Location: Novak, Tyson, 1997 @ c766311d9b19 / novak_tyson_1997_SBML.xml

Author:

Catherine Lloyd <c.lloyd@auckland.ac.nz>

Date:

2010-06-02 03:57:17+12:00

Desc:

Updated documentation in CellML model file. Added SBML model to see if PMR2 can handle the different file format.

Permanent Source URI:

http://models.cellml.org/workspace/novak_tyson_1997/rawfile/c766311d9b19330df40da1c0afcdc92dd2591cf9/novak_tyson_1997_SBML.xml

<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version3" metaid="_000000" level="2" version="3">
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	<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<articleinfo>
				<title>Modelling the Control of DNA Replication in Fission Yeast</title>
				<author>
					<firstname>Catherine</firstname>
					<surname>Lloyd</surname>
					<affiliation>
						<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
           This SBML version of the Novak-Tyson 1997 model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team. For more information please refer to the <ulink url="http://www.ebi.ac.uk/biomodels/legal.html">terms of use</ulink>. It is being included in the CellML model repository as proof of concept - that PMR2 is able to store models in formats other than CellML. Also, in the case of this particular model, the CellML version is unable to capture the switiching events in the original model. By contrast these can be described in the SBML version of the model. Further this is a test to see how PMR2 handles MIRIAM annotations.
          </para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
ABSTRACT: A central event in the eukaryotic cell cycle is the decision to commence DNA replication (S phase). Strict controls normally operate to prevent repeated rounds of DNA replication without intervening mitoses ("endoreplication") or initiation of mitosis before DNA is fully replicated ("mitotic catastrophe"). Some of the genetic interactions involved in these controls have recently been identified in yeast. From this evidence we propose a molecular mechanism of "Start" control in Schizosaccharomyces pombe. Using established principles of biochemical kinetics, we compare the properties of this model in detail with the observed behavior of various mutant strains of fission yeast: wee1(-) (size control at Start), cdc13Delta and rum1(OP) (endoreplication), and wee1(-) rum1Delta (rapid division cycles of diminishing cell size). We discuss essential features of the mechanism that are responsible for characteristic properties of Start control in fission yeast, to expose our proposal to crucial experimental tests.
</para>				
				<para>
The original paper reference is cited below:
</para>
				<para>
Modeling the control of DNA replication in fission yeast, Bela Novak and John J. Tyson, 1997, <emphasis>Proceedings of the National Academy of Sciences</emphasis>, 94, 9147-9152.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9256450&amp;dopt=Abstract">PubMed ID: 9256450</ulink>
				</para>
				<informalfigure float="0" id="fig_reaction_diagram">
					<mediaobject>
						<imageobject>
							<objectinfo>
								<title>cell diagram</title>
							</objectinfo>
							<imagedata fileref="novak_1997.png"/>
						</imageobject>
					</mediaobject>
					<caption>A schematic diagram of the reaction mechanism which describes the G<subscript>1</subscript>/S and G<subscript>2</subscript>/M controls in fission yeast.</caption>
				</informalfigure>

			</sect1>
		</article>
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        </rdf:RDF>
      </annotation>
    </species>
    <species metaid="metaid_0000087" id="Cdc25B" name="BoundCdc25" compartment="Cell" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000087">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:uniprot:P06652"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
    </species>
    <species metaid="metaid_0000088" id="Rum1Total" name="TotalRum1" compartment="Cell" hasOnlySubstanceUnits="true">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000088">
            <bqbiol:is>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:uniprot:P40380"/>
              </rdf:Bag>
            </bqbiol:is>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
    </species>
    <species metaid="metaid_0000089" id="Cdc13Total" name="TotalCdc13" compartment="Cell" hasOnlySubstanceUnits="true">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000089">
            <bqbiol:is>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:uniprot:P10815"/>
              </rdf:Bag>
            </bqbiol:is>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
    </species>
    <species metaid="metaid_0000090" id="Cig2Total" name="TotalCig2" compartment="Cell" hasOnlySubstanceUnits="true">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000090">
            <bqbiol:is>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:uniprot:P36630"/>
              </rdf:Bag>
            </bqbiol:is>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
    </species>
  </listOfSpecies>
  <listOfParameters>
    <parameter metaid="metaid_0000019" id="mu" name="mu" value="0.00495">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">mass growth rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000020" id="Mass" name="Mass" value="0.49" constant="false"/>
    <parameter metaid="metaid_0000021" id="k1" name="k1" value="0.015">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">G2K production rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000022" id="k2prime" name="k2&apos;" value="0.05"/>
    <parameter metaid="metaid_0000023" id="k3" name="k3" value="0.09375">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Rum1 production rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000024" id="k4" name="k4" value="0.1875">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Rum1 degradation rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000025" id="k5" name="k5" value="0.00175">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">G1k production rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000026" id="k6prime" name="k6&apos;" value="0"/>
    <parameter metaid="metaid_0000027" id="k7" name="k7" value="100">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Rum1/G2K binding rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000028" id="k7r" name="k7r" value="0.1">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">G2R dissociation rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000029" id="k8" name="k8" value="10">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Rum1/G1K binding rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000030" id="k8r" name="k8r" value="0.1"/>
    <parameter metaid="metaid_0000031" id="kc" name="kc" value="1"/>
    <parameter metaid="metaid_0000032" id="kcr" name="kcr" value="0.25"/>
    <parameter metaid="metaid_0000033" id="ki" name="ki" value="0.4"/>
    <parameter metaid="metaid_0000034" id="kir" name="kir" value="0.1"/>
    <parameter metaid="metaid_0000035" id="kp" name="kp" value="3.25" constant="false">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Rum1 Phosphorylation Rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000036" id="ku" name="ku" value="0.2"/>
    <parameter metaid="metaid_0000037" id="kur" name="kur" value="0.1"/>
    <parameter metaid="metaid_0000038" id="ku2" name="ku2" value="1"/>
    <parameter metaid="metaid_0000039" id="kur2" name="kur2" value="0.3"/>
    <parameter metaid="metaid_0000040" id="kw" name="kw" value="1"/>
    <parameter metaid="metaid_0000041" id="kwr" name="kwr" value="0.25"/>
    <parameter metaid="metaid_0000042" id="V2" name="V2" value="0.25"/>
    <parameter metaid="metaid_0000043" id="V2prime" name="V2&apos;" value="0.0075"/>
    <parameter metaid="metaid_0000044" id="V6" name="V6" value="7.5"/>
    <parameter metaid="metaid_0000045" id="V6prime" name="V6&apos;" value="0.0375"/>
    <parameter metaid="metaid_0000046" id="V25" name="V25" value="0.5"/>
    <parameter metaid="metaid_0000047" id="V25prime" name="V25&apos;" value="0.025"/>
    <parameter metaid="metaid_0000048" id="Vw" name="Vw" value="0.35"/>
    <parameter metaid="metaid_0000049" id="Vwprime" name="Vw&apos;" value="0.035"/>
    <parameter metaid="metaid_0000050" id="Kmc" name="Kmc" value="0.1"/>
    <parameter metaid="metaid_0000051" id="Kmcr" name="Kmcr" value="0.1"/>
    <parameter metaid="metaid_0000052" id="Kmi" name="Kmi" value="0.01"/>
    <parameter metaid="metaid_0000053" id="Kmir" name="Kmir" value="0.01"/>
    <parameter metaid="metaid_0000054" id="Kmp" name="Kmp" value="0.001"/>
    <parameter metaid="metaid_0000055" id="Kmu" name="Kmu" value="0.01"/>
    <parameter metaid="metaid_0000056" id="Kmur" name="Kmur" value="0.01"/>
    <parameter metaid="metaid_0000057" id="Kmu2" name="Kmu2" value="0.05"/>
    <parameter metaid="metaid_0000058" id="Kmur2" name="Kmur2" value="0.05"/>
    <parameter metaid="metaid_0000059" id="Kmw" name="Kmw" value="0.1"/>
    <parameter metaid="metaid_0000060" id="Kmwr" name="Kmwr" value="0.1"/>
    <parameter metaid="metaid_0000061" id="alpha" name="alpha" value="0.25"/>
    <parameter metaid="metaid_0000062" id="beta" name="beta" value="0.05"/>
    <parameter metaid="metaid_0000063" id="Cig1" name="Cig1" value="0"/>
    <parameter metaid="metaid_0000064" id="k2" name="k2" constant="false">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Cdc13/Cdc2 dissociation rate (degradation of G2K)</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000065" id="k6" name="k6" constant="false">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Cig2/Cdc2 dissociation rate (degradation of G1K)</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000066" id="kwee" name="kwee" constant="false">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Cdc2 phosphorylation rate</p>
      </notes>
    </parameter>
    <parameter metaid="metaid_0000067" id="k25" name="k25" constant="false">
      <notes>
        <p xmlns="http://www.w3.org/1999/xhtml">Cdc2 dephosphorylation rate</p>
      </notes>
    </parameter>
  </listOfParameters>
  <listOfRules>
    <rateRule metaid="rule1" variable="Mass">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <times/>
          <ci> Mass </ci>
          <ci> mu </ci>
        </apply>
      </math>
    </rateRule>
    <assignmentRule metaid="rule2" variable="IEB">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <minus/>
          <cn type="integer"> 1 </cn>
          <ci> IE </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule3" variable="UbEB">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <minus/>
          <cn type="integer"> 1 </cn>
          <ci> UbE </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule4" variable="UbE2B">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <minus/>
          <cn type="integer"> 1 </cn>
          <ci> UbE2 </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule5" variable="Wee1B">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <minus/>
          <cn type="integer"> 1 </cn>
          <ci> Wee1 </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule6" variable="Cdc25B">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <minus/>
          <cn type="integer"> 1 </cn>
          <ci> Cdc25 </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule7" variable="Rum1Total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> G1R </ci>
          <ci> G2R </ci>
          <ci> PG2R </ci>
          <ci> R </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule8" variable="Cdc13Total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> G2K </ci>
          <ci> G2R </ci>
          <ci> PG2 </ci>
          <ci> PG2R </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule9" variable="Cig2Total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> G1K </ci>
          <ci> G1R </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule10" variable="k2">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <apply>
            <times/>
            <ci> UbE </ci>
            <ci> V2 </ci>
          </apply>
          <apply>
            <times/>
            <apply>
              <minus/>
              <cn type="integer"> 1 </cn>
              <ci> UbE </ci>
            </apply>
            <ci> V2prime </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule11" variable="k6">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <apply>
            <times/>
            <ci> UbE2 </ci>
            <ci> V6 </ci>
          </apply>
          <apply>
            <times/>
            <apply>
              <minus/>
              <cn type="integer"> 1 </cn>
              <ci> UbE2 </ci>
            </apply>
            <ci> V6prime </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule12" variable="kwee">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <apply>
            <times/>
            <ci> Vwprime </ci>
            <apply>
              <minus/>
              <cn type="integer"> 1 </cn>
              <ci> Wee1 </ci>
            </apply>
          </apply>
          <apply>
            <times/>
            <ci> Vw </ci>
            <ci> Wee1 </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule13" variable="k25">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <apply>
            <times/>
            <ci> Cdc25 </ci>
            <ci> V25 </ci>
          </apply>
          <apply>
            <times/>
            <apply>
              <minus/>
              <cn type="integer"> 1 </cn>
              <ci> Cdc25 </ci>
            </apply>
            <ci> V25prime </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule14" variable="MPF">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> G2K </ci>
          <apply>
            <times/>
            <ci> beta </ci>
            <ci> PG2 </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="rule15" variable="SPF">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> Cig1 </ci>
          <apply>
            <times/>
            <ci> alpha </ci>
            <ci> G1K </ci>
          </apply>
          <ci> MPF </ci>
        </apply>
      </math>
    </assignmentRule>
  </listOfRules>
  <listOfReactions>
    <reaction metaid="metaid_0000091" id="G2K_Creation" name="Cdc13_Cdc2 creation" reversible="false" fast="false">
      <listOfProducts>
        <speciesReference species="G2K"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> k1 </ci>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000092" id="G1K_Creation" name="Cig2_Cdc2 creation" reversible="false" fast="false">
      <listOfProducts>
        <speciesReference species="G1K"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> k5 </ci>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000093" id="Cdc2Phos" name="Cdc2 phosphorylation" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000093">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:ec-code:2.7.10.2"/>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006468"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
            <bqbiol:hasPart>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:reactome:REACT_6178"/>
                <rdf:li rdf:resource="urn:miriam:reactome:REACT_6257"/>
              </rdf:Bag>
            </bqbiol:hasPart>
            <bqbiol:hasPart>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:reactome:REACT_6327"/>
                <rdf:li rdf:resource="urn:miriam:reactome:REACT_6294"/>
              </rdf:Bag>
            </bqbiol:hasPart>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G2K"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="PG2"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="Wee1"/>
        <modifierSpeciesReference species="Cdc25"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <times/>
              <ci> G2K </ci>
              <ci> kwee </ci>
            </apply>
            <apply>
              <times/>
              <ci> k25 </ci>
              <ci> PG2 </ci>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000094" id="G2R_Creation" name="binding of Rum1 with Cdc13_Cdc2" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000094">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006461"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G2K"/>
        <speciesReference species="R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="G2R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <times/>
              <ci> G2K </ci>
              <ci> k7 </ci>
              <ci> R </ci>
            </apply>
            <apply>
              <times/>
              <ci> G2R </ci>
              <ci> k7r </ci>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000095" id="PG2R_Creation" name="binding of Rum1 with Cdc13_P-Cdc2" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000095">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006461"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="PG2"/>
        <speciesReference species="R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="PG2R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <times/>
              <ci> k7 </ci>
              <ci> PG2 </ci>
              <ci> R </ci>
            </apply>
            <apply>
              <times/>
              <ci> k7r </ci>
              <ci> PG2R </ci>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000096" id="Rum1DegInG2R" name="Rum1 degradation in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000096">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G2R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="G2K"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G2R </ci>
            <ci> k4 </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000097" id="Rum1Deg" name="Rum1 degradation in solution" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000097">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="R"/>
      </listOfReactants>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> k4 </ci>
            <ci> R </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000098" id="Rum1DegInPG2R" name="Rum1 degradation in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000098">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="PG2R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="PG2"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> k4 </ci>
            <ci> PG2R </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000099" id="RumDegInG1R" name="Rum1 degradation in Rum1_Cig2_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000099">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G1R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="G1K"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G1R </ci>
            <ci> k4 </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000100" id="G2K_dissoc" name="Cdc13 degradation in Cdc13_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000100">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G2K"/>
      </listOfReactants>
      <listOfModifiers>
        <modifierSpeciesReference species="UbE"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G2K </ci>
            <ci> k2 </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000101" id="PG2_dissoc" name="Cdc13 degradation in Cdc13_P-Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000101">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="PG2"/>
      </listOfReactants>
      <listOfModifiers>
        <modifierSpeciesReference species="UbE"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> k2 </ci>
            <ci> PG2 </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000102" id="G1K_Dissociation" name="Cig2 degradation in Cig2_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000102">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G1K"/>
      </listOfReactants>
      <listOfModifiers>
        <modifierSpeciesReference species="UbE2"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G1K </ci>
            <ci> k6 </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000103" id="PG2R_Dissociation" name="Cdc13 degradation in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000103">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="PG2R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> k2prime </ci>
            <ci> PG2R </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000104" id="G2R_Dissociation" name="Cdc13 degradation in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000104">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G2R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G2R </ci>
            <ci> k2prime </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000105" id="G1R_Dissociation" name="Cig2 degradation in Rum1_Cig2_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000105">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0008054"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G1R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G1R </ci>
            <ci> k6prime </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000106" id="G1R_Binding" name="Binding of Rum1 to Cig2_Cdc2" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000106">
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              <rdf:Bag>
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              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G1K"/>
        <speciesReference species="R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="G1R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <times/>
              <ci> G1K </ci>
              <ci> k8 </ci>
              <ci> R </ci>
            </apply>
            <apply>
              <times/>
              <ci> G1R </ci>
              <ci> k8r </ci>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000107" id="G2R_Dissociation_UbE" name="UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000107">
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              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:kegg.pathway:spo04120"/>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="G2R"/>
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      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="UbE"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> G2R </ci>
            <ci> k2 </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000108" id="PG2R_Dissociation_UbE" name="UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000108">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:kegg.pathway:spo04120"/>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="PG2R"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="UbE"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> k2 </ci>
            <ci> PG2R </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000109" id="Rum1_Production" name="Rum1 creation" reversible="false" fast="false">
      <listOfProducts>
        <speciesReference species="R"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> k3 </ci>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000110" id="Rum1_Deg_SPF" name="Rum1 degradation by SPF" reversible="false" fast="false">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000110">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0030163"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="R"/>
      </listOfReactants>
      <listOfModifiers>
        <modifierSpeciesReference species="SPF"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> kp </ci>
              <ci> Mass </ci>
              <ci> R </ci>
              <ci> SPF </ci>
            </apply>
            <apply>
              <plus/>
              <ci> Kmp </ci>
              <ci> R </ci>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000111" id="IE_Reaction" name="IE production &amp; degradation" fast="false">
      <listOfReactants>
        <speciesReference species="IEB"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="IE"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="MPF"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> IEB </ci>
                <ci> ki </ci>
                <ci> MPF </ci>
              </apply>
              <apply>
                <plus/>
                <ci> IEB </ci>
                <ci> Kmi </ci>
              </apply>
            </apply>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> IE </ci>
                <ci> kir </ci>
              </apply>
              <apply>
                <plus/>
                <ci> IE </ci>
                <ci> Kmir </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000112" id="UbE_Reaction" name="UbE production &amp; degradation" fast="false">
      <listOfReactants>
        <speciesReference species="UbEB"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="UbE"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="IE"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> IE </ci>
                <ci> ku </ci>
                <ci> UbEB </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Kmu </ci>
                <ci> UbEB </ci>
              </apply>
            </apply>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kur </ci>
                <ci> UbE </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Kmur </ci>
                <ci> UbE </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000113" id="UbE2_Reaction" name="UbE2 production &amp; degradation" fast="false">
      <listOfReactants>
        <speciesReference species="UbE2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="UbE2"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="MPF"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> ku2 </ci>
                <ci> MPF </ci>
                <ci> UbE2B </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Kmu2 </ci>
                <ci> UbE2B </ci>
              </apply>
            </apply>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kur2 </ci>
                <ci> UbE2 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Kmur2 </ci>
                <ci> UbE2 </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000114" id="Wee1_Reaction" name="Wee1 production &amp; degradation" fast="false">
      <listOfReactants>
        <speciesReference species="Wee1B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="Wee1"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="MPF"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kwr </ci>
                <ci> Wee1B </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Kmwr </ci>
                <ci> Wee1B </ci>
              </apply>
            </apply>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kw </ci>
                <ci> MPF </ci>
                <ci> Wee1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Kmw </ci>
                <ci> Wee1 </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction metaid="metaid_0000115" id="Cdc25_Reaction" name="Cdc25 production &amp; degradation" fast="false">
      <listOfReactants>
        <speciesReference species="Cdc25B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="Cdc25"/>
      </listOfProducts>
      <listOfModifiers>
        <modifierSpeciesReference species="MPF"/>
      </listOfModifiers>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <minus/>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Cdc25B </ci>
                <ci> kc </ci>
                <ci> MPF </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Cdc25B </ci>
                <ci> Kmc </ci>
              </apply>
            </apply>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Cdc25 </ci>
                <ci> kcr </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Cdc25 </ci>
                <ci> Kmcr </ci>
              </apply>
            </apply>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
  </listOfReactions>
  <listOfEvents>
    <event metaid="metaid_0000116" id="Start" name="S-Phase Start">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000116">
            <bqbiol:is>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0045750"/>
              </rdf:Bag>
            </bqbiol:is>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <trigger>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <geq/>
            <ci> SPF </ci>
            <cn> 0.1 </cn>
          </apply>
        </math>
      </trigger>
      <delay>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <cn type="integer"> 60 </cn>
        </math>
      </delay>
      <listOfEventAssignments>
        <eventAssignment variable="kp">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <ci> kp </ci>
              <cn type="integer"> 2 </cn>
            </apply>
          </math>
        </eventAssignment>
      </listOfEventAssignments>
    </event>
    <event metaid="metaid_0000117" id="Division" name="Cell Division">
      <annotation>
        <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
          <rdf:Description rdf:about="#metaid_0000117">
            <bqbiol:is>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0051301"/>
              </rdf:Bag>
            </bqbiol:is>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <trigger>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <leq/>
            <ci> UbE </ci>
            <cn> 0.1 </cn>
          </apply>
        </math>
      </trigger>
      <listOfEventAssignments>
        <eventAssignment variable="kp">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <cn type="integer"> 2 </cn>
              <ci> kp </ci>
            </apply>
          </math>
        </eventAssignment>
        <eventAssignment variable="Mass">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <ci> Mass </ci>
              <cn type="integer"> 2 </cn>
            </apply>
          </math>
        </eventAssignment>
      </listOfEventAssignments>
    </event>
  </listOfEvents>
</model>
</sbml>