- Author:
- rcai987 <devnull@localhost>
- Date:
- 2015-01-20 11:36:37+13:00
- Desc:
- Added annotations to dougherty_wright_yew_2005 model
- Permanent Source URI:
- http://models.cellml.org/workspace/dougherty_wright_yew_2005/rawfile/895e9277b109f41a4833b24c9616d47aa1e6ef8d/dougherty_wright_yew_2005.cellml
<?xml version='1.0'?>
<!--
This CellML file was generated on 17/07/2008 at 1:40:20 at p.m. using:
COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
-->
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<title>Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model runs in both OpenCell and COR and the units are consistent. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Abstract: We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
</para>
<para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="dougherty_2005.png"/>
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<caption>Schematic diagram of the Dougherty et al model.</caption>
</informalfigure>
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons, Daniel P. Dougherty, Geraldine A. Wright, Alice C. Yew, 2005,
<emphasis>Proceeding of the National Academy of Sciences</emphasis>
, 102, 10415- 10420. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16027364 &dopt=Abstract">PubMed ID: 16027364 </ulink>
</para>
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<vCard:Given xml:lang="en">Daniel</vCard:Given>
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<dc:title xml:lang="en">Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</dc:title>
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<dcterms:W3CDTF xml:lang="en">2005-05-25 00:00</dcterms:W3CDTF>
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<rdf:value xml:lang="en">This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.</rdf:value>
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