- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 07:50:05+12:00
- Desc:
- committing version01 of novak_tyson_1997
- Permanent Source URI:
- http://models.cellml.org/workspace/novak_tyson_1997/rawfile/02f859329e218ea8412f52c44ce800161de9290b/novak_tyson_1997.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : novak_model_1997.xml
CREATED : 22nd April 2003
LAST MODIFIED : 22nd April 2003
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Novak and Tyson's
1997 model of the control of DNA replication in fission yeast.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="novak_tyson_1997_version01" name="novak_tyson_1997_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Control of DNA Replication in Fission Yeast</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
The molecular mechanisms which underlie the control of the eukaryotic cell cycle are beginning to be elucidated by studies of fission yeast. One event of particular importance is the initiation of DNA replication (the S phase). Tight controls usually exist to prevent repeated phases of DNA replication without nuclear (mitosis) and cellular (cytokinesis) division occurring. Similarly, until DNA replication is complete, the initiation of mitosis is inhibited.
</para>
<para>
Fission yeast cells carrying the mutant genes <emphasis>wee1<superscript>-</superscript>
</emphasis> and <emphasis>cdc25<superscript>OP</superscript>
</emphasis> initiate mitosis before DNA replication is complete, suggesting that the products of the wild type genes play an essential role in the G<subscript>2</subscript> checkpoint controls that delay division until DNA replication is complete. Similarly, in cells with a mutant copy of either the <emphasis>cdc2</emphasis>, <emphasis>cdc13</emphasis>, or <emphasis>Rum1</emphasis> genes, the G<subscript>1</subscript> checkpoint fails, and DNA synthesis begins before the cell has divided, resulting in a polyploid cell.
</para>
<para>
Based on this experimental data, Bela Novak and John Tyson have developed a mathematical model describing the control of DNA replication in fission yeast. Using principles of biochemical kinetics (mass action and Michaelis-Menten reaction kinetics), the reaction mechanism shown in the figure below is converted into a set of differential equations. These rate equations describe how the concentrations of the main control variables change over time.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.pnas.org/cgi/content/abstract/94/17/9147">Modeling the control of DNA replication in fission yeast</ulink>, Bela Novak and John J. Tyson, 1997, <ulink url="http://www.pnas.org/">
<emphasis>Proceedings of the National Academy of Sciences</emphasis>
</ulink>, 94, 9147-9152. (A <ulink url="http://www.pnas.org/cgi/reprint/94/17/9147.pdf">PDF version</ulink> of the article is available to subscribers on the journal website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9256450&dopt=Abstract">PubMed ID: 9256450</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="novak_1997.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the reaction mechanism which describes the G<subscript>1</subscript>/S and G<subscript>2</subscript>/M controls in fission yeast.</caption>
</informalfigure>
<para>
Please note that the following switches in the published model are not included in the CellML description:
<itemizedlist>
<listitem>
<para>
(i) When SPF crosses 0.1 from below, S phase is initiated (Start).
</para>
</listitem>
<listitem>
<para>
(ii) When UbE crosses 0.1 from above, the cell divides functionally (mass->mass/2), although visible cytokinesis may be delayed.
</para>
</listitem>
<listitem>
<para>
(iii) 60 min after Start, kp is divided by 2, and at cell division kp is multiplied by 2.
</para>
</listitem>
</itemizedlist>
(taken from Table 1 of the cited reference).
</para>
</sect1>
</article>
</documentation>
<!--
Below, we define some additional units for association with variables and
constants within the model.
-->
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="minute">
<unit units="second" multiplier="60.0"/>
</units>
<units name="flux">
<unit units="millimolar"/>
<unit units="minute" exponent="-1"/>
</units>
<units name="first_order_rate_constant">
<unit units="minute" exponent="-1"/>
</units>
<component name="environment">
<variable units="minute" public_interface="out" name="time"/>
</component>
<!--
The following components describe all the reactants and products involved in
reactions.
-->
<component name="rate_constants">
<variable units="first_order_rate_constant" public_interface="out" name="k1" initial_value="0.015"/>
<variable units="first_order_rate_constant" public_interface="out" name="k2"/>
<variable units="first_order_rate_constant" public_interface="out" name="k2_" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="k3" initial_value="0.09375"/>
<variable units="first_order_rate_constant" public_interface="out" name="k4" initial_value="0.1875"/>
<variable units="first_order_rate_constant" public_interface="out" name="k4_"/>
<variable units="first_order_rate_constant" public_interface="out" name="k5" initial_value="0.00175"/>
<variable units="first_order_rate_constant" public_interface="out" name="k6"/>
<variable units="first_order_rate_constant" public_interface="out" name="k6_" initial_value="0.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="k7" initial_value="100.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="k7r" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="k8" initial_value="10.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="k8r" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kwee"/>
<variable units="first_order_rate_constant" public_interface="out" name="k25"/>
<variable units="first_order_rate_constant" public_interface="out" name="ku" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kp" initial_value="3.25"/>
<variable units="first_order_rate_constant" public_interface="out" name="kur" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ku2" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kur2" initial_value="0.3"/>
<variable units="first_order_rate_constant" public_interface="out" name="kc" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kcr" initial_value="0.25"/>
<variable units="first_order_rate_constant" public_interface="out" name="kw" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kwr" initial_value="0.25"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki" initial_value="0.4"/>
<variable units="first_order_rate_constant" public_interface="out" name="kir" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="mu" initial_value="0.00495"/>
<variable units="dimensionless" public_interface="out" name="Kmu2" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Kmur2" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Kmi" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Kmir" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Kmw" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Kmwr" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Kmu" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Kmur" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Kmc" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Kmcr" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Kmp" initial_value="0.001"/>
<variable units="first_order_rate_constant" name="V2" initial_value="0.25"/>
<variable units="first_order_rate_constant" name="V2_" initial_value="0.0075"/>
<variable units="first_order_rate_constant" name="V6" initial_value="7.5"/>
<variable units="first_order_rate_constant" name="V6_" initial_value="0.375"/>
<variable units="first_order_rate_constant" name="V25" initial_value="0.5"/>
<variable units="first_order_rate_constant" name="V25_" initial_value="0.025"/>
<variable units="first_order_rate_constant" name="Vw" initial_value="0.35"/>
<variable units="first_order_rate_constant" name="Vw_" initial_value="0.035"/>
<variable units="dimensionless" public_interface="in" name="Cdc25"/>
<variable units="dimensionless" public_interface="in" name="UbE"/>
<variable units="dimensionless" public_interface="in" name="UbE2"/>
<variable units="dimensionless" public_interface="in" name="Wee1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="k2_calculation">
<eq/>
<ci> k2 </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> V2_ </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> UbE </ci>
</apply>
</apply>
<apply>
<times/>
<ci> V2 </ci>
<ci> UbE </ci>
</apply>
</apply>
</apply>
<apply id="k6_calculation">
<eq/>
<ci> k6 </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> V6_ </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> UbE2 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> V6 </ci>
<ci> UbE2 </ci>
</apply>
</apply>
</apply>
<apply id="kwee_calculation">
<eq/>
<ci> kwee </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> Vw_ </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> Wee1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> Vw </ci>
<ci> Wee1 </ci>
</apply>
</apply>
</apply>
<apply id="k25_calculation">
<eq/>
<ci> k25 </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> V25_ </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> Cdc25 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> V25 </ci>
<ci> Cdc25 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="concentration_variables">
<variable units="dimensionless" public_interface="out" name="SPF"/>
<variable units="dimensionless" public_interface="out" name="MPF"/>
<variable units="dimensionless" name="alpha" initial_value="0.25"/>
<variable units="dimensionless" name="beta" initial_value="0.05"/>
<variable units="dimensionless" public_interface="in" name="G1K"/>
<variable units="dimensionless" public_interface="in" name="G2K"/>
<variable units="dimensionless" public_interface="in" name="PG2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="MPF_calculation">
<eq/>
<ci> MPF </ci>
<apply>
<plus/>
<ci> G2K </ci>
<apply>
<times/>
<ci> beta </ci>
<ci> PG2 </ci>
</apply>
</apply>
</apply>
<apply id="SPF_calculation">
<eq/>
<ci> SPF </ci>
<apply>
<plus/>
<ci> MPF </ci>
<apply>
<times/>
<ci> alpha </ci>
<ci> G1K </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="G2K" name="G2K">
<variable units="dimensionless" public_interface="out" name="G2K"/>
<variable units="first_order_rate_constant" public_interface="in" name="k1"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2"/>
<variable units="first_order_rate_constant" public_interface="in" name="k4"/>
<variable units="first_order_rate_constant" public_interface="in" name="k7"/>
<variable units="first_order_rate_constant" public_interface="in" name="k7r"/>
<variable units="first_order_rate_constant" public_interface="in" name="k25"/>
<variable units="first_order_rate_constant" public_interface="in" name="kwee"/>
<variable units="dimensionless" public_interface="in" name="PG2"/>
<variable units="dimensionless" public_interface="in" name="G2R"/>
<variable units="dimensionless" public_interface="in" name="R"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="G2K_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> G2K </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> k1 </ci>
<apply>
<times/>
<ci> k25 </ci>
<ci> PG2 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> k7r </ci>
<ci> k4 </ci>
</apply>
<ci> G2R </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> k2 </ci>
<ci> kwee </ci>
<apply>
<times/>
<ci> k7 </ci>
<ci> R </ci>
</apply>
</apply>
<ci> G2K </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="R" name="R">
<variable units="dimensionless" public_interface="out" name="R"/>
<variable units="first_order_rate_constant" public_interface="in" name="k3"/>
<variable units="first_order_rate_constant" public_interface="in" name="k4"/>
<variable units="first_order_rate_constant" public_interface="in" name="kp"/>
<variable units="first_order_rate_constant" public_interface="in" name="k7"/>
<variable units="first_order_rate_constant" public_interface="in" name="k8"/>
<variable units="first_order_rate_constant" public_interface="in" name="k8r"/>
<variable units="dimensionless" public_interface="in" name="Kmp"/>
<variable units="first_order_rate_constant" public_interface="in" name="k7r"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2_"/>
<variable units="first_order_rate_constant" public_interface="in" name="k6_"/>
<variable units="dimensionless" public_interface="in" name="G1R"/>
<variable units="dimensionless" public_interface="in" name="G2K"/>
<variable units="dimensionless" public_interface="in" name="G1K"/>
<variable units="dimensionless" public_interface="in" name="PG2"/>
<variable units="dimensionless" public_interface="in" name="PG2R"/>
<variable units="dimensionless" public_interface="in" name="G2R"/>
<variable units="dimensionless" public_interface="in" name="SPF"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="R_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> R </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> k3 </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> k7r </ci>
<ci> k2 </ci>
<ci> k2_ </ci>
</apply>
<apply>
<plus/>
<ci> G2R </ci>
<ci> PG2R </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> k8r </ci>
<ci> k6_ </ci>
</apply>
<ci> G1R </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k4 </ci>
<ci> R </ci>
</apply>
<apply>
<times/>
<ci> k7 </ci>
<ci> R </ci>
<apply>
<plus/>
<ci> G2K </ci>
<ci> PG2 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> k8 </ci>
<ci> R </ci>
<ci> G1K </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> kp </ci>
<ci> R </ci>
<ci> SPF </ci>
<ci> mass </ci>
</apply>
<apply>
<plus/>
<ci> Kmp </ci>
<ci> R </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="G1K" name="G1K">
<variable units="dimensionless" public_interface="out" name="G1K"/>
<variable units="first_order_rate_constant" public_interface="in" name="k5"/>
<variable units="first_order_rate_constant" public_interface="in" name="k6"/>
<variable units="first_order_rate_constant" public_interface="in" name="k8"/>
<variable units="first_order_rate_constant" public_interface="in" name="k4"/>
<variable units="first_order_rate_constant" public_interface="in" name="k8r"/>
<variable units="dimensionless" public_interface="in" name="G1R"/>
<variable units="dimensionless" public_interface="in" name="R"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="G1K_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> G1K </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> k5 </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> k8r </ci>
<ci> k4 </ci>
</apply>
<ci> G1R </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> k6 </ci>
<ci> k8 </ci>
<ci> R </ci>
</apply>
<ci> G1K </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="G2R" name="G2R">
<variable units="dimensionless" public_interface="out" name="G2R"/>
<variable units="first_order_rate_constant" public_interface="in" name="k7"/>
<variable units="first_order_rate_constant" public_interface="in" name="k4"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2"/>
<variable units="first_order_rate_constant" public_interface="in" name="k7r"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2_"/>
<variable units="dimensionless" public_interface="in" name="G2K"/>
<variable units="dimensionless" public_interface="in" name="R"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="G2R_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> G2R </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> k7 </ci>
<ci> R </ci>
<ci> G2K </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> k7r </ci>
<ci> k4 </ci>
<ci> k2 </ci>
<ci> k2_ </ci>
</apply>
<ci> G2R </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="IE" name="IE">
<rdf:RDF>
<rdf:Description rdf:about="IE">
<dc:title>IE</dc:title>
<dcterms:alternative>intermediary enzyme</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="dimensionless" public_interface="out" name="IE"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki"/>
<variable units="first_order_rate_constant" public_interface="in" name="kir"/>
<variable units="dimensionless" public_interface="in" name="Kmi"/>
<variable units="dimensionless" public_interface="in" name="Kmir"/>
<variable units="dimensionless" public_interface="in" name="MPF"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="IE_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> IE </ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ki </ci>
<ci> MPF </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> IE </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Kmi </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
<ci> IE </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> kir </ci>
<ci> IE </ci>
</apply>
<apply>
<plus/>
<ci> Kmir </ci>
<ci> IE </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="UbE2">
<variable units="dimensionless" public_interface="out" name="UbE2"/>
<variable units="first_order_rate_constant" public_interface="in" name="ku2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kur2"/>
<variable units="dimensionless" public_interface="in" name="Kmu2"/>
<variable units="dimensionless" public_interface="in" name="Kmur2"/>
<variable units="dimensionless" public_interface="in" name="MPF"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="UbE2_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> UbE2 </ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ku2 </ci>
<ci> MPF </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> UbE2 </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Kmu2 </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
<ci> UbE2 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> kur2 </ci>
<ci> UbE2 </ci>
</apply>
<apply>
<plus/>
<ci> Kmur2 </ci>
<ci> UbE2 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Wee1">
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<variable units="dimensionless" public_interface="in" name="Kmw"/>
<variable units="dimensionless" public_interface="in" name="MPF"/>
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<variable units="first_order_rate_constant" public_interface="in" name="k6_"/>
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<variable units="first_order_rate_constant" public_interface="in" name="k7r"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="PG2R_diff_eq">
<eq/>
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<variable units="first_order_rate_constant" public_interface="in" name="kur"/>
<variable units="first_order_rate_constant" public_interface="in" name="ku"/>
<variable units="dimensionless" public_interface="in" name="Kmur"/>
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<variable units="dimensionless" public_interface="in" name="IE"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="UbE_diff_eq">
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<variable units="minute" public_interface="in" name="time"/>
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<dc:title>
Novak and Tyson's 1997 model of the control of DNA replication in
fission yeast.
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The University of Auckland, Bioengineering Institute
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<dcterms:alternative>Rum1</dcterms:alternative>
<dc:title>R</dc:title>
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<rdf:Description rdf:about="#PG2R">
<dcterms:alternative>Cdc13-P-Cdc2-Rum1 complex</dcterms:alternative>
<dc:title>PG2R</dc:title>
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<rdf:Description rdf:about="rdf:#5d5a1e14-ab16-4d0f-96cf-33c59d1974f2">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
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<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
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<dcterms:W3CDTF>1997-08</dcterms:W3CDTF>
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<dcterms:alternative>Cig2-Cdc2-Rum1 complex</dcterms:alternative>
<dc:title>G1R</dc:title>
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<rdf:Description rdf:about="rdf:#589e8825-8847-464c-956f-a729ddfd7210">
<vCard:FN>Catherine Lloyd</vCard:FN>
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<vCard:ORG rdf:resource="rdf:#fabdb507-cef9-492f-ba19-8fd108a49514"/>
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<rdf:Description rdf:about="rdf:#9952ee14-00c2-4b90-b992-9fdf0c276ce4">
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<rdf:Description rdf:about="rdf:#2450c081-3ff9-488d-b35e-720766902cec">
<vCard:Given>Bela</vCard:Given>
<vCard:Family>Novak</vCard:Family>
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<rdf:Description rdf:about="#PG2">
<dcterms:alternative>Cdc13-P-Cdc2 complex</dcterms:alternative>
<dc:title>PG2</dc:title>
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<rdf:Description rdf:about="#G2R">
<dcterms:alternative>Cdc13-Cdc2-Rum1 complex</dcterms:alternative>
<dc:title>G2R</dc:title>
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<rdf:Description rdf:about="rdf:#82a33734-a261-4a6e-b581-0acb0bfd2b4b">
<dc:creator rdf:resource="rdf:#c189f8cc-496e-4291-8500-12873542d211"/>
<dc:title>
Modeling the control of DNA replication in fission yeast
</dc:title>
<bqs:volume>94</bqs:volume>
<bqs:first_page>9147</bqs:first_page>
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<bqs:last_page>9152</bqs:last_page>
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<rdf:Description rdf:about="#G2K">
<dcterms:alternative>Cdc13-Cdc2 complex</dcterms:alternative>
<dc:title>G2K</dc:title>
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<rdf:Description rdf:about="rdf:#be822e7f-ebf2-4571-b69a-13746a8c4c52">
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<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
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<bqs:Pubmed_id>9256450</bqs:Pubmed_id>
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<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>cell cycle</rdf:value>
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<vCard:N rdf:resource="rdf:#5d5a1e14-ab16-4d0f-96cf-33c59d1974f2"/>
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<rdf:Description rdf:about="rdf:#fabdb507-cef9-492f-ba19-8fd108a49514">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
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<rdf:Description rdf:about="#G1K">
<dcterms:alternative>Cig2-Cdc2 complex</dcterms:alternative>
<dc:title>G1K</dc:title>
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<rdf:Description rdf:about="rdf:#41445910-d771-465a-803f-9f0cfbd9d46e">
<vCard:Given>John</vCard:Given>
<vCard:Family>Tyson</vCard:Family>
<vCard:Other>J</vCard:Other>
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<dcterms:W3CDTF>2003-04-22</dcterms:W3CDTF>
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This is the CellML description of Novak and Tyson's 1997 model of the
control of DNA replication in fission yeast.
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<dcterms:W3CDTF>2007-06-15T10:32:36+12:00</dcterms:W3CDTF>
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<rdf:Description rdf:about="rdf:#59cf831c-e7a8-4efa-bae2-abbcb8759f8b">
<dc:title>
Proceedings of the National Academy of Sciences USA
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</model>
