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Izakov, Katsnelson, Blyakhman, Markhasin, Shkylar, 1991
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Cooperative Effects Due to Calcium Binding by Troponin and Their Consequences for Contraction and Relaxation of Cardiac Muscle Under Various Conditions of Mechanical Loading
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Model Mathematics
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Component: environment
Component: equations
V_1
=
0.1
V_max
Ca
=
Ca_m
1
-
ⅇ
-
a_c
time
2
2
if
time
≦
t_d
Ca_m
1
-
ⅇ
-
a_c
time
2
ⅇ
-
b_c
time
-
t_d
2
2
otherwise
C_2
=
C_20
pi_n
phi_A_1
pi_n
=
pi_min
if
0.75
≦
n
∧
n
≦
1
pi_min
2
n
-
0.5
if
0.25
≦
n
∧
n
<
0.75
1
otherwise
phi_A_1
=
ⅇ
-
q_k
A_1
S
=
0.5
l_1
+
S_0
A
=
A_1
S
1
d
d
time
A_1
=
C_1
Ca
TnC
-
A_1
-
C_20
pi_n
phi_A_1
A_1
n
=
n_1
n_2
n_1
=
0
if
g_1
l_1
+
g_2
<
0
g_1
l_1
+
g_2
if
0
≦
g_1
l_1
+
g_2
∧
g_1
l_1
+
g_2
≦
1
1
otherwise
d
d
time
n_2
=
q_V
m_0
G_V
-
n_2
q_V
=
q_1
-
q_2
V
V_max
if
V
≦
0
q_3
otherwise
G_V
=
1
+
0.6
V
V_max
V
=
-
dl_1_dt
F_V
=
a
1
+
V
V_max
a
-
V
V_max
p_V
=
F_V
G_V
P_CE
=
lambda
S
A_1
n
p_V
P_PE
=
beta_2
ⅇ
alpha_2
l_2
-
1
P_SE
=
beta_1
ⅇ
alpha_1
l_2
-
l_1
-
1
Component: user_defined
dl_1_dt
=
0
l_1
=
0
if
200
≦
time
∧
time
≦
201
0
otherwise
l_2
=
l_1
+
1.87
Source
Derived from workspace
Izakov, Katsnelson, Blyakhman, Markhasin, Shkylar, 1991
at changeset
f6baf68c4c3f
.
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Creative Commons Attribution 3.0 Unported License
.
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Cooperative Effects Due to Calcium Binding by Troponin and Their Consequences for Contraction and Relaxation of Cardiac Muscle Under Various Conditions of Mechanical Loading