- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-06 13:45:37+12:00
- Desc:
- Fix link
- Permanent Source URI:
- http://models.cellml.org/workspace/bbb/rawfile/dae650de17f8b7b3452457ea55ddcf4e319579ea/exposure/exposure_frontpage.rst
About
====================
Landing page for the ATP-sensitive potassium channel (**K-ATP**).
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is activated by internal ATP. K-ATP is part of the inward rectifying (K-ir) family
Some isoforms are also G-protein regulated.
Pictures
===================
.. figure:: exposure/6m85_assembly-1.jpeg
:width: 50%
:align: center
:alt: kir2.2
Fig. 1. Visualisation of the KIR2.2 channel. Image from the RCSB PDB (RCSB.org) of PDB ID 1BNA (H.R. Drew, R.M. Wing, T. Takano, C. Broka, S. Tanaka, K. Itakura, R.E.Dickerson, Structure of a B-DNA dodecamer: conformation and dynamics (1981) Proc.Natl.Acad.Sci.USA 78: 2179-2183)
Subfamilies
===================
The following list contains the known isoforms of K-ATP.
.. csv-table:: Variants within the human species
:header: "Channel name", x, "Alias", Gene, Structure, Interacts with
:widths: 7,3, 7,7,7, 7
KCNJx, 1, ROMK1, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P48048/entry>`_, `SMR 1 <https://swissmodel.expasy.org/repository/uniprot/P48048?csm=DF01C89B16BE6205>`_
" ", 5, Kir3.4 , `Uniprot 5 <https://www.uniprot.org/uniprotkb/P48544/entry>`_, `SMR 5 <https://swissmodel.expasy.org/repository/uniprot/P48544?csm=7C14A6B0B7EA0FD4>`_, G protein
" ", 6, Kir3.2 , `Uniprot 6 <https://www.uniprot.org/uniprotkb/P48051/entry>`_, `SMR 6 <https://swissmodel.expasy.org/repository/uniprot/P48051?csm=7A02F6B0FBF8B7D4>`_, G protein
" ", 8, Kir6.1 , `Uniprot 8 <https://www.uniprot.org/uniprotkb/Q15842/entry>`_, `SMR 8 <https://swissmodel.expasy.org/repository/uniprot/Q15842?csm=973EAA5900C6447C>`_
" ", 10, Kir4.1/1.2 , `Uniprot 10 <https://www.uniprot.org/uniprotkb/P78508/entry>`_, `SMR 10 <https://swissmodel.expasy.org/repository/uniprot/P78508?csm=D9DA013FF4003533>`_
" ", 11, Kir6.2 , `Uniprot 11 <https://www.uniprot.org/uniprotkb/Q14654/entry>`_, `PDB 11 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6C3O>`_, ABCC9
" ", 12, Kir2.2 , `Uniprot 12 <https://www.uniprot.org/uniprotkb/Q14500/entry>`_, `SMR 12 <https://swissmodel.expasy.org/repository/uniprot/Q14500?csm=082027A1765B6F4E>`_
" ", 14, kir2.4 , `Uniprot 14 <https://www.uniprot.org/uniprotkb/Q9UNX9/entry>`_, `SMR 14 <https://swissmodel.expasy.org/repository/uniprot/Q9UNX9?csm=9442E664007D1B7C>`_
" ", 15, Kir4.2/Kir1.3 , `Uniprot 15 <https://www.uniprot.org/uniprotkb/Q99712/entry>`_, `SMR 15 <https://swissmodel.expasy.org/repository/uniprot/Q99712?csm=CECCB4EDF827B24D>`_
" ", 18, kir2.6 , `Uniprot 18 <https://www.uniprot.org/uniprotkb/B7U540/entry>`_, `SMR 18 <https://swissmodel.expasy.org/repository/uniprot/B7U540?csm=284FC956E6139DD0>`_
ABCC8, NA, SUR1 , `Uniprot SUR1 <https://www.uniprot.org/uniprotkb/Q09428/entry>`_, `PDB SUR1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6C3O>`_, KCNJ11
ABCC9, NA, SUR2 , `Uniprot SUR2 <https://www.uniprot.org/uniprotkb/O60706/entry>`_, `SMR SUR2 <https://swissmodel.expasy.org/repository/uniprot/O60706?csm=55508C9343AB1218>`_, KCNJ11
The KCNJx protein forms the pore of the channel. Column 'Interacts with' contains the experimentally-proven interactions this protein makes with other proteins, which generally help in regulating the activity of KCNJx.
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`Potassium channels in the heart: structure, function and regulation <https://doi.org/10.1113/jp272864>`_", "Grandi et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_K_ATP <https://models.physiomeproject.org/workspace/83a>`_", "S Fong"
"`Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study*^ <https://models.physiomeproject.org/e/260>`_", "Faber and Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
..
Other annotations
..
===================
