Current_Ito.cellml

About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
DOI:https://dx.doi.org/10.1113%2FJP277724

Figure 06

Transient outward potassium current (Ito) model

Current_Ito.cellml is the main CellML file which contains the formulation for the transient outward current. Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

  1. fig6_to.py
  2. Current_Ito.cellml
  3. Current_Ito.sedml
  4. parameter_Ito.cellml
  5. parameter.cellml
  6. gating_Ito.cellml
  7. unit.cellml

To reproduce Figure 6, save all the files to the same folder and execute the following script from the command line:

$ cd [PathToThisFile]

$ [PathToOpenCOR]/pythonshell fig6_to.py

Transient outward potassium current model

A, optimized activation with dataset-specific model fits. B. I-V curves, C, Time constant of Ito activation gate. D, Time constant of Ito inactivation gate.