- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-10-22 14:11:10+13:00
- Desc:
- Fix info by removing wrong isoforms. Remove picture
- Permanent Source URI:
- http://models.cellml.org/workspace/bbb/rawfile/0ad856b71bca4ed0c0d1b27034ed9917097a8501/exposure/exposure_frontpage.rst
About
====================
Landing page for the ATP-sensitive potassium channel (**K-ATP**).
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is inhibited by internal ATP. K-ATP is part of the inward rectifying (K-ir) family
All K-ATP channels are composed of four pore-forming channel subunits Kir6, and four regulatory sulfonylurea receptor SUR subunits.
Subfamilies
===================
The following list contains the known isoforms of K-ATP.
.. csv-table:: Variants within the human species
:header: "Channel name", "Alias", Gene, Structure, Interacts with
:widths: 7, 7,7,7, 7
KCNJ8, Kir6.1 , `Uniprot 8 <https://www.uniprot.org/uniprotkb/Q15842/entry>`_, `SMR 8 <https://swissmodel.expasy.org/repository/uniprot/Q15842?csm=973EAA5900C6447C>`_ , ABCC9
KCNJ11, Kir6.2 , `Uniprot 11 <https://www.uniprot.org/uniprotkb/Q14654/entry>`_, `PDB 11 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6C3O>`_, ABCC8
ABCC8, SUR1 , `Uniprot SUR1 <https://www.uniprot.org/uniprotkb/Q09428/entry>`_, `PDB SUR1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6C3O>`_, KCNJ11
ABCC9, SUR2 , `Uniprot SUR2 <https://www.uniprot.org/uniprotkb/O60706/entry>`_, `SMR SUR2 <https://swissmodel.expasy.org/repository/uniprot/O60706?csm=55508C9343AB1218>`_, KCNJ8
The KCNJx protein forms the pore of the channel. Column 'Interacts with' contains the experimentally-proven interactions this protein makes with other proteins, which generally help in regulating the activity of KCNJx.
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`KATP Channel Function: More than Meets the Eye <https://doi.org/10.1093/function/zqab070>`_", "Shyng"
"'KATP Channels and Cardiovascular Disease: Suddenly a Syndrome <https://doi.org/10.1161/CIRCRESAHA.112.300514>", "Singh and Grange"
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_K_ATP <https://models.physiomeproject.org/workspace/83a>`_", "S Fong"
"`Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study*^ <https://models.physiomeproject.org/e/260>`_", "Faber and Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
..
Other annotations
..
===================
