- Author:
- Andy Lo <alo006@aucklanduni.ac.nz>
- Date:
- 2023-05-31 17:05:22+12:00
- Desc:
- N/A
- Permanent Source URI:
- http://models.cellml.org/workspace/b15/rawfile/1bb17a12714d5b11afa41b16169808d2511bce0c/ShelleyCardiacAPModel.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="ShelleyCardiacAPModel" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="uM" units_ref="uM"/>
<units name="mM_per_sec" units_ref="mM_per_sec"/>
<units name="uM_per_sec" units_ref="uM_per_sec"/>
<units name="pL" units_ref="pL"/>
<units name="m_to_u" units_ref="m_to_u"/>
</import>
<import xlink:href="units_and_constants/constants_BG.cellml">
<component component_ref="constants" name="constants"/>
</import>
<import xlink:href="units_and_constants/ion_valency.cellml">
<component component_ref="ion_valences" name="ion_valences"/>
</import>
<import xlink:href="BG_NCX_MichaelParameters.cellml">
<component component_ref="NCX_MichaelParameters" name="NCX_MichaelParameters"/>
</import>
<import xlink:href="BG_NaK_MichaelParameters.cellml">
<component component_ref="NaK_MichaelParameters" name="NaK_MichaelParameters"/>
</import>
<import xlink:href="BG_fast_Na_MichaelParameters.cellml">
<component component_ref="fast_Na_MichaelParameters" name="fast_Na_MichaelParameters"/>
</import>
<import xlink:href="BG_LCC_MichaelParameters.cellml">
<component component_ref="LCC_MichaelParameters" name="LCC_MichaelParameters"/>
</import>
<import xlink:href="BG_K1_MichaelParameters.cellml">
<component component_ref="K1_MichaelParameters" name="K1_MichaelParameters"/>
</import>
<import xlink:href="BG_Kp_MichaelParameters.cellml">
<component component_ref="Kp_MichaelParameters" name="Kp_MichaelParameters"/>
</import>
<import xlink:href="BG_K_MichaelParameters.cellml">
<component component_ref="K_MichaelParameters" name="K_MichaelParameters"/>
</import>
<import xlink:href="BG_cmdn_MichaelParameters.cellml">
<component component_ref="CMDN_buffer_MichaelParameters" name="CMDN_buffer_MichaelParameters"/>
</import>
<import xlink:href="BG_trpn_MichaelParameters.cellml">
<component component_ref="TRPN_buffer_MichaelParameters" name="TRPN_buffer_MichaelParameters"/>
</import>
<component name="Michaelmodel_environment">
<variable initial_value="0" name="t" public_interface="out" units="second"/>
<!-- External stimulus-->
<variable name="I_stim" units="fA"/>
<variable initial_value="1" name="stimPeriod" units="second"/>
<variable initial_value="0.0001" name="stimDuration" units="second"/>
<variable name="tPeriod" units="second"/>
<variable initial_value="153400" name="C_mic_model" units="fF"/>
<variable initial_value="96485" name="F_mic_model" units="C_per_mol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tPeriod</ci>
<apply>
<minus/>
<ci>t</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>t</ci>
<ci>stimPeriod</ci>
</apply>
</apply>
<ci>stimPeriod</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_stim</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="volt">0.03</cn>
<ci>C_mic_model</ci>
</apply>
<ci>stimDuration</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>tPeriod</ci>
<cn cellml:units="second">0.3</cn>
</apply>
<apply>
<leq/>
<ci>tPeriod</ci>
<apply>
<plus/>
<cn cellml:units="second">0.3</cn>
<ci>stimDuration</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="fA">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<!-- Membrane -->
<variable initial_value="-13039" name="q_mem" public_interface="out" units="fC"/>
<variable name="V_mem" units="volt"/>
<!-- calcium concentration constant-->
<variable initial_value="9.3276" name="q_Ca_o" public_interface="out" units="fmol"/>
<variable initial_value="0.00456" name="q_Ca_i" public_interface="out" units="fmol"/>
<!-- sodium concentration constant-->
<variable initial_value="725.48" name="q_Na_o" public_interface="out" units="fmol"/>
<variable initial_value="380" name="q_Na_i" public_interface="out" units="fmol"/>
<!-- Potassium concentration constant-->
<variable initial_value="27.9828" name="q_K_o" public_interface="out" units="fmol"/>
<variable initial_value="5510" name="q_K_i" public_interface="out" units="fmol"/>
<!-- Intermediate species concentration-->
<variable initial_value="0.0030534" name="q_H_i" public_interface="out" units="fmol"/>
<variable initial_value="15.0898" name="q_Pi" public_interface="out" units="fmol"/>
<variable initial_value="1.33" name="q_MgADP" public_interface="out" units="fmol"/>
<variable initial_value="264.1" name="q_MgATP" public_interface="out" units="fmol"/>
<!-- initial values (I_NCX)-->
<variable initial_value="0.00072174" name="q_P1_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.00072174" name="q_P2_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.00072174" name="q_P3_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.00072174" name="q_P4_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.00072174" name="q_P5_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.00072174" name="q_P6_NCX" public_interface="out" units="fmol"/>
<!-- I_NCX imports-->
<variable name="v_Ca_o_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Ca_i_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Na_o_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Na_i_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_NCX" public_interface="in" units="fA"/>
<!-- initial values (I_NaK)-->
<variable initial_value="0.0078543" name="q_P7" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P14" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P15" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P1" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P2" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P3" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P4" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P5" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P6" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P10" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P11" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P12" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P13" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P8" public_interface="out" units="fmol"/>
<variable initial_value="0.0078543" name="q_P9" public_interface="out" units="fmol"/>
<!-- I_NaK imports-->
<variable name="v_K_o_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_K_i_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Na_o_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Na_i_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_H_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_MgADP_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_MgATP_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Pi_NaK" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_NaK" public_interface="in" units="fA"/>
<!-- initial values (I_Na)-->
<variable initial_value="0.00012033" name="q_S000_Na" public_interface="out" units="fmol"/>
<variable initial_value="1.337e-05" name="q_S010_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.0111e-05" name="q_S100_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.4568e-06" name="q_S110_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.4568e-06" name="q_S200_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.952e-07" name="q_S210_Na" public_interface="out" units="fmol"/>
<variable initial_value="1.6507e-07" name="q_S300_Na" public_interface="out" units="fmol"/>
<variable initial_value="1.8341e-08" name="q_S310_Na" public_interface="out" units="fmol"/>
<variable initial_value="1.337e-05" name="q_S001_Na" public_interface="out" units="fmol"/>
<variable initial_value="1.4856e-06" name="q_S011_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.4568e-06" name="q_S101_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.952e-07" name="q_S111_Na" public_interface="out" units="fmol"/>
<variable initial_value="4.952e-07" name="q_S201_Na" public_interface="out" units="fmol"/>
<variable initial_value="5.5022e-08" name="q_S211_Na" public_interface="out" units="fmol"/>
<variable initial_value="1.8341e-08" name="q_S301_Na" public_interface="out" units="fmol"/>
<variable initial_value="2.0379e-09" name="q_S311_Na" public_interface="out" units="fmol"/>
<!-- I_Na imports-->
<variable name="v_Na" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_Na" public_interface="in" units="fA"/>
<!-- initial values (LCC)-->
<variable initial_value="3.6989e-07" name="q_S000_LCC" public_interface="out" units="fmol"/>
<variable initial_value="7.3239e-05" name="q_S010_LCC" public_interface="out" units="fmol"/>
<variable initial_value="3.6989e-07" name="q_S020_LCC" public_interface="out" units="fmol"/>
<variable initial_value="3.7363e-09" name="q_S100_LCC" public_interface="out" units="fmol"/>
<variable initial_value="7.3979e-07" name="q_S110_LCC" public_interface="out" units="fmol"/>
<variable initial_value="3.7363e-09" name="q_S120_LCC" public_interface="out" units="fmol"/>
<variable initial_value="4.1099e-08" name="q_S001_LCC" public_interface="out" units="fmol"/>
<variable initial_value="8.1377e-06" name="q_S011_LCC" public_interface="out" units="fmol"/>
<variable initial_value="4.1099e-08" name="q_S021_LCC" public_interface="out" units="fmol"/>
<variable initial_value="4.1514e-10" name="q_S101_LCC" public_interface="out" units="fmol"/>
<variable initial_value="8.2199e-08" name="q_S111_LCC" public_interface="out" units="fmol"/>
<variable initial_value="4.1514e-10" name="q_S121_LCC" public_interface="out" units="fmol"/>
<!-- LCC imports-->
<variable name="v_Ca_o_LCC" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Ca_i_LCC" public_interface="in" units="fmol_per_sec"/>
<variable name="v_K_o_LCC" public_interface="in" units="fmol_per_sec"/>
<variable name="v_K_i_LCC" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_LCC" public_interface="in" units="fA"/>
<!-- initial values (I_K1)-->
<variable initial_value="5.6606e-06" name="q_C_K1" public_interface="out" units="fmol"/>
<variable initial_value="1.4151e-06" name="q_O_K1" public_interface="out" units="fmol"/>
<!-- I_K1 imports-->
<variable name="v_K1" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_K1" public_interface="in" units="fA"/>
<!-- initial values (I_Kp)-->
<variable initial_value="9.6314e-07" name="q_C_Kp" public_interface="out" units="fmol"/>
<variable initial_value="2.4078e-07" name="q_O_Kp" public_interface="out" units="fmol"/>
<!-- I_Kp imports-->
<variable name="v_Kp" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_Kp" public_interface="in" units="fA"/>
<!-- initial values (I_K)-->
<variable initial_value="4.5648e-06" name="q_S00_K" public_interface="out" units="fmol"/>
<variable initial_value="1.1412e-06" name="q_S01_K" public_interface="out" units="fmol"/>
<variable initial_value="2.2824e-06" name="q_S10_K" public_interface="out" units="fmol"/>
<variable initial_value="5.706e-07" name="q_S11_K" public_interface="out" units="fmol"/>
<variable initial_value="2.853e-07" name="q_S20_K" public_interface="out" units="fmol"/>
<variable initial_value="7.1325e-08" name="q_S21_K" public_interface="out" units="fmol"/>
<!-- I_K imports-->
<variable name="v_K" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_K" public_interface="in" units="fA"/>
<!-- initial values (CMDN)-->
<variable initial_value="1.8088" name="q_CMDN" public_interface="out" units="fmol"/>
<variable initial_value="0.0912" name="q_CMDN_Ca" public_interface="out" units="fmol"/>
<!-- CMDN imports-->
<variable name="v_b2" public_interface="in" units="fmol_per_sec"/>
<!-- initial values (TRPN)-->
<variable initial_value="2.1452" name="q_TRPN" public_interface="out" units="fmol"/>
<variable initial_value="0.51484" name="q_TRPN_Ca" public_interface="out" units="fmol"/>
<!-- TRPN imports-->
<variable name="v_b1" public_interface="in" units="fmol_per_sec"/>
<!-- External stimulus current (using potassium ions)-->
<variable name="v_K_stim" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v_K_stim</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>F_mic_model</ci>
</apply>
<ci>I_stim</ci>
</apply>
</apply>
<!-- ODEs-->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ca_o</ci>
</apply>
<apply>
<plus/>
<ci>v_Ca_o_NCX</ci>
<ci>v_Ca_o_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ca_i</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_Ca_i_NCX</ci>
<ci>v_Ca_i_LCC</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_b2</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_b1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_CMDN</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v_b2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_CMDN_Ca</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_b2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_TRPN</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>v_b1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_TRPN_Ca</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_b1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Na_o</ci>
</apply>
<apply>
<plus/>
<ci>v_Na</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_Na_o_NaK</ci>
</apply>
<ci>v_Na_o_NCX</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Na_i</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_Na_i_NaK</ci>
</apply>
<ci>v_Na_i_NCX</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_K_o</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_K_o_NaK</ci>
</apply>
<ci>v_K_o_LCC</ci>
<ci>v_K1</ci>
<ci>v_K</ci>
<ci>v_Kp</ci>
</apply>
<ci>v_K_stim</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_K_i</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>v_K_i_NaK</ci>
</apply>
<ci>v_K_i_LCC</ci>
</apply>
<ci>v_K1</ci>
</apply>
<ci>v_K</ci>
</apply>
<ci>v_Kp</ci>
</apply>
<ci>v_K_stim</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_H_i</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>v_H_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_MgADP</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>v_MgADP_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_MgATP</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>v_MgATP_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Pi</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>v_Pi_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_mem</ci>
</apply>
<apply>
<plus/>
<ci>I_mem_Na</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>I_mem_NaK</ci>
</apply>
<ci>I_mem_NCX</ci>
<ci>I_mem_LCC</ci>
<ci>I_mem_K1</ci>
<ci>I_mem_K</ci>
<ci>I_mem_Kp</ci>
<ci>I_stim</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mem</ci>
<apply>
<divide/>
<ci>q_mem</ci>
<ci>C_mic_model</ci>
</apply>
</apply>
</math>
</component>
<component name="MichaelModel_parameters">
<!-- Ca parameters-->
<variable initial_value="0.022218" name="K_Ca_i" public_interface="out" units="per_fmol"/>
<variable initial_value="0.16293" name="K_Ca_o" public_interface="out" units="per_fmol"/>
<variable initial_value="2" name="zCa" public_interface="out" units="dimensionless"/>
<!-- Na parameters-->
<variable initial_value="0.017678" name="K_Na_o" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0024108" name="K_Na_i" public_interface="out" units="per_fmol"/>
<variable initial_value="1" name="zNa" public_interface="out" units="dimensionless"/>
<!-- K parameters-->
<variable initial_value="0.0080926" name="K_K_i" public_interface="out" units="per_fmol"/>
<variable initial_value="0.059344" name="K_K_o" public_interface="out" units="per_fmol"/>
<variable initial_value="1" name="zK" public_interface="out" units="dimensionless"/>
<variable initial_value="0.5" name="nK" public_interface="out" units="dimensionless"/>
<!-- Intermediate species parameters-->
<variable initial_value="3.6718" name="K_MgATP" public_interface="out" units="per_fmol"/>
<variable initial_value="7.1044e-05" name="K_MgADP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.060187" name="K_Pi" public_interface="out" units="per_fmol"/>
<variable initial_value="0.060187" name="K_H" public_interface="out" units="per_fmol"/>
<!-- I_NCX parameters-->
<variable initial_value="256862.245" name="kappa_1_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="21141816.1231" name="kappa_2_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6834.2872" name="kappa_3_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="21141816.1231" name="kappa_4_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="256862.245" name="kappa_5_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.7753" name="kappa_6_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="160144852.2746" name="K_1_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="407.3479" name="K_2_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="22191.7214" name="K_3_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="119580.5289" name="K_4_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="10363474.1803" name="K_5_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="199.44" name="K_6_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="3" name="nNa_o_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="3" name="nNa_i_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="-0.55679" name="zf_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="0.44321" name="zr_NCX" public_interface="out" units="dimensionless"/>
<!-- I_Na parameters-->
<variable initial_value="32.858" name="kappa_Na" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0073376" name="K_000_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="23718.0222" name="K_001_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="17499.8767" name="K_010_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="56566767727.4036" name="K_011_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="1.5633e-05" name="K_100_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="50.5317" name="K_101_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="37.2839" name="K_110_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="120516694.0958" name="K_111_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="9.9918e-08" name="K_200_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="0.32298" name="K_201_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="0.2383" name="K_210_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="770290.0911" name="K_211_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="1.9159e-09" name="K_300_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="0.006193" name="K_301_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0045694" name="K_310_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="14770.0739" name="K_311_Na" public_interface="out" units="per_fmol"/>
<variable initial_value="0.045709" name="kappa_h000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.4141e-08" name="kappa_h001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="21.4544" name="kappa_h100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.6373e-06" name="kappa_h101" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3356.675" name="kappa_h200" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0010384" name="kappa_h201" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="175057.5863" name="kappa_h300" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.054157" name="kappa_h301" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.017824" name="kappa_j000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="7.4736e-09" name="kappa_j010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="8.3662" name="kappa_j100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.5079e-06" name="kappa_j110" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1308.9427" name="kappa_j200" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00054883" name="kappa_j210" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="68264.0876" name="kappa_j300" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.028623" name="kappa_j310" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="5117405.6443" name="kappa_m000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.5832" name="kappa_m001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.1457" name="kappa_m010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.6381e-07" name="kappa_m011" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1601300127.6001" name="kappa_m100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="495.389" name="kappa_m101" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="671.4132" name="kappa_m110" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00020771" name="kappa_m111" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="125266701374.7363" name="kappa_m200" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="38753.3515" name="kappa_m201" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="52523.3901" name="kappa_m210" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.016249" name="kappa_m211" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="-4.1892" name="z_fh" public_interface="out" units="dimensionless"/>
<variable initial_value="-4.0381" name="z_fj" public_interface="out" units="dimensionless"/>
<variable initial_value="0.49541" name="z_fm" public_interface="out" units="dimensionless"/>
<variable initial_value="1.2995" name="z_rh" public_interface="out" units="dimensionless"/>
<variable initial_value="1.4281" name="z_rj" public_interface="out" units="dimensionless"/>
<variable initial_value="-2.4284" name="z_rm" public_interface="out" units="dimensionless"/>
<!-- LCC parameters-->
<variable initial_value="31.5432" name="kappa_LCC_Ca1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="58.9849" name="kappa_LCC_Ca2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.068076" name="kappa_LCC_K1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.1273" name="kappa_LCC_K2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="369.4994" name="kappa_d000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.31102" name="kappa_d001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="9.1161" name="kappa_d010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0076733" name="kappa_d011" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="17.0469" name="kappa_d020" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.014349" name="kappa_d021" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.68071" name="kappa_f1_000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00057297" name="kappa_f1_001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3.3802" name="kappa_f1_100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0028452" name="kappa_f1_101" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.2467" name="kappa_f2_000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0010494" name="kappa_f2_001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.1907" name="kappa_f2_100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0052109" name="kappa_f2_101" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3502.1028" name="kappa_f3_010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.9478" name="kappa_f3_011" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="17390.563" name="kappa_f3_110" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="14.6381" name="kappa_f3_111" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="106492.3187" name="kappa_fCa000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="528814.1044" name="kappa_fCa100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2627.333" name="kappa_fCa010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="13046.6757" name="kappa_fCa110" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4913.0371" name="kappa_fCa020" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="24396.9083" name="kappa_fCa120" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.3174" name="K_000_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="53.3957" name="K_010_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="28.5543" name="K_020_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.26529" name="K_100_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="10.7528" name="K_110_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="5.7502" name="K_120_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="1565.0581" name="K_001_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="63435.6844" name="K_011_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="33923.3476" name="K_021_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="315.1706" name="K_101_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="12774.6463" name="K_111_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="6831.4667" name="K_121_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="2.1404" name="z_fd" public_interface="out" units="dimensionless"/>
<variable initial_value="-1.1495" name="z_ff1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.72162" name="z_ff2" public_interface="out" units="dimensionless"/>
<variable initial_value="4.2933" name="z_ff3" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="z_rCa" public_interface="out" units="dimensionless"/>
<variable initial_value="-2.1404" name="z_rd" public_interface="out" units="dimensionless"/>
<variable initial_value="1.8993" name="z_rf1" public_interface="out" units="dimensionless"/>
<variable initial_value="-0.52288" name="z_rf2" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="z_rf3" public_interface="out" units="dimensionless"/>
<!-- I_NaK parameters-->
<variable initial_value="104.5833" name="kappa_1_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="270075.4148" name="kappa_2_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="906610.9954" name="kappa_3_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3509448.0698" name="kappa_4_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="5858.2952" name="kappa_5_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="8.3375" name="kappa_6_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.1523" name="kappa_7_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.1055" name="kappa_8_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2150.4256" name="kappa_9_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1045757.658" name="kappa_10_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="311526.5915" name="kappa_11_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1873089.8475" name="kappa_12_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="168.3622" name="kappa_13_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="22.4585" name="kappa_14_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0049006" name="kappa_15_NaK" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="321178904.6865" name="K_1_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="31093.1227" name="K_2_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="12.0404" name="K_3_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="3.1105" name="K_4_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="3.2141" name="K_5_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="170.6981" name="K_6_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="10036.4321" name="K_7_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="31550.6969" name="K_8_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="9874266.4618" name="K_9_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="5076.1941" name="K_10_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="10.4383" name="K_11_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="1.7361" name="K_12_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="1.155" name="K_13_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="319.1183" name="K_14_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="6250238.4012" name="K_15_NaK" public_interface="out" units="per_fmol"/>
<variable initial_value="-5301.979" name="zF_5" public_interface="out" units="C_per_mol"/>
<variable initial_value="-91183.021" name="zF_8" public_interface="out" units="C_per_mol"/>
<!-- I_K1 parameters-->
<variable initial_value="1.329" name="K_C_K1" public_interface="out" units="per_fmol"/>
<variable initial_value="15967.3543" name="K_O_K1" public_interface="out" units="per_fmol"/>
<variable initial_value="25.0154" name="kappa_K1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="848.2812" name="kappa_gK1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.033569" name="z_fK1" public_interface="out" units="dimensionless"/>
<variable initial_value="3.1153" name="z_rK1" public_interface="out" units="dimensionless"/>
<!-- I_Kp parameters-->
<variable initial_value="41.6265" name="K_C_Kp" public_interface="out" units="per_fmol"/>
<variable initial_value="145.607" name="K_O_Kp" public_interface="out" units="per_fmol"/>
<variable initial_value="252.3419" name="kappa_Kp" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="24.0195" name="kappa_gKp" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0" name="z_f_Kp" public_interface="out" units="dimensionless"/>
<variable initial_value="-4.4669" name="z_r_Kp" public_interface="out" units="dimensionless"/>
<!-- I_K parameters-->
<variable initial_value="43947.9368" name="kappa_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.034684" name="kappa_X00_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.13462" name="kappa_X10_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.20012" name="kappa_X01_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.77675" name="kappa_X11_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="7.7389" name="kappa_i00_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="60.0742" name="kappa_i10_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="116.5836" name="kappa_i20_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="128.6868" name="K_S00_K" public_interface="out" units="per_fmol"/>
<variable initial_value="16.5777" name="K_S10_K" public_interface="out" units="per_fmol"/>
<variable initial_value="8.5423" name="K_S20_K" public_interface="out" units="per_fmol"/>
<variable initial_value="22.3033" name="K_S01_K" public_interface="out" units="per_fmol"/>
<variable initial_value="2.8732" name="K_S11_K" public_interface="out" units="per_fmol"/>
<variable initial_value="1.4805" name="K_S21_K" public_interface="out" units="per_fmol"/>
<variable initial_value="0.51923" name="z_fX" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="z_fXi" public_interface="out" units="dimensionless"/>
<variable initial_value="-0.73169" name="z_rX" public_interface="out" units="dimensionless"/>
<variable initial_value="0.83216" name="z_rXi" public_interface="out" units="dimensionless"/>
<!-- CMDN parameters-->
<variable initial_value="22.0647" name="K_CMDN" public_interface="out" units="per_fmol"/>
<variable initial_value="0.044337" name="K_CMDN_Ca" public_interface="out" units="per_fmol"/>
<variable initial_value="0.022218" name="K_Ca_i" public_interface="out" units="per_fmol"/>
<variable initial_value="1412.6324" name="kappa_b2" public_interface="out" units="fmol_per_sec"/>
<!-- TRPN parameters-->
<variable initial_value="0.022218" name="K_Ca_i" public_interface="out" units="per_fmol"/>
<variable initial_value="37.1165" name="K_TRPN" public_interface="out" units="per_fmol"/>
<variable initial_value="0.015668" name="K_TRPN_Ca" public_interface="out" units="per_fmol"/>
<variable initial_value="839.7697" name="kappa_b1" public_interface="out" units="fmol_per_sec"/>
</component>
<connection>
<map_components component_1="constants" component_2="NCX_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="fast_Na_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="LCC_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="NaK_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="K1_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="Kp_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="K_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
</connection>
<connection>
<map_components component_1="constants" component_2="CMDN_buffer_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="TRPN_buffer_MichaelParameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="NCX_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_Ca_o" variable_2="q_Ca_o"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
<map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
<map_variables variable_1="q_P1_NCX" variable_2="q_P1_NCX"/>
<map_variables variable_1="q_P2_NCX" variable_2="q_P2_NCX"/>
<map_variables variable_1="q_P3_NCX" variable_2="q_P3_NCX"/>
<map_variables variable_1="q_P4_NCX" variable_2="q_P4_NCX"/>
<map_variables variable_1="q_P5_NCX" variable_2="q_P5_NCX"/>
<map_variables variable_1="q_P6_NCX" variable_2="q_P6_NCX"/>
<map_variables variable_1="v_Ca_o_NCX" variable_2="v_Ca_o_NCX"/>
<map_variables variable_1="v_Ca_i_NCX" variable_2="v_Ca_i_NCX"/>
<map_variables variable_1="v_Na_o_NCX" variable_2="v_Na_o_NCX"/>
<map_variables variable_1="v_Na_i_NCX" variable_2="v_Na_i_NCX"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_NCX" variable_2="I_mem_NCX"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="fast_Na_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
<map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
<map_variables variable_1="q_S000_Na" variable_2="q_S000_Na"/>
<map_variables variable_1="q_S010_Na" variable_2="q_S010_Na"/>
<map_variables variable_1="q_S100_Na" variable_2="q_S100_Na"/>
<map_variables variable_1="q_S110_Na" variable_2="q_S110_Na"/>
<map_variables variable_1="q_S200_Na" variable_2="q_S200_Na"/>
<map_variables variable_1="q_S210_Na" variable_2="q_S210_Na"/>
<map_variables variable_1="q_S300_Na" variable_2="q_S300_Na"/>
<map_variables variable_1="q_S310_Na" variable_2="q_S310_Na"/>
<map_variables variable_1="q_S001_Na" variable_2="q_S001_Na"/>
<map_variables variable_1="q_S011_Na" variable_2="q_S011_Na"/>
<map_variables variable_1="q_S101_Na" variable_2="q_S101_Na"/>
<map_variables variable_1="q_S111_Na" variable_2="q_S111_Na"/>
<map_variables variable_1="q_S201_Na" variable_2="q_S201_Na"/>
<map_variables variable_1="q_S211_Na" variable_2="q_S211_Na"/>
<map_variables variable_1="q_S301_Na" variable_2="q_S301_Na"/>
<map_variables variable_1="q_S311_Na" variable_2="q_S311_Na"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_Na" variable_2="I_mem_Na"/>
<map_variables variable_1="v_Na" variable_2="v_Na"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="LCC_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="q_Ca_o" variable_2="q_Ca_o"/>
<map_variables variable_1="q_K_i" variable_2="q_K_i"/>
<map_variables variable_1="q_K_o" variable_2="q_K_o"/>
<map_variables variable_1="q_S000_LCC" variable_2="q_S000_LCC"/>
<map_variables variable_1="q_S010_LCC" variable_2="q_S010_LCC"/>
<map_variables variable_1="q_S020_LCC" variable_2="q_S020_LCC"/>
<map_variables variable_1="q_S100_LCC" variable_2="q_S100_LCC"/>
<map_variables variable_1="q_S110_LCC" variable_2="q_S110_LCC"/>
<map_variables variable_1="q_S120_LCC" variable_2="q_S120_LCC"/>
<map_variables variable_1="q_S001_LCC" variable_2="q_S001_LCC"/>
<map_variables variable_1="q_S011_LCC" variable_2="q_S011_LCC"/>
<map_variables variable_1="q_S021_LCC" variable_2="q_S021_LCC"/>
<map_variables variable_1="q_S101_LCC" variable_2="q_S101_LCC"/>
<map_variables variable_1="q_S111_LCC" variable_2="q_S111_LCC"/>
<map_variables variable_1="q_S121_LCC" variable_2="q_S121_LCC"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="v_Ca_o_LCC" variable_2="v_Ca_o_LCC"/>
<map_variables variable_1="v_Ca_i_LCC" variable_2="v_Ca_i_LCC"/>
<map_variables variable_1="v_K_o_LCC" variable_2="v_K_o_LCC"/>
<map_variables variable_1="v_K_i_LCC" variable_2="v_K_i_LCC"/>
<map_variables variable_1="I_mem_LCC" variable_2="I_mem_LCC"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="NaK_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_K_o" variable_2="q_K_o"/>
<map_variables variable_1="q_K_i" variable_2="q_K_i"/>
<map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
<map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
<map_variables variable_1="q_H_i" variable_2="q_H_i"/>
<map_variables variable_1="q_MgADP" variable_2="q_MgADP"/>
<map_variables variable_1="q_MgATP" variable_2="q_MgATP"/>
<map_variables variable_1="q_Pi" variable_2="q_Pi"/>
<map_variables variable_1="q_P7" variable_2="q_P7"/>
<map_variables variable_1="q_P14" variable_2="q_P14"/>
<map_variables variable_1="q_P15" variable_2="q_P15"/>
<map_variables variable_1="q_P1" variable_2="q_P1"/>
<map_variables variable_1="q_P2" variable_2="q_P2"/>
<map_variables variable_1="q_P3" variable_2="q_P3"/>
<map_variables variable_1="q_P4" variable_2="q_P4"/>
<map_variables variable_1="q_P5" variable_2="q_P5"/>
<map_variables variable_1="q_P6" variable_2="q_P6"/>
<map_variables variable_1="q_P10" variable_2="q_P10"/>
<map_variables variable_1="q_P11" variable_2="q_P11"/>
<map_variables variable_1="q_P12" variable_2="q_P12"/>
<map_variables variable_1="q_P13" variable_2="q_P13"/>
<map_variables variable_1="q_P8" variable_2="q_P8"/>
<map_variables variable_1="q_P9" variable_2="q_P9"/>
<map_variables variable_1="v_K_o_NaK" variable_2="v_K_o_NaK"/>
<map_variables variable_1="v_K_i_NaK" variable_2="v_K_i_NaK"/>
<map_variables variable_1="v_Na_o_NaK" variable_2="v_Na_o_NaK"/>
<map_variables variable_1="v_Na_i_NaK" variable_2="v_Na_i_NaK"/>
<map_variables variable_1="v_H_NaK" variable_2="v_H_NaK"/>
<map_variables variable_1="v_MgADP_NaK" variable_2="v_MgADP_NaK"/>
<map_variables variable_1="v_MgATP_NaK" variable_2="v_MgATP_NaK"/>
<map_variables variable_1="v_Pi_NaK" variable_2="v_Pi_NaK"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_NaK" variable_2="I_mem_NaK"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="K1_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_K_o" variable_2="q_K_o"/>
<map_variables variable_1="q_K_i" variable_2="q_K_i"/>
<map_variables variable_1="q_C_K1" variable_2="q_C_K1"/>
<map_variables variable_1="q_O_K1" variable_2="q_O_K1"/>
<map_variables variable_1="v_K1" variable_2="v_K1"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_K1" variable_2="I_mem_K1"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="Kp_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_K_o" variable_2="q_K_o"/>
<map_variables variable_1="q_K_i" variable_2="q_K_i"/>
<map_variables variable_1="q_C_Kp" variable_2="q_C_Kp"/>
<map_variables variable_1="q_O_Kp" variable_2="q_O_Kp"/>
<map_variables variable_1="v_Kp" variable_2="v_Kp"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_Kp" variable_2="I_mem_Kp"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="K_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_K_o" variable_2="q_K_o"/>
<map_variables variable_1="q_K_i" variable_2="q_K_i"/>
<map_variables variable_1="q_S00_K" variable_2="q_S00_K"/>
<map_variables variable_1="q_S01_K" variable_2="q_S01_K"/>
<map_variables variable_1="q_S10_K" variable_2="q_S10_K"/>
<map_variables variable_1="q_S11_K" variable_2="q_S11_K"/>
<map_variables variable_1="q_S20_K" variable_2="q_S20_K"/>
<map_variables variable_1="q_S21_K" variable_2="q_S21_K"/>
<map_variables variable_1="v_K" variable_2="v_K"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_K" variable_2="I_mem_K"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="CMDN_buffer_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_CMDN" variable_2="q_CMDN"/>
<map_variables variable_1="q_CMDN_Ca" variable_2="q_CMDN_Ca"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="v_b2" variable_2="v_b2"/>
</connection>
<connection>
<map_components component_1="Michaelmodel_environment" component_2="TRPN_buffer_MichaelParameters"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_TRPN" variable_2="q_TRPN"/>
<map_variables variable_1="q_TRPN_Ca" variable_2="q_TRPN_Ca"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="v_b1" variable_2="v_b1"/>
</connection>
<connection>
<map_components component_1="NCX_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_1_NCX" variable_2="K_1_NCX"/>
<map_variables variable_1="K_2_NCX" variable_2="K_2_NCX"/>
<map_variables variable_1="K_3_NCX" variable_2="K_3_NCX"/>
<map_variables variable_1="K_4_NCX" variable_2="K_4_NCX"/>
<map_variables variable_1="K_5_NCX" variable_2="K_5_NCX"/>
<map_variables variable_1="K_6_NCX" variable_2="K_6_NCX"/>
<map_variables variable_1="K_Ca_o" variable_2="K_Ca_o"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
<map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
<map_variables variable_1="kappa_1_NCX" variable_2="kappa_1_NCX"/>
<map_variables variable_1="kappa_2_NCX" variable_2="kappa_2_NCX"/>
<map_variables variable_1="kappa_3_NCX" variable_2="kappa_3_NCX"/>
<map_variables variable_1="kappa_4_NCX" variable_2="kappa_4_NCX"/>
<map_variables variable_1="kappa_5_NCX" variable_2="kappa_5_NCX"/>
<map_variables variable_1="kappa_6_NCX" variable_2="kappa_6_NCX"/>
<map_variables variable_1="nNa_o_NCX" variable_2="nNa_o_NCX"/>
<map_variables variable_1="nNa_i_NCX" variable_2="nNa_i_NCX"/>
<map_variables variable_1="zf_NCX" variable_2="zf_NCX"/>
<map_variables variable_1="zr_NCX" variable_2="zr_NCX"/>
</connection>
<connection>
<map_components component_1="fast_Na_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_000_Na" variable_2="K_000_Na"/>
<map_variables variable_1="K_001_Na" variable_2="K_001_Na"/>
<map_variables variable_1="K_010_Na" variable_2="K_010_Na"/>
<map_variables variable_1="K_011_Na" variable_2="K_011_Na"/>
<map_variables variable_1="K_100_Na" variable_2="K_100_Na"/>
<map_variables variable_1="K_101_Na" variable_2="K_101_Na"/>
<map_variables variable_1="K_110_Na" variable_2="K_110_Na"/>
<map_variables variable_1="K_111_Na" variable_2="K_111_Na"/>
<map_variables variable_1="K_200_Na" variable_2="K_200_Na"/>
<map_variables variable_1="K_201_Na" variable_2="K_201_Na"/>
<map_variables variable_1="K_210_Na" variable_2="K_210_Na"/>
<map_variables variable_1="K_211_Na" variable_2="K_211_Na"/>
<map_variables variable_1="K_300_Na" variable_2="K_300_Na"/>
<map_variables variable_1="K_301_Na" variable_2="K_301_Na"/>
<map_variables variable_1="K_310_Na" variable_2="K_310_Na"/>
<map_variables variable_1="K_311_Na" variable_2="K_311_Na"/>
<map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
<map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
<map_variables variable_1="kappa_Na" variable_2="kappa_Na"/>
<map_variables variable_1="kappa_h000" variable_2="kappa_h000"/>
<map_variables variable_1="kappa_h001" variable_2="kappa_h001"/>
<map_variables variable_1="kappa_h100" variable_2="kappa_h100"/>
<map_variables variable_1="kappa_h101" variable_2="kappa_h101"/>
<map_variables variable_1="kappa_h200" variable_2="kappa_h200"/>
<map_variables variable_1="kappa_h201" variable_2="kappa_h201"/>
<map_variables variable_1="kappa_h300" variable_2="kappa_h300"/>
<map_variables variable_1="kappa_h301" variable_2="kappa_h301"/>
<map_variables variable_1="kappa_j000" variable_2="kappa_j000"/>
<map_variables variable_1="kappa_j010" variable_2="kappa_j010"/>
<map_variables variable_1="kappa_j100" variable_2="kappa_j100"/>
<map_variables variable_1="kappa_j110" variable_2="kappa_j110"/>
<map_variables variable_1="kappa_j200" variable_2="kappa_j200"/>
<map_variables variable_1="kappa_j210" variable_2="kappa_j210"/>
<map_variables variable_1="kappa_j300" variable_2="kappa_j300"/>
<map_variables variable_1="kappa_j310" variable_2="kappa_j310"/>
<map_variables variable_1="kappa_m000" variable_2="kappa_m000"/>
<map_variables variable_1="kappa_m001" variable_2="kappa_m001"/>
<map_variables variable_1="kappa_m010" variable_2="kappa_m010"/>
<map_variables variable_1="kappa_m011" variable_2="kappa_m011"/>
<map_variables variable_1="kappa_m100" variable_2="kappa_m100"/>
<map_variables variable_1="kappa_m101" variable_2="kappa_m101"/>
<map_variables variable_1="kappa_m110" variable_2="kappa_m110"/>
<map_variables variable_1="kappa_m111" variable_2="kappa_m111"/>
<map_variables variable_1="kappa_m200" variable_2="kappa_m200"/>
<map_variables variable_1="kappa_m201" variable_2="kappa_m201"/>
<map_variables variable_1="kappa_m210" variable_2="kappa_m210"/>
<map_variables variable_1="kappa_m211" variable_2="kappa_m211"/>
<map_variables variable_1="zNa" variable_2="zNa"/>
<map_variables variable_1="z_fh" variable_2="z_fh"/>
<map_variables variable_1="z_fj" variable_2="z_fj"/>
<map_variables variable_1="z_fm" variable_2="z_fm"/>
<map_variables variable_1="z_rh" variable_2="z_rh"/>
<map_variables variable_1="z_rj" variable_2="z_rj"/>
<map_variables variable_1="z_rm" variable_2="z_rm"/>
</connection>
<connection>
<map_components component_1="LCC_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="K_Ca_o" variable_2="K_Ca_o"/>
<map_variables variable_1="K_K_i" variable_2="K_K_i"/>
<map_variables variable_1="K_K_o" variable_2="K_K_o"/>
<map_variables variable_1="kappa_LCC_Ca1" variable_2="kappa_LCC_Ca1"/>
<map_variables variable_1="kappa_LCC_Ca2" variable_2="kappa_LCC_Ca2"/>
<map_variables variable_1="kappa_LCC_K1" variable_2="kappa_LCC_K1"/>
<map_variables variable_1="kappa_LCC_K2" variable_2="kappa_LCC_K2"/>
<map_variables variable_1="kappa_d000" variable_2="kappa_d000"/>
<map_variables variable_1="kappa_d010" variable_2="kappa_d010"/>
<map_variables variable_1="kappa_d020" variable_2="kappa_d020"/>
<map_variables variable_1="kappa_d001" variable_2="kappa_d001"/>
<map_variables variable_1="kappa_d011" variable_2="kappa_d011"/>
<map_variables variable_1="kappa_d021" variable_2="kappa_d021"/>
<map_variables variable_1="kappa_f1_000" variable_2="kappa_f1_000"/>
<map_variables variable_1="kappa_f1_100" variable_2="kappa_f1_100"/>
<map_variables variable_1="kappa_f1_001" variable_2="kappa_f1_001"/>
<map_variables variable_1="kappa_f1_101" variable_2="kappa_f1_101"/>
<map_variables variable_1="kappa_f2_000" variable_2="kappa_f2_000"/>
<map_variables variable_1="kappa_f2_100" variable_2="kappa_f2_100"/>
<map_variables variable_1="kappa_f2_001" variable_2="kappa_f2_001"/>
<map_variables variable_1="kappa_f2_101" variable_2="kappa_f2_101"/>
<map_variables variable_1="kappa_f3_010" variable_2="kappa_f3_010"/>
<map_variables variable_1="kappa_f3_110" variable_2="kappa_f3_110"/>
<map_variables variable_1="kappa_f3_011" variable_2="kappa_f3_011"/>
<map_variables variable_1="kappa_f3_111" variable_2="kappa_f3_111"/>
<map_variables variable_1="kappa_fCa000" variable_2="kappa_fCa000"/>
<map_variables variable_1="kappa_fCa100" variable_2="kappa_fCa100"/>
<map_variables variable_1="kappa_fCa010" variable_2="kappa_fCa010"/>
<map_variables variable_1="kappa_fCa110" variable_2="kappa_fCa110"/>
<map_variables variable_1="kappa_fCa020" variable_2="kappa_fCa020"/>
<map_variables variable_1="kappa_fCa120" variable_2="kappa_fCa120"/>
<map_variables variable_1="K_000_LCC" variable_2="K_000_LCC"/>
<map_variables variable_1="K_010_LCC" variable_2="K_010_LCC"/>
<map_variables variable_1="K_020_LCC" variable_2="K_020_LCC"/>
<map_variables variable_1="K_100_LCC" variable_2="K_100_LCC"/>
<map_variables variable_1="K_110_LCC" variable_2="K_110_LCC"/>
<map_variables variable_1="K_120_LCC" variable_2="K_120_LCC"/>
<map_variables variable_1="K_001_LCC" variable_2="K_001_LCC"/>
<map_variables variable_1="K_011_LCC" variable_2="K_011_LCC"/>
<map_variables variable_1="K_021_LCC" variable_2="K_021_LCC"/>
<map_variables variable_1="K_101_LCC" variable_2="K_101_LCC"/>
<map_variables variable_1="K_111_LCC" variable_2="K_111_LCC"/>
<map_variables variable_1="K_121_LCC" variable_2="K_121_LCC"/>
<map_variables variable_1="z_rCa" variable_2="z_rCa"/>
<map_variables variable_1="z_fd" variable_2="z_fd"/>
<map_variables variable_1="z_ff1" variable_2="z_ff1"/>
<map_variables variable_1="z_ff2" variable_2="z_ff2"/>
<map_variables variable_1="z_ff3" variable_2="z_ff3"/>
<map_variables variable_1="z_rd" variable_2="z_rd"/>
<map_variables variable_1="z_rf1" variable_2="z_rf1"/>
<map_variables variable_1="z_rf2" variable_2="z_rf2"/>
<map_variables variable_1="z_rf3" variable_2="z_rf3"/>
<map_variables variable_1="zCa" variable_2="zCa"/>
<map_variables variable_1="zK" variable_2="zK"/>
</connection>
<connection>
<map_components component_1="NaK_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_10_NaK" variable_2="K_10_NaK"/>
<map_variables variable_1="K_11_NaK" variable_2="K_11_NaK"/>
<map_variables variable_1="K_12_NaK" variable_2="K_12_NaK"/>
<map_variables variable_1="K_13_NaK" variable_2="K_13_NaK"/>
<map_variables variable_1="K_14_NaK" variable_2="K_14_NaK"/>
<map_variables variable_1="K_15_NaK" variable_2="K_15_NaK"/>
<map_variables variable_1="K_1_NaK" variable_2="K_1_NaK"/>
<map_variables variable_1="K_2_NaK" variable_2="K_2_NaK"/>
<map_variables variable_1="K_3_NaK" variable_2="K_3_NaK"/>
<map_variables variable_1="K_4_NaK" variable_2="K_4_NaK"/>
<map_variables variable_1="K_5_NaK" variable_2="K_5_NaK"/>
<map_variables variable_1="K_6_NaK" variable_2="K_6_NaK"/>
<map_variables variable_1="K_7_NaK" variable_2="K_7_NaK"/>
<map_variables variable_1="K_8_NaK" variable_2="K_8_NaK"/>
<map_variables variable_1="K_9_NaK" variable_2="K_9_NaK"/>
<map_variables variable_1="K_H" variable_2="K_H"/>
<map_variables variable_1="K_K_o" variable_2="K_K_o"/>
<map_variables variable_1="K_K_i" variable_2="K_K_i"/>
<map_variables variable_1="K_MgADP" variable_2="K_MgADP"/>
<map_variables variable_1="K_MgATP" variable_2="K_MgATP"/>
<map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
<map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
<map_variables variable_1="K_Pi" variable_2="K_Pi"/>
<map_variables variable_1="kappa_10_NaK" variable_2="kappa_10_NaK"/>
<map_variables variable_1="kappa_11_NaK" variable_2="kappa_11_NaK"/>
<map_variables variable_1="kappa_12_NaK" variable_2="kappa_12_NaK"/>
<map_variables variable_1="kappa_13_NaK" variable_2="kappa_13_NaK"/>
<map_variables variable_1="kappa_14_NaK" variable_2="kappa_14_NaK"/>
<map_variables variable_1="kappa_15_NaK" variable_2="kappa_15_NaK"/>
<map_variables variable_1="kappa_1_NaK" variable_2="kappa_1_NaK"/>
<map_variables variable_1="kappa_2_NaK" variable_2="kappa_2_NaK"/>
<map_variables variable_1="kappa_3_NaK" variable_2="kappa_3_NaK"/>
<map_variables variable_1="kappa_4_NaK" variable_2="kappa_4_NaK"/>
<map_variables variable_1="kappa_5_NaK" variable_2="kappa_5_NaK"/>
<map_variables variable_1="kappa_6_NaK" variable_2="kappa_6_NaK"/>
<map_variables variable_1="kappa_7_NaK" variable_2="kappa_7_NaK"/>
<map_variables variable_1="kappa_8_NaK" variable_2="kappa_8_NaK"/>
<map_variables variable_1="kappa_9_NaK" variable_2="kappa_9_NaK"/>
<map_variables variable_1="zF_5" variable_2="zF_5"/>
<map_variables variable_1="zF_8" variable_2="zF_8"/>
</connection>
<connection>
<map_components component_1="K1_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_C_K1" variable_2="K_C_K1"/>
<map_variables variable_1="K_K_o" variable_2="K_K_o"/>
<map_variables variable_1="K_K_i" variable_2="K_K_i"/>
<map_variables variable_1="K_O_K1" variable_2="K_O_K1"/>
<map_variables variable_1="kappa_K1" variable_2="kappa_K1"/>
<map_variables variable_1="kappa_gK1" variable_2="kappa_gK1"/>
<map_variables variable_1="nK" variable_2="nK"/>
<map_variables variable_1="zK" variable_2="zK"/>
<map_variables variable_1="z_fK1" variable_2="z_fK1"/>
<map_variables variable_1="z_rK1" variable_2="z_rK1"/>
</connection>
<connection>
<map_components component_1="Kp_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_C_Kp" variable_2="K_C_Kp"/>
<map_variables variable_1="K_K_o" variable_2="K_K_o"/>
<map_variables variable_1="K_K_i" variable_2="K_K_i"/>
<map_variables variable_1="K_O_Kp" variable_2="K_O_Kp"/>
<map_variables variable_1="kappa_Kp" variable_2="kappa_Kp"/>
<map_variables variable_1="kappa_gKp" variable_2="kappa_gKp"/>
<map_variables variable_1="zK" variable_2="zK"/>
<map_variables variable_1="z_f_Kp" variable_2="z_f_Kp"/>
<map_variables variable_1="z_r_Kp" variable_2="z_r_Kp"/>
</connection>
<connection>
<map_components component_1="K_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_S00_K" variable_2="K_S00_K"/>
<map_variables variable_1="K_S01_K" variable_2="K_S01_K"/>
<map_variables variable_1="K_S10_K" variable_2="K_S10_K"/>
<map_variables variable_1="K_S11_K" variable_2="K_S11_K"/>
<map_variables variable_1="K_S20_K" variable_2="K_S20_K"/>
<map_variables variable_1="K_S21_K" variable_2="K_S21_K"/>
<map_variables variable_1="K_K_o" variable_2="K_K_o"/>
<map_variables variable_1="K_K_i" variable_2="K_K_i"/>
<map_variables variable_1="kappa_K" variable_2="kappa_K"/>
<map_variables variable_1="kappa_X00_K" variable_2="kappa_X00_K"/>
<map_variables variable_1="kappa_X01_K" variable_2="kappa_X01_K"/>
<map_variables variable_1="kappa_X10_K" variable_2="kappa_X10_K"/>
<map_variables variable_1="kappa_X11_K" variable_2="kappa_X11_K"/>
<map_variables variable_1="kappa_i00_K" variable_2="kappa_i00_K"/>
<map_variables variable_1="kappa_i10_K" variable_2="kappa_i10_K"/>
<map_variables variable_1="kappa_i20_K" variable_2="kappa_i20_K"/>
<map_variables variable_1="nK" variable_2="nK"/>
<map_variables variable_1="zK" variable_2="zK"/>
<map_variables variable_1="z_fX" variable_2="z_fX"/>
<map_variables variable_1="z_fXi" variable_2="z_fXi"/>
<map_variables variable_1="z_rX" variable_2="z_rX"/>
<map_variables variable_1="z_rXi" variable_2="z_rXi"/>
</connection>
<connection>
<map_components component_1="CMDN_buffer_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_CMDN" variable_2="K_CMDN"/>
<map_variables variable_1="K_CMDN_Ca" variable_2="K_CMDN_Ca"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="kappa_b2" variable_2="kappa_b2"/>
</connection>
<connection>
<map_components component_1="TRPN_buffer_MichaelParameters" component_2="MichaelModel_parameters"/>
<map_variables variable_1="K_TRPN" variable_2="K_TRPN"/>
<map_variables variable_1="K_TRPN_Ca" variable_2="K_TRPN_Ca"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="kappa_b1" variable_2="kappa_b1"/>
</connection>
</model>
