Location: Cooling, Hunter, Crampin, 2009 @ 72522699f3c9 / ShenCalciumProtocol / NFATMyocyte_ShenProtocol_Submodel.cellml

Author:

mcoo001 <devnull@localhost>

Date:

2010-01-11 15:42:20+13:00

Desc:

Added CellML v1.1 files for the three calcium protocols. Also added description files for exposures for all 3 protocols. Removed the old 'dummy' CellML 1.0 file that pointed to the v1.1 files.

Permanent Source URI:

http://models.cellml.org/workspace/cooling_hunter_crampin_2009/rawfile/72522699f3c9c9e4af77679c76eac18158c9e2be/ShenCalciumProtocol/NFATMyocyte_ShenProtocol_Submodel.cellml

<?xml version="1.0" encoding="utf-8"?>

<model
    name="NFATMyocyte_ShenProtocol"
    cmeta:id="NFATMyocyte_ShenProtocol"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
    xmlns:xlink="http://www.w3.org/1999/xlink">
    
    <import xlink:href="calcium_ShenProtocol.cellml">
            <component name="calcium" component_ref="calcium" />
        </import>
        <import xlink:href="calcineurin_ShenProtocol.cellml">
                    <component name="calcineurin" component_ref="calcineurin" />
        </import>
        <import xlink:href="NFATCycling_ShenProtocol.cellml">
                    <component name="NFAT_Cycling" component_ref="NFAT_Cycling" />
        </import>
        
        <rdf:RDF
            xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
            xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
            xmlns:bqs="http://www.cellml.org/bqs/1.0#"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:dcterms="http://purl.org/dc/terms/"
            xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="#NFATCycling_ShenProtocol">
                <dc:creator rdf:parseType="Resource">
                    <vCard:N rdf:parseType="Resource">
                        <vCard:Family>Cooling</vCard:Family>
                        <vCard:Given>Michael</vCard:Given>
                    </vCard:N>
                    <vCard:EMAIL rdf:parseType="Resource">
                        <rdf:value>m.cooling@auckland.ac.nz</rdf:value>
                        <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
                    </vCard:EMAIL>
                </dc:creator>
        
                <dc:title>Cooling's NFAT Cycling Myocyte Model: Shen-derived protocol</dc:title>
            </rdf:Description>
</rdf:RDF>
        
        <!--
        *******************************************************
        ***         U   N   I   T   S                       ***
        *******************************************************
        -->
        
   <units name="s">
      <unit units="second"/>
   </units>
   
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="nM">
         <unit units="mole" prefix="nano"/>
         <unit units="liter" exponent="-1"/>
      </units>
   
   <!--
     *********************************************************
     ***       C   O   M   P   O   N   E   N   T   S       ***
     *********************************************************
     -->
   
  <component name="environment">
          <variable name="t" units="s" private_interface="out"/>
     </component>
     
     
    <component name="geometry">
         <variable name="Ccn" units="dimensionless" initial_value="50" private_interface="out"/>
    </component>
   
      <component name="NFAT_Cycling_interface">
          <variable name="nuclearNFAT" units="nM"/>
          <variable name="NFATN_n" units="nM" public_interface="in"/>
          <variable name="NFATp_n" units="nM" public_interface="in"/>
   
          <math xmlns="http://www.w3.org/1998/Math/MathML">
              <apply>
                      <eq/>
                      <ci>nuclearNFAT</ci>
                      <apply>
                         <plus/>
                         <ci>NFATN_n</ci>
                         <ci>NFATp_n</ci>
                      </apply>
            </apply>
          </math>
   </component>
   
   
<group>
    <relationship_ref relationship="encapsulation" />
        <component_ref component="environment">
            <component_ref component="geometry">
                <component_ref component="calcium"/>
                <component_ref component="calcineurin"/>
                <component_ref component="NFAT_Cycling"/>
                <component_ref component="NFAT_Cycling_interface"/>
             </component_ref>
        </component_ref>
</group>   

   
<connection>
    <map_components
        component_1="environment" component_2="calcium" />
    <map_variables variable_1="t" variable_2="t" />
</connection>

<connection>
    <map_components component_1="environment" component_2="calcineurin" />
        <map_variables variable_1="t" variable_2="t" />
</connection>

<connection>
    <map_components component_1="environment" component_2="NFAT_Cycling" />
        <map_variables variable_1="t" variable_2="t" />
</connection>

<connection>
    <map_components component_1="geometry" component_2="NFAT_Cycling" />
        <map_variables variable_1="Ccn" variable_2="Ccn" />
</connection>

<connection>
    <map_components component_1="calcium" component_2="calcineurin" />
        <map_variables variable_1="Ca" variable_2="Ca" />
</connection>

<connection>
    <map_components component_1="calcineurin" component_2="NFAT_Cycling" />
        <map_variables variable_1="act_Napp" variable_2="act_N" />
        <map_variables variable_1="Ntot" variable_2="Ntot" />
</connection>

<connection>
    <map_components component_1="NFAT_Cycling_interface" component_2="NFAT_Cycling" />
        <map_variables variable_1="NFATN_n" variable_2="NFATN_n" />
        <map_variables variable_1="NFATp_n" variable_2="NFATp_n" />
</connection>
   

</model>