- Author:
- jonna <devnull@localhost>
- Date:
- 2009-08-31 09:45:26+12:00
- Desc:
- Model File
- Permanent Source URI:
- http://models.cellml.org/workspace/gross_and_hopfer_1998/rawfile/77054497c5c4d61b352f83972865c4d4ae379d6d/gross_and_hopfer_1998.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 28/08/2009 at 1:20:47 at p.m. using:
COR (0.9.31.1265)
Copyright 2002-2009 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
-->
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<variable name="C3" units="pmol_per_cm2" public_interface="out"/>
<variable name="C4" units="pmol_per_cm2" public_interface="out"/>
<variable name="C5" units="pmol_per_cm2" public_interface="out"/>
<variable name="C6" units="pmol_per_cm2" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C1_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>f_4</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_5</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_1</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_2</ci>
<ci>f_1</ci>
<ci>f_4</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>f_1</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>f_1</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>f_1</ci>
</apply>
<apply>
<times/>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>b_6</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_4</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>f_1</ci>
<ci>f_2</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>b_6</ci>
<ci>f_2</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>b_6</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_5</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_4</ci>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_3</ci>
</apply>
<apply>
<times/>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>b_6</ci>
<ci>f_2</ci>
<ci>f_3</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>b_6</ci>
<ci>f_3</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_4</ci>
<ci>b_5</ci>
<ci>b_6</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C5_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_6</ci>
</apply>
<apply>
<times/>
<ci>b_5</ci>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_4</ci>
</apply>
<apply>
<times/>
<ci>b_5</ci>
<ci>b_6</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_4</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_5</ci>
<ci>b_6</ci>
<ci>f_3</ci>
<ci>f_4</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_5</ci>
<ci>b_6</ci>
<ci>f_4</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_5</ci>
<ci>b_6</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C6_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_1</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_5</ci>
</apply>
<apply>
<times/>
<ci>b_6</ci>
<ci>f_2</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_5</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_6</ci>
<ci>f_3</ci>
<ci>f_4</ci>
<ci>f_5</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_6</ci>
<ci>f_4</ci>
<ci>f_5</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_6</ci>
<ci>f_5</ci>
</apply>
<apply>
<times/>
<ci>b_1</ci>
<ci>b_2</ci>
<ci>b_3</ci>
<ci>b_4</ci>
<ci>b_6</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C_sum</ci>
<apply>
<plus/>
<ci>C1_sum</ci>
<ci>C2_sum</ci>
<ci>C3_sum</ci>
<ci>C4_sum</ci>
<ci>C5_sum</ci>
<ci>C6_sum</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_T</ci>
<ci>C1_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_T</ci>
<ci>C2_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_T</ci>
<ci>C3_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_T</ci>
<ci>C4_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C5</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_T</ci>
<ci>C5_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C6</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_T</ci>
<ci>C6_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="NBC_current">
<variable name="f_3" units="per_second" public_interface="in"/>
<variable name="b_3" units="per_second" public_interface="in"/>
<variable name="f_6" units="per_second" public_interface="in"/>
<variable name="b_6" units="per_second" public_interface="in"/>
<variable name="C_1" units="pmol_per_cm2" public_interface="in"/>
<variable name="C_3" units="pmol_per_cm2" public_interface="in"/>
<variable name="C_4" units="pmol_per_cm2" public_interface="in"/>
<variable name="C_6" units="pmol_per_cm2" public_interface="in"/>
<variable name="C1" units="pmol_per_cm2" public_interface="in"/>
<variable name="C3" units="pmol_per_cm2" public_interface="in"/>
<variable name="C4" units="pmol_per_cm2" public_interface="in"/>
<variable name="C6" units="pmol_per_cm2" public_interface="in"/>
<variable name="delta_z" units="dimensionless" public_interface="in"/>
<variable name="n" units="dimensionless" public_interface="in"/>
<variable name="m" units="dimensionless" public_interface="in"/>
<variable name="F" units="C_per_mol" public_interface="in"/>
<variable name="I_NBC" units="pA_per_cm2" public_interface="out"/>
<variable name="I_NBC_SS" units="pA_per_cm2" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_NBC</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>delta_z</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>b_6</ci>
<ci>C_1</ci>
</apply>
<apply>
<times/>
<ci>f_6</ci>
<ci>C_6</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>delta_z</ci>
<ci>n</ci>
</apply>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>f_3</ci>
<ci>C_3</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>C_4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NBC_SS</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>delta_z</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>b_6</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>f_6</ci>
<ci>C6</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>delta_z</ci>
<ci>n</ci>
</apply>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>f_3</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rate_constants" component_2="ion_concentrations"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="HCO3_i" variable_2="HCO3_i"/>
<map_variables variable_1="HCO3_o" variable_2="HCO3_o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rate_constants" component_2="kinetic_equations"/>
<map_variables variable_1="f_1" variable_2="f_1"/>
<map_variables variable_1="b_1" variable_2="b_1"/>
<map_variables variable_1="f_2" variable_2="f_2"/>
<map_variables variable_1="b_2" variable_2="b_2"/>
<map_variables variable_1="f_3" variable_2="f_3"/>
<map_variables variable_1="b_3" variable_2="b_3"/>
<map_variables variable_1="f_4" variable_2="f_4"/>
<map_variables variable_1="b_4" variable_2="b_4"/>
<map_variables variable_1="f_5" variable_2="f_5"/>
<map_variables variable_1="b_5" variable_2="b_5"/>
<map_variables variable_1="f_6" variable_2="f_6"/>
<map_variables variable_1="b_6" variable_2="b_6"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rate_constants" component_2="king_altman_states"/>
<map_variables variable_1="f_1" variable_2="f_1"/>
<map_variables variable_1="b_1" variable_2="b_1"/>
<map_variables variable_1="f_2" variable_2="f_2"/>
<map_variables variable_1="b_2" variable_2="b_2"/>
<map_variables variable_1="f_3" variable_2="f_3"/>
<map_variables variable_1="b_3" variable_2="b_3"/>
<map_variables variable_1="f_4" variable_2="f_4"/>
<map_variables variable_1="b_4" variable_2="b_4"/>
<map_variables variable_1="f_5" variable_2="f_5"/>
<map_variables variable_1="b_5" variable_2="b_5"/>
<map_variables variable_1="f_6" variable_2="f_6"/>
<map_variables variable_1="b_6" variable_2="b_6"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rate_constants" component_2="NBC_current"/>
<map_variables variable_1="f_3" variable_2="f_3"/>
<map_variables variable_1="b_3" variable_2="b_3"/>
<map_variables variable_1="f_6" variable_2="f_6"/>
<map_variables variable_1="b_6" variable_2="b_6"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="NBC_current" component_2="parameters"/>
<map_variables variable_1="delta_z" variable_2="delta_z"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="NBC_current" component_2="kinetic_equations"/>
<map_variables variable_1="C_1" variable_2="C_1"/>
<map_variables variable_1="C_3" variable_2="C_3"/>
<map_variables variable_1="C_4" variable_2="C_4"/>
<map_variables variable_1="C_6" variable_2="C_6"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="NBC_current" component_2="king_altman_states"/>
<map_variables variable_1="C1" variable_2="C1"/>
<map_variables variable_1="C3" variable_2="C3"/>
<map_variables variable_1="C4" variable_2="C4"/>
<map_variables variable_1="C6" variable_2="C6"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="kinetic_equations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="kinetic_equations" component_2="parameters"/>
<map_variables variable_1="C_T" variable_2="C_T"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="king_altman_states" component_2="parameters"/>
<map_variables variable_1="C_T" variable_2="C_T"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rate_constants" component_2="parameters"/>
<map_variables variable_1="f0_1" variable_2="f0_1"/>
<map_variables variable_1="b0_1" variable_2="b0_1"/>
<map_variables variable_1="f0_2" variable_2="f0_2"/>
<map_variables variable_1="b0_2" variable_2="b0_2"/>
<map_variables variable_1="f0_3" variable_2="f0_3"/>
<map_variables variable_1="b0_3" variable_2="b0_3"/>
<map_variables variable_1="f0_4" variable_2="f0_4"/>
<map_variables variable_1="b0_4" variable_2="b0_4"/>
<map_variables variable_1="f0_5" variable_2="f0_5"/>
<map_variables variable_1="b0_5" variable_2="b0_5"/>
<map_variables variable_1="f0_6" variable_2="f0_6"/>
<map_variables variable_1="b0_6" variable_2="b0_6"/>
<map_variables variable_1="delta_z" variable_2="delta_z"/>
<map_variables variable_1="delta_m" variable_2="delta_m"/>
<map_variables variable_1="delta_n" variable_2="delta_n"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_pp" variable_2="alpha_pp"/>
<map_variables variable_1="beta_p" variable_2="beta_p"/>
<map_variables variable_1="beta_pp" variable_2="beta_pp"/>
<map_variables variable_1="C_T" variable_2="C_T"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="u" variable_2="u"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="parameters"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
</model>
