- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-06 13:59:18+12:00
- Desc:
- Init
- Permanent Source URI:
- http://models.cellml.org/workspace/bc6/rawfile/a09b1f1ccea90593237586aa942e9b252b5ffc2e/exposure/exposure_frontpage.rst
About
====================
Landing page for the muscarinic potassium channel (**K-ACh**).
Other names include: G protein-coupled inwardly rectifying potassium channel (**GIRK**)
This channel transports potassium ions across the plasma membrane according to the concentration gradient, and is activated through muscarinic receptors that are in turn activated by acetylcholine (ACh). K-ACh is part of the inward rectifying (K-ir) family.
These channels are heterotetramers composed of two GIRK1 and two GIRK4 subunits.
Pictures
===================
..
.. figure:: exposure/6m85_assembly-1.jpeg
:width: 50%
:align: center
:alt: kir2.2
Fig. 1. Visualisation of the KIR2.2 channel. Image from the RCSB PDB (RCSB.org) of PDB ID 1BNA (H.R. Drew, R.M. Wing, T. Takano, C. Broka, S. Tanaka, K. Itakura, R.E.Dickerson, Structure of a B-DNA dodecamer: conformation and dynamics (1981) Proc.Natl.Acad.Sci.USA 78: 2179-2183)
Subfamilies
===================
The following list contains the constituents of K-ACh.
.. csv-table:: Variants within the human species
:header: "Channel name", "Alias", Gene, Structure
:widths: 7,7,7,7
KCNJ3, GIRK1/Kir3.1, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P48549/entry>`_, `SMR 1 <https://swissmodel.expasy.org/repository/uniprot/P48549?csm=825A28ACE2873269>`_
KCNJ5, GIRK4/Kir3.4, `Uniprot 4 <https://www.uniprot.org/uniprotkb/P48544/entry>`_, `SMR 4 <https://swissmodel.expasy.org/repository/uniprot/P48544?csm=7C14A6B0B7EA0FD4>`_
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates <https://doi.org/10.1073/pnas.95.3.1307>`_", "Liang Sui et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_K_ACh <https://models.physiomeproject.org/workspace/bbf>`_", "S Fong"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"I(KACh) inward rectifier potassium channel complex", "`Gene Ontology <https://www.ebi.ac.uk/QuickGO/term/GO:1990566>`_"
