- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2007-12-04 04:00:45+13:00
- Desc:
- committing version05 of sakmann_spindler_bryant_linz_noble_2000
- Permanent Source URI:
- http://models.cellml.org/workspace/sakmann_spindler_bryant_linz_noble_2000/rawfile/ff053f13f4679d08bc15b54da6ef748eba9ea959/sakmann_spindler_bryant_linz_noble_2000_c.cellml
<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 03/10/2007 at 17:01:58 using:
COR (0.9.31.793)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" name="sakmann_spindler_bryant_linz_noble_2000_endo-cell" cmeta:id="sakmann_spindler_bryant_linz_noble_2000_endo-cell">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Distribution of a Persistent Sodium Current Across theVentricular Wall in Guinea Pigs</title>
<author>
<firstname>Penny</firstname>
<surname>Noble</surname>
<affiliation>
<shortaffil>Oxford University</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model has been curated and unit-checked and is known to run in COR and PCEnv. This variant is parameterised for the cardiac ENDOCARDIAL CELL.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
This model was based on the paper "Distribution of a Persistent Sodium Current Across theVentricular Wall in Guinea Pigs" by Bernhard F.A.S. Sakmann, Anthony J. Spindler, Simon M. Bryant, Klaus W. Linz and Denis Noble.
Reference: Circulation Research 2000 Nov 10;87(10):910-4.
</para>
<para>
The following is the abstract from the paper:
"A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes bywhole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium,midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P,0.05) smaller IpNathan subendocardial and subepicardial myocytes. There was no significant difference in IpNa current density betweensubepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion ofaction potential duration across the ventricular wall."
</para>
</sect1>
</article>
</documentation>
<units name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="per_millivolt_second">
<unit units="millivolt" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="microS">
<unit units="siemens" prefix="micro"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="microS_per_microF">
<unit units="microS"/>
<unit units="microF" exponent="-1"/>
</units>
<units name="per_microF">
<unit units="microF" exponent="-1"/>
</units>
<units name="nanoA">
<unit units="ampere" prefix="nano"/>
</units>
<units name="mA_nA">
<unit units="ampere" prefix="milli"/>
<unit units="nanoA" exponent="-1"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="ampere" prefix="nano"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millimolar_second">
<unit units="millimolar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit units="mole" prefix="kilo" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="micrometre3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units name="litre_micrometre3">
<unit units="litre"/>
<unit units="micrometre3" exponent="-1"/>
</units>
<component name="environment">
<variable units="second" public_interface="out" name="time"/>
</component>
<component name="membrane">
<variable units="millivolt" public_interface="out" name="V" initial_value="-89.1374183"/>
<variable units="joule_per_kilomole_kelvin" public_interface="out" name="R" initial_value="8314.472"/>
<variable units="kelvin" public_interface="out" name="T" initial_value="310"/>
<variable units="coulomb_per_mole" public_interface="out" name="F" initial_value="96485.3415"/>
<variable units="microF" public_interface="out" name="Cm" initial_value="0.00012"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="nanoA" public_interface="in" name="i_K1"/>
<variable units="nanoA" public_interface="in" name="i_to"/>
<variable units="nanoA" public_interface="in" name="i_Kr"/>
<variable units="nanoA" public_interface="in" name="i_Ks"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_K_cyt"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_K_ds"/>
<variable units="nanoA" public_interface="in" name="i_NaK"/>
<variable units="nanoA" public_interface="in" name="i_Na"/>
<variable units="nanoA" public_interface="in" name="i_b_Na"/>
<variable units="nanoA" public_interface="in" name="i_p_Na"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Na_cyt"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Na_ds"/>
<variable units="nanoA" public_interface="in" name="i_NaCa_cyt"/>
<variable units="nanoA" public_interface="in" name="i_NaCa_ds"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Ca_cyt"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Ca_ds"/>
<variable units="nanoA" public_interface="in" name="i_b_Ca"/>
<variable units="nanoA" name="i_Stim"/>
<variable units="second" name="stim_start" initial_value="0.1"/>
<variable units="second" name="stim_end" initial_value="10000"/>
<variable units="second" name="stim_period" initial_value="1"/>
<variable units="second" name="stim_duration" initial_value="0.003"/>
<variable units="nanoA" name="stim_amplitude" initial_value="-2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="nanoA">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_Stim</ci>
<ci>i_K1</ci>
<ci>i_to</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_NaK</ci>
<ci>i_Na</ci>
<ci>i_b_Na</ci>
<ci>i_p_Na</ci>
<ci>i_Ca_L_Na_cyt</ci>
<ci>i_Ca_L_Na_ds</ci>
<ci>i_NaCa_cyt</ci>
<ci>i_NaCa_ds</ci>
<ci>i_Ca_L_Ca_cyt</ci>
<ci>i_Ca_L_Ca_ds</ci>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_K_ds</ci>
<ci>i_b_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="reversal_potentials">
<variable units="millivolt" public_interface="out" name="E_Na"/>
<variable units="millivolt" public_interface="out" name="E_K"/>
<variable units="millivolt" public_interface="out" name="E_Ks"/>
<variable units="millivolt" public_interface="out" name="E_Ca"/>
<variable units="millivolt" public_interface="out" name="E_mh"/>
<variable units="dimensionless" name="P_kna" initial_value="0.03"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>P_kna</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<ci>P_kna</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_mh</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Na_o</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>K_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Na_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable units="nanoA" public_interface="out" name="i_K1"/>
<variable units="millimolar" public_interface="out" name="K_mk1" initial_value="10"/>
<variable units="microS" name="g_K1" initial_value="0.2"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>K_mk1</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_potassium_current">
<variable units="nanoA" public_interface="out" name="i_Kr"/>
<variable units="microS" name="g_Kr"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="microF" public_interface="in" name="Cm"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="xr"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Kr</ci>
<apply>
<times/>
<ci>Cm</ci>
<cn cellml:units="microS_per_microF">5.563</cn>
<apply>
<root/>
<apply>
<divide/>
<ci>K_o</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_Kr</ci>
<ci>xr</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
<cn cellml:units="millivolt">22.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_potassium_current_xr_gate">
<variable units="dimensionless" public_interface="out" name="xr" initial_value="1.98e-5"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="per_second" name="alpha_xr"/>
<variable units="per_second" name="beta_xr"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xr</ci>
<apply>
<divide/>
<cn cellml:units="per_second">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">21.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xr</ci>
<apply>
<divide/>
<cn cellml:units="per_second">0.001</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00138</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.2</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.123</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00061</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.9</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.145</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.9</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xr</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_xr</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>xr</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_xr</ci>
<ci>xr</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_potassium_current">
<variable units="nanoA" public_interface="out" name="i_Ks"/>
<variable units="microS" name="g_Ks"/>
<variable units="millivolt" public_interface="in" name="E_Ks"/>
<variable units="microF" public_interface="in" name="Cm"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="xs"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ks</ci>
<apply>
<times/>
<ci>Cm</ci>
<cn cellml:units="microS_per_microF">17.5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<power/>
<ci>xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_potassium_current_xs_gate">
<variable units="dimensionless" public_interface="out" name="xs" initial_value="0.0381477"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="per_second" name="alpha_xs"/>
<variable units="per_second" name="beta_xs"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xs</ci>
<apply>
<divide/>
<cn cellml:units="per_second">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">1.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">16.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xs</ci>
<apply>
<divide/>
<cn cellml:units="per_second">0.001</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0000719</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.148</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.000131</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0687</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_xs</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>xs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_xs</ci>
<ci>xs</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
<variable units="nanoA" public_interface="out" name="i_Na"/>
<variable units="microS" name="g_Na"/>
<variable units="per_microF" name="nachanneldensity" initial_value="1075"/>
<variable units="microS" name="gnachannel" initial_value="20"/>
<variable units="millivolt" public_interface="in" name="E_mh"/>
<variable units="microF" public_interface="in" name="Cm"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="m"/>
<variable units="dimensionless" private_interface="in" name="h"/>
<variable units="dimensionless" private_interface="in" name="proton"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>nachanneldensity</ci>
<ci>Cm</ci>
<ci>gnachannel</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.26</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>proton</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1000</cn>
<cn cellml:units="dimensionless">2.5119e-6</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.34</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.58</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_m_gate">
<variable units="dimensionless" public_interface="out" name="m" initial_value="0.0026891"/>
<variable units="per_second" name="alpha_m"/>
<variable units="per_second" name="beta_m"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="millivolt" name="delta_m" initial_value="1e-5"/>
<variable units="millivolt" name="E0_m"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_m</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">41</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">2000</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_m</ci>
</apply>
<ci>delta_m</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">200</cn>
<ci>E0_m</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<ci>E0_m</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_second">8000</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.056</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">66</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_h_gate">
<variable units="dimensionless" public_interface="out" name="h" initial_value="0.9873107"/>
<variable units="per_second" name="alpha_h"/>
<variable units="per_second" name="beta_h"/>
<variable units="dimensionless" public_interface="out" name="proton" initial_value="3.98e-5"/>
<variable units="millivolt" name="shifth"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>shifth</ci>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="millivolt">32.7</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<divide/>
<ci>proton</ci>
<cn cellml:units="dimensionless">1000</cn>
</apply>
<cn cellml:units="dimensionless">2.5119e-6</cn>
</apply>
</apply>
</apply>
<cn cellml:units="millivolt">32.18</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="per_second">20</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.125</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<ci>shifth</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="per_second">2000</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">320</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<ci>shifth</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="persistent_sodium_current">
<variable units="nanoA" public_interface="out" name="i_p_Na"/>
<variable units="microS" name="g_pna" initial_value="0.0045"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="microF" public_interface="in" name="Cm"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_p_Na</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<cn cellml:units="per_microF">1000000</cn>
<ci>g_pna</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">51.0795</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">56.5076</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.6215</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable units="nanoA" public_interface="out" name="i_b_Na"/>
<variable units="microS" name="g_bna" initial_value="0.0006"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Na</ci>
<apply>
<times/>
<ci>g_bna</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel">
<variable units="nanoA" public_interface="out" name="i_Ca_L_Ca_cyt"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L_K_cyt"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L_Na_cyt"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L_Ca_ds"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L_K_ds"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L_Na_ds"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L"/>
<variable units="nanoA_per_millimolar" name="P_Ca_L" initial_value="0.11"/>
<variable units="dimensionless" name="P_CaK" initial_value="0.002"/>
<variable units="dimensionless" name="P_CaNa" initial_value="0.01"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_i"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_ds"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="d"/>
<variable units="dimensionless" private_interface="in" name="f"/>
<variable units="dimensionless" private_interface="in" name="f2"/>
<variable units="dimensionless" private_interface="in" name="f2ds"/>
<variable units="millimolar" private_interface="out" name="Km_f2" initial_value="100000"/>
<variable units="millimolar" private_interface="out" name="Km_f2ds" initial_value="0.001"/>
<variable units="per_second" public_interface="out" private_interface="out" name="R_decay" initial_value="20"/>
<variable units="dimensionless" name="FrICa" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L_Ca_cyt</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FrICa</ci>
</apply>
<cn cellml:units="dimensionless">4</cn>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">100</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_K_cyt</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FrICa</ci>
</apply>
<ci>P_CaK</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>K_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Na_cyt</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FrICa</ci>
</apply>
<ci>P_CaNa</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Na_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Na_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Ca_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>FrICa</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2ds</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">100</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_K_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>FrICa</ci>
<ci>P_CaK</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2ds</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>K_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L_Na_ds</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>FrICa</ci>
<ci>P_CaNa</ci>
<ci>P_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f2ds</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Na_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">50</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Na_o</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<plus/>
<ci>i_Ca_L_Ca_cyt</ci>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_Na_cyt</ci>
<ci>i_Ca_L_Ca_ds</ci>
<ci>i_Ca_L_K_ds</ci>
<ci>i_Ca_L_Na_ds</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_d_gate">
<variable units="dimensionless" public_interface="out" name="d" initial_value="1.44e-4"/>
<variable units="per_second" name="alpha_d"/>
<variable units="per_second" name="beta_d"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="millivolt" name="E0_d"/>
<variable units="dimensionless" name="speed_d" initial_value="3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_d</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">24</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_d</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">120</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_d</ci>
</apply>
<cn cellml:units="millivolt">0.0001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">30</cn>
<ci>E0_d</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>E0_d</ci>
</apply>
<cn cellml:units="millivolt">7.2</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_d</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">120</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_d</ci>
</apply>
<cn cellml:units="millivolt">0.0001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">12</cn>
<ci>E0_d</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>E0_d</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.5</cn>
<cn cellml:units="millivolt">7.2</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<times/>
<ci>speed_d</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_d</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>d</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_d</ci>
<ci>d</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_gate">
<variable units="dimensionless" public_interface="out" name="f" initial_value="0.9999993"/>
<variable units="per_second" name="alpha_f"/>
<variable units="per_second" name="beta_f"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" name="speed_f" initial_value="0.3"/>
<variable units="millivolt" name="delta_f" initial_value="0.0001"/>
<variable units="millivolt" name="E0_f"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_f</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">34</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_f</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">25</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_f</ci>
</apply>
<ci>delta_f</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">6.25</cn>
<ci>E0_f</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>E0_f</ci>
<cn cellml:units="millivolt">5.1</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_f</ci>
<apply>
<divide/>
<cn cellml:units="per_second">12</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">34</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<times/>
<ci>speed_f</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_f</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>f</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_f</ci>
<ci>f</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f2_gate">
<variable units="dimensionless" public_interface="out" name="f2" initial_value="0.254433"/>
<variable units="millimolar" public_interface="in" name="Km_f2"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f2</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="per_second">1</cn>
<apply>
<times/>
<cn cellml:units="per_second">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<ci>Ca_i</ci>
<apply>
<plus/>
<ci>Km_f2</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<ci>f2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f2ds_gate">
<variable units="dimensionless" public_interface="out" name="f2ds" initial_value="0.9292189"/>
<variable units="millimolar" public_interface="in" name="Km_f2ds"/>
<variable units="per_second" public_interface="in" name="R_decay"/>
<variable units="millimolar" public_interface="in" name="Ca_ds"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f2ds</ci>
</apply>
<apply>
<times/>
<ci>R_decay</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<ci>Ca_ds</ci>
<apply>
<plus/>
<ci>Km_f2ds</ci>
<ci>Ca_ds</ci>
</apply>
</apply>
<ci>f2ds</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable units="nanoA" public_interface="out" name="i_b_Ca"/>
<variable units="microS" name="g_bca" initial_value="0.00025"/>
<variable units="millivolt" public_interface="in" name="E_Ca"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Ca</ci>
<apply>
<times/>
<ci>g_bca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current">
<variable units="nanoA" public_interface="out" name="i_to"/>
<variable units="microS" name="g_to" initial_value="0.005"/>
<variable units="dimensionless" name="g_tos" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="dimensionless" private_interface="in" name="s"/>
<variable units="dimensionless" private_interface="in" name="r"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>g_to</ci>
<apply>
<plus/>
<ci>g_tos</ci>
<apply>
<times/>
<ci>s</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>g_tos</ci>
</apply>
</apply>
</apply>
<ci>r</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_s_gate">
<variable units="dimensionless" public_interface="out" name="s" initial_value="0.7352365"/>
<variable units="per_second" name="alpha_s"/>
<variable units="per_second" name="beta_s"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_s</ci>
<apply>
<times/>
<cn cellml:units="per_second">0.033</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_s</ci>
<apply>
<divide/>
<cn cellml:units="per_second">33</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.125</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_s</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>s</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_s</ci>
<ci>s</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_r_gate">
<variable units="dimensionless" public_interface="out" name="r" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">333</cn>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<ci>r</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable units="nanoA" public_interface="out" name="i_NaK"/>
<variable units="nanoA" name="i_NaK_max" initial_value="0.7"/>
<variable units="millimolar" name="K_mK" initial_value="1"/>
<variable units="millimolar" name="K_mNa" initial_value="40"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_mK</ci>
<ci>K_o</ci>
</apply>
</apply>
<ci>Na_i</ci>
</apply>
<apply>
<plus/>
<ci>K_mNa</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger">
<variable units="nanoA" public_interface="out" name="i_NaCa"/>
<variable units="nanoA" public_interface="out" name="i_NaCa_cyt"/>
<variable units="nanoA" public_interface="out" name="i_NaCa_ds"/>
<variable units="nanoA" name="k_NaCa" initial_value="0.00012"/>
<variable units="dimensionless" name="n_NaCa" initial_value="3"/>
<variable units="dimensionless" name="d_NaCa" initial_value="0"/>
<variable units="dimensionless" name="gamma" initial_value="0.5"/>
<variable units="dimensionless" name="FRiNaCa" initial_value="0.001"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millimolar" public_interface="in" name="Ca_ds"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa_cyt</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>FRiNaCa</ci>
</apply>
<ci>k_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="millimolar4">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_ds</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>FRiNaCa</ci>
<ci>k_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_ds</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="millimolar4">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_ds</ci>
<apply>
<power/>
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_ds</ci>
<cn cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<plus/>
<ci>i_NaCa_cyt</ci>
<ci>i_NaCa_ds</ci>
</apply>
</apply>
</math>
</component>
<component name="sarcoplasmic_reticulum_calcium_pump">
<variable units="millimolar_per_second" public_interface="out" name="i_up"/>
<variable units="dimensionless" name="K_1"/>
<variable units="millimolar" name="K_2"/>
<variable units="millimolar" name="K_cyca" initial_value="0.0003"/>
<variable units="dimensionless" name="K_xcs" initial_value="0.4"/>
<variable units="millimolar" name="K_srca" initial_value="0.5"/>
<variable units="millimolar_per_second" name="alpha_up" initial_value="0.4"/>
<variable units="millimolar_per_second" name="beta_up" initial_value="0.03"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millimolar" public_interface="in" name="Ca_up"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_srca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>K_2</ci>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<apply>
<times/>
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_cyca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_up</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_i</ci>
<ci>K_2</ci>
</apply>
<ci>alpha_up</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<ci>K_2</ci>
</apply>
<ci>beta_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_translocation">
<variable units="millimolar_per_second" public_interface="out" name="i_trans"/>
<variable units="millimolar" public_interface="in" name="Ca_rel"/>
<variable units="millimolar" public_interface="in" name="Ca_up"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_trans</ci>
<apply>
<times/>
<cn cellml:units="per_second">50</cn>
<apply>
<minus/>
<ci>Ca_up</ci>
<ci>Ca_rel</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_release">
<variable units="millimolar_per_second" public_interface="out" name="i_rel"/>
<variable units="dimensionless" name="VoltDep"/>
<variable units="dimensionless" name="RegBindSite"/>
<variable units="dimensionless" name="CaiReg"/>
<variable units="dimensionless" name="CadsReg"/>
<variable units="per_second" name="ActRate"/>
<variable units="per_second" name="InactRate"/>
<variable units="per_second" name="K_leak_rate" initial_value="0.05"/>
<variable units="per_second" name="K_m_rel" initial_value="250"/>
<variable units="millimolar" name="K_m_Ca_cyt" initial_value="0.0005"/>
<variable units="millimolar" name="K_m_Ca_ds" initial_value="0.01"/>
<variable units="dimensionless" name="PrecFrac"/>
<variable units="dimensionless" name="ActFrac" initial_value="0.0101647"/>
<variable units="dimensionless" name="ProdFrac" initial_value="0.9584464"/>
<variable units="dimensionless" name="SpeedRel"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millimolar" public_interface="in" name="Ca_ds"/>
<variable units="millimolar" public_interface="in" name="Ca_rel"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>VoltDep</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.08</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaiReg</ci>
<apply>
<divide/>
<ci>Ca_i</ci>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>K_m_Ca_cyt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CadsReg</ci>
<apply>
<divide/>
<ci>Ca_ds</ci>
<apply>
<plus/>
<ci>Ca_ds</ci>
<ci>K_m_Ca_ds</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RegBindSite</ci>
<apply>
<plus/>
<ci>CaiReg</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>CaiReg</ci>
</apply>
<ci>CadsReg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ActRate</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_second">0</cn>
<ci>VoltDep</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">500</cn>
<apply>
<power/>
<ci>RegBindSite</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>InactRate</ci>
<apply>
<plus/>
<cn cellml:units="per_second">60</cn>
<apply>
<times/>
<cn cellml:units="per_second">500</cn>
<apply>
<power/>
<ci>RegBindSite</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>SpeedRel</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">5</cn>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>PrecFrac</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ActFrac</ci>
</apply>
<ci>ProdFrac</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ActFrac</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>PrecFrac</ci>
<ci>SpeedRel</ci>
<ci>ActRate</ci>
</apply>
<apply>
<times/>
<ci>ActFrac</ci>
<ci>SpeedRel</ci>
<ci>InactRate</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ProdFrac</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ActFrac</ci>
<ci>SpeedRel</ci>
<ci>InactRate</ci>
</apply>
<apply>
<times/>
<ci>SpeedRel</ci>
<cn cellml:units="per_second">1</cn>
<ci>ProdFrac</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_rel</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>ActFrac</ci>
<apply>
<plus/>
<ci>ActFrac</ci>
<cn cellml:units="dimensionless">0.25</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>K_m_rel</ci>
</apply>
<ci>K_leak_rate</ci>
</apply>
<ci>Ca_rel</ci>
</apply>
</apply>
</math>
</component>
<component name="extracellular_sodium_concentration">
<variable units="millimolar" public_interface="out" name="Na_o" initial_value="140"/>
</component>
<component name="intracellular_sodium_concentration">
<variable units="millimolar" public_interface="out" name="Na_i" initial_value="5.6633707"/>
<variable units="micrometre3" public_interface="in" name="V_i"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="nanoA" public_interface="in" name="i_Na"/>
<variable units="nanoA" public_interface="in" name="i_b_Na"/>
<variable units="nanoA" public_interface="in" name="i_p_Na"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Na_cyt"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Na_ds"/>
<variable units="nanoA" public_interface="in" name="i_NaK"/>
<variable units="nanoA" public_interface="in" name="i_NaCa_cyt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_p_Na</ci>
<ci>i_b_Na</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa_cyt</ci>
</apply>
<ci>i_Ca_L_Na_cyt</ci>
<ci>i_Ca_L_Na_ds</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="extracellular_calcium_concentration">
<variable units="millimolar" public_interface="out" name="Ca_o" initial_value="2"/>
</component>
<component name="extracellular_potassium_concentration">
<variable units="millimolar" public_interface="out" name="K_o" initial_value="4"/>
</component>
<component name="intracellular_potassium_concentration">
<variable units="millimolar" public_interface="out" name="K_i" initial_value="138.7963753"/>
<variable units="micrometre3" public_interface="in" name="V_i"/>
<variable units="nanoA" public_interface="in" name="i_K1"/>
<variable units="nanoA" public_interface="in" name="i_Kr"/>
<variable units="nanoA" public_interface="in" name="i_Ks"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_K_cyt"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_K_ds"/>
<variable units="nanoA" public_interface="in" name="i_to"/>
<variable units="nanoA" public_interface="in" name="i_NaK"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_K1</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_Ca_L_K_cyt</ci>
<ci>i_Ca_L_K_ds</ci>
<ci>i_to</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_calcium_concentration">
<variable units="millimolar" public_interface="out" name="Ca_i" initial_value="5.44e-5"/>
<variable units="millimolar" public_interface="out" name="Ca_ds" initial_value="0.0018991"/>
<variable units="millimolar" public_interface="out" name="Ca_up" initial_value="0.7625025"/>
<variable units="millimolar" public_interface="out" name="Ca_rel" initial_value="0.7368094"/>
<variable units="millimolar" name="Ca_Calmod" initial_value="0.0018544"/>
<variable units="millimolar" name="Ca_Trop" initial_value="0.0012852"/>
<variable units="millimolar" name="Calmod" initial_value="0.02"/>
<variable units="millimolar" name="Trop" initial_value="0.05"/>
<variable units="per_millimolar_second" name="alpha_Calmod" initial_value="100000"/>
<variable units="per_second" name="beta_Calmod" initial_value="50"/>
<variable units="per_millimolar_second" name="alpha_Trop" initial_value="100000"/>
<variable units="per_second" name="beta_Trop" initial_value="200"/>
<variable units="micrometre" name="radius" initial_value="12"/>
<variable units="micrometre" name="length" initial_value="74"/>
<variable units="micrometre3" public_interface="out" name="V_i"/>
<variable units="micrometre3" name="V_Cell"/>
<variable units="dimensionless" name="V_i_ratio"/>
<variable units="dimensionless" name="V_ds_ratio" initial_value="0.1"/>
<variable units="dimensionless" name="V_rel_ratio" initial_value="0.1"/>
<variable units="dimensionless" name="V_e_ratio" initial_value="0.4"/>
<variable units="dimensionless" name="V_up_ratio" initial_value="0.01"/>
<variable units="per_second" name="Kdecay" initial_value="10"/>
<variable units="millimolar_per_second" public_interface="in" name="i_up"/>
<variable units="millimolar_per_second" public_interface="in" name="i_trans"/>
<variable units="millimolar_per_second" public_interface="in" name="i_rel"/>
<variable units="nanoA" public_interface="in" name="i_NaCa_cyt"/>
<variable units="nanoA" public_interface="in" name="i_NaCa_ds"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Ca_cyt"/>
<variable units="nanoA" public_interface="in" name="i_Ca_L_Ca_ds"/>
<variable units="nanoA" public_interface="in" name="i_b_Ca"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_Cell</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3.141592654</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>radius</ci>
<cn cellml:units="dimensionless">1000</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>length</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>V_i_ratio</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>V_e_ratio</ci>
</apply>
<ci>V_up_ratio</ci>
</apply>
<ci>V_rel_ratio</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<times/>
<ci>V_Cell</ci>
<ci>V_i_ratio</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Ca_L_Ca_cyt</ci>
<ci>i_b_Ca</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa_cyt</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa_ds</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_ds</ci>
<ci>V_ds_ratio</ci>
<ci>Kdecay</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_rel</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>V_i_ratio</ci>
</apply>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calmod</ci>
</apply>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Trop</ci>
</apply>
</apply>
<ci>i_up</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_ds</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<ci>i_Ca_L_Ca_ds</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_ds_ratio</ci>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_ds</ci>
<ci>Kdecay</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_up</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>V_i_ratio</ci>
<ci>V_up_ratio</ci>
</apply>
<ci>i_up</ci>
</apply>
<ci>i_trans</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_rel</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>V_up_ratio</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>i_trans</ci>
</apply>
<ci>i_rel</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calmod</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_Calmod</ci>
<ci>Ca_i</ci>
<apply>
<minus/>
<ci>Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Trop</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_Trop</ci>
<ci>Ca_i</ci>
<apply>
<minus/>
<ci>Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f2_gate"/>
<component_ref component="L_type_Ca_channel_f2ds_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_potassium_current">
<component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_potassium_current">
<component_ref component="slow_delayed_rectifier_potassium_current_xs_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current"/>
<component_ref component="persistent_sodium_current"/>
<component_ref component="sodium_background_current"/>
<component_ref component="calcium_background_current"/>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_s_gate"/>
<component_ref component="transient_outward_current_r_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="sodium_calcium_exchanger"/>
<component_ref component="sarcoplasmic_reticulum_calcium_pump"/>
<component_ref component="calcium_translocation"/>
<component_ref component="calcium_release"/>
<component_ref component="extracellular_sodium_concentration"/>
<component_ref component="intracellular_sodium_concentration"/>
<component_ref component="extracellular_potassium_concentration"/>
<component_ref component="intracellular_potassium_concentration"/>
<component_ref component="extracellular_calcium_concentration"/>
<component_ref component="intracellular_calcium_concentration"/>
<component_ref component="reversal_potentials"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f2_gate"/>
<component_ref component="L_type_Ca_channel_f2ds_gate"/>
</component_ref>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_s_gate"/>
<component_ref component="transient_outward_current_r_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_potassium_current">
<component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_potassium_current">
<component_ref component="slow_delayed_rectifier_potassium_current_xs_gate"/>
</component_ref>
</group>
<connection>
<map_components component_2="environment" component_1="membrane"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="reversal_potentials"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="fast_sodium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="L_type_Ca_channel"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="time_independent_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="persistent_sodium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_background_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="calcium_background_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="transient_outward_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_potassium_pump"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_calcium_exchanger"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="intracellular_sodium_concentration"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="intracellular_potassium_concentration"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="intracellular_calcium_concentration"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sarcoplasmic_reticulum_calcium_pump"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="calcium_translocation"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="calcium_release"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="membrane" component_1="calcium_release"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="reversal_potentials" component_1="membrane"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Na" variable_1="i_Na"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Ca_L_Ca_cyt" variable_1="i_Ca_L_Ca_cyt"/>
<map_variables variable_2="i_Ca_L_Ca_ds" variable_1="i_Ca_L_Ca_ds"/>
<map_variables variable_2="i_Ca_L_Na_cyt" variable_1="i_Ca_L_Na_cyt"/>
<map_variables variable_2="i_Ca_L_Na_ds" variable_1="i_Ca_L_Na_ds"/>
<map_variables variable_2="i_Ca_L_K_cyt" variable_1="i_Ca_L_K_cyt"/>
<map_variables variable_2="i_Ca_L_K_ds" variable_1="i_Ca_L_K_ds"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifier_potassium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Kr" variable_1="i_Kr"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="slow_delayed_rectifier_potassium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Ks" variable_1="i_Ks"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="transient_outward_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_to" variable_1="i_to"/>
</connection>
<connection>
<map_components component_2="time_independent_potassium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_K1" variable_1="i_K1"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="persistent_sodium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_p_Na" variable_1="i_p_Na"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="sodium_background_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_Na" variable_1="i_b_Na"/>
</connection>
<connection>
<map_components component_2="calcium_background_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_Ca" variable_1="i_b_Ca"/>
</connection>
<connection>
<map_components component_2="sodium_potassium_pump" component_1="membrane"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
</connection>
<connection>
<map_components component_2="sodium_calcium_exchanger" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_NaCa_cyt" variable_1="i_NaCa_cyt"/>
<map_variables variable_2="i_NaCa_ds" variable_1="i_NaCa_ds"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="membrane"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="membrane"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="membrane"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="sodium_background_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="persistent_sodium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="time_independent_potassium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifier_potassium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="slow_delayed_rectifier_potassium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Ks" variable_1="E_Ks"/>
</connection>
<connection>
<map_components component_2="transient_outward_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="calcium_background_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Ca" variable_1="E_Ca"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_mh" variable_1="E_mh"/>
</connection>
<connection>
<map_components component_2="extracellular_potassium_concentration" component_1="reversal_potentials"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="extracellular_sodium_concentration" component_1="reversal_potentials"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="reversal_potentials"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="reversal_potentials"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="extracellular_calcium_concentration" component_1="reversal_potentials"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="reversal_potentials"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
</connection>
<connection>
<map_components component_2="extracellular_potassium_concentration" component_1="time_independent_potassium_current"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="time_independent_potassium_current"/>
<map_variables variable_2="i_K1" variable_1="i_K1"/>
</connection>
<connection>
<map_components component_2="extracellular_potassium_concentration" component_1="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_2="i_Kr" variable_1="i_Kr"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_2="i_Ks" variable_1="i_Ks"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="fast_sodium_current"/>
<map_variables variable_2="i_Na" variable_1="i_Na"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="sodium_background_current"/>
<map_variables variable_2="i_b_Na" variable_1="i_b_Na"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="persistent_sodium_current"/>
<map_variables variable_2="i_p_Na" variable_1="i_p_Na"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="L_type_Ca_channel"/>
<map_variables variable_2="i_Ca_L_Na_cyt" variable_1="i_Ca_L_Na_cyt"/>
<map_variables variable_2="i_Ca_L_Na_ds" variable_1="i_Ca_L_Na_ds"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="L_type_Ca_channel"/>
<map_variables variable_2="i_Ca_L_Ca_cyt" variable_1="i_Ca_L_Ca_cyt"/>
<map_variables variable_2="i_Ca_L_Ca_ds" variable_1="i_Ca_L_Ca_ds"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Ca_ds" variable_1="Ca_ds"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="L_type_Ca_channel"/>
<map_variables variable_2="i_Ca_L_K_cyt" variable_1="i_Ca_L_K_cyt"/>
<map_variables variable_2="i_Ca_L_K_ds" variable_1="i_Ca_L_K_ds"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="extracellular_potassium_concentration" component_1="L_type_Ca_channel"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="extracellular_sodium_concentration" component_1="L_type_Ca_channel"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="extracellular_calcium_concentration" component_1="L_type_Ca_channel"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="calcium_background_current"/>
<map_variables variable_2="i_b_Ca" variable_1="i_b_Ca"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="sodium_potassium_pump"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="extracellular_potassium_concentration" component_1="sodium_potassium_pump"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="sodium_potassium_pump"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
</connection>
<connection>
<map_components component_2="intracellular_potassium_concentration" component_1="transient_outward_current"/>
<map_variables variable_2="i_to" variable_1="i_to"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="sodium_calcium_exchanger"/>
<map_variables variable_2="i_NaCa_cyt" variable_1="i_NaCa_cyt"/>
<map_variables variable_2="i_NaCa_ds" variable_1="i_NaCa_ds"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Ca_ds" variable_1="Ca_ds"/>
</connection>
<connection>
<map_components component_2="intracellular_sodium_concentration" component_1="sodium_calcium_exchanger"/>
<map_variables variable_2="i_NaCa_cyt" variable_1="i_NaCa_cyt"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="extracellular_sodium_concentration" component_1="sodium_calcium_exchanger"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="extracellular_calcium_concentration" component_1="sodium_calcium_exchanger"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="sarcoplasmic_reticulum_calcium_pump"/>
<map_variables variable_2="i_up" variable_1="i_up"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Ca_up" variable_1="Ca_up"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="calcium_translocation"/>
<map_variables variable_2="i_trans" variable_1="i_trans"/>
<map_variables variable_2="Ca_rel" variable_1="Ca_rel"/>
<map_variables variable_2="Ca_up" variable_1="Ca_up"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="calcium_release"/>
<map_variables variable_2="i_rel" variable_1="i_rel"/>
<map_variables variable_2="Ca_rel" variable_1="Ca_rel"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Ca_ds" variable_1="Ca_ds"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifier_potassium_current_xr_gate" component_1="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_2="xr" variable_1="xr"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="slow_delayed_rectifier_potassium_current_xs_gate" component_1="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_2="xs" variable_1="xs"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current_m_gate" component_1="fast_sodium_current"/>
<map_variables variable_2="m" variable_1="m"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current_h_gate" component_1="fast_sodium_current"/>
<map_variables variable_2="h" variable_1="h"/>
<map_variables variable_2="proton" variable_1="proton"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel_d_gate" component_1="L_type_Ca_channel"/>
<map_variables variable_2="d" variable_1="d"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel_f_gate" component_1="L_type_Ca_channel"/>
<map_variables variable_2="f" variable_1="f"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel_f2_gate" component_1="L_type_Ca_channel"/>
<map_variables variable_2="f2" variable_1="f2"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Km_f2" variable_1="Km_f2"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel_f2ds_gate" component_1="L_type_Ca_channel"/>
<map_variables variable_2="f2ds" variable_1="f2ds"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="Ca_ds" variable_1="Ca_ds"/>
<map_variables variable_2="Km_f2ds" variable_1="Km_f2ds"/>
<map_variables variable_2="R_decay" variable_1="R_decay"/>
</connection>
<connection>
<map_components component_2="transient_outward_current_s_gate" component_1="transient_outward_current"/>
<map_variables variable_2="s" variable_1="s"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="transient_outward_current_r_gate" component_1="transient_outward_current"/>
<map_variables variable_2="r" variable_1="r"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="intracellular_sodium_concentration"/>
<map_variables variable_2="V_i" variable_1="V_i"/>
</connection>
<connection>
<map_components component_2="intracellular_calcium_concentration" component_1="intracellular_potassium_concentration"/>
<map_variables variable_2="V_i" variable_1="V_i"/>
</connection>
<rdf:RDF>
<rdf:Seq rdf:about="rdf:#citationAuthorsSeq">
<rdf:li rdf:resource="rdf:#$Nm3CR1"/>
<rdf:li rdf:resource="rdf:#$Om3CR1"/>
<rdf:li rdf:resource="rdf:#$Pm3CR1"/>
<rdf:li rdf:resource="rdf:#$Qm3CR1"/>
<rdf:li rdf:resource="rdf:#$Rm3CR1"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#citationAuthorsSeq"/>
<rdf:Seq rdf:about="rdf:#e33e6bc2-e6f9-4d9f-82c4-6423c46c9bd7">
<rdf:li rdf:resource="rdf:#c28a0a0f-8e1f-4a5f-9a99-083cf1c9ce9f"/>
<rdf:li rdf:resource="rdf:#4ba17af7-8dea-4543-a0eb-3de183a2cffc"/>
<rdf:li rdf:resource="rdf:#c044c1b9-1d41-4a84-a905-4361de8304a0"/>
<rdf:li rdf:resource="rdf:#4b225720-c1c6-4f68-93d6-6ad220d07c5b"/>
<rdf:li rdf:resource="rdf:#7f32c747-5a6e-4c28-a6b0-d3fb50ea46e0"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#a2ef47a5-c54d-414a-bdcf-506f9dd4cf19">
<vCard:Given>K</vCard:Given>
<vCard:Family>Linz</vCard:Family>
<vCard:Other>W</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author5Vcard">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#author5VcardN"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7eab7723-4e0f-4915-95f2-12f5966b873d">
<vCard:Orgname>Oxford University</vCard:Orgname>
<vCard:Orgunit>Department of Physiology, Anatomy & Genetics</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author5VcardN">
<vCard:Given>D</vCard:Given>
<vCard:Family>Noble</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b9929b22-4b48-429c-b5c9-26151e0326be">
<dcterms:W3CDTF>2000-11-10</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#af24f975-e7ea-4bb1-a812-d5c700449b87">
<vCard:ORG rdf:resource="rdf:#c72d1512-ac00-4eb7-bd1c-ba872320640c"/>
<vCard:EMAIL rdf:resource="rdf:#3c5534d8-c77c-486c-8771-0ea136844a84"/>
<vCard:N rdf:resource="rdf:#c6cb4f69-54c9-4d3b-8a89-8d136ddd7d8c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author1VcardN">
<vCard:Given>B</vCard:Given>
<vCard:Family>Sakmann</vCard:Family>
<vCard:Other>F</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2f24b7c3-ea27-41e8-b4f5-7e04cc650d81">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>penny.noble@dpag.ox.ac.uk</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$Sm3CR1">
<ns7:boundIntervals rdf:resource="rdf:#$Tm3CR1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$Um3CR1">
<ns7:endingValue>3</ns7:endingValue>
<ns7:nonstandard-pointDensity>100000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.001</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="#sakmann_spindler_bryant_linz_noble_2000_endo-cell">
<ns7:simulation rdf:resource="rdf:#$Sm3CR1"/>
<ns7:simulation rdf:resource="rdf:#$YLVPD2"/>
<bqs:reference rdf:resource="rdf:#19ef52b3-d322-4567-bff4-ce93f23ef3ac"/>
<cmeta:comment rdf:resource="rdf:#019a306a-f19d-4d78-978e-f2b4a70ed573"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#82af34ff-9315-4eb5-8cc2-1919d01c1a35">
<dcterms:W3CDTF>2006-01-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author3VcardN">
<vCard:Given>S</vCard:Given>
<vCard:Family>Bryant</vCard:Family>
<vCard:Other>M</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>Department of Physiology, Anatomy & Genetics, University of Oxford</dc:publisher>
<cmeta:comment rdf:resource="rdf:#8af31fdf-cee2-4938-b3cf-a6fae4d5dbeb"/>
<dcterms:created rdf:resource="rdf:#4c557d68-f965-451c-acff-367576a9b199"/>
<dc:creator rdf:resource="rdf:#dc9ee6be-9866-4b33-9db5-26f54e34acc5"/>
<cmeta:modification rdf:resource="rdf:#dab41a0a-f0cc-405e-bc97-5d842cf28dc6"/>
<cmeta:modification rdf:resource="rdf:#3a537388-d98d-4238-a086-e2e925937002"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3a537388-d98d-4238-a086-e2e925937002">
<dcterms:modified rdf:resource="rdf:#a1adce5b-10ac-4b29-896a-7fa0fc75eb6d"/>
<rdf:value>This model has been curated by Penny Noble of Oxford University</rdf:value>
<cmeta:modifier rdf:resource="rdf:#de86b86b-9403-4b46-a09b-614636cc3fe4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#90b18d53-13c9-4f60-83ab-d5f159c67596">
<vCard:Given>D</vCard:Given>
<vCard:Family>Noble</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5e5bfc3b-8578-4104-84ea-c1d982384d91">
<vCard:Given>Penny</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#de86b86b-9403-4b46-a09b-614636cc3fe4">
<vCard:N rdf:resource="rdf:#3149ba84-3fb6-4aba-900c-a8cd510cbf61"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$Tm3CR1">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$Um3CR1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a66f8f7d-2f57-4df9-8822-7944d82feb24">
<dcterms:W3CDTF>2007-12-04T15:59:02+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4b225720-c1c6-4f68-93d6-6ad220d07c5b">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#a2ef47a5-c54d-414a-bdcf-506f9dd4cf19"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4c557d68-f965-451c-acff-367576a9b199">
<dcterms:W3CDTF>2007-10-03T00:00:00+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author4Vcard">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#author4VcardN"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a940cd07-d5cc-4b26-a40b-d8b18b3fe5ef">
<dc:title>Circulation Research</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a1adce5b-10ac-4b29-896a-7fa0fc75eb6d">
<dcterms:W3CDTF>2006-12-12T15:55:00+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3149ba84-3fb6-4aba-900c-a8cd510cbf61">
<vCard:Given>Penny</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author2Vcard">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#author2VcardN"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author2VcardN">
<vCard:Given>A</vCard:Given>
<vCard:Family>Spindler</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4ba17af7-8dea-4543-a0eb-3de183a2cffc">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#aea9a764-5de7-4212-82b5-fc7da6eb10ec"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$.LVPD2">
<ns7:nonstandard-pointDensity>100000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.001</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c109b70b-15a8-4081-8181-13cf43f53827">
<dc:creator rdf:resource="rdf:#e33e6bc2-e6f9-4d9f-82c4-6423c46c9bd7"/>
<dc:title>Distribution of a persistent sodium current across the ventricular wall in guinea pigs</dc:title>
<bqs:volume>87 10</bqs:volume>
<bqs:first_page>910</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#a940cd07-d5cc-4b26-a40b-d8b18b3fe5ef"/>
<dcterms:issued rdf:resource="rdf:#b9929b22-4b48-429c-b5c9-26151e0326be"/>
<bqs:last_page>914</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$ZLVPD2">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$.LVPD2"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8af31fdf-cee2-4938-b3cf-a6fae4d5dbeb">
<dc:creator rdf:resource="rdf:#903f09b0-5a57-4176-bb52-3c7c57ee1dea"/>
<rdf:value>This model has been curated and unit-checked and is known to run in COR and PCEnv. This variant is parameterised for the cardiac ENDOCARDIAL CELL.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c72d1512-ac00-4eb7-bd1c-ba872320640c">
<vCard:Orgname>unknown</vCard:Orgname>
<vCard:Orgunit>unknown</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c28a0a0f-8e1f-4a5f-9a99-083cf1c9ce9f">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#44b367cf-a5aa-4dda-a199-7dd1d1a92070"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c044c1b9-1d41-4a84-a905-4361de8304a0">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#9cf833fc-94ef-41c8-a46e-555f487b7046"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#dc9ee6be-9866-4b33-9db5-26f54e34acc5">
<vCard:ORG rdf:resource="rdf:#7eab7723-4e0f-4915-95f2-12f5966b873d"/>
<vCard:EMAIL rdf:resource="rdf:#2f24b7c3-ea27-41e8-b4f5-7e04cc650d81"/>
<vCard:N rdf:resource="rdf:#5e5bfc3b-8578-4104-84ea-c1d982384d91"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#dab41a0a-f0cc-405e-bc97-5d842cf28dc6">
<dcterms:modified rdf:resource="rdf:#a66f8f7d-2f57-4df9-8822-7944d82feb24"/>
<rdf:value>Units checked, curated.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#7f44d5e7-4837-463d-875e-ed7738b8a0c1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#44b367cf-a5aa-4dda-a199-7dd1d1a92070">
<vCard:Given>B</vCard:Given>
<vCard:Family>Sakmann</vCard:Family>
<vCard:Other>F</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#aea9a764-5de7-4212-82b5-fc7da6eb10ec">
<vCard:Given>A</vCard:Given>
<vCard:Family>Spindler</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#903f09b0-5a57-4176-bb52-3c7c57ee1dea">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8f533a6e-daf6-4b29-952e-6a0a647141d0">
<vCard:Given>Penny</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author4VcardN">
<vCard:Given>K</vCard:Given>
<vCard:Family>Linz</vCard:Family>
<vCard:Other>W</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9cf833fc-94ef-41c8-a46e-555f487b7046">
<vCard:Given>S</vCard:Given>
<vCard:Family>Bryant</vCard:Family>
<vCard:Other>M</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author1Vcard">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#author1VcardN"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#019a306a-f19d-4d78-978e-f2b4a70ed573">
<dc:creator rdf:resource="rdf:#cc697039-623f-44cf-a566-e6905cd4b8a2"/>
<rdf:value>This model was based on the paper "Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs" by Bernhard F.A.S. Sakmann, Anthony J. Spindler, Simon M. Bryant, Klaus W. Linz and Denis Noble.
Reference: Circulation Research 2000 Nov 10;87(10):910-4. </rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3c5534d8-c77c-486c-8771-0ea136844a84">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>unknown</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7f32c747-5a6e-4c28-a6b0-d3fb50ea46e0">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#90b18d53-13c9-4f60-83ab-d5f159c67596"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cc697039-623f-44cf-a566-e6905cd4b8a2">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author3Vcard">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#author3VcardN"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c6cb4f69-54c9-4d3b-8a89-8d136ddd7d8c">
<vCard:Given>unknown</vCard:Given>
<vCard:Family>unknown</vCard:Family>
<vCard:Other>unknown</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#19ef52b3-d322-4567-bff4-ce93f23ef3ac">
<bqs:Pubmed_id>11073887</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#c109b70b-15a8-4081-8181-13cf43f53827"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$YLVPD2">
<ns7:boundIntervals rdf:resource="rdf:#$ZLVPD2"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7f44d5e7-4837-463d-875e-ed7738b8a0c1">
<vCard:N rdf:resource="rdf:#8f533a6e-daf6-4b29-952e-6a0a647141d0"/>
</rdf:Description>
<rdf:Description rdf:about="">
<dcterms:created rdf:resource="rdf:#82af34ff-9315-4eb5-8cc2-1919d01c1a35"/>
<dc:creator rdf:resource="rdf:#af24f975-e7ea-4bb1-a812-d5c700449b87"/>
</rdf:Description>
</rdf:RDF>
</model>