- Author:
- Andy Lo <alo006@aucklanduni.ac.nz>
- Date:
- 2023-05-30 11:52:15+12:00
- Desc:
- N/A
- Permanent Source URI:
- http://models.cellml.org/workspace/b10/rawfile/362168106caa6e4eb42021f4dad428f54101f6a7/LG_Na_voltage_clamp.cellml
<?xml version='1.0' encoding='UTF-8'?>
<!-- FILE : LR_II_model_1994.xml
CREATED : 28th March 2002
LAST MODIFIED : 30th July 2003
AUTHOR : Catherine Lloyd
The Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the CellML Metadata 1.0 Specification released on 16th
January, 2002.
DESCRIPTION : This file contains a CellML description of the mammalian
ventricular action potential based on the Luo-Rudy II model, 1994. This model
is a development of the LR-I model. In particular, the LR-II model describes
the processes which regulate [Ca]i (intracellular Calcium concentration), and
the movement of calcium ions through the cell and to and from the sarcoplasmic
reticulum.
CHANGES:
18/07/2002 - CML - Added more metadata.
09/04/2003 - AAC - Added publication date information.
05/06/2003 - CML - Fixed MathML in a few components.
30/07/2003 - CML - Fixed MathML in a few components.
-->
<model cmeta:id="luo_rudy_1994" name="luo_rudy_1994" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="ms">
<unit prefix="milli" units="second"/>
</units>
<units name="per_ms">
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="per_mm">
<unit exponent="-1" prefix="milli" units="metre"/>
</units>
<units name="mV">
<unit prefix="milli" units="volt"/>
</units>
<units name="mV_per_ms">
<unit units="mV"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="per_mV">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="per_mV_ms">
<unit exponent="-1" units="mV"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="mS_per_mm2">
<unit prefix="milli" units="siemens"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="uF_per_mm2">
<unit prefix="micro" units="farad"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="uA_per_mm2">
<unit prefix="micro" units="ampere"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="mM_per_ms">
<unit units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="mM">
<unit prefix="nano" units="mole"/>
<unit exponent="-3" prefix="milli" units="metre"/>
</units>
<units name="gas_constant_units">
<unit prefix="pico" units="joule"/>
<unit exponent="-1" prefix="nano" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="faradays_constant_units">
<unit prefix="nano" units="coulomb"/>
<unit exponent="-1" prefix="nano" units="mole"/>
</units>
<units name="mm_per_ms">
<unit prefix="milli" units="metre"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="mm2">
<unit exponent="2" prefix="milli" units="metre"/>
</units>
<component cmeta:id="environment" name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="ms"/>
</component>
<component cmeta:id="membrane" name="membrane">
<variable cmeta:id="membrane_V" initial_value="-70" name="V" public_interface="out" units="mV"/>
<variable initial_value="8.3145e3" name="R" public_interface="out" units="gas_constant_units"/>
<variable initial_value="310.0" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96845.0" name="F" public_interface="out" units="faradays_constant_units"/>
<variable name="dV_dt" public_interface="out" units="mV_per_ms"/>
<variable initial_value="0.01" name="Cm" units="uF_per_mm2"/>
<variable name="I_st" units="uA_per_mm2"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="i_Na" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_L" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K1" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Kp" public_interface="in" units="uA_per_mm2"/>
<variable name="i_p_Ca" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Na_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaK" public_interface="in" units="uA_per_mm2"/>
<variable name="i_ns_Ca" public_interface="in" units="uA_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="dV_dt_eq">
<eq/>
<ci>dV_dt</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<apply>
<minus/>
<ci>I_st</ci>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Ca_L</ci>
<ci>i_K</ci>
<ci>i_K1</ci>
<ci>i_Kp</ci>
<ci>i_NaCa</ci>
<ci>i_p_Ca</ci>
<ci>i_Na_b</ci>
<ci>i_Ca_b</ci>
<ci>i_NaK</ci>
<ci>i_ns_Ca</ci>
</apply>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
<variable initial_value="1e3" name="stimPeriod" units="dimensionless"/>
<variable initial_value="0.5" name="stimDuration" units="dimensionless"/>
<variable initial_value="0.5" name="stimCurrent" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_st</ci>
<piecewise>
<piece>
<ci>stimCurrent</ci>
<apply>
<lt/>
<apply>
<rem/>
<ci>time</ci>
<ci>stimPeriod</ci>
</apply>
<ci>stimDuration</ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply id="membrane_voltage_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<ci>dV_dt</ci>
</apply>
</math>
</component>
<component cmeta:id="fast_sodium_current" name="fast_sodium_current">
<variable name="i_Na" public_interface="out" units="uA_per_mm2"/>
<variable name="E_Na" public_interface="out" units="mV"/>
<variable initial_value="0.16" name="g_Na" units="mS_per_mm2"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<variable name="j" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="i_Na_calculation">
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply id="E_Na_calculation">
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="fast_sodium_current_m_gate" name="fast_sodium_current_m_gate">
<variable initial_value="0.0" name="m" public_interface="out" units="dimensionless"/>
<variable name="alpha_m" units="per_ms"/>
<variable name="beta_m" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_m_calculation">
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.32</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="beta_m_calculation">
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V_clamp</ci>
</apply>
<cn cellml:units="mV">11.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="dm_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="fast_sodium_current_h_gate" name="fast_sodium_current_h_gate">
<variable initial_value="1.0" name="h" public_interface="out" units="dimensionless"/>
<variable name="alpha_h" units="per_ms"/>
<variable name="beta_h" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_h_calculation">
<eq/>
<ci>alpha_h</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_ms">0.135</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="mV">80.0</cn>
<ci>V_clamp</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">6.8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V_clamp</ci>
<apply>
<minus/>
<cn cellml:units="mV">40.0</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_ms">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply id="beta_h_calculation">
<eq/>
<ci>beta_h</ci>
<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_ms">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="mV">0.079</cn>
<ci>V_clamp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_ms">310000.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.35</cn>
<ci>V_clamp</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V_clamp</ci>
<apply>
<minus/>
<cn cellml:units="mV">40.0</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<cn cellml:units="ms">0.13</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">10.66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">11.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply id="dh_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="fast_sodium_current_j_gate" name="fast_sodium_current_j_gate">
<variable initial_value="1.0" name="j" public_interface="out" units="dimensionless"/>
<variable name="alpha_j" units="per_ms"/>
<variable name="beta_j" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_j_calculation">
<eq/>
<ci>alpha_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV_ms">127140.0</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.2444</cn>
<ci>V_clamp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.00003474</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.04391</cn>
</apply>
<ci>V_clamp</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">37.78</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.311</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V_clamp</ci>
<apply>
<minus/>
<cn cellml:units="mV">40.0</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_ms">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply id="beta_j_calculation">
<eq/>
<ci>beta_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_ms">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.01052</cn>
</apply>
<ci>V_clamp</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V_clamp</ci>
<apply>
<minus/>
<cn cellml:units="mV">40.0</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_ms">0.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.0000002535</cn>
</apply>
<ci>V_clamp</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">32.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply id="dj_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_j</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>j</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_j</ci>
<ci>j</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel" name="L_type_Ca_channel">
<variable name="i_Ca_L" public_interface="out" units="uA_per_mm2"/>
<variable name="i_CaCa" public_interface="out" units="uA_per_mm2"/>
<variable name="i_CaK" public_interface="out" units="uA_per_mm2"/>
<variable name="i_CaNa" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="0.75" name="gamma_Nai" public_interface="out" units="dimensionless"/>
<variable initial_value="0.75" name="gamma_Nao" public_interface="out" units="dimensionless"/>
<variable initial_value="0.75" name="gamma_Ki" public_interface="out" units="dimensionless"/>
<variable initial_value="0.75" name="gamma_Ko" public_interface="out" units="dimensionless"/>
<variable name="I_CaCa" units="uA_per_mm2"/>
<variable name="I_CaK" units="uA_per_mm2"/>
<variable name="I_CaNa" units="uA_per_mm2"/>
<variable initial_value="5.4e-6" name="P_Ca" units="mm_per_ms"/>
<variable initial_value="6.75e-9" name="P_Na" units="mm_per_ms"/>
<variable initial_value="1.93e-9" name="P_K" units="mm_per_ms"/>
<variable initial_value="1.0" name="gamma_Cai" units="dimensionless"/>
<variable initial_value="0.34" name="gamma_Cao" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Cai" private_interface="out" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="d" private_interface="in" units="dimensionless"/>
<variable name="f" private_interface="in" units="dimensionless"/>
<variable name="f_Ca" private_interface="in" units="dimensionless"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="i_CaCa_calculation">
<eq/>
<ci>i_CaCa</ci>
<apply>
<times/>
<ci>d</ci>
<ci>f</ci>
<ci>f_Ca</ci>
<ci>I_CaCa</ci>
</apply>
</apply>
<apply id="i_CaNa_calculation">
<eq/>
<ci>i_CaNa</ci>
<apply>
<times/>
<ci>d</ci>
<ci>f</ci>
<ci>f_Ca</ci>
<ci>I_CaNa</ci>
</apply>
</apply>
<apply id="i_CaK_calculation">
<eq/>
<ci>i_CaK</ci>
<apply>
<times/>
<ci>d</ci>
<ci>f</ci>
<ci>f_Ca</ci>
<ci>I_CaK</ci>
</apply>
</apply>
<apply id="I_CaCa_calculation">
<eq/>
<ci>I_CaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Ca</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V_clamp</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Cai</ci>
<ci>Cai</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Cao</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply id="I_CaNa_calculation">
<eq/>
<ci>I_CaNa</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Na</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">1.0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V_clamp</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Nai</ci>
<ci>Nai</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Nao</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply id="I_CaK_calculation">
<eq/>
<ci>I_CaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_K</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">1.0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V_clamp</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Ki</ci>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Ko</ci>
<ci>Ko</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply id="i_Ca_L_calculation">
<eq/>
<ci>i_Ca_L</ci>
<apply>
<plus/>
<ci>i_CaCa</ci>
<ci>i_CaK</ci>
<ci>i_CaNa</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel_d_gate" name="L_type_Ca_channel_d_gate">
<variable initial_value="0.0" name="d" public_interface="out" units="dimensionless"/>
<variable name="alpha_d" units="per_ms"/>
<variable name="beta_d" units="per_ms"/>
<variable name="d_infinity" units="dimensionless"/>
<variable name="tau_d" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_d_calculation">
<eq/>
<ci>alpha_d</ci>
<apply>
<divide/>
<ci>d_infinity</ci>
<ci>tau_d</ci>
</apply>
</apply>
<apply id="d_infinity_calculation">
<eq/>
<ci>d_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
<cn cellml:units="mV">6.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="tau_d_calculation">
<eq/>
<ci>tau_d</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>d_infinity</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
<cn cellml:units="mV">6.24</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.035</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="beta_d_calculation">
<eq/>
<ci>beta_d</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>d_infinity</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
<apply id="dd_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_d</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>d</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_d</ci>
<ci>d</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel_f_gate" name="L_type_Ca_channel_f_gate">
<variable initial_value="1.0" name="f" public_interface="out" units="dimensionless"/>
<variable name="alpha_f" units="per_ms"/>
<variable name="beta_f" units="per_ms"/>
<variable name="f_infinity" units="dimensionless"/>
<variable name="tau_f" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_f_calculation">
<eq/>
<ci>alpha_f</ci>
<apply>
<divide/>
<ci>f_infinity</ci>
<ci>tau_f</ci>
</apply>
</apply>
<apply id="f_infinity_calculation">
<eq/>
<ci>f_infinity</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">35.06</cn>
</apply>
<cn cellml:units="mV">8.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mV">50.0</cn>
<ci>V_clamp</ci>
</apply>
<cn cellml:units="mV">20.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="tau_f_calculation">
<eq/>
<ci>tau_f</ci>
<apply>
<divide/>
<cn cellml:units="ms">1.0</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0197</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_mV">0.0337</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
</apply>
</apply>
<apply id="beta_f_calculation">
<eq/>
<ci>beta_f</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>f_infinity</ci>
</apply>
<ci>tau_f</ci>
</apply>
</apply>
<apply id="df_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_f</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>f</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_f</ci>
<ci>f</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel_f_Ca_gate" name="L_type_Ca_channel_f_Ca_gate">
<variable name="f_Ca" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6e-3" name="Km_Ca" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="f_Ca_calculation">
<eq/>
<ci>f_Ca</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Km_Ca</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_dependent_potassium_current" name="time_dependent_potassium_current">
<variable name="i_K" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="2.82e-3" name="g_K_max" units="mS_per_mm2"/>
<variable name="g_K" units="mS_per_mm2"/>
<variable name="E_K" units="mV"/>
<variable initial_value="0.01833" name="PR_NaK" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="X" private_interface="in" units="dimensionless"/>
<variable name="Xi" private_interface="in" units="dimensionless"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="g_K_calculation">
<eq/>
<ci>g_K</ci>
<apply>
<times/>
<ci>g_K_max</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="E_K_calculation">
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<ci>PR_NaK</ci>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>PR_NaK</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="i_K_calculation">
<eq/>
<ci>i_K</ci>
<apply>
<times/>
<ci>g_K</ci>
<apply>
<power/>
<ci>X</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Xi</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_dependent_potassium_current_X_gate" name="time_dependent_potassium_current_X_gate">
<variable initial_value="0.0" name="X" public_interface="out" units="dimensionless"/>
<variable name="alpha_X" units="per_ms"/>
<variable name="beta_X" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_X_calculation">
<eq/>
<ci>alpha_X</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.0000719</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.148</cn>
</apply>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="beta_X_calculation">
<eq/>
<ci>beta_X</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_ms">0.000131</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0687</cn>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="dX_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_X</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>X</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_X</ci>
<ci>X</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_dependent_potassium_current_Xi_gate" name="time_dependent_potassium_current_Xi_gate">
<variable name="Xi" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="Xi_calculation">
<eq/>
<ci>Xi</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">56.26</cn>
</apply>
<cn cellml:units="mV">32.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_independent_potassium_current" name="time_independent_potassium_current">
<variable name="i_K1" public_interface="out" units="uA_per_mm2"/>
<variable name="E_K1" private_interface="out" public_interface="out" units="mV"/>
<variable initial_value="7.5e-3" name="g_K1_max" units="mS_per_mm2"/>
<variable name="g_K1" units="mS_per_mm2"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="K1_infinity" private_interface="in" units="dimensionless"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="g_K1_calculation">
<eq/>
<ci>g_K1</ci>
<apply>
<times/>
<ci>g_K1_max</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="E_K1_calculation">
<eq/>
<ci>E_K1</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="i_K1_calculation">
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<ci>K1_infinity</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_K1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_independent_potassium_current_K1_gate" name="time_independent_potassium_current_K1_gate">
<variable name="K1_infinity" public_interface="out" units="dimensionless"/>
<variable name="alpha_K1" units="per_ms"/>
<variable name="beta_K1" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="E_K1" public_interface="in" units="mV"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="alpha_K1_calculation">
<eq/>
<ci>alpha_K1</ci>
<apply>
<divide/>
<cn cellml:units="per_ms">1.02</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.2385</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_K1</ci>
</apply>
<cn cellml:units="mV">59.215</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="beta_K1_calculation">
<eq/>
<ci>beta_K1</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_ms">0.49124</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.08032</cn>
<apply>
<minus/>
<apply>
<plus/>
<ci>V_clamp</ci>
<cn cellml:units="mV">5.476</cn>
</apply>
<ci>E_K1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.06175</cn>
<apply>
<minus/>
<ci>V_clamp</ci>
<apply>
<plus/>
<ci>E_K1</ci>
<cn cellml:units="mV">594.31</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.5143</cn>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_K1</ci>
</apply>
<cn cellml:units="mV">4.753</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="K1_infinity_calculation">
<eq/>
<ci>K1_infinity</ci>
<apply>
<divide/>
<ci>alpha_K1</ci>
<apply>
<plus/>
<ci>alpha_K1</ci>
<ci>beta_K1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="plateau_potassium_current" name="plateau_potassium_current">
<variable name="i_Kp" public_interface="out" units="uA_per_mm2"/>
<variable name="E_Kp" units="mV"/>
<variable initial_value="1.83e-4" name="g_Kp" units="mS_per_mm2"/>
<variable name="Kp" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="E_K1" public_interface="in" units="mV"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="E_Kp_calculation">
<eq/>
<ci>E_Kp</ci>
<ci>E_K1</ci>
</apply>
<apply id="Kp_calculation">
<eq/>
<ci>Kp</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mV">7.488</cn>
<ci>V_clamp</ci>
</apply>
<cn cellml:units="mV">5.98</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="i_Kp_calculation">
<eq/>
<ci>i_Kp</ci>
<apply>
<times/>
<ci>g_Kp</ci>
<ci>Kp</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_Kp</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="sarcolemmal_calcium_pump" name="sarcolemmal_calcium_pump">
<variable name="i_p_Ca" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="0.5e-3" name="K_mpCa" units="mM"/>
<variable initial_value="1.15e-2" name="I_pCa" units="uA_per_mm2"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_p_Ca_calculation">
<eq/>
<ci>i_p_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_pCa</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>K_mpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="sodium_background_current" name="sodium_background_current">
<variable name="i_Na_b" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="1.41e-5" name="g_Nab" units="mS_per_mm2"/>
<variable name="E_NaN" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="E_Na" public_interface="in" units="mV"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="E_NaN_calculation">
<eq/>
<ci>E_NaN</ci>
<ci>E_Na</ci>
</apply>
<apply id="i_Na_b_calculation">
<eq/>
<ci>i_Na_b</ci>
<apply>
<times/>
<ci>g_Nab</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_NaN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="calcium_background_current" name="calcium_background_current">
<variable name="i_Ca_b" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="3.016e-5" name="g_Cab" units="mS_per_mm2"/>
<variable name="E_CaN" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="E_CaN_calculation">
<eq/>
<ci>E_CaN</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="i_Ca_b_calculation">
<eq/>
<ci>i_Ca_b</ci>
<apply>
<times/>
<ci>g_Cab</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>E_CaN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="sodium_potassium_pump" name="sodium_potassium_pump">
<variable name="i_NaK" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="1.5e-2" name="I_NaK" units="uA_per_mm2"/>
<variable name="f_NaK" units="dimensionless"/>
<variable initial_value="10.0" name="K_mNai" units="mM"/>
<variable initial_value="1.5" name="K_mKo" units="mM"/>
<variable name="sigma" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="f_NaK_calculation">
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V_clamp</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="sigma_calculation">
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<cn cellml:units="dimensionless">7.0</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply id="i_NaK_calculation">
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>I_NaK</ci>
<ci>f_NaK</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_mNai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>K_mKo</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="non_specific_calcium_activated_current" name="non_specific_calcium_activated_current">
<variable name="i_ns_Ca" public_interface="out" units="uA_per_mm2"/>
<variable name="i_ns_Na" public_interface="out" units="uA_per_mm2"/>
<variable name="i_ns_K" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="1.75e-9" name="P_ns_Ca" units="mm_per_ms"/>
<variable name="gamma_Nai" public_interface="in" units="dimensionless"/>
<variable name="gamma_Nao" public_interface="in" units="dimensionless"/>
<variable name="gamma_Ki" public_interface="in" units="dimensionless"/>
<variable name="gamma_Ko" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="I_ns_Na" units="uA_per_mm2"/>
<variable name="I_ns_K" units="uA_per_mm2"/>
<variable initial_value="1.2e-3" name="K_m_ns_Ca" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="Vns" units="mV"/>
<variable name="EnsCa" units="mV"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="EnsCa_calculation">
<eq/>
<ci>EnsCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Nao</ci>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="Vns_calculation">
<eq/>
<ci>Vns</ci>
<apply>
<minus/>
<ci>V_clamp</ci>
<ci>EnsCa</ci>
</apply>
</apply>
<apply id="i_ns_Na_calculation">
<eq/>
<ci>i_ns_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_ns_Na</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_ns_Ca</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="i_ns_K_calculation">
<eq/>
<ci>i_ns_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_ns_K</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_ns_Ca</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="i_ns_Ca_calculation">
<eq/>
<ci>i_ns_Ca</ci>
<apply>
<plus/>
<ci>i_ns_Na</ci>
<ci>i_ns_K</ci>
</apply>
</apply>
<apply id="I_ns_Na_calculation">
<eq/>
<ci>I_ns_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ns_Ca</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">1.0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Vns</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Nai</ci>
<ci>Nai</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Vns</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Nao</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Vns</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply id="I_ns_K_calculation">
<eq/>
<ci>I_ns_K</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ns_Ca</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">1.0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Vns</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Ki</ci>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Vns</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Ko</ci>
<ci>Ko</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Vns</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Na_Ca_exchanger" name="Na_Ca_exchanger">
<variable name="i_NaCa" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="20.0" name="K_NaCa" units="uA_per_mm2"/>
<variable initial_value="87.5" name="K_mNa" units="mM"/>
<variable initial_value="1.38" name="K_mCa" units="mM"/>
<variable initial_value="0.1" name="K_sat" units="dimensionless"/>
<variable initial_value="0.35" name="eta" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="V_clamp" units="mV"/>
<variable initial_value="-80" name="V_hold" units="mV"/>
<variable initial_value="-70" name="V_test" units="mV"/>
<variable initial_value="-80" name="V_return" units="mV"/>
<variable initial_value="0.5" name="time_hold" units="ms"/>
<variable initial_value="2.5" name="time_testend" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_hold</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_hold</ci>
</apply>
</piece>
<piece>
<ci>V_test</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>time_testend</ci>
</apply>
</piece>
<otherwise>
<ci>V_return</ci>
</otherwise>
</piecewise>
</apply>
<apply id="Na_Ca_exchanger">
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_NaCa</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<ci>K_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>V_clamp</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="calcium_fluxes_in_the_SR" name="calcium_fluxes_in_the_SR">
<variable name="i_rel" public_interface="out" units="mM_per_ms"/>
<variable name="i_up" public_interface="out" units="mM_per_ms"/>
<variable name="i_leak" public_interface="out" units="mM_per_ms"/>
<variable name="i_tr" public_interface="out" units="mM_per_ms"/>
<variable name="G_rel" units="per_ms"/>
<variable name="G_rel_peak" units="per_ms"/>
<variable initial_value="60.0" name="G_rel_max" units="per_ms"/>
<variable initial_value="2.0" name="tau_on" units="ms"/>
<variable initial_value="2.0" name="tau_off" units="ms"/>
<variable initial_value="0.0" name="t_CICR" units="ms"/>
<variable initial_value="180.0" name="tau_tr" units="ms"/>
<variable initial_value="0.8e-3" name="K_mrel" units="mM"/>
<variable initial_value="0.92e-3" name="K_mup" units="mM"/>
<variable name="K_leak" units="per_ms"/>
<variable initial_value="0.005" name="I_up" units="mM_per_ms"/>
<variable initial_value="15.0" name="Ca_NSR_max" units="mM"/>
<variable initial_value="0.0" name="delta_Ca_i2" units="mM"/>
<variable initial_value="0.18e-3" name="delta_Ca_ith" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Ca_JSR" public_interface="in" units="mM"/>
<variable name="Ca_NSR" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_rel_calculation">
<eq/>
<ci>i_rel</ci>
<apply>
<times/>
<ci>G_rel</ci>
<apply>
<minus/>
<ci>Ca_JSR</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply id="G_rel_calculation">
<eq/>
<ci>G_rel</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>G_rel_peak</ci>
<apply>
<minus/>
<ci>delta_Ca_i2</ci>
<ci>delta_Ca_ith</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>K_mrel</ci>
<ci>delta_Ca_i2</ci>
</apply>
<ci>delta_Ca_ith</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>t_CICR</ci>
</apply>
<ci>tau_on</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>t_CICR</ci>
</apply>
<ci>tau_off</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="G_rel_peak_calculation">
<eq/>
<ci>G_rel_peak</ci>
<piecewise>
<piece>
<cn cellml:units="per_ms">0.0</cn>
<apply>
<lt/>
<ci>delta_Ca_i2</ci>
<ci>delta_Ca_ith</ci>
</apply>
</piece>
<otherwise>
<ci>G_rel_max</ci>
</otherwise>
</piecewise>
</apply>
<apply id="i_up_calculation">
<eq/>
<ci>i_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_up</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>Cai</ci>
<ci>K_mup</ci>
</apply>
</apply>
</apply>
<apply id="i_leak_calcualtion">
<eq/>
<ci>i_leak</ci>
<apply>
<times/>
<ci>K_leak</ci>
<ci>Ca_NSR</ci>
</apply>
</apply>
<apply id="K_leak_calculation">
<eq/>
<ci>K_leak</ci>
<apply>
<divide/>
<ci>I_up</ci>
<ci>Ca_NSR_max</ci>
</apply>
</apply>
<apply id="i_tr_calculation">
<eq/>
<ci>i_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ionic_concentrations" name="ionic_concentrations">
<variable initial_value="10.0" name="Nai" public_interface="out" units="mM"/>
<variable initial_value="140.0" name="Nao" public_interface="out" units="mM"/>
<variable initial_value="0.12e-3" name="Cai" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Cao" public_interface="out" units="mM"/>
<variable initial_value="145.0" name="Ki" public_interface="out" units="mM"/>
<variable initial_value="5.4" name="Ko" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Ca_JSR" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Ca_NSR" public_interface="out" units="mM"/>
<variable initial_value="200" name="Am" units="per_mm"/>
<variable initial_value="0.68" name="V_myo" units="dimensionless"/>
<variable initial_value="0.0048" name="V_JSR" units="dimensionless"/>
<variable initial_value="0.0552" name="V_NSR" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="i_Na" public_interface="in" units="uA_per_mm2"/>
<variable name="i_CaNa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Na_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_ns_Na" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_NaK" public_interface="in" units="uA_per_mm2"/>
<variable name="i_CaCa" public_interface="in" units="uA_per_mm2"/>
<variable name="i_CaK" public_interface="in" units="uA_per_mm2"/>
<variable name="i_p_Ca" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Ca_b" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_K1" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Kp" public_interface="in" units="uA_per_mm2"/>
<variable name="i_ns_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_tr" public_interface="in" units="mM_per_ms"/>
<variable name="i_rel" public_interface="in" units="mM_per_ms"/>
<variable name="i_leak" public_interface="in" units="mM_per_ms"/>
<variable name="i_up" public_interface="in" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="sodium_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_CaNa</ci>
<ci>i_Na_b</ci>
<ci>i_ns_Na</ci>
<apply>
<times/>
<ci>i_NaCa</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply id="calcium_internal_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaCa</ci>
<ci>i_p_Ca</ci>
<ci>i_Ca_b</ci>
</apply>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_rel</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_myo</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_leak</ci>
<ci>i_up</ci>
</apply>
<ci>V_NSR</ci>
</apply>
<ci>V_myo</ci>
</apply>
</apply>
</apply>
<apply id="potassium_internal_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaK</ci>
<ci>i_K</ci>
<ci>i_K1</ci>
<ci>i_Kp</ci>
<ci>i_ns_K</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>i_NaK</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<ci>Am</ci>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply id="calcium_JSR_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_JSR</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>i_rel</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_tr</ci>
<ci>V_NSR</ci>
</apply>
<ci>V_JSR</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="calcium_NSR_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_NSR</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_leak</ci>
<ci>i_tr</ci>
</apply>
<ci>i_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f_Ca_gate"/>
</component_ref>
<component_ref component="time_dependent_potassium_current">
<component_ref component="time_dependent_potassium_current_X_gate"/>
<component_ref component="time_dependent_potassium_current_Xi_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current">
<component_ref component="time_independent_potassium_current_K1_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes_in_the_SR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="plateau_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump"/>
<map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_calcium_activated_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_ns_Ca" variable_2="i_ns_Ca"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ionic_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_CaCa" variable_2="i_CaCa"/>
<map_variables variable_1="i_CaNa" variable_2="i_CaNa"/>
<map_variables variable_1="i_CaK" variable_2="i_CaK"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="time_independent_potassium_current"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_ns_Na" variable_2="i_ns_Na"/>
<map_variables variable_1="i_ns_K" variable_2="i_ns_K"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes_in_the_SR" component_2="ionic_concentrations"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
<map_variables variable_1="i_tr" variable_2="i_tr"/>
<map_variables variable_1="i_leak" variable_2="i_leak"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
<map_variables variable_1="Ca_NSR" variable_2="Ca_NSR"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="non_specific_calcium_activated_current"/>
<map_variables variable_1="gamma_Nao" variable_2="gamma_Nao"/>
<map_variables variable_1="gamma_Nai" variable_2="gamma_Nai"/>
<map_variables variable_1="gamma_Ko" variable_2="gamma_Ko"/>
<map_variables variable_1="gamma_Ki" variable_2="gamma_Ki"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_Ca_gate"/>
<map_variables variable_1="f_Ca" variable_2="f_Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_X_gate"/>
<map_variables variable_1="X" variable_2="X"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_Xi_gate"/>
<map_variables variable_1="Xi" variable_2="Xi"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
<map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
</model>
