_h_gate.tau_h">
    <dcterms:description>time constant of sodium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#P_HVA_calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#P_HVA_calcium_current_m_gate.sigma_m">
    <dcterms:description>half-maximal activation potential of P-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current_h_gate.h_infinity">
    <dcterms:description>steady state function of sodium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current_h_gate.theta_h">
    <dcterms:description>saturation potential of sodium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane_V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current_z_gate.i_N">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>N-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_SK">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>calcium-dependent potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_h_gate.theta_h">
    <dcterms:description>saturation potential of T-type calcium current inactivation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_h_gate.h_infinity">
    <dcterms:description>steady state function of fast transient potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current.i_P">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>P-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.C">
    <dcterms:description>whole cell capacitance</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_i_T">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>T-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_leak">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>leak current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#delayed_rectifier_current_n_gate.theta_n">
    <dcterms:description>saturation potential of delayed rectifier potassium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#P_HVA_calcium_current_i_P">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>P-type calcium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current.E_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>potassium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current.E_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>sodium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current.h">
    <dcterms:description>fast transient potassium current inactivation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#calcium_dependent_potassium_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.m">
    <dcterms:description>fast transient potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_m_gate.theta_1">
    <dcterms:description>saturation potential of T-type calcium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current.E_Ca">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>calcium reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current.m">
    <dcterms:description>hyperpolarisation-activated current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_H">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>hyperpolarisation-activated current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current_h_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#sodium_current_m_gate.sigma_m">
    <dcterms:description>half-maximal potential of sodium current activation gate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.m_infinity">
    <dcterms:description>steady state function of fast transient potassium current activation variable</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current.E_H">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>hyperpolarisation-activated current reversal potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#LVA_calcium_current_m_gate.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#delayed_rectifier_current.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#stimulus_protocol.time">
    <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#membrane.i_Na">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>sodium current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#N_HVA_calcium_current_m_gate.V">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
    <dcterms:description>membrane potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#hyperpolarization_activated_current_m_gate.sigma_1">
    <dcterms:description>half-maximal activation potential of hyperpolarisation-activated current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./purvis_butera_2005.cellml#fast_transient_potassium_current_m_gate.theta_m">
    <dcterms:description>saturation potential of fast transient potassium current activation gate</dcterms:description>
  </rdf:Description>
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    <semsim:hasCellMLdocumentation>&lt;documentation xmlns="http://cellml.org/tmp-documentation"&gt;&#xD;
  &lt;article&gt;&#xD;
    &lt;articleinfo&gt;&#xD;
      &lt;title&gt;Ionic current model of a hypoglossal motoneuron&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Geoffrey&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Nunns&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
      &lt;/author&gt;&#xD;
    &lt;/articleinfo&gt;&#xD;
    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This CellML model is known to run in both OpenCell and COR and the units have been checked and are consistent. The model recreates the published results.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: We have developed a single-compartment, electrophysiological, hypoglossal motoneuron (HM) model based primarily on experimental data from neonatal rat HMs. The model is able to reproduce the fine features of the HM action potential: the fast afterhyperpolarization, the afterdepolarization, and the medium-duration afterhyperpolarization (mAHP). The model also reproduces the repetitive firing properties seen in neonatal HMs and replicates the neuron's response to pharmacological experiments. The model was used to study the role of specific ionic currents in HM firing and how variations in the densities of these currents may account for age-dependent changes in excitability seen in HMs. By varying the density of a fast inactivating calcium current, the model alternates between accelerating and adapting firing patterns. Modeling the age-dependent increase in H current density accounts for the decrease in mAHP duration observed experimentally, but does not fully account for the decrease in input resistance. An increase in the density of the voltage-dependent potassium currents and the H current is required to account for the decrease in input resistance. These changes also account for the age-dependent decrease in action potential duration.&lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_reaction_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
          &lt;imageobject&gt;&#xD;
            &lt;objectinfo&gt;&#xD;
              &lt;title&gt;model diagram&lt;/title&gt;&#xD;
            &lt;/objectinfo&gt;&#xD;
            &lt;imagedata fileref="purvis_2005.png" /&gt;&#xD;
          &lt;/imageobject&gt;&#xD;
        &lt;/mediaobject&gt;&#xD;
        &lt;caption&gt;A schematic diagram of the cell model.  It is composed of ten ionic currents across the plasma membrane: a fast sodium current, INa; a delayed rectifier potassium current, IK; a persistent sodium current,  INaP; a passive leakage current, IL; a LVA calcium current, IT; an N-type HVA calcium current, IN; a P-type HVA calcium current, IP; a calcium-dependent potassium current, ISK; a fast-transient potassium current, IA; and finally, a hyperpolarisation-activated current, IH.&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        Ionic current model of a hypoglossal motoneuron, Robert J. Butera, Jr., Liston K. Purvis, 2005,&#xD;
        &lt;emphasis&gt;Journal of Neurophysiology&lt;/emphasis&gt;&#xD;
        , 93, 723-733.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=15653786&amp;amp;dopt=Abstract"&gt;PubMed ID: 15653786&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
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