- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2010-07-05 15:05:21+12:00
- Desc:
- Tidied session file
- Permanent Source URI:
- http://models.cellml.org/workspace/novak_tyson_1997/rawfile/3614b6d39b91d78e0038bbd113814686c316616b/novak_tyson_1997_SBML.xml
<?xml version="1.0" encoding="UTF-8"?>
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<dc:title>SBML version of the model</dc:title>
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<vCard:Family>Le Novère</vCard:Family>
<vCard:Given>Nicolas</vCard:Given>
</vCard:N>
<vCard:EMAIL>lenov@ebi.ac.uk</vCard:EMAIL>
<vCard:ORG>
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</vCard:ORG>
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</vCard:N>
<vCard:EMAIL>bshapiro@jpl.nasa.gov</vCard:EMAIL>
<vCard:ORG>
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</vCard:ORG>
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</dcterms:created>
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<listOfParameters>
<parameter metaid="metaid_0000019" id="mu" name="mu" value="0.00495">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">mass growth rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000020" id="Mass" name="Mass" value="0.49" constant="false"/>
<parameter metaid="metaid_0000021" id="k1" name="k1" value="0.015">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">G2K production rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000022" id="k2prime" name="k2'" value="0.05"/>
<parameter metaid="metaid_0000023" id="k3" name="k3" value="0.09375">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Rum1 production rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000024" id="k4" name="k4" value="0.1875">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Rum1 degradation rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000025" id="k5" name="k5" value="0.00175">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">G1k production rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000026" id="k6prime" name="k6'" value="0"/>
<parameter metaid="metaid_0000027" id="k7" name="k7" value="100">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Rum1/G2K binding rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000028" id="k7r" name="k7r" value="0.1">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">G2R dissociation rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000029" id="k8" name="k8" value="10">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Rum1/G1K binding rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000030" id="k8r" name="k8r" value="0.1"/>
<parameter metaid="metaid_0000031" id="kc" name="kc" value="1"/>
<parameter metaid="metaid_0000032" id="kcr" name="kcr" value="0.25"/>
<parameter metaid="metaid_0000033" id="ki" name="ki" value="0.4"/>
<parameter metaid="metaid_0000034" id="kir" name="kir" value="0.1"/>
<parameter metaid="metaid_0000035" id="kp" name="kp" value="3.25" constant="false">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Rum1 Phosphorylation Rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000036" id="ku" name="ku" value="0.2"/>
<parameter metaid="metaid_0000037" id="kur" name="kur" value="0.1"/>
<parameter metaid="metaid_0000038" id="ku2" name="ku2" value="1"/>
<parameter metaid="metaid_0000039" id="kur2" name="kur2" value="0.3"/>
<parameter metaid="metaid_0000040" id="kw" name="kw" value="1"/>
<parameter metaid="metaid_0000041" id="kwr" name="kwr" value="0.25"/>
<parameter metaid="metaid_0000042" id="V2" name="V2" value="0.25"/>
<parameter metaid="metaid_0000043" id="V2prime" name="V2'" value="0.0075"/>
<parameter metaid="metaid_0000044" id="V6" name="V6" value="7.5"/>
<parameter metaid="metaid_0000045" id="V6prime" name="V6'" value="0.0375"/>
<parameter metaid="metaid_0000046" id="V25" name="V25" value="0.5"/>
<parameter metaid="metaid_0000047" id="V25prime" name="V25'" value="0.025"/>
<parameter metaid="metaid_0000048" id="Vw" name="Vw" value="0.35"/>
<parameter metaid="metaid_0000049" id="Vwprime" name="Vw'" value="0.035"/>
<parameter metaid="metaid_0000050" id="Kmc" name="Kmc" value="0.1"/>
<parameter metaid="metaid_0000051" id="Kmcr" name="Kmcr" value="0.1"/>
<parameter metaid="metaid_0000052" id="Kmi" name="Kmi" value="0.01"/>
<parameter metaid="metaid_0000053" id="Kmir" name="Kmir" value="0.01"/>
<parameter metaid="metaid_0000054" id="Kmp" name="Kmp" value="0.001"/>
<parameter metaid="metaid_0000055" id="Kmu" name="Kmu" value="0.01"/>
<parameter metaid="metaid_0000056" id="Kmur" name="Kmur" value="0.01"/>
<parameter metaid="metaid_0000057" id="Kmu2" name="Kmu2" value="0.05"/>
<parameter metaid="metaid_0000058" id="Kmur2" name="Kmur2" value="0.05"/>
<parameter metaid="metaid_0000059" id="Kmw" name="Kmw" value="0.1"/>
<parameter metaid="metaid_0000060" id="Kmwr" name="Kmwr" value="0.1"/>
<parameter metaid="metaid_0000061" id="alpha" name="alpha" value="0.25"/>
<parameter metaid="metaid_0000062" id="beta" name="beta" value="0.05"/>
<parameter metaid="metaid_0000063" id="Cig1" name="Cig1" value="0"/>
<parameter metaid="metaid_0000064" id="k2" name="k2" constant="false">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Cdc13/Cdc2 dissociation rate (degradation of G2K)</p>
</notes>
</parameter>
<parameter metaid="metaid_0000065" id="k6" name="k6" constant="false">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Cig2/Cdc2 dissociation rate (degradation of G1K)</p>
</notes>
</parameter>
<parameter metaid="metaid_0000066" id="kwee" name="kwee" constant="false">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Cdc2 phosphorylation rate</p>
</notes>
</parameter>
<parameter metaid="metaid_0000067" id="k25" name="k25" constant="false">
<notes>
<p xmlns="http://www.w3.org/1999/xhtml">Cdc2 dephosphorylation rate</p>
</notes>
</parameter>
</listOfParameters>
<listOfRules>
<rateRule metaid="rule1" variable="Mass">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> Mass </ci>
<ci> mu </ci>
</apply>
</math>
</rateRule>
<assignmentRule metaid="rule2" variable="IEB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> IE </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule3" variable="UbEB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> UbE </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule4" variable="UbE2B">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> UbE2 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule5" variable="Wee1B">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> Wee1 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule6" variable="Cdc25B">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> Cdc25 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule7" variable="Rum1Total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> G1R </ci>
<ci> G2R </ci>
<ci> PG2R </ci>
<ci> R </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule8" variable="Cdc13Total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> G2K </ci>
<ci> G2R </ci>
<ci> PG2 </ci>
<ci> PG2R </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule9" variable="Cig2Total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> G1K </ci>
<ci> G1R </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule10" variable="k2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<times/>
<ci> UbE </ci>
<ci> V2 </ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> UbE </ci>
</apply>
<ci> V2prime </ci>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule11" variable="k6">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<times/>
<ci> UbE2 </ci>
<ci> V6 </ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> UbE2 </ci>
</apply>
<ci> V6prime </ci>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule12" variable="kwee">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<times/>
<ci> Vwprime </ci>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> Wee1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> Vw </ci>
<ci> Wee1 </ci>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule13" variable="k25">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<times/>
<ci> Cdc25 </ci>
<ci> V25 </ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn type="integer"> 1 </cn>
<ci> Cdc25 </ci>
</apply>
<ci> V25prime </ci>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule14" variable="MPF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> G2K </ci>
<apply>
<times/>
<ci> beta </ci>
<ci> PG2 </ci>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="rule15" variable="SPF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> Cig1 </ci>
<apply>
<times/>
<ci> alpha </ci>
<ci> G1K </ci>
</apply>
<ci> MPF </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction metaid="metaid_0000091" id="G2K_Creation" name="Cdc13_Cdc2 creation" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="G2K"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> k1 </ci>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000092" id="G1K_Creation" name="Cig2_Cdc2 creation" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="G1K"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> k5 </ci>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000093" id="Cdc2Phos" name="Cdc2 phosphorylation" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000093">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ec-code:2.7.10.2"/>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006468"/>
</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:reactome:REACT_6178"/>
<rdf:li rdf:resource="urn:miriam:reactome:REACT_6257"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:reactome:REACT_6327"/>
<rdf:li rdf:resource="urn:miriam:reactome:REACT_6294"/>
</rdf:Bag>
</bqbiol:hasPart>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="G2K"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="PG2"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="Wee1"/>
<modifierSpeciesReference species="Cdc25"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> G2K </ci>
<ci> kwee </ci>
</apply>
<apply>
<times/>
<ci> k25 </ci>
<ci> PG2 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000094" id="G2R_Creation" name="binding of Rum1 with Cdc13_Cdc2" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000094">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006461"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="G2K"/>
<speciesReference species="R"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="G2R"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> G2K </ci>
<ci> k7 </ci>
<ci> R </ci>
</apply>
<apply>
<times/>
<ci> G2R </ci>
<ci> k7r </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000095" id="PG2R_Creation" name="binding of Rum1 with Cdc13_P-Cdc2" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000095">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006461"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="PG2"/>
<speciesReference species="R"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="PG2R"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> k7 </ci>
<ci> PG2 </ci>
<ci> R </ci>
</apply>
<apply>
<times/>
<ci> k7r </ci>
<ci> PG2R </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000096" id="Rum1DegInG2R" name="Rum1 degradation in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000096">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="G2R"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="G2K"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> G2R </ci>
<ci> k4 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000097" id="Rum1Deg" name="Rum1 degradation in solution" reversible="false" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000097">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="R"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k4 </ci>
<ci> R </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000098" id="Rum1DegInPG2R" name="Rum1 degradation in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000098">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="PG2R"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="PG2"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k4 </ci>
<ci> PG2R </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000099" id="RumDegInG1R" name="Rum1 degradation in Rum1_Cig2_Cdc2" reversible="false" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000099">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="G1R"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="G1K"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> G1R </ci>
<ci> k4 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000100" id="G2K_dissoc" name="Cdc13 degradation in Cdc13_Cdc2" reversible="false" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000100">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference species="G2K"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="UbE"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> G2K </ci>
<ci> k2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_0000101" id="PG2_dissoc" name="Cdc13 degradation in Cdc13_P-Cdc2" reversible="false" fast="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#metaid_0000101">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
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<times/>
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<ci> k6prime </ci>
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<apply>
<times/>
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<ci> k8 </ci>
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<apply>
<times/>
<ci> G1R </ci>
<ci> k8r </ci>
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<divide/>
<apply>
<times/>
<ci> kp </ci>
<ci> Mass </ci>
<ci> R </ci>
<ci> SPF </ci>
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<apply>
<plus/>
<ci> Kmp </ci>
<ci> R </ci>
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<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> IEB </ci>
<ci> ki </ci>
<ci> MPF </ci>
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<apply>
<plus/>
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<ci> Kmi </ci>
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<apply>
<divide/>
<apply>
<times/>
<ci> IE </ci>
<ci> kir </ci>
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<apply>
<plus/>
<ci> IE </ci>
<ci> Kmir </ci>
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</apply>
</apply>
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<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> IE </ci>
<ci> ku </ci>
<ci> UbEB </ci>
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<apply>
<plus/>
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<ci> UbEB </ci>
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<apply>
<divide/>
<apply>
<times/>
<ci> kur </ci>
<ci> UbE </ci>
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<apply>
<plus/>
<ci> Kmur </ci>
<ci> UbE </ci>
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</apply>
</apply>
</math>
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<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ku2 </ci>
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<apply>
<plus/>
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<ci> UbE2B </ci>
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<apply>
<divide/>
<apply>
<times/>
<ci> kur2 </ci>
<ci> UbE2 </ci>
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<apply>
<plus/>
<ci> Kmur2 </ci>
<ci> UbE2 </ci>
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</apply>
</math>
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<minus/>
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<divide/>
<apply>
<times/>
<ci> kwr </ci>
<ci> Wee1B </ci>
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<plus/>
<ci> Kmwr </ci>
<ci> Wee1B </ci>
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<apply>
<divide/>
<apply>
<times/>
<ci> kw </ci>
<ci> MPF </ci>
<ci> Wee1 </ci>
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<apply>
<plus/>
<ci> Kmw </ci>
<ci> Wee1 </ci>
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</apply>
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<apply>
<times/>
<ci> Cdc25B </ci>
<ci> kc </ci>
<ci> MPF </ci>
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<plus/>
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<ci> Kmc </ci>
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<divide/>
<apply>
<times/>
<ci> Cdc25 </ci>
<ci> kcr </ci>
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<apply>
<plus/>
<ci> Cdc25 </ci>
<ci> Kmcr </ci>
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</apply>
</apply>
</math>
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<geq/>
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<apply>
<leq/>
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<apply>
<times/>
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<ci> kp </ci>
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<apply>
<divide/>
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