Model Mathematics

Component: environment

Component: BMK1

ddtimeBMK1=v10b-v10a

Component: MRNA

ddtimeMRNA=v19-v18

Component: NFATc

ddtimeNFATc=v14-v1+v15

Component: NFATn

ddtimeNFATn=v1+v16-v17+v18

Component: NFATpc

ddtimeNFATpc=v2+v15-v9+v14

Component: NFATpn

ddtimeNFATpn=v17-v2+v16

Component: GSK3betac

ddtimeGSK3betac=v12b+v15b-v3+v12a+v15a

Component: GSK3betan

ddtimeGSK3betan=v3+v17b-v17a

Component: CaNc

ddtimeCaNc=-v6

Component: CaNc_star

ddtimeCaNc_star=v6+v11b+v13b+v14b-v4+v7+v11a+v13a+v14a

Component: CaNn_star

ddtimeCaNn_star=v4+v16b-v16a

Component: CaNn

ddtimeCaNn=-v6

Component: CaM

ddtimeCaM=-v5

Component: CaMCa

ddtimeCaMCa=v5-v6

Component: MCIP

ddtimeMCIP=v11-v7+v10+v19

Component: MCIPp

ddtimeMCIPp=v10+v13-v11+v12

Component: MCIPpp

ddtimeMCIPpp=v12-v8+v13

Component: Comp1

ddtimeComp1=v7

Component: Comp2

ddtimeComp2=v8

Component: Comp3

ddtimeComp3=v9

Component: P1433

ddtimeP1433=-v8+v9

Component: MCIP_BMK1

ddtimeMCIP_BMK1=v10a-v10b

Component: MCIPp_CaNc_star

ddtimeMCIPp_CaNc_star=v11a-v11b

Component: MCIPp_GSK3betac

ddtimeMCIPp_GSK3betac=v12a-v12b

Component: MCIPpp_CaNc_star

ddtimeMCIPpp_CaNc_star=v13a-v13b

Component: NFATpc_CaNc_star

ddtimeNFATpc_CaNc_star=v14a-v14b

Component: NFATc_GSK3betac

ddtimeNFATc_GSK3betac=v15a-v15b

Component: NFATpn_CaNn_star

ddtimeNFATpn_CaNn_star=v16a-v16b

Component: NFATn_GSK3betan

ddtimeNFATn_GSK3betan=v17a-v17b

Component: v1

v1 = k29 NFATc

Component: v2

v2 = k30 NFATpn

Component: v3

v3 = k31 GSK3betac - k32 GSK3betan

Component: v4

v4 = k33 CaNc_star - k34 CaNn_star

Component: v5

v5 = k1 CaM Ca 4 - k2 CaMCa

Component: v6

v6 = k3 CaMCa CaNc - k4 CaNc_star

Component: v7

v7 = k5 CaNc_star MCIP - k6 Comp1

Component: v8

v8 = k19 P1433 MCIPpp - k20 Comp2

Component: v9

v9 = k27 NFATpc P1433 - k28 Comp3

Component: v10

v10a = k7 MCIP BMK1 - k8 MCIP_BMK1 v10b = k9 MCIP_BMK1 v10 = v10a + v10b

Component: v11

v11a = k10 MCIPp CaNc_star - k11 MCIPp_CaNc_star v11b = k12 MCIPp_CaNc_star v11 = v11a + v11b

Component: v12

v12a = k13 MCIPp GSK3betac - k14 MCIPp_GSK3betac v12b = k15 MCIPp_GSK3betac v12 = v12a + v12b

Component: v13

v13a = k16 MCIPpp CaNc_star - k17 MCIPpp_CaNc_star v13b = k18 MCIPpp_CaNc_star v13 = v13a + v13b

Component: v14

v14a = k21 NFATpc CaNc_star - k22 NFATpc_CaNc_star v14b = k23 NFATpc_CaNc_star v14 = v14a + v14b

Component: v15

v15a = k24 NFATc GSK3betac - k25 NFATc_GSK3betac v15b = k26 NFATc_GSK3betac v15 = v15a + v15b

Component: v16

v16a = k35 NFATpn CaNn_star - k36 NFATpn_CaNn_star v16b = k37 NFATpn_CaNn_star v16 = v16a + v16b

Component: v17

v17a = k38 NFATn GSK3betan - k39 NFATn_GSK3betan v17b = k40 NFATn_GSK3betan v17 = v17a + v17b

Component: v18

v18 = k41 NFATn - k42 MRNA

Component: v19

v19 = k43 MRNA -ln 2.0 t_half MCIP

Component: model_parameters