- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 07:46:51+12:00
- Desc:
- committing version01 of spiro_parkinson_othmer_1997
- Permanent Source URI:
- http://models.cellml.org/workspace/spiro_parkinson_othmer_1997/rawfile/e1791b439c04f43c1ff67eee2601772a1b5cd690/spiro_parkinson_othmer_1997.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : bacterial_chemotaxis_1997.xml
CREATED : 29th October 2001
LAST MODIFIED : 9th April 2003
AUTHOR : Catherine Lloyd
Department of Engineering Science
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on 10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification .
DESCRIPTION : This file contains a CellML description of Spiro, Parkinson and Othmer's 1997 model of excitation and adaptation in bacterial chemotaxis.
CHANGES:
22/01/2002 - AAC - Updated metadata to conform to the 16/1/02 CellML Metadata
1.0 Specification.
19/07/2002 - CML - Added more metadata.
09/04/2003 - AAC - Added publication date information.
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:pathway_editor="http://www.physiome.com/pathway_editor/1.0#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" pathway_editor:rendering_config_file="Bacterial chemotaxis CellMLrender.xml" cmeta:id="spiro_parkinson_othmer_1997_version01" name="spiro_parkinson_othmer_1997_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Model Of Excitation And Adaptation In Bacterial Chemotaxis</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In 1997, Peter A. Spiro, John S. Parkinson and Hans G. Othmer published a mathematical model which examined the mechanisms of excitation and adaptation in bacterial chemotaxis (see the figure below). Chemotaxis is the process by which a cell alters its speed or frequency of turning in response to an extracellular chemical stimulus. It is an example of a signal transduction pathway, with features of extreme sensitivity, signal amplification and adaptation: bacteria only respond to changes in their environment rather than to the absolute state of their environment.
</para>
<para>
In their model, Peter A. Spiro, John S. Parkinson and Hans G. Othmer describe how the phosphorylation cascade and signal amplification account for the extreme bacterial sensitivity to stimuli and how the receptor's multiple methylation states allow adaptation to occur.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.pnas.org/cgi/content/abstract/94/14/7263">A model of excitation and adaptation in bacterial chemotaxis</ulink>, Peter A. Spiro, John S. Parkinson and Hans G. Othmer, 1997, <ulink url="http://www.pnas.org/">
<emphasis>Proc. Natl. Acad. Sci. USA</emphasis>
</ulink>, 94, 7263-7268. (<ulink url="http://www.pnas.org/cgi/content/full/94/14/7263">Full text</ulink> and <ulink url="http://www.pnas.org/cgi/reprint/94/14/7263.pdf">PDF</ulink> versions of the article are available to subscribers on the PNAS website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9207079&dopt=Abstract">PubMed ID: 9207079</ulink>
</para>
<informalfigure float="0" id="fig_pathway_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>the conventional rendering of a bacterial chemotaxis pathway</title>
</objectinfo>
<imagedata fileref="spiro_1997.png"/>
</imageobject>
</mediaobject>
<caption>A rendering of a bacterial chemotaxis pathway.</caption>
</informalfigure>
<para>
In CellML, models are thought of as connected networks of discrete components. These components may correspond to physiologically separated regions or chemically distinct objects, or may be useful modelling abstractions. This model has 61 components representing chemically distinct objects (23 chemical species and 38 reactions) and one component defined for modelling convenience which stores the universal variable time. Because this model has so many components, its CellML rendering would be complex. For an example of a CellML rendering of a reaction pathway see The Bhalla Iyengar EGF Pathway Model, 1999.
</para>
</sect1>
</article>
</documentation>
<!--
Below, we define some additional units for association with variables and
constants within the model. The identifiers are fairly self-explanatory.
-->
<units name="molar">
<unit units="mole"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="micromolar">
<unit units="molar" prefix="micro"/>
</units>
<units name="flux">
<unit units="micromolar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="first_order_rate_constant">
<unit units="second" exponent="-1"/>
</units>
<units name="second_order_rate_constant">
<unit units="molar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<component name="global_variables">
<variable units="second" public_interface="out" name="time"/>
</component>
<component name="Tar">
<variable units="micromolar" public_interface="out" name="Tar" initial_value="8.0"/>
<variable units="flux" public_interface="in" name="delta_Tar_T2_synthesis"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
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<ci>time</ci>
</bvar>
<ci>Tar</ci>
</apply>
<ci>delta_Tar_T2_synthesis</ci>
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</component>
<component name="CheW">
<variable units="micromolar" public_interface="out" name="CheW" initial_value="8.0"/>
<variable units="flux" public_interface="in" name="delta_CheW_T2_synthesis"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CheW</ci>
</apply>
<ci>delta_CheW_T2_synthesis</ci>
</apply>
</math>
</component>
<component name="CheA">
<variable units="micromolar" public_interface="out" name="CheA" initial_value="8.0"/>
<variable units="flux" public_interface="in" name="delta_CheA_T2_synthesis"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
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</bvar>
<ci>CheA</ci>
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<ci>delta_CheA_T2_synthesis</ci>
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<component name="T2">
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<variable units="flux" public_interface="in" name="delta_T2_T2_synthesis"/>
<variable units="flux" public_interface="in" name="delta_T2_T2_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_T2_T2_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_T2_T3_demethylation"/>
<variable units="flux" public_interface="in" name="delta_T2_LT2_synthesis"/>
<variable units="flux" public_interface="in" name="delta_T2_T2_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_T2_T2_methylation"/>
<variable units="second" public_interface="in" name="time"/>
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<apply>
<eq/>
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<diff/>
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</bvar>
<ci>T2</ci>
</apply>
<apply>
<plus/>
<ci>delta_T2_T2_synthesis</ci>
<ci>delta_T2_T2_dephosphorylation_by_CheB</ci>
<ci>delta_T2_T2_dephosphorylation_by_CheY</ci>
<ci>delta_T2_T3_demethylation</ci>
<ci>delta_T2_LT2_synthesis</ci>
<ci>delta_T2_T2_phosphorylation</ci>
<ci>delta_T2_T2_methylation</ci>
</apply>
</apply>
</math>
</component>
<component name="T3">
<variable units="micromolar" public_interface="out" name="T3"/>
<variable units="flux" public_interface="in" name="delta_T3_T3_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_T3_T3_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_T3_T4_demethylation"/>
<variable units="flux" public_interface="in" name="delta_T3_T2_methylation"/>
<variable units="flux" public_interface="in" name="delta_T3_LT3_synthesis"/>
<variable units="flux" public_interface="in" name="delta_T3_T3_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_T3_T3_demethylation"/>
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<variable units="second" public_interface="in" name="time"/>
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<apply>
<eq/>
<apply>
<diff/>
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<ci>T3</ci>
</apply>
<apply>
<plus/>
<ci>delta_T3_T3_dephosphorylation_by_CheB</ci>
<ci>delta_T3_T3_dephosphorylation_by_CheY</ci>
<ci>delta_T3_T4_demethylation</ci>
<ci>delta_T3_T2_methylation</ci>
<ci>delta_T3_LT3_synthesis</ci>
<ci>delta_T3_T3_phosphorylation</ci>
<ci>delta_T3_T3_demethylation</ci>
<ci>delta_T3_T3_methylation</ci>
</apply>
</apply>
</math>
</component>
<component name="CheR">
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<component name="T4">
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<variable units="flux" public_interface="in" name="delta_T4_T4_dephosphorylation_by_CheY"/>
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<variable units="flux" public_interface="in" name="delta_T4_LT4_synthesis"/>
<variable units="flux" public_interface="in" name="delta_T4_T4_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_T4_T4_demethylation"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
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<ci>time</ci>
</bvar>
<ci>T4</ci>
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<apply>
<plus/>
<ci>delta_T4_T4_dephosphorylation_by_CheB</ci>
<ci>delta_T4_T4_dephosphorylation_by_CheY</ci>
<ci>delta_T4_T3_methylation</ci>
<ci>delta_T4_T4_phosphorylation</ci>
<ci>delta_T4_LT4_synthesis</ci>
<ci>delta_T4_T4_demethylation</ci>
</apply>
</apply>
</math>
</component>
<component name="L">
<variable units="micromolar" public_interface="out" name="L" initial_value="1.0"/>
<variable units="flux" public_interface="in" name="delta_L_LT2_synthesis"/>
<variable units="flux" public_interface="in" name="delta_L_LT3_synthesis"/>
<variable units="flux" public_interface="in" name="delta_L_LT4_synthesis"/>
<variable units="flux" public_interface="in" name="delta_L_L_T2P_binding"/>
<variable units="flux" public_interface="in" name="delta_L_L_T3P_binding"/>
<variable units="flux" public_interface="in" name="delta_L_L_T4P_binding"/>
<variable units="second" public_interface="in" name="time"/>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>L</ci>
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<apply>
<plus/>
<ci>delta_L_LT2_synthesis</ci>
<ci>delta_L_LT3_synthesis</ci>
<ci>delta_L_LT4_synthesis</ci>
<ci>delta_L_L_T2P_binding</ci>
<ci>delta_L_L_T3P_binding</ci>
<ci>delta_L_L_T4P_binding</ci>
</apply>
</apply>
</math>
</component>
<component name="LT2">
<variable units="micromolar" public_interface="out" name="LT2"/>
<variable units="flux" public_interface="in" name="delta_LT2_LT2_synthesis"/>
<variable units="flux" public_interface="in" name="delta_LT2_LT2P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_LT2_LT2P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_LT2_LT3_demethylation"/>
<variable units="flux" public_interface="in" name="delta_LT2_LT2_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_LT2_LT2_methylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<apply>
<plus/>
<ci>delta_LT2_LT2_synthesis</ci>
<ci>delta_LT2_LT2P_dephosphorylation_by_CheB</ci>
<ci>delta_LT2_LT2P_dephosphorylation_by_CheY</ci>
<ci>delta_LT2_LT3_demethylation</ci>
<ci>delta_LT2_LT2_phosphorylation</ci>
<ci>delta_LT2_LT2_methylation</ci>
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<component name="LT3">
<variable units="micromolar" public_interface="out" name="LT3"/>
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<variable units="flux" public_interface="in" name="delta_LT3_LT3P_dephosphorylation_by_CheB"/>
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<variable units="flux" public_interface="in" name="delta_LT3_LT3_demethylation"/>
<variable units="flux" public_interface="in" name="delta_LT3_LT2_methylation"/>
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<variable units="flux" public_interface="in" name="delta_LT3_LT4_demethylation"/>
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<variable units="second" public_interface="in" name="time"/>
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<plus/>
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<ci>delta_LT3_LT3P_dephosphorylation_by_CheB</ci>
<ci>delta_LT3_LT3P_dephosphorylation_by_CheY</ci>
<ci>delta_LT3_LT4_demethylation</ci>
<ci>delta_LT3_LT2_methylation</ci>
<ci>delta_LT3_LT3_phosphorylation</ci>
<ci>delta_LT3_LT3_demethylation</ci>
<ci>delta_LT3_LT3_methylation</ci>
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</apply>
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<component name="LT4">
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<ci>delta_LT4_LT4P_dephosphorylation_by_CheB</ci>
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<ci>delta_CheB_P_T4_dephosphorylation_by_CheB</ci>
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<ci>delta_CheB_P_T4_demethylation</ci>
<ci>delta_CheB_P_LT3_demethylation</ci>
<ci>delta_CheB_P_LT4_demethylation</ci>
<ci>delta_CheB_P_CheB_P_dephosphorylation</ci>
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</apply>
</math>
</component>
<component name="CheY_P">
<variable units="micromolar" public_interface="out" name="CheY_P"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_T2_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_T3_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_T4_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_LT2P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_LT3P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_LT4P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_CheY_P_CheY_P_dephosphorylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CheY_P</ci>
</apply>
<apply>
<plus/>
<ci>delta_CheY_P_T2_dephosphorylation_by_CheY</ci>
<ci>delta_CheY_P_T3_dephosphorylation_by_CheY</ci>
<ci>delta_CheY_P_T4_dephosphorylation_by_CheY</ci>
<ci>delta_CheY_P_LT2P_dephosphorylation_by_CheY</ci>
<ci>delta_CheY_P_LT3P_dephosphorylation_by_CheY</ci>
<ci>delta_CheY_P_LT4P_dephosphorylation_by_CheY</ci>
<ci>delta_CheY_P_CheY_P_dephosphorylation</ci>
</apply>
</apply>
</math>
</component>
<component name="CheZ">
<variable units="micromolar" public_interface="out" name="CheZ" initial_value="40.0"/>
<variable units="flux" public_interface="in" name="delta_CheZ_CheY_P_dephosphorylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CheZ</ci>
</apply>
<ci>delta_CheZ_CheY_P_dephosphorylation</ci>
</apply>
</math>
</component>
<component name="T2P">
<variable units="micromolar" public_interface="out" name="T2P"/>
<variable units="flux" public_interface="in" name="delta_T2P_T2_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_T2P_T2_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_T2P_T2_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_T2P_L_T2P_binding"/>
<variable units="flux" public_interface="in" name="delta_T2P_T2P_methylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>T2P</ci>
</apply>
<apply>
<plus/>
<ci>delta_T2P_T2_phosphorylation</ci>
<ci>delta_T2P_T2_dephosphorylation_by_CheB</ci>
<ci>delta_T2P_T2_dephosphorylation_by_CheY</ci>
<ci>delta_T2P_L_T2P_binding</ci>
<ci>delta_T2P_T2P_methylation</ci>
</apply>
</apply>
</math>
</component>
<component name="T3P">
<variable units="micromolar" public_interface="out" name="T3P"/>
<variable units="flux" public_interface="in" name="delta_T3P_T3_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_T3P_T2P_methylation"/>
<variable units="flux" public_interface="in" name="delta_T3P_T3_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_T3P_T3_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_T3P_L_T3P_binding"/>
<variable units="flux" public_interface="in" name="delta_T3P_T3P_methylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>T3P</ci>
</apply>
<apply>
<plus/>
<ci>delta_T3P_T3_phosphorylation</ci>
<ci>delta_T3P_T2P_methylation</ci>
<ci>delta_T3P_T3_dephosphorylation_by_CheB</ci>
<ci>delta_T3P_T3_dephosphorylation_by_CheY</ci>
<ci>delta_T3P_L_T3P_binding</ci>
<ci>delta_T3P_T3P_methylation</ci>
</apply>
</apply>
</math>
</component>
<component name="T4P">
<variable units="micromolar" public_interface="out" name="T4P"/>
<variable units="flux" public_interface="in" name="delta_T4P_T4_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_T4P_T3P_methylation"/>
<variable units="flux" public_interface="in" name="delta_T4P_T4_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_T4P_T4_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_T4P_L_T4P_binding"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>T4P</ci>
</apply>
<apply>
<plus/>
<ci>delta_T4P_T4_phosphorylation</ci>
<ci>delta_T4P_T3P_methylation</ci>
<ci>delta_T4P_T4_dephosphorylation_by_CheB</ci>
<ci>delta_T4P_T4_dephosphorylation_by_CheY</ci>
<ci>delta_T4P_L_T4P_binding</ci>
</apply>
</apply>
</math>
</component>
<component name="LT2P">
<variable units="micromolar" public_interface="out" name="LT2P"/>
<variable units="flux" public_interface="in" name="delta_LT2P_L_T2P_binding"/>
<variable units="flux" public_interface="in" name="delta_LT2P_LT2_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_LT2P_LT2P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_LT2P_LT2P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_LT2P_LT2P_methylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LT2P</ci>
</apply>
<apply>
<plus/>
<ci>delta_LT2P_L_T2P_binding</ci>
<ci>delta_LT2P_LT2_phosphorylation</ci>
<ci>delta_LT2P_LT2P_dephosphorylation_by_CheB</ci>
<ci>delta_LT2P_LT2P_dephosphorylation_by_CheY</ci>
<ci>delta_LT2P_LT2P_methylation</ci>
</apply>
</apply>
</math>
</component>
<component name="LT3P">
<variable units="micromolar" public_interface="out" name="LT3P"/>
<variable units="flux" public_interface="in" name="delta_LT3P_L_T3P_binding"/>
<variable units="flux" public_interface="in" name="delta_LT3P_LT3_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_LT3P_LT2P_methylation"/>
<variable units="flux" public_interface="in" name="delta_LT3P_LT3P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_LT3P_LT3P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="in" name="delta_LT3P_LT3P_methylation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LT3P</ci>
</apply>
<apply>
<plus/>
<ci>delta_LT3P_L_T3P_binding</ci>
<ci>delta_LT3P_LT3_phosphorylation</ci>
<ci>delta_LT3P_LT2P_methylation</ci>
<ci>delta_LT3P_LT3P_dephosphorylation_by_CheY</ci>
<ci>delta_LT3P_LT3P_dephosphorylation_by_CheB</ci>
<ci>delta_LT3P_LT3P_methylation</ci>
</apply>
</apply>
</math>
</component>
<component name="LT4P">
<variable units="micromolar" public_interface="out" name="LT4P"/>
<variable units="flux" public_interface="in" name="delta_LT4P_L_T4P_binding"/>
<variable units="flux" public_interface="in" name="delta_LT4P_LT4_phosphorylation"/>
<variable units="flux" public_interface="in" name="delta_LT4P_LT3P_methylation"/>
<variable units="flux" public_interface="in" name="delta_LT4P_LT4P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="in" name="delta_LT4P_LT4P_dephosphorylation_by_CheY"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LT4P</ci>
</apply>
<apply>
<plus/>
<ci>delta_LT4P_L_T4P_binding</ci>
<ci>delta_LT4P_LT4_phosphorylation</ci>
<ci>delta_LT4P_LT3P_methylation</ci>
<ci>delta_LT4P_LT4P_dephosphorylation_by_CheB</ci>
<ci>delta_LT4P_LT4P_dephosphorylation_by_CheY</ci>
</apply>
</apply>
</math>
</component>
<component name="T2_synthesis">
<variable units="micromolar" public_interface="in" name="CheA"/>
<variable units="micromolar" public_interface="in" name="CheW"/>
<variable units="micromolar" public_interface="in" name="Tar"/>
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="flux" public_interface="out" name="delta_CheA_T2_synthesis"/>
<variable units="flux" public_interface="out" name="delta_CheW_T2_synthesis"/>
<variable units="flux" public_interface="out" name="delta_Tar_T2_synthesis"/>
<variable units="flux" public_interface="out" name="delta_T2_T2_synthesis"/>
<variable units="second_order_rate_constant" name="k0" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheA">
<role stoichiometry="1" delta_variable="delta_CheA_T2_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="CheW">
<role stoichiometry="1" delta_variable="delta_CheW_T2_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="Tar">
<role stoichiometry="1" delta_variable="delta_Tar_T2_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="T2">
<role stoichiometry="1" delta_variable="delta_T2_T2_synthesis" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k0</ci>
<ci>CheA</ci>
<ci>CheW</ci>
<ci>Tar</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT2_synthesis">
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="micromolar" public_interface="in" name="L"/>
<variable units="micromolar" public_interface="in" name="LT2"/>
<variable units="flux" public_interface="out" name="delta_T2_LT2_synthesis"/>
<variable units="flux" public_interface="out" name="delta_L_LT2_synthesis"/>
<variable units="flux" public_interface="out" name="delta_LT2_LT2_synthesis"/>
<variable units="second_order_rate_constant" name="k1" initial_value="1.0"/>
<variable units="first_order_rate_constant" name="k1_" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="yes">
<variable_ref variable="T2">
<role stoichiometry="1" direction="forward" delta_variable="delta_T2_LT2_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="L">
<role stoichiometry="1" direction="forward" delta_variable="delta_L_LT2_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="LT2">
<role stoichiometry="1" direction="forward" delta_variable="delta_LT2_LT2_synthesis" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>T2</ci>
<ci>L</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k1_</ci>
<ci>LT2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T2_phosphorylation">
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="micromolar" public_interface="in" name="T2P"/>
<variable units="flux" public_interface="out" name="delta_T2_T2_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_Pi_T2_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_T2P_T2_phosphorylation"/>
<variable units="first_order_rate_constant" name="k2" initial_value="15.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T2">
<role stoichiometry="1" delta_variable="delta_T2_T2_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_T2_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T2P">
<role stoichiometry="1" delta_variable="delta_T2P_T2_phosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k2</ci>
<ci>T2</ci>
<ci>Pi</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T2_dephosphorylation_by_CheB">
<variable units="micromolar" public_interface="in" name="T2P"/>
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="flux" public_interface="out" name="delta_T2P_T2_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_T2_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_T2_T2_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_T2_dephosphorylation_by_CheB"/>
<variable units="second_order_rate_constant" name="k3" initial_value="800000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T2P">
<role stoichiometry="1" delta_variable="delta_T2P_T2_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_T2_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="T2">
<role stoichiometry="1" delta_variable="delta_T2_T2_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_T2_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k3</ci>
<ci>T2P</ci>
<ci>CheB</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T2_dephosphorylation_by_CheY">
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="micromolar" public_interface="in" name="T2P"/>
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="flux" public_interface="out" name="delta_CheY_T2_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_T2P_T2_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_T2_T2_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_T2_dephosphorylation_by_CheY"/>
<variable units="second_order_rate_constant" name="k4" initial_value="3.0E7"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_T2_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="T2P">
<role stoichiometry="1" delta_variable="delta_T2P_T2_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="T2">
<role stoichiometry="1" delta_variable="delta_T2_T2_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_T2_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k4</ci>
<ci>CheY</ci>
<ci>T2P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="CheB_P_dephosphorylation">
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_CheB_P_dephosphorylation"/>
<variable units="flux" public_interface="out" name="delta_CheB_CheB_P_dephosphorylation"/>
<variable units="flux" public_interface="out" name="delta_Pi_CheB_P_dephosphorylation"/>
<variable units="first_order_rate_constant" name="k5" initial_value="0.35"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_CheB_P_dephosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_CheB_P_dephosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_CheB_P_dephosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k5</ci>
<ci>CheB_P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="CheY_P_dephosphorylation">
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="micromolar" public_interface="in" name="CheZ"/>
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_CheY_P_dephosphorylation"/>
<variable units="flux" public_interface="out" name="delta_CheZ_CheY_P_dephosphorylation"/>
<variable units="flux" public_interface="out" name="delta_CheY_CheY_P_dephosphorylation"/>
<variable units="second_order_rate_constant" name="k6" initial_value="500000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_CheY_P_dephosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="CheZ">
<role stoichiometry="1" delta_variable="delta_CheZ_CheY_P_dephosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_CheY_P_dephosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k6</ci>
<ci>CheY_P</ci>
<ci>CheZ</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3_synthesis">
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="micromolar" public_interface="in" name="L"/>
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="flux" public_interface="out" name="delta_T3_LT3_synthesis"/>
<variable units="flux" public_interface="out" name="delta_L_LT3_synthesis"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT3_synthesis"/>
<variable units="second_order_rate_constant" name="k7" initial_value="70000000.0"/>
<variable units="first_order_rate_constant" name="k7_" initial_value="70.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="yes">
<variable_ref variable="T3">
<role stoichiometry="1" direction="forward" delta_variable="delta_T3_LT3_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="L">
<role stoichiometry="1" direction="forward" delta_variable="delta_L_LT3_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3">
<role stoichiometry="1" direction="forward" delta_variable="delta_LT3_LT3_synthesis" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k7</ci>
<ci>T3</ci>
<ci>L</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k7_</ci>
<ci>LT3</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT4_synthesis">
<variable units="micromolar" public_interface="in" name="L"/>
<variable units="micromolar" public_interface="in" name="T4"/>
<variable units="micromolar" public_interface="in" name="LT4"/>
<variable units="flux" public_interface="out" name="delta_L_LT4_synthesis"/>
<variable units="flux" public_interface="out" name="delta_T4_LT4_synthesis"/>
<variable units="flux" public_interface="out" name="delta_LT4_LT4_synthesis"/>
<variable units="second_order_rate_constant" name="k8" initial_value="70000000.0"/>
<variable units="first_order_rate_constant" name="k8_" initial_value="70.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="yes">
<variable_ref variable="L">
<role stoichiometry="1" direction="forward" delta_variable="delta_L_LT4_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="T4">
<role stoichiometry="1" direction="forward" delta_variable="delta_T4_LT4_synthesis" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4">
<role stoichiometry="1" direction="forward" delta_variable="delta_LT4_LT4_synthesis" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k8</ci>
<ci>L</ci>
<ci>T4</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k8_</ci>
<ci>LT4</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T3_phosphorylation">
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="micromolar" public_interface="in" name="T3P"/>
<variable units="flux" public_interface="out" name="delta_T3_T3_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_Pi_T3_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_T3P_T3_phosphorylation"/>
<variable units="first_order_rate_constant" name="k9" initial_value="45.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T3_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_T3_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T3P">
<role stoichiometry="1" delta_variable="delta_T3P_T3_phosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k9</ci>
<ci>T3</ci>
<ci>Pi</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T3_dephosphorylation_by_CheB">
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="T3P"/>
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="flux" public_interface="out" name="delta_CheB_T3_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_T3P_T3_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_T3_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_T3_T3_dephosphorylation_by_CheB"/>
<variable units="second_order_rate_constant" name="k10" initial_value="800000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_T3_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="T3P">
<role stoichiometry="1" delta_variable="delta_T3P_T3_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_T3_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T3_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k10</ci>
<ci>CheB</ci>
<ci>T3P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T3_dephosphorylation_by_CheY">
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="micromolar" public_interface="in" name="T3P"/>
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="flux" public_interface="out" name="delta_CheY_T3_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_T3P_T3_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_T3_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_T3_T3_dephosphorylation_by_CheY"/>
<variable units="second_order_rate_constant" name="k11" initial_value="30000000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_T3_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="T3P">
<role stoichiometry="1" delta_variable="delta_T3P_T3_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_T3_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T3_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k11</ci>
<ci>CheY</ci>
<ci>T3P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T4_phosphorylation">
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="micromolar" public_interface="in" name="T4"/>
<variable units="micromolar" public_interface="in" name="T4P"/>
<variable units="flux" public_interface="out" name="delta_Pi_T4_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_T4_T4_phosphorylation"/> <variable units="flux" public_interface="out" name="delta_T4P_T4_phosphorylation"/>
<variable units="first_order_rate_constant" name="k12" initial_value="48.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_T4_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T4">
<role stoichiometry="1" delta_variable="delta_T4_T4_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T4P">
<role stoichiometry="1" delta_variable="delta_T4P_T4_phosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k12</ci>
<ci>Pi</ci>
<ci>T4</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T4_dephosphorylation_by_CheB">
<variable units="micromolar" public_interface="in" name="T4P"/>
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="T4"/>
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="flux" public_interface="out" name="delta_T4P_T4_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_T4_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_T4_T4_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_T4_dephosphorylation_by_CheB"/>
<variable units="second_order_rate_constant" name="k13" initial_value="800000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T4P">
<role stoichiometry="1" delta_variable="delta_T4P_T4_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_T4_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="T4">
<role stoichiometry="1" delta_variable="delta_T4_T4_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_T4_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k13</ci>
<ci>T4P</ci>
<ci>CheB</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T4_dephosphorylation_by_CheY">
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="micromolar" public_interface="in" name="T4P"/>
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="micromolar" public_interface="in" name="T4"/>
<variable units="flux" public_interface="out" name="delta_CheY_T4_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_T4P_T4_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_T4_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_T4_T4_dephosphorylation_by_CheY"/>
<variable units="second_order_rate_constant" name="k14" initial_value="30000000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_T4_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="T4P">
<role stoichiometry="1" delta_variable="delta_T4P_T4_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_T4_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="T4">
<role stoichiometry="1" delta_variable="delta_T4_T4_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k14</ci>
<ci>CheY</ci>
<ci>T4P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="L_T2P_binding">
<variable units="micromolar" public_interface="in" name="L"/>
<variable units="micromolar" public_interface="in" name="T2P"/>
<variable units="micromolar" public_interface="in" name="LT2P"/>
<variable units="flux" public_interface="out" name="delta_L_L_T2P_binding"/>
<variable units="flux" public_interface="out" name="delta_T2P_L_T2P_binding"/>
<variable units="flux" public_interface="out" name="delta_LT2P_L_T2P_binding"/>
<variable units="second_order_rate_constant" name="k15" initial_value="70000000.0"/>
<variable units="first_order_rate_constant" name="k15_" initial_value="70.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="yes">
<variable_ref variable="L">
<role stoichiometry="1" direction="forward" delta_variable="delta_L_L_T2P_binding" role="reactant"/>
</variable_ref>
<variable_ref variable="T2P">
<role stoichiometry="1" direction="forward" delta_variable="delta_T2P_L_T2P_binding" role="reactant"/>
</variable_ref>
<variable_ref variable="LT2P">
<role stoichiometry="1" direction="forward" delta_variable="delta_LT2P_L_T2P_binding" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k15</ci>
<ci>L</ci>
<ci>T2P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k15_</ci>
<ci>LT2P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="L_T3P_binding">
<variable units="micromolar" public_interface="in" name="L"/>
<variable units="micromolar" public_interface="in" name="T3P"/>
<variable units="micromolar" public_interface="in" name="LT3P"/>
<variable units="flux" public_interface="out" name="delta_L_L_T3P_binding"/>
<variable units="flux" public_interface="out" name="delta_T3P_L_T3P_binding"/>
<variable units="flux" public_interface="out" name="delta_LT3P_L_T3P_binding"/>
<variable units="second_order_rate_constant" name="k16" initial_value="70000000.0"/>
<variable units="first_order_rate_constant" name="k16_" initial_value="70.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="yes">
<variable_ref variable="L">
<role stoichiometry="1" direction="forward" delta_variable="delta_L_L_T3P_binding" role="reactant"/>
</variable_ref>
<variable_ref variable="T3P">
<role stoichiometry="1" direction="forward" delta_variable="delta_T3P_L_T3P_binding" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3P">
<role stoichiometry="1" direction="forward" delta_variable="delta_LT3P_L_T3P_binding" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k16</ci>
<ci>L</ci>
<ci>T3P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k16_</ci>
<ci>LT3P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="L_T4P_binding">
<variable units="micromolar" public_interface="in" name="T4P"/>
<variable units="micromolar" public_interface="in" name="L"/>
<variable units="micromolar" public_interface="in" name="LT4P"/>
<variable units="flux" public_interface="out" name="delta_T4P_L_T4P_binding"/>
<variable units="flux" public_interface="out" name="delta_L_L_T4P_binding"/>
<variable units="flux" public_interface="out" name="delta_LT4P_L_T4P_binding"/>
<variable units="second_order_rate_constant" name="k17" initial_value="70000000.0"/>
<variable units="first_order_rate_constant" name="k17_" initial_value="70.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="yes">
<variable_ref variable="T4P">
<role stoichiometry="1" direction="forward" delta_variable="delta_T4P_L_T4P_binding" role="reactant"/>
</variable_ref>
<variable_ref variable="L">
<role stoichiometry="1" direction="forward" delta_variable="delta_L_L_T4P_binding" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4P">
<role stoichiometry="1" direction="forward" delta_variable="delta_LT4P_L_T4P_binding" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k17</ci>
<ci>T4P</ci>
<ci>L</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k17_</ci>
<ci>LT4P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT2_phosphorylation">
<variable units="micromolar" public_interface="in" name="LT2"/>
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="micromolar" public_interface="in" name="LT2P"/>
<variable units="flux" public_interface="out" name="delta_LT2_LT2_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_Pi_LT2_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_LT2P_LT2_phosphorylation"/>
<variable units="first_order_rate_constant" name="k18" initial_value="0.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT2">
<role stoichiometry="1" delta_variable="delta_LT2_LT2_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_LT2_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT2P">
<role stoichiometry="1" delta_variable="delta_LT2P_LT2_phosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k18</ci>
<ci>LT2</ci>
<ci>Pi</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT2P_dephosphorylation_by_CheB">
<variable units="micromolar" public_interface="in" name="LT2P"/>
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="LT2"/>
<variable units="flux" public_interface="out" name="delta_LT2P_LT2P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_LT2P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_LT2P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_LT2_LT2P_dephosphorylation_by_CheB"/>
<variable units="second_order_rate_constant" name="k19" initial_value="800000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT2P">
<role stoichiometry="1" delta_variable="delta_LT2P_LT2P_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_LT2P_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_LT2P_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="LT2">
<role stoichiometry="1" delta_variable="delta_LT2_LT2P_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k19</ci>
<ci>LT2P</ci>
<ci>CheB</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT2P_dephosphorylation_by_CheY">
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="micromolar" public_interface="in" name="LT2P"/>
<variable units="micromolar" public_interface="in" name="LT2"/>
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="flux" public_interface="out" name="delta_CheY_LT2P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_LT2P_LT2P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_LT2_LT2P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_LT2P_dephosphorylation_by_CheY"/>
<variable units="second_order_rate_constant" name="k20" initial_value="30000000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_LT2P_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="LT2P">
<role stoichiometry="1" delta_variable="delta_LT2P_LT2P_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="LT2">
<role stoichiometry="1" delta_variable="delta_LT2_LT2P_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_LT2P_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k20</ci>
<ci>CheY</ci>
<ci>LT2P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3_phosphorylation">
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="micromolar" public_interface="in" name="LT3P"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT3_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_Pi_LT3_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_LT3P_LT3_phosphorylation"/>
<variable units="first_order_rate_constant" name="k21" initial_value="16.5"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT3_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_LT3_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3P">
<role stoichiometry="1" delta_variable="delta_LT3P_LT3_phosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k21</ci>
<ci>LT3</ci>
<ci>Pi</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3P_dephosphorylation_by_CheB">
<variable units="micromolar" public_interface="in" name="LT3P"/>
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="flux" public_interface="out" name="delta_LT3P_LT3P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_LT3P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_LT3P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT3P_dephosphorylation_by_CheB"/>
<variable units="second_order_rate_constant" name="k22" initial_value="800000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT3P">
<role stoichiometry="1" delta_variable="delta_LT3P_LT3P_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_LT3P_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_LT3P_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT3P_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k22</ci>
<ci>LT3P</ci>
<ci>CheB</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3P_dephosphorylation_by_CheY">
<variable units="micromolar" public_interface="in" name="LT3P"/>
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="flux" public_interface="out" name="delta_LT3P_LT3P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_LT3P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT3P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_LT3P_dephosphorylation_by_CheY"/>
<variable units="second_order_rate_constant" name="k23" initial_value="30000000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT3P">
<role stoichiometry="1" delta_variable="delta_LT3P_LT3P_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_LT3P_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT3P_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_LT3P_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k23</ci>
<ci>LT3P</ci>
<ci>CheY</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT4_phosphorylation">
<variable units="micromolar" public_interface="in" name="LT4"/>
<variable units="micromolar" public_interface="in" name="Pi"/>
<variable units="micromolar" public_interface="in" name="LT4P"/>
<variable units="flux" public_interface="out" name="delta_LT4_LT4_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_Pi_LT4_phosphorylation"/>
<variable units="flux" public_interface="out" name="delta_LT4P_LT4_phosphorylation"/>
<variable units="first_order_rate_constant" name="k24" initial_value="34.56"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT4">
<role stoichiometry="1" delta_variable="delta_LT4_LT4_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="Pi">
<role stoichiometry="1" delta_variable="delta_Pi_LT4_phosphorylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4P">
<role stoichiometry="1" delta_variable="delta_LT4P_LT4_phosphorylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k24</ci>
<ci>LT4</ci>
<ci>Pi</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT4P_dephosphorylation_by_CheB">
<variable units="micromolar" public_interface="in" name="CheB"/>
<variable units="micromolar" public_interface="in" name="LT4P"/>
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="LT4"/>
<variable units="flux" public_interface="out" name="delta_CheB_LT4P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_LT4P_LT4P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_LT4P_dephosphorylation_by_CheB"/>
<variable units="flux" public_interface="out" name="delta_LT4_LT4P_dephosphorylation_by_CheB"/>
<variable units="second_order_rate_constant" name="k25" initial_value="800000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB">
<role stoichiometry="1" delta_variable="delta_CheB_LT4P_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4P">
<role stoichiometry="1" delta_variable="delta_LT4P_LT4P_dephosphorylation_by_CheB" role="reactant"/>
</variable_ref>
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_LT4P_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="LT4">
<role stoichiometry="1" delta_variable="delta_LT4_LT4P_dephosphorylation_by_CheB" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k25</ci>
<ci>CheB</ci>
<ci>LT4P</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT4P_dephosphorylation_by_CheY">
<variable units="micromolar" public_interface="in" name="LT4P"/>
<variable units="micromolar" public_interface="in" name="CheY"/>
<variable units="micromolar" public_interface="in" name="CheY_P"/>
<variable units="micromolar" public_interface="in" name="LT4"/>
<variable units="flux" public_interface="out" name="delta_LT4P_LT4P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_LT4P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_CheY_P_LT4P_dephosphorylation_by_CheY"/>
<variable units="flux" public_interface="out" name="delta_LT4_LT4P_dephosphorylation_by_CheY"/>
<variable units="second_order_rate_constant" name="k26" initial_value="30000000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT4P">
<role stoichiometry="1" delta_variable="delta_LT4P_LT4P_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="CheY">
<role stoichiometry="1" delta_variable="delta_CheY_LT4P_dephosphorylation_by_CheY" role="reactant"/>
</variable_ref>
<variable_ref variable="CheY_P">
<role stoichiometry="1" delta_variable="delta_CheY_P_LT4P_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="LT4">
<role stoichiometry="1" delta_variable="delta_LT4_LT4P_dephosphorylation_by_CheY" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k26</ci>
<ci>LT4P</ci>
<ci>CheY</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T3_demethylation">
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_T3_demethylation"/>
<variable units="flux" public_interface="out" name="delta_T3_T3_demethylation"/>
<variable units="flux" public_interface="out" name="delta_T2_T3_demethylation"/>
<variable units="second_order_rate_constant" name="k27" initial_value="400000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_T3_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T3_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T2">
<role stoichiometry="1" delta_variable="delta_T2_T3_demethylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k27</ci>
<ci>CheB_P</ci>
<ci>T3</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T4_demethylation">
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="T4"/>
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_T4_demethylation"/>
<variable units="flux" public_interface="out" name="delta_T4_T4_demethylation"/>
<variable units="flux" public_interface="out" name="delta_T3_T4_demethylation"/>
<variable units="second_order_rate_constant" name="k28" initial_value="30000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_T4_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T4">
<role stoichiometry="1" delta_variable="delta_T4_T4_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T4_demethylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k28</ci>
<ci>CheB_P</ci>
<ci>T4</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3_demethylation">
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="micromolar" public_interface="in" name="LT2"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_LT3_demethylation"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT3_demethylation"/>
<variable units="flux" public_interface="out" name="delta_LT2_LT3_demethylation"/>
<variable units="second_order_rate_constant" name="k29" initial_value="400000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_LT3_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT3_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT2">
<role stoichiometry="1" delta_variable="delta_LT2_LT3_demethylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k29</ci>
<ci>CheB_P</ci>
<ci>LT3</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT4_demethylation">
<variable units="micromolar" public_interface="in" name="CheB_P"/>
<variable units="micromolar" public_interface="in" name="LT4"/>
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="flux" public_interface="out" name="delta_CheB_P_LT4_demethylation"/>
<variable units="flux" public_interface="out" name="delta_LT4_LT4_demethylation"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT4_demethylation"/>
<variable units="second_order_rate_constant" name="k30" initial_value="30000.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="CheB_P">
<role stoichiometry="1" delta_variable="delta_CheB_P_LT4_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4">
<role stoichiometry="1" delta_variable="delta_LT4_LT4_demethylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT4_demethylation" role="product"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k30</ci>
<ci>CheB_P</ci>
<ci>LT4</ci>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T2_methylation">
<variable units="micromolar" public_interface="in" name="T2"/>
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_T2_T2_methylation"/>
<variable units="flux" public_interface="out" name="delta_T3_T2_methylation"/>
<variable units="micromolar" name="km31" initial_value="0.6"/>
<variable units="first_order_rate_constant" name="vmax31" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T2">
<role stoichiometry="1" delta_variable="delta_T2_T2_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T2_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T2</ci>
<ci>vmax31</ci>
</apply>
<apply>
<plus/>
<ci>km31</ci>
<ci>T2</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T3_methylation">
<variable units="micromolar" public_interface="in" name="T3"/>
<variable units="micromolar" public_interface="in" name="T4"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_T3_T3_methylation"/>
<variable units="flux" public_interface="out" name="delta_T4_T3_methylation"/>
<variable units="micromolar" name="km32" initial_value="0.6"/>
<variable units="first_order_rate_constant" name="vmax32" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T3">
<role stoichiometry="1" delta_variable="delta_T3_T3_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T4">
<role stoichiometry="1" delta_variable="delta_T4_T3_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T3</ci>
<ci>vmax32</ci>
</apply>
<apply>
<plus/>
<ci>km32</ci>
<ci>T3</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT2_methylation">
<variable units="micromolar" public_interface="in" name="LT2"/>
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_LT2_LT2_methylation"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT2_methylation"/>
<variable units="micromolar" name="km33" initial_value="0.89"/>
<variable units="first_order_rate_constant" name="vmax33" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT2">
<role stoichiometry="1" delta_variable="delta_LT2_LT2_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT2_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>LT2</ci>
<ci>vmax33</ci>
</apply>
<apply>
<plus/>
<ci>km33</ci>
<ci>LT2</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3_methylation">
<variable units="micromolar" public_interface="in" name="LT3"/>
<variable units="micromolar" public_interface="in" name="LT4"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_LT3_LT3_methylation"/>
<variable units="flux" public_interface="out" name="delta_LT4_LT3_methylation"/>
<variable units="first_order_rate_constant" name="vmax34" initial_value="1.0"/>
<variable units="micromolar" name="km34" initial_value="0.62"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT3">
<role stoichiometry="1" delta_variable="delta_LT3_LT3_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4">
<role stoichiometry="1" delta_variable="delta_LT4_LT3_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>LT3</ci>
<ci>vmax34</ci>
</apply>
<apply>
<plus/>
<ci>km34</ci>
<ci>LT3</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T2P_methylation">
<variable units="micromolar" public_interface="in" name="T2P"/>
<variable units="micromolar" public_interface="in" name="T3P"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_T2P_T2P_methylation"/>
<variable units="flux" public_interface="out" name="delta_T3P_T2P_methylation"/>
<variable units="micromolar" name="km35" initial_value="0.6"/>
<variable units="first_order_rate_constant" name="vmax35" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T2P">
<role stoichiometry="1" delta_variable="delta_T2P_T2P_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T3P">
<role stoichiometry="1" delta_variable="delta_T3P_T2P_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T2P</ci>
<ci>vmax35</ci>
</apply>
<apply>
<plus/>
<ci>km35</ci>
<ci>T2P</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="T3P_methylation">
<variable units="micromolar" public_interface="in" name="T3P"/>
<variable units="micromolar" public_interface="in" name="T4P"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_T3P_T3P_methylation"/>
<variable units="flux" public_interface="out" name="delta_T4P_T3P_methylation"/>
<variable units="micromolar" name="km36" initial_value="0.6"/>
<variable units="first_order_rate_constant" name="vmax36" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="T3P">
<role stoichiometry="1" delta_variable="delta_T3P_T3P_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="T4P">
<role stoichiometry="1" delta_variable="delta_T4P_T3P_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T3P</ci>
<ci>vmax36</ci>
</apply>
<apply>
<plus/>
<ci>km36</ci>
<ci>T3P</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT2P_methylation">
<variable units="micromolar" public_interface="in" name="LT2P"/>
<variable units="micromolar" public_interface="in" name="LT3P"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_LT2P_LT2P_methylation"/>
<variable units="flux" public_interface="out" name="delta_LT3P_LT2P_methylation"/>
<variable units="micromolar" name="km37" initial_value="0.89"/>
<variable units="first_order_rate_constant" name="vmax37" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT2P">
<role stoichiometry="1" delta_variable="delta_LT2P_LT2P_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT3P">
<role stoichiometry="1" delta_variable="delta_LT3P_LT2P_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>LT2P</ci>
<ci>vmax37</ci>
</apply>
<apply>
<plus/>
<ci>km37</ci>
<ci>LT2P</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<component name="LT3P_methylation">
<variable units="micromolar" public_interface="in" name="LT3P"/>
<variable units="micromolar" public_interface="in" name="LT4P"/>
<variable units="micromolar" public_interface="in" name="CheR"/>
<variable units="flux" public_interface="out" name="delta_LT3P_LT3P_methylation"/>
<variable units="flux" public_interface="out" name="delta_LT4P_LT3P_methylation"/>
<variable units="micromolar" name="km38" initial_value="0.89"/>
<variable units="first_order_rate_constant" name="vmax38" initial_value="1.0"/>
<variable units="flux" name="rate"/>
<reaction reversible="no">
<variable_ref variable="LT3P">
<role stoichiometry="1" delta_variable="delta_LT3P_LT3P_methylation" role="reactant"/>
</variable_ref>
<variable_ref variable="LT4P">
<role stoichiometry="1" delta_variable="delta_LT4P_LT3P_methylation" role="product"/>
</variable_ref>
<variable_ref variable="CheR">
<role role="catalyst"/>
</variable_ref>
<variable_ref variable="rate">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>LT3P</ci>
<ci>vmax38</ci>
</apply>
<apply>
<plus/>
<ci>km38</ci>
<ci>LT3P</ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<connection>
<map_components component_2="T2_synthesis" component_1="Tar"/>
<map_variables variable_2="Tar" variable_1="Tar"/>
<map_variables variable_2="delta_Tar_T2_synthesis" variable_1="delta_Tar_T2_synthesis"/>
</connection>
<connection>
<map_components component_2="T2_synthesis" component_1="CheW"/>
<map_variables variable_2="CheW" variable_1="CheW"/>
<map_variables variable_2="delta_CheW_T2_synthesis" variable_1="delta_CheW_T2_synthesis"/>
</connection>
<connection>
<map_components component_2="T2_synthesis" component_1="CheA"/>
<map_variables variable_2="CheA" variable_1="CheA"/>
<map_variables variable_2="delta_CheA_T2_synthesis" variable_1="delta_CheA_T2_synthesis"/>
</connection>
<connection>
<map_components component_2="T2_synthesis" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_T2_synthesis" variable_1="delta_T2_T2_synthesis"/>
</connection>
<connection>
<map_components component_2="T2_dephosphorylation_by_CheB" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_T2_dephosphorylation_by_CheB" variable_1="delta_T2_T2_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T2_dephosphorylation_by_CheY" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_T2_dephosphorylation_by_CheY" variable_1="delta_T2_T2_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="T3_demethylation" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_T3_demethylation" variable_1="delta_T2_T3_demethylation"/>
</connection>
<connection>
<map_components component_2="LT2_synthesis" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_LT2_synthesis" variable_1="delta_T2_LT2_synthesis"/>
</connection>
<connection>
<map_components component_2="T2_phosphorylation" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_T2_phosphorylation" variable_1="delta_T2_T2_phosphorylation"/>
</connection>
<connection>
<map_components component_2="T2_methylation" component_1="T2"/>
<map_variables variable_2="T2" variable_1="T2"/>
<map_variables variable_2="delta_T2_T2_methylation" variable_1="delta_T2_T2_methylation"/>
</connection>
<connection>
<map_components component_2="T3_dephosphorylation_by_CheB" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T3_dephosphorylation_by_CheB" variable_1="delta_T3_T3_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T3_dephosphorylation_by_CheY" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T3_dephosphorylation_by_CheY" variable_1="delta_T3_T3_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="T4_demethylation" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T4_demethylation" variable_1="delta_T3_T4_demethylation"/>
</connection>
<connection>
<map_components component_2="T2_methylation" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T2_methylation" variable_1="delta_T3_T2_methylation"/>
</connection>
<connection>
<map_components component_2="LT3_synthesis" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_LT3_synthesis" variable_1="delta_T3_LT3_synthesis"/>
</connection>
<connection>
<map_components component_2="T3_phosphorylation" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T3_phosphorylation" variable_1="delta_T3_T3_phosphorylation"/>
</connection>
<connection>
<map_components component_2="T3_demethylation" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T3_demethylation" variable_1="delta_T3_T3_demethylation"/>
</connection>
<connection>
<map_components component_2="T3_methylation" component_1="T3"/>
<map_variables variable_2="T3" variable_1="T3"/>
<map_variables variable_2="delta_T3_T3_methylation" variable_1="delta_T3_T3_methylation"/>
</connection>
<connection>
<map_components component_2="T2_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="T3_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="LT2_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="LT3_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="T2P_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="T3P_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="LT2P_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="LT3P_methylation" component_1="CheR"/>
<map_variables variable_2="CheR" variable_1="CheR"/>
</connection>
<connection>
<map_components component_2="T4_dephosphorylation_by_CheB" component_1="T4"/>
<map_variables variable_2="T4" variable_1="T4"/>
<map_variables variable_2="delta_T4_T4_dephosphorylation_by_CheB" variable_1="delta_T4_T4_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T4_dephosphorylation_by_CheY" component_1="T4"/>
<map_variables variable_2="T4" variable_1="T4"/>
<map_variables variable_2="delta_T4_T4_dephosphorylation_by_CheY" variable_1="delta_T4_T4_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="T3_methylation" component_1="T4"/>
<map_variables variable_2="T4" variable_1="T4"/>
<map_variables variable_2="delta_T4_T3_methylation" variable_1="delta_T4_T3_methylation"/>
</connection>
<connection>
<map_components component_2="LT4_synthesis" component_1="T4"/>
<map_variables variable_2="T4" variable_1="T4"/>
<map_variables variable_2="delta_T4_LT4_synthesis" variable_1="delta_T4_LT4_synthesis"/>
</connection>
<connection>
<map_components component_2="T4_phosphorylation" component_1="T4"/>
<map_variables variable_2="T4" variable_1="T4"/>
<map_variables variable_2="delta_T4_T4_phosphorylation" variable_1="delta_T4_T4_phosphorylation"/>
</connection>
<connection>
<map_components component_2="T4_demethylation" component_1="T4"/>
<map_variables variable_2="T4" variable_1="T4"/>
<map_variables variable_2="delta_T4_T4_demethylation" variable_1="delta_T4_T4_demethylation"/>
</connection>
<connection>
<map_components component_2="LT2_synthesis" component_1="L"/>
<map_variables variable_2="L" variable_1="L"/>
<map_variables variable_2="delta_L_LT2_synthesis" variable_1="delta_L_LT2_synthesis"/>
</connection>
<connection>
<map_components component_2="LT3_synthesis" component_1="L"/>
<map_variables variable_2="L" variable_1="L"/>
<map_variables variable_2="delta_L_LT3_synthesis" variable_1="delta_L_LT3_synthesis"/>
</connection>
<connection>
<map_components component_2="LT4_synthesis" component_1="L"/>
<map_variables variable_2="L" variable_1="L"/>
<map_variables variable_2="delta_L_LT4_synthesis" variable_1="delta_L_LT4_synthesis"/>
</connection>
<connection>
<map_components component_2="L_T2P_binding" component_1="L"/>
<map_variables variable_2="L" variable_1="L"/>
<map_variables variable_2="delta_L_L_T2P_binding" variable_1="delta_L_L_T2P_binding"/>
</connection>
<connection>
<map_components component_2="L_T3P_binding" component_1="L"/>
<map_variables variable_2="L" variable_1="L"/>
<map_variables variable_2="delta_L_L_T3P_binding" variable_1="delta_L_L_T3P_binding"/>
</connection>
<connection>
<map_components component_2="L_T4P_binding" component_1="L"/>
<map_variables variable_2="L" variable_1="L"/>
<map_variables variable_2="delta_L_L_T4P_binding" variable_1="delta_L_L_T4P_binding"/>
</connection>
<connection>
<map_components component_2="LT2_synthesis" component_1="LT2"/>
<map_variables variable_2="LT2" variable_1="LT2"/>
<map_variables variable_2="delta_LT2_LT2_synthesis" variable_1="delta_LT2_LT2_synthesis"/>
</connection>
<connection>
<map_components component_2="LT2P_dephosphorylation_by_CheB" component_1="LT2"/>
<map_variables variable_2="LT2" variable_1="LT2"/>
<map_variables variable_2="delta_LT2_LT2P_dephosphorylation_by_CheB" variable_1="delta_LT2_LT2P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT2P_dephosphorylation_by_CheY" component_1="LT2"/>
<map_variables variable_2="LT2" variable_1="LT2"/>
<map_variables variable_2="delta_LT2_LT2P_dephosphorylation_by_CheY" variable_1="delta_LT2_LT2P_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="LT3_demethylation" component_1="LT2"/>
<map_variables variable_2="LT2" variable_1="LT2"/>
<map_variables variable_2="delta_LT2_LT3_demethylation" variable_1="delta_LT2_LT3_demethylation"/>
</connection>
<connection>
<map_components component_2="LT2_phosphorylation" component_1="LT2"/>
<map_variables variable_2="LT2" variable_1="LT2"/>
<map_variables variable_2="delta_LT2_LT2_phosphorylation" variable_1="delta_LT2_LT2_phosphorylation"/>
</connection>
<connection>
<map_components component_2="LT2_methylation" component_1="LT2"/>
<map_variables variable_2="LT2" variable_1="LT2"/>
<map_variables variable_2="delta_LT2_LT2_methylation" variable_1="delta_LT2_LT2_methylation"/>
</connection>
<connection>
<map_components component_2="LT3_synthesis" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT3_synthesis" variable_1="delta_LT3_LT3_synthesis"/>
</connection>
<connection>
<map_components component_2="LT3P_dephosphorylation_by_CheB" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT3P_dephosphorylation_by_CheB" variable_1="delta_LT3_LT3P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT3P_dephosphorylation_by_CheY" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT3P_dephosphorylation_by_CheY" variable_1="delta_LT3_LT3P_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="LT4_demethylation" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT4_demethylation" variable_1="delta_LT3_LT4_demethylation"/>
</connection>
<connection>
<map_components component_2="LT2_methylation" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT2_methylation" variable_1="delta_LT3_LT2_methylation"/>
</connection>
<connection>
<map_components component_2="LT3_phosphorylation" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT3_phosphorylation" variable_1="delta_LT3_LT3_phosphorylation"/>
</connection>
<connection>
<map_components component_2="LT3_demethylation" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT3_demethylation" variable_1="delta_LT3_LT3_demethylation"/>
</connection>
<connection>
<map_components component_2="LT3_methylation" component_1="LT3"/>
<map_variables variable_2="LT3" variable_1="LT3"/>
<map_variables variable_2="delta_LT3_LT3_methylation" variable_1="delta_LT3_LT3_methylation"/>
</connection>
<connection>
<map_components component_2="LT4_synthesis" component_1="LT4"/>
<map_variables variable_2="LT4" variable_1="LT4"/>
<map_variables variable_2="delta_LT4_LT4_synthesis" variable_1="delta_LT4_LT4_synthesis"/>
</connection>
<connection>
<map_components component_2="LT4P_dephosphorylation_by_CheB" component_1="LT4"/>
<map_variables variable_2="LT4" variable_1="LT4"/>
<map_variables variable_2="delta_LT4_LT4P_dephosphorylation_by_CheB" variable_1="delta_LT4_LT4P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT4P_dephosphorylation_by_CheY" component_1="LT4"/>
<map_variables variable_2="LT4" variable_1="LT4"/>
<map_variables variable_2="delta_LT4_LT4P_dephosphorylation_by_CheY" variable_1="delta_LT4_LT4P_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="LT3_methylation" component_1="LT4"/>
<map_variables variable_2="LT4" variable_1="LT4"/>
<map_variables variable_2="delta_LT4_LT3_methylation" variable_1="delta_LT4_LT3_methylation"/>
</connection>
<connection>
<map_components component_2="LT4_phosphorylation" component_1="LT4"/>
<map_variables variable_2="LT4" variable_1="LT4"/>
<map_variables variable_2="delta_LT4_LT4_phosphorylation" variable_1="delta_LT4_LT4_phosphorylation"/>
</connection>
<connection>
<map_components component_2="LT4_demethylation" component_1="LT4"/>
<map_variables variable_2="LT4" variable_1="LT4"/>
<map_variables variable_2="delta_LT4_LT4_demethylation" variable_1="delta_LT4_LT4_demethylation"/>
</connection>
<connection>
<map_components component_2="CheB_P_dephosphorylation" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_CheB_P_dephosphorylation" variable_1="delta_CheB_CheB_P_dephosphorylation"/>
</connection>
<connection>
<map_components component_2="T2_dephosphorylation_by_CheB" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_T2_dephosphorylation_by_CheB" variable_1="delta_CheB_T2_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T3_dephosphorylation_by_CheB" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_T3_dephosphorylation_by_CheB" variable_1="delta_CheB_T3_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T4_dephosphorylation_by_CheB" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_T4_dephosphorylation_by_CheB" variable_1="delta_CheB_T4_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT2P_dephosphorylation_by_CheB" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_LT2P_dephosphorylation_by_CheB" variable_1="delta_CheB_LT2P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT3P_dephosphorylation_by_CheB" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_LT3P_dephosphorylation_by_CheB" variable_1="delta_CheB_LT3P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT4P_dephosphorylation_by_CheB" component_1="CheB"/>
<map_variables variable_2="CheB" variable_1="CheB"/>
<map_variables variable_2="delta_CheB_LT4P_dephosphorylation_by_CheB" variable_1="delta_CheB_LT4P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="CheY_P_dephosphorylation" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_CheY_P_dephosphorylation" variable_1="delta_CheY_CheY_P_dephosphorylation"/>
</connection>
<connection>
<map_components component_2="T2_dephosphorylation_by_CheY" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_T2_dephosphorylation_by_CheY" variable_1="delta_CheY_T2_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="T3_dephosphorylation_by_CheY" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_T3_dephosphorylation_by_CheY" variable_1="delta_CheY_T3_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="T4_dephosphorylation_by_CheY" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_T4_dephosphorylation_by_CheY" variable_1="delta_CheY_T4_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="LT2P_dephosphorylation_by_CheY" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_LT2P_dephosphorylation_by_CheY" variable_1="delta_CheY_LT2P_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="LT3P_dephosphorylation_by_CheY" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_LT3P_dephosphorylation_by_CheY" variable_1="delta_CheY_LT3P_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="LT4P_dephosphorylation_by_CheY" component_1="CheY"/>
<map_variables variable_2="CheY" variable_1="CheY"/>
<map_variables variable_2="delta_CheY_LT4P_dephosphorylation_by_CheY" variable_1="delta_CheY_LT4P_dephosphorylation_by_CheY"/>
</connection>
<connection>
<map_components component_2="T2_dephosphorylation_by_CheB" component_1="CheB_P"/>
<map_variables variable_2="CheB_P" variable_1="CheB_P"/>
<map_variables variable_2="delta_CheB_P_T2_dephosphorylation_by_CheB" variable_1="delta_CheB_P_T2_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T3_dephosphorylation_by_CheB" component_1="CheB_P"/>
<map_variables variable_2="CheB_P" variable_1="CheB_P"/>
<map_variables variable_2="delta_CheB_P_T3_dephosphorylation_by_CheB" variable_1="delta_CheB_P_T3_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="T4_dephosphorylation_by_CheB" component_1="CheB_P"/>
<map_variables variable_2="CheB_P" variable_1="CheB_P"/>
<map_variables variable_2="delta_CheB_P_T4_dephosphorylation_by_CheB" variable_1="delta_CheB_P_T4_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT2P_dephosphorylation_by_CheB" component_1="CheB_P"/>
<map_variables variable_2="CheB_P" variable_1="CheB_P"/>
<map_variables variable_2="delta_CheB_P_LT2P_dephosphorylation_by_CheB" variable_1="delta_CheB_P_LT2P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT3P_dephosphorylation_by_CheB" component_1="CheB_P"/>
<map_variables variable_2="CheB_P" variable_1="CheB_P"/>
<map_variables variable_2="delta_CheB_P_LT3P_dephosphorylation_by_CheB" variable_1="delta_CheB_P_LT3P_dephosphorylation_by_CheB"/>
</connection>
<connection>
<map_components component_2="LT4P_dephosphorylation_by_CheB" component_1="CheB_P"/>
<map_variables variable_2="CheB_P" variable_1="CheB_P"/>
<map_variables variable_2="delta_CheB_P_LT4P_dephosphorylation_by_CheB" variable_1="delta_CheB_P_LT4P_dephosphorylation_by_CheB"/>
</connection>
<connection>
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<dcterms:W3CDTF>2001-10-29</dcterms:W3CDTF>
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<vCard:FN>Catherine Lloyd</vCard:FN>
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<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Research Group</vCard:Orgunit>
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<dc:title>
A model of excitation and adaptation in bacterial chemotaxis
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<bqs:volume>94</bqs:volume>
<bqs:first_page>7263</bqs:first_page>
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<dc:title>
A model of excitation and adaptation in bacterial chemotaxis
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<cmeta:species>Escherichia coli</cmeta:species>
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<vCard:Given>Peter</vCard:Given>
<vCard:Family>Spiro</vCard:Family>
<vCard:Other>A</vCard:Other>
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