- Author:
- Ethan Choi <mcho099@aucklanduni.ac.nz>
- Date:
- 2010-01-07 15:57:35+13:00
- Desc:
- Curated, figures can be replicated.
- Permanent Source URI:
- http://models.cellml.org/workspace/revilla_garcia-ramos_2003/rawfile/1a6c7dcde9837872ddc3d8783477cd2cc8e9bb1c/revilla_garcia-ramos_2003.cellml
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<!-- FILE : revilla_garcia-ramos_2003.cellml
CREATED : 25th October 2004
LAST MODIFIED : 7th January 2010
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Revilla and Garcia-Ramos's 2003 dynamic model for HIV-1 therapy.
-->
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<title>A Dynamic Model For HIV-1 Therapy</title>
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<para>This model has been built with the differential expressions in Revilla and Garcia-Ramos' 2003 paper for a dynamic model for HIV-1 therapy. This file is known to run in OpenCell to reproduce all panels in figure 2. The initial conditions [x, y, z, v, w] can be altered to replicate the different panels [single infected system (a): x=200, y=0, z=0, v=10^-6, w=0], [system with double infection (b): x=3, y=6, z=0, v=149, w=1], [alternate system with double infection (c): same as b, but alpha=0.016], and current parameterization is set to replicate figure2b. Note that in the paper, the figure diagrams are scaled logarithmically.</para>
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>Current therapies for acquired immunodeficiency syndrome (AIDS) include inhibitors of the enzymes required for the replication of the human immunodeficiency virus (HIV-1). An alternative therapeutic approach uses genetically modified viruses which are then capable of regulating infections by other viruses. The genetically modified virus is able to infect and kill host cells which are already infected with HIV-1, resulting in a decrease in the viral load.</para>
<para>This information has been obtained from <emphasis>in vitro</emphasis> experiments. The potential effectiveness of this treatment for reducing viral load <emphasis>in vivo</emphasis> has not been tested. In the study described here, Revilla and Garcia-Ramos model the potential interactions between HIV-1, its host cell, and a recombinant virus in an <emphasis>in vivo</emphasis> context (see the figure below). Model simulations suggest that the use of recombinant viruses could be effective as a treatment for reducing an individual's HIV-1 load. </para>
<para>The complete original paper reference is cited below:</para>
<para>Fighting a virus with a virus: a dynamic model for HIV-1 therapy, Tomas Revilla and Gisela Garcia-Ramos, 2003, <emphasis>Mathematical Biosciences</emphasis>, 185, 191-203. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/12941536">PubMed ID: 12941536</ulink></para>
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