- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-10 10:11:14+12:00
- Desc:
- Fixes
- Permanent Source URI:
- http://models.cellml.org/workspace/bc8/rawfile/dd03ec87ec46fda49ce43b4b81c0da35ba7767a4/exposure/exposure_frontpage.rst
About
====================
Landing page for the inwardly rectifying potassium channel (**KIR**).
This channel transports potassium ions across the plasma membrane according to the concentration gradient. They are activated by phosphatidylinositol 4,5-biphosphate (PIP2).
This family includes seven subfamilies, including the **KACh** and **K-ATP** channels.
Other names for this channel: **IRK**
Pictures
===================
..
.. figure:: exposure/6m85_assembly-1.jpeg
:width: 50%
:align: center
:alt: KIR2.2
Fig. 1. Visualisation of the KIR2.2 channel. Image from the RCSB PDB (RCSB.org) of PDB ID 1BNA (H.R. Drew, R.M. Wing, T. Takano, C. Broka, S. Tanaka, K. Itakura, R.E.Dickerson, Structure of a B-DNA dodecamer: conformation and dynamics (1981) Proc.Natl.Acad.Sci.USA 78: 2179-2183)
Subfamilies
===================
The following list contains the seven known subfamilies within the KIR family.
.. csv-table:: Variants within the human species
:header: "KCNJx", KIR, "Alias", Gene, Structure, Interacts with
:widths: 4,4, 7,7,7, 9
1, 1.1, ROMK11, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P48048/entry>`_, `SMR 1 <https://swissmodel.expasy.org/repository/uniprot/P48048?csm=DF01C89B16BE6205>`_," "
2, 2.1, IRK1, `Uniprot 2 <https://www.uniprot.org/uniprotkb/P63252/entry>`_, `EBI 2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6SPZ>`_,Homo-/hetero-multimeric association with KCNJ4
3, 3.1, KACh/GIRK1, `Uniprot 3 <https://www.uniprot.org/uniprotkb/P48549/entry>`_, `SMR 3 <https://swissmodel.expasy.org/repository/uniprot/P48549?csm=825A28ACE2873269>`_,G proteins
4, 2.3, IRK3, `Uniprot 4 <https://www.uniprot.org/uniprotkb/P48050/entry>`_, `EBI 4 <https://www.ebi.ac.uk/pdbe-srv/view/entry/3GJ9>`_,Homo-/hetero-multimeric association with KCNJ2 and KCNJ12
5, 3.4, GIRK4/KACh, `Uniprot 5 <https://www.uniprot.org/uniprotkb/P48544/entry>`_, `SMR 5 <https://swissmodel.expasy.org/repository/uniprot/P48544?csm=7C14A6B0B7EA0FD4>`_,G proteins
6, 3.2, GIRK2, `Uniprot 6 <https://www.uniprot.org/uniprotkb/P48051/entry>`_, `SMR 6 <https://swissmodel.expasy.org/repository/uniprot/P48051?csm=7A02F6B0FBF8B7D4>`_,G proteins
8, 6.1, K_ATP, `Uniprot 8 <https://www.uniprot.org/uniprotkb/Q15842/entry>`_, `Alphafold 8 <https://alphafold.ebi.ac.uk/entry/Q15842>`_,G proteins
9, 3.3, " ", `Uniprot 9 <https://www.uniprot.org/uniprotkb/Q92806/entry>`_, `SMR 9 <https://swissmodel.expasy.org/repository/uniprot/Q92806?csm=C6F79F80A37B01C9>`_,G proteins
10, 4.1, K_ATP, `Uniprot 10 <https://www.uniprot.org/uniprotkb/P78508/entry>`_, `SMR 10 <https://swissmodel.expasy.org/repository/uniprot/P78508?csm=D9DA013FF4003533>`_,Heterodimer with KIR5.1
11, 6.2, K_ATP, `Uniprot 11 <https://www.uniprot.org/uniprotkb/Q14654/entry>`_, `EBI 11 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6C3O>`_, G proteins. Interacts with ABCC8/ABCC9
12, 2.2, IRK2, `Uniprot 12 <https://www.uniprot.org/uniprotkb/Q14500/entry>`_, `SMR 12 <https://swissmodel.expasy.org/repository/uniprot/Q14500?csm=082027A1765B6F4E>`_,Heteromer with KCNJ4
13, 7.1, " ", `Uniprot 13 <https://www.uniprot.org/uniprotkb/O60928/entry>`_, `SMR 13 <https://swissmodel.expasy.org/repository/uniprot/O60928?csm=0C49D0DBC619BC50>`_, " "
14, 2.4, IRK4, `Uniprot 14 <https://www.uniprot.org/uniprotkb/Q9UNX9/entry>`_, `SMR 14 <https://swissmodel.expasy.org/repository/uniprot/Q9UNX9?csm=9442E664007D1B7C>`_, " "
15, 4.2/1.3, K_ATP, `Uniprot 15 <https://www.uniprot.org/uniprotkb/Q99712/entry>`_, `SMR 15 <https://swissmodel.expasy.org/repository/uniprot/Q99712?csm=CECCB4EDF827B24D>`_, " "
16, 5.1, " ", `Uniprot 16 <https://www.uniprot.org/uniprotkb/Q9NPI9/entry>`_, `SMR 16 <https://swissmodel.expasy.org/repository/uniprot/Q9NPI9?csm=1E241B4C15CBD264>`_,Heterodimer with KIR4.1
18, 2.6, " ", `Uniprot 18 <https://www.uniprot.org/uniprotkb/B7U540/entry>`_, `SMR 18 <https://swissmodel.expasy.org/repository/uniprot/B7U540?csm=284FC956E6139DD0>`_, " "
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles <https://doi.org/10.1152/physrev.00021.2009>`_", "Hibino et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_K_ACh <https://models.physiomeproject.org/workspace/bbf>`_", "S Fong"
"`BG_K_ATP <https://models.physiomeproject.org/workspace/83a>`_", "S Fong"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"Inward rectifier potassium channel complex", "`Gene Ontology <https://www.ebi.ac.uk/QuickGO/term/GO:1902937>`_"
