Current_Ica.cellml

About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
DOI:https://dx.doi.org/10.1113%2FJP277724

Figure 04

Calcium current model

Current_Ica.cellml is the main CellML files which contains the formulation for L-type calcium current. Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

  1. Fig4_CaL.py
  2. Current_Ica.cellml
  3. Current_Ica.sedml
  4. parameter_Ica.cellml
  5. parameter.cellml
  6. gating_Ica.cellml
  7. unit.cellml

To reproduce Figure 4, save all the files to the same folder and execute the following script from the command line:

$ cd [PathToThisFile]

$ [PathToOpenCOR]/pythonshell Fig4_CaL.py

Calcium current model

A, L-type calcium current (ICaL) steady-state inactivation and activation curves with dataset-specific model optimized to experimental data. The L-type calcium model used in the baseline cellular model is shown in black. B, I-V curves for ICaL, C, time constants of ICaL activation gate. D, time constants of ICaL inactivation gate.