- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2009-04-01 23:45:38+13:00
- Desc:
- committing version01 of elowitz_leibler_2000
- Permanent Source URI:
- http://models.cellml.org/workspace/elowitz_leibler_2000/rawfile/862b52f02aba0f479bd9de70bbd9aaee26330d4c/elowitz_leibler_2000.cellml
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<title>A synthetic oscillatory network of transcriptional regulators. </title>
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<surname>Lim</surname>
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<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
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<title>Model Status</title>
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This CellML version of the model has been checked PCEnv and the model runs to replicate the original published results as depicted in figure 1c of the paper. The units have been checked and are consistent.
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<para>
ABSTRACT: Networks of interacting biomolecules carry out many essential functions in living cells, but the 'design principles' underlying the
functioning of such intracellular networks remain poorly understood, despite intensive efforts including quantitative analysis of relatively simple systems. Here we present a complementary approach to this problem: the design and construction of a synthetic network to implement a particular function.
</para>
<para>
We used three transcriptional repressor systems that are not part of any natural biological clock to build an oscillating network, termed
the repressilator, in Escherichia coli. The network periodically induces the synthesis of green fluorescent protein as a readout of
its state in individual cells. The resulting oscillations, with typical periods of hours, are slower than the cell-division cycle, so the
state of the oscillator has to be transmitted from generation to generation. This artificial clock displays noisy behaviour, possibly
because of stochastic fluctuations of its components. Such 'rational network design' may lead both to the engineering of
new cellular behaviours and to an improved understanding of naturally occurring networks.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.nature.com/nature/journal/v403/n6767/full/403335a0.html">A synthetic oscillatory network of transcriptional regulators</ulink>, Michael B. Elowitz and Stanislas Leibler, 2000, <ulink url="http://www.nature.com/nature/index.html">
<emphasis> Nature: International Weekly Journal of Science</emphasis>
</ulink>, 403, 335-338. (A <ulink url="http://www.nature.com/nature/journal/v403/n6767/pdf/403335a0.pdf">PDF version</ulink> of the article is available to subscribers on the journal website.) <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10659856">PubMed ID: 10659856</ulink>
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The original published equations were scaled and modified with reference to the same model on the Biomodels database.</rdf:value>
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<dc:title>A Synthetic Oscillatory Network of Transciptional Regulators</dc:title>
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