Location: Albrecht, Colegrove, Hongpaisan, Pivovarova, Andrews, Friel, 2001 @ 7fb33358bf25 / albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001.cellml

Author:
rcai987 <devnull@localhost>
Date:
2015-01-06 14:39:24+13:00
Desc:
Added annotations to albrecht_colegrove_hongpaisan...
Permanent Source URI:
http://models.cellml.org/workspace/albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001/rawfile/7fb33358bf25c4f067170946631842807b267ea2/albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001.cellml

<?xml version="1.0"?>
<!--  FILE :  albrecht_model_2001.xml

CREATED :  25th March 2002

LAST MODIFIED : 9th April 2003

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Albrecht et al's
2001 model of calcium-induced calcium release in sympathetic neurons.

CHANGES:  
  18/07/2002 - CML - Added more metadata.
  09/04/2003 - AAC - Added publication date information.  
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:base="file:///H:/Summer Research/Ray's 2nd/albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001.cellml" cmeta:id="albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001_version01" name="albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Multiple Modes of Calcium-induced Calcium Release in Sympathetic Neurons</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model is consistently represented within the CellML but contains sets of algebraic equations that prevent the model from being solved in currently available software - 03/08.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
Calcium is an important signalling ion, and changes in Ca<superscript>2+</superscript> concentration ([Ca<superscript>2+</superscript>]) regulate diverse processes in many cellular compartments.  In excitable cells, depolarisation-induced Ca<superscript>2+</superscript> entry increases [Ca<superscript>2+</superscript>]<subscript>i</subscript>, leading to secondary changes in [Ca<superscript>2+</superscript>] within organelles such as mitochondria and ER that regulate specific Ca<superscript>2+</superscript>-sensitive targets within these organelles.  Although mitochondria accumulate Ca<superscript>2+</superscript> in response to depolarisation-evoked [Ca<superscript>2+</superscript>]<subscript>i</subscript> elevations (see <ulink url="${HTML_EXMPL_COLEGROVE_MODEL}">The Colegrove <emphasis>et al</emphasis> Model Of Mitochondrial Ca<superscript>2+</superscript> Uptake And Release, 2000</ulink>), the ER has been described as either a Ca<superscript>2+</superscript> source or sink.  Different modes of net ER Ca<superscript>2+</superscript> transport are expected to have very different effects on cytoplasmic and intraluminal Ca<superscript>2+</superscript> signals and on the processes they regulate.   
</para>

<para>
In their 2001 model, Meredith A. Albrecht, Stephen L. Colegrove, Jarin Hongpaisan, Natalia B. Pivovarova, S. Brian Andrews and David D. Friel have examined the relationship between changes in [Ca<superscript>2+</superscript>]<subscript>i</subscript> and [Ca<superscript>2+</superscript>]<subscript>ER</subscript> during weak depolarisation in sympathetic neurons.  The total Ca<superscript>2+</superscript> flux during the recovery phase following membrane depolarisation was divided into four components (see <xref linkend="fig_cell_diagram"/> below).  One representing net Ca<superscript>2+</superscript> extrusion across the plasma membrane (J<subscript>extru</subscript>), one representing Ca<superscript>2+</superscript> entry through voltage-gated Ca<superscript>2+</superscript> channels (J<subscript>ICa</subscript>), one representing ER Ca<superscript>2+</superscript> uptake via a Ca<superscript>2+</superscript> ATPase (J<subscript>SERCA</subscript>) and one representing passive ER Ca<superscript>2+</superscript> release.  This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
<ulink url="http://www.jgp.org/cgi/content/abstract/118/1/83">Multiple Modes of Calcium-induced Calcium Release in Sympathetic Neurons I:  Attenuation of Endoplasmic Reticulum Ca<superscript>2+</superscript> Accumulation at Low [Ca<superscript>2+</superscript>]<subscript>i</subscript> during Weak Depolarisation</ulink>, Meredith A. Albrecht, Stephen L. Colegrove, Jarin Hongpaisan, Natalia B. Pivovarova, S. Brian Andrews and David D. Friel, 2001, <ulink url="http://www.jgp.org/">
            <emphasis>The Journal Of General Physiology</emphasis>
          </ulink>, 118, 83-100.  (<ulink url="http://www.jgp.org/cgi/content/full/118/1/83">Full text</ulink> and <ulink url="http://www.jgp.org/cgi/reprint/118/1/83.pdf">PDF</ulink> versions of the article are available for Journal Members on the JGP website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11429446&amp;dopt=Abstract">PubMed ID: 11429446</ulink>  
</para>


<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell schematic for the model</title>
    </objectinfo>
    <imagedata fileref="albrecht_2001.png"/>
  </imageobject>
</mediaobject>
<caption>Schematic of the model indicating Ca<superscript>2+</superscript> compartmentation in the extracellular matrix, cytosol and the ER and pathways for Ca<superscript>2+</superscript> ion movement between the compartments.</caption>
</informalfigure>

</sect1>
</article>
</documentation>
  
  
  <!--
    Below, we define some additional units for association with variables and
    constants within the model. The identifiers are fairly self-explanatory.
  -->
  
  <units name="per_second">
    <unit exponent="-1" units="second"/>
  </units>
  
  <units name="millivolt">
    <unit prefix="milli" units="volt"/>
  </units>
  
  <units name="millimolar">
    <unit prefix="milli" units="mole"/>
    <unit exponent="-1" units="litre"/>
  </units>
  
  <units name="micromolar">
    <unit prefix="micro" units="mole"/>
    <unit exponent="-1" units="litre"/>
  </units>
  
  <units name="nanomolar">
    <unit prefix="nano" units="mole"/>
    <unit exponent="-1" units="litre"/>
  </units>
  
  <units name="nanomolar_per_second">
    <unit units="nanomolar"/>
    <unit exponent="-1" units="second"/>
  </units>
  
  <units name="micromolar_per_second">
    <unit units="micromolar"/>
    <unit exponent="-1" units="second"/>
  </units>
  
  <units name="micro_litre">
    <unit prefix="micro" units="litre"/>
  </units>
  
  <units name="coulomb_per_millimole">
    <unit units="coulomb"/>
    <unit exponent="-1" prefix="milli" units="mole"/>
  </units>
  
  <units name="picoA">
    <unit prefix="pico" units="ampere"/>
  </units>
  
  <!--
    The "environment" component is used to declare variables that are used by
    all or most of the other components, in this case just "time".
  -->
  <component name="environment">
    <variable name="time" public_interface="out" units="second"/>
  </component>
  
  <component cmeta:id="id_00001" name="total_cytoplasmic_Ca_flux">
    <variable cmeta:id="id_00007" name="J_ICa" public_interface="out" units="nanomolar_per_second"/>
    <variable name="v_i" public_interface="out" units="micro_litre"/>
    <variable name="k_i" public_interface="out" units="dimensionless"/>
   
    <variable initial_value="96.5" name="F" units="coulomb_per_millimole"/>
    <variable cmeta:id="id_00008" name="I_Ca" units="picoA"/>
   
    <variable name="time" public_interface="in" units="second"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_ICa_calculation">
        <eq/>
        <ci> J_ICa </ci>
        <apply>
          <divide/>
          <ci> I_Ca </ci>
          <apply>
            <times/>
            <cn cellml:units="dimensionless"> 2.0 </cn>
            <ci> F </ci>
            <ci> v_i </ci>
            <ci> k_i </ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component cmeta:id="id_00002" name="Ca_extrusion_across_the_plasma_membrane">
    <variable cmeta:id="id_00017" name="J_pm" public_interface="out" units="nanomolar_per_second"/>
   
    <variable name="J_extru" units="nanomolar_per_second"/>
    <variable cmeta:id="id_00018" initial_value="0.00000015" name="k_leak" units="per_second"/>
    <variable initial_value="25.0" name="Vmax_extru" units="nanomolar_per_second"/>
    <variable initial_value="386.0" name="EC50_extru" units="nanomolar"/>
    <variable initial_value="2.4" name="n_extru" units="dimensionless"/>
    <variable cmeta:id="id_00010" initial_value="2.0" name="Ca_o" units="millimolar"/>
   
    <variable cmeta:id="id_00019" name="J_ICa" public_interface="in" units="nanomolar_per_second"/>
    <variable cmeta:id="id_00009" name="Ca_i" public_interface="in" units="nanomolar"/>
    <variable name="time" public_interface="in" units="second"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_pm_calculation">
        <eq/>
        <ci> J_pm </ci>
        <apply>
          <plus/>
          <ci> J_extru </ci>
          <ci> J_ICa </ci>
        </apply>
      </apply>
      
      <apply id="J_extru_calculation">
        <eq/>
        <ci> J_extru </ci>
        <apply>
          <plus/>
          <apply>
            <times/>
            <ci> k_leak </ci>
            <apply>
              <minus/>
              <ci> Ca_i </ci>
              <ci> Ca_o </ci>
            </apply>
          </apply>    
          <apply>
            <divide/>
            <ci> Vmax_extru </ci>
            <apply>
              <plus/>
              <cn cellml:units="dimensionless"> 1.0 </cn>
              <apply>
                <power/>
                <apply>
                  <divide/>
                  <ci> EC50_extru </ci>
                  <ci> Ca_i </ci>
                </apply>
                <ci> n_extru </ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component cmeta:id="id_00003" name="Ca_uptake_by_SR_Ca_ATPase">        
    <variable cmeta:id="id_00020" name="J_SERCA" public_interface="out" units="nanomolar_per_second"/>
    
    <variable cmeta:id="id_00021" initial_value="70.0" name="Vmax_SERCA" units="nanomolar_per_second"/>
    <variable cmeta:id="id_00022" initial_value="700.0" name="EC50_SERCA" units="nanomolar"/>
    <variable cmeta:id="id_00023" initial_value="1.0" name="n_SERCA" units="dimensionless"/>
   
    <variable cmeta:id="id_00011" name="Ca_i" public_interface="in" units="nanomolar"/>
    <variable name="time" public_interface="in" units="second"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_SERCA_calculation">
        <eq/>
        <ci> J_SERCA </ci>
        <apply>
          <divide/>
          <ci> Vmax_SERCA </ci>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless"> 1.0 </cn>
            <apply>
              <power/>
              <apply>
                <divide/>
                <ci> EC50_SERCA </ci>
                <ci> Ca_i </ci>
              </apply>
              <ci> n_SERCA </ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component cmeta:id="id_00004" name="ER_Ca_release">     
    <variable cmeta:id="id_00024" name="J_ER" public_interface="out" units="nanomolar_per_second"/>       
   
    <variable cmeta:id="id_00025" name="P_ER" units="per_second"/>
    <variable initial_value="0.0000178" name="P_basal" units="per_second"/>
    <variable cmeta:id="id_00036" initial_value="0.0009" name="Pmax_RyR" units="per_second"/>
    <variable cmeta:id="id_00035" initial_value="1.0" name="EC50_RyR" units="micromolar"/>
    <variable cmeta:id="id_00034" initial_value="1.0" name="n_RyR" units="dimensionless"/>
    <variable name="J_release" units="nanomolar_per_second"/>
    
    <variable cmeta:id="id_00031" name="J_SERCA" public_interface="in" units="nanomolar_per_second"/>
    <variable cmeta:id="id_00012" name="Ca_i" public_interface="in" units="nanomolar"/>
    <variable cmeta:id="id_00013" name="Ca_ER" public_interface="in" units="nanomolar"/>         
    <variable name="time" public_interface="in" units="second"/>        
            
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_release_calculation">
        <eq/>
        <ci> J_release </ci>
        <apply>
          <times/>
          <ci> P_ER </ci>
          <apply>
            <minus/>
            <ci> Ca_i </ci>
            <ci> Ca_ER </ci> 
          </apply>
        </apply>
      </apply>
      
      <apply id="J_ER_calculation">
        <eq/>
        <ci> J_ER </ci>
        <apply>
          <plus/>
          <ci> J_SERCA </ci>
          <ci> J_release </ci>
        </apply>
      </apply>
      
      <apply id="P_ER_calculation">
        <eq/>
        <ci> P_ER </ci>
        <apply>
          <plus/>
          <ci> P_basal </ci>
          <apply>
            <divide/>
            <ci> Pmax_RyR </ci>
            <apply>
              <plus/>
              <cn cellml:units="dimensionless"> 1.0 </cn>
              <apply>
                <power/>
                <apply>
                  <divide/>
                  <ci> EC50_RyR </ci>
                  <ci> Ca_i </ci>
                </apply>
                <ci> n_RyR </ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component cmeta:id="id_00005" name="cytoplasmic_calcium">
    <variable cmeta:id="id_00014" name="Ca_i" public_interface="out" units="nanomolar"/>
    
    <variable name="J_i" units="nanomolar_per_second"/>
    
    <variable cmeta:id="id_00026" name="J_ER" public_interface="in" units="nanomolar_per_second"/>
    <variable cmeta:id="id_00033" name="J_pm" public_interface="in" units="nanomolar_per_second"/>
    <variable name="time" public_interface="in" units="second"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="Ca_i_diff_eq">
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci> time </ci>
          </bvar>
          <ci> Ca_i </ci>
        </apply>
        <apply>
          <minus/>
          <ci> J_i </ci>
        </apply>
      </apply>
      
      <apply id="J_i_calculation">
        <eq/>
        <ci> J_i </ci>
        <apply>
          <plus/>
          <ci> J_pm </ci>
          <ci> J_ER </ci>
        </apply>
      </apply>
    </math>
  </component>
  
  <component cmeta:id="id_00006" name="intraluminal_calcium">
    <variable cmeta:id="id_00015" name="Ca_ER" public_interface="out" units="nanomolar"/>
    
    <variable cmeta:id="id_00027" name="v_ER" units="micro_litre"/>
    <variable cmeta:id="id_00028" name="k_ER" units="dimensionless"/>
    <variable cmeta:id="id_00029" initial_value="0.01" name="gamma_ER" units="dimensionless"/>
   
    <variable cmeta:id="id_00016" name="Ca_i" public_interface="in" units="nanomolar"/>
    <variable name="v_i" public_interface="in" units="micro_litre"/>
    <variable name="k_i" public_interface="in" units="dimensionless"/>
    <variable cmeta:id="id_00030" name="J_ER" public_interface="in" units="nanomolar_per_second"/>
    <variable cmeta:id="id_00032" name="J_SERCA" public_interface="in" units="nanomolar_per_second"/>
    <variable name="time" public_interface="in" units="second"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="Ca_ER_diff_eq">
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci> time </ci>
          </bvar>
          <ci> Ca_ER </ci>
        </apply>
        <apply>
          <divide/>
          <ci> J_ER </ci>
          <ci> gamma_ER </ci>
        </apply>
      </apply>
      
      <apply id="gamma_ER_calculation">
        <eq/>
        <ci> gamma_ER </ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <ci> v_ER </ci>
            <ci> k_ER </ci>
          </apply>
          <apply>
            <times/>
            <ci> v_i </ci>
            <ci> k_i </ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <connection>
    <map_components component_1="total_cytoplasmic_Ca_flux" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="Ca_extrusion_across_the_plasma_membrane" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="Ca_uptake_by_SR_Ca_ATPase" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="ER_Ca_release" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="cytoplasmic_calcium" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="intraluminal_calcium" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="total_cytoplasmic_Ca_flux" component_2="Ca_extrusion_across_the_plasma_membrane"/>
    <map_variables variable_1="J_ICa" variable_2="J_ICa"/>
  </connection>
  
  <connection>
    <map_components component_1="total_cytoplasmic_Ca_flux" component_2="intraluminal_calcium"/>
    <map_variables variable_1="v_i" variable_2="v_i"/>
    <map_variables variable_1="k_i" variable_2="k_i"/>
  </connection>
  
  <connection>
    <map_components component_1="Ca_extrusion_across_the_plasma_membrane" component_2="cytoplasmic_calcium"/>
    <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
    <map_variables variable_1="J_pm" variable_2="J_pm"/>
  </connection>
  
  <connection>
    <map_components component_1="Ca_uptake_by_SR_Ca_ATPase" component_2="cytoplasmic_calcium"/>
    <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
  </connection> 
  
  <connection>
    <map_components component_1="Ca_uptake_by_SR_Ca_ATPase" component_2="ER_Ca_release"/>
    <map_variables variable_1="J_SERCA" variable_2="J_SERCA"/>
  </connection>
  
  <connection>
    <map_components component_1="Ca_uptake_by_SR_Ca_ATPase" component_2="intraluminal_calcium"/>
    <map_variables variable_1="J_SERCA" variable_2="J_SERCA"/>
  </connection>
  
  <connection>
    <map_components component_1="ER_Ca_release" component_2="cytoplasmic_calcium"/>
    <map_variables variable_1="J_ER" variable_2="J_ER"/>
    <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
  </connection> 
  
  <connection>
    <map_components component_1="ER_Ca_release" component_2="intraluminal_calcium"/>
    <map_variables variable_1="J_ER" variable_2="J_ER"/>
    <map_variables variable_1="Ca_ER" variable_2="Ca_ER"/>
  </connection>
  
  <connection>
    <map_components component_1="cytoplasmic_calcium" component_2="intraluminal_calcium"/>
    <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
  </connection> 





<rdf:RDF><rdf:Description rdf:about="#id_00001"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:66835"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00002"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63841"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00003"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00004"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00005"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00006"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00007"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00008"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00009"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00010"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00011"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00012"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00013"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00014"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00015"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00016"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00017"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63841"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00018"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0022840"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00019"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00020"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00021"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00022"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00023"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00024"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00025"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00026"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00027"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00028"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00029"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00030"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:63842"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00031"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00032"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00033"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005886"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00034"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:62492"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00035"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:62492"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00036"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/fma/FMA:62492"/></isVersionOf></rdf:Description></rdf:RDF></model>