Rendering of the source text

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<!--
This CellML file was generated on 7/04/2010 at 12:07:34 at p.m. using:

COR (0.9.31.1371)
Copyright 2002-2010 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
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		<article>
			<articleinfo>
				<title>Common Phenotype of Resting Mouse EDL and SOL Muscles: Equal ATPase and Glycolytic Flux During Transient Anoxia</title>
				<author>
					<firstname>Geoffrey</firstname>
					<surname>Nunns</surname>
					<affiliation>
						<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
				This model describes the extensor digitorum longus muscle during resting state. It runs in PCEnv, COR and OpenCell to reproduce the original matlab, provided by the model authors. The units are consistent throughout. 
				</para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
ABSTRACT: Rates of ATPase and glycolysis are several times faster in actively contracting mouse extensor digitorum longus muscle (EDL) than soleus (SOL), but we find these rates are not distinguishable at rest. We use a transient anoxic perturbation of steady state energy balance to decrease PCr reversibly and to measure the rates of ATPase and of lactate production without muscle activation or contraction. The rate of glycolytic ATP synthesis is less than the ATPase rate, accounting for the continual PCr decrease during anoxia in both muscles. We fit a mathematical model validated with properties of enzymes and solutes measured in vitro and appropriate for the transient perturbation of these muscles to experimental data to test whether the model accounts for the results. Simulations showed equal rates of ATPase and lactate production in both muscles. ATPase controls glycolytic flux by feedback from its products. Adenylate kinase function is critical because rise in [AMP] is necessary to activate glycogen phosphorylase. ATPase is the primary source of H+ production. The sum of contributions of the thirteen reactions of the glycogenolytic and glycolytic network to total proton load is negligible. The stoichiometry of lactate and H+ production is near unity. These results identify a default state of energy metabolism for resting muscle in which there is no difference in the metabolic phenotype of EDL and SOL. Therefore additional control mechanisms, involving higher ATPase flux and [Ca++], must exist to explain for the well-known difference in glycolytic rates in fast-twitch and slow-twitch muscles in actively contracting muscle.
</para>
				<para>
The original paper reference is cited below:
</para>
				<para>
Common Phenotype of Resting Mouse EDL and SOL Muscles: Equal ATPase and Glycolytic Flux During Transient Anoxia, Kalyan Vinnakota, Joshua Rusk, Lauren Palmer, Eric Shankland and Martin J. Kushmeric, 2010, <emphasis>Journal of Physiology</emphasis>, Epub, 1-56.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=20308252&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 20308252</ulink>
				</para>
			</sect1>
		</article>
	</documentation>



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            <eq/>
            <ci>d</ci>
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            <eq/>
            <ci>e_</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
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            <eq/>
            <ci>Lo</ci>
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         <apply>
            <eq/>
            <ci>Vffald</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.0412</cn>
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            <eq/>
            <ci>Kald_fbp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">5   <sep/>
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         </apply>
         <apply>
            <eq/>
            <ci>Kald_dhap</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2   <sep/>
            -3</cn>
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         <apply>
            <eq/>
            <ci>Kald_gap</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vfftpi</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.348</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Ktpi_gap</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.2   <sep/>
            -4</cn>
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         <apply>
            <eq/>
            <ci>Ktpi_dhap</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">6.1   <sep/>
            -4</cn>
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         <apply>
            <eq/>
            <ci>Vbbg3pdh</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.631</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kg3pdh_g3p</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.8   <sep/>
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         <apply>
            <eq/>
            <ci>Kg3pdh_nad</ci>
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            <eq/>
            <ci>Kg3pdh_dhap</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2.2   <sep/>
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         <apply>
            <eq/>
            <ci>Kg3pdh_nadh</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">8   <sep/>
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         </apply>
         <apply>
            <eq/>
            <ci>Vffgad</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.1865</cn>
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         <apply>
            <eq/>
            <ci>Kgapdh_gap</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2.5   <sep/>
            -6</cn>
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         <apply>
            <eq/>
            <ci>Kgapdh_nad</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">9   <sep/>
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         </apply>
         <apply>
            <eq/>
            <ci>Kgapdh_pi</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2.9   <sep/>
            -4</cn>
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         <apply>
            <eq/>
            <ci>Kgapdh_bpg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">8   <sep/>
            -7</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kgapdh_nadh</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.3   <sep/>
            -6</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vbbpgk</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.0212</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpgk_bpg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpgk_adp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">8   <sep/>
            -6</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpgk_3pg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.2   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpgk_atp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.5   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vffpgm</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.2046</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpgm_3pg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpgm_2pg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.4   <sep/>
            -5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vffen</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">1.943</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Ken_2pg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Ken_pep</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.7   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vffpk</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.0996</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpk_pep</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">8   <sep/>
            -5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpk_adp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpk_pyr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">7.05   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kpk_atp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.13   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vffldh</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.2687</cn>
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         <apply>
            <eq/>
            <ci>Kldh_pyr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.35   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kldh_nadh</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2   <sep/>
            -6</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kldh_lac</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.7   <sep/>
            -2</cn>
         </apply>
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            <eq/>
            <ci>Kldh_nad</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">8.49   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>VforCK</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">11.1371</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_pcr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.11   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_iatp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.5   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_iadp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1.35   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_ipcr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.9   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_cr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.8   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_Iadp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">0.015   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_Ipcr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.9   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_Icr</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">58   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_Iatp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">4.346   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kck_Ii</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">1   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vfadk</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">2.5627</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kadk_amp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.2   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kadk_atp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">2.7   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kadk_adp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">3.5   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kut</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_minute">0.0827</cn>
         </apply>
         <apply>
            <eq/>
            <ci>VmaxOxPhos</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.0037</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kmadp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">4.8339   <sep/>
            -5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>nnHH</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.429</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vmax_MCT</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0.00462138</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Klac1</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="molar">25.5   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKmct1</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8.89</cn>
         </apply>
         <apply>
            <eq/>
            <ci>PSVCO2</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_minute">2.3084</cn>
         </apply>
         <apply>
            <eq/>
            <ci>X_CA</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">740</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kf_hydrCO2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_minute">0.0469</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">60</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Keq_CA</ci>
            <apply>
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               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.157</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kb_hydrCO2</ci>
            <apply>
               <divide/>
               <ci>kf_hydrCO2</ci>
               <ci>Keq_CA</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Flow</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="liter_per_minute">4   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>V_cell</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="liter">55   <sep/>
               -3</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.67</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
               -3</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_ec</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="liter">0.149   <sep/>
               -3</cn>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">55   <sep/>
                     -3</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="liter">1   <sep/>
                  -3</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>bufcapfixed</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">0.0141865</cn>
         </apply>
      </math>
   </component>
   <component name="equilibrium_constants">
      <variable name="T" public_interface="out" units="kelvin"/>
      <variable name="I" public_interface="out" units="molar"/>
      <variable name="k" public_interface="out" units="molar"/>
      <variable name="c0" public_interface="out" units="molar"/>
      <variable name="R" public_interface="out" units="kilojoule_per_mole_per_kelvin"/>
      <variable name="B" public_interface="out" units="per_half_molar"/>
      <variable name="I1" public_interface="out" units="molar"/>
      <variable name="alphadebye" public_interface="out" units="per_half_molar"/>
      <variable name="IcorrpKa" public_interface="out" units="dimensionless"/>
      <variable name="RTalpha" public_interface="out" units="kilojoule_half_liter_per_3_half_mole"/>
      <variable name="IcorrdeltaGpof" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_Pi" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_Pi" public_interface="out" units="dimensionless"/>
      <variable name="pKak_Pi" public_interface="out" units="dimensionless"/>
      <variable name="P_Pi" public_interface="out" units="dimensionless"/>
      <variable name="HPi2" public_interface="out" units="dimensionless"/>
      <variable name="H2Pi1" public_interface="out" units="dimensionless"/>
      <variable name="kPi" public_interface="out" units="dimensionless"/>
      <variable name="mgPi" public_interface="out" units="dimensionless"/>
      <variable name="Navg_Pi" public_interface="out" units="dimensionless"/>
      <variable name="dNavgPidH" public_interface="out" units="per_molar"/>
      <variable name="NH_HPi2" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_HPi2" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_HPi2" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_ATP" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_ATP" public_interface="out" units="dimensionless"/>
      <variable name="pKak_ATP" public_interface="out" units="dimensionless"/>
      <variable name="P_ATP" public_interface="out" units="dimensionless"/>
      <variable name="ATP4" public_interface="out" units="dimensionless"/>
      <variable name="HATP3" public_interface="out" units="dimensionless"/>
      <variable name="mgATP2" public_interface="out" units="dimensionless"/>
      <variable name="kATP" public_interface="out" units="dimensionless"/>
      <variable name="Navg_ATP" public_interface="out" units="dimensionless"/>
      <variable name="dNavgATPdH" public_interface="out" units="per_molar"/>
      <variable name="NH_ATP4" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_ATP4" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_ATP4" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKak_ADP" public_interface="out" units="dimensionless"/>
      <variable name="pKa1_ADP" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_ADP" public_interface="out" units="dimensionless"/>
      <variable name="P_ADP" public_interface="out" units="dimensionless"/>
      <variable name="ADP3" public_interface="out" units="dimensionless"/>
      <variable name="HADP2" public_interface="out" units="dimensionless"/>
      <variable name="mgADP" public_interface="out" units="dimensionless"/>
      <variable name="kADP" public_interface="out" units="dimensionless"/>
      <variable name="Navg_ADP" public_interface="out" units="dimensionless"/>
      <variable name="dNavgADPdH" public_interface="out" units="per_molar"/>
      <variable name="NH_ADP3" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_ADP3" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_ADP3" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_AMP" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_AMP" public_interface="out" units="dimensionless"/>
      <variable name="P_AMP" public_interface="out" units="dimensionless"/>
      <variable name="AMP2" public_interface="out" units="dimensionless"/>
      <variable name="HAMP1" public_interface="out" units="dimensionless"/>
      <variable name="mgAMP" public_interface="out" units="dimensionless"/>
      <variable name="Navg_AMP" public_interface="out" units="dimensionless"/>
      <variable name="dNavgAMPdH" public_interface="out" units="per_molar"/>
      <variable name="NH_AMP2" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_AMP2" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_AMP2" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKak_PCR" public_interface="out" units="dimensionless"/>
      <variable name="pKa1_PCR" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_PCR" public_interface="out" units="dimensionless"/>
      <variable name="P_PCR" public_interface="out" units="dimensionless"/>
      <variable name="HPCR" public_interface="out" units="dimensionless"/>
      <variable name="H2PCR" public_interface="out" units="dimensionless"/>
      <variable name="kPCR" public_interface="out" units="dimensionless"/>
      <variable name="mgPCR" public_interface="out" units="dimensionless"/>
      <variable name="Navg_PCR" public_interface="out" units="dimensionless"/>
      <variable name="dNavgPCRdH" public_interface="out" units="per_molar"/>
      <variable name="NH_HPCR" public_interface="out" units="dimensionless"/>
      <variable name="pKa1_CR" public_interface="out" units="dimensionless"/>
      <variable name="P_CR" public_interface="out" units="dimensionless"/>
      <variable name="HCR" public_interface="out" units="dimensionless"/>
      <variable name="H2CR" public_interface="out" units="dimensionless"/>
      <variable name="Navg_CR" public_interface="out" units="dimensionless"/>
      <variable name="dNavgCRdH" public_interface="out" units="per_molar"/>
      <variable name="NH_HCR" public_interface="out" units="dimensionless"/>
      <variable name="pKa1_G1P" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_G1P" public_interface="out" units="dimensionless"/>
      <variable name="P_G1P" public_interface="out" units="dimensionless"/>
      <variable name="UG1P" public_interface="out" units="dimensionless"/>
      <variable name="HG1P" public_interface="out" units="dimensionless"/>
      <variable name="mgG1P" public_interface="out" units="dimensionless"/>
      <variable name="Navg_G1P" public_interface="out" units="dimensionless"/>
      <variable name="dNavgG1PdH" public_interface="out" units="per_molar"/>
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      <variable name="deltaGpof_UG1P" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_G6P" public_interface="out" units="dimensionless"/>
      <variable name="P_G6P" public_interface="out" units="dimensionless"/>
      <variable name="UG6P" public_interface="out" units="dimensionless"/>
      <variable name="HG6P" public_interface="out" units="dimensionless"/>
      <variable name="Navg_G6P" public_interface="out" units="dimensionless"/>
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      <variable name="dNavgG6Pdmg" public_interface="out" units="per_molar"/>
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      <variable name="deltaGpof_UG6P" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_F6P" public_interface="out" units="dimensionless"/>
      <variable name="P_F6P" public_interface="out" units="dimensionless"/>
      <variable name="UF6P" public_interface="out" units="dimensionless"/>
      <variable name="HF6P" public_interface="out" units="dimensionless"/>
      <variable name="Navg_F6P" public_interface="out" units="dimensionless"/>
      <variable name="dNavgF6PdH" public_interface="out" units="per_molar"/>
      <variable name="NH_UF6P" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_UF6P" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_UF6P" public_interface="out" units="kilojoule_per_mole"/>
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      <variable name="pKamg_FDP" public_interface="out" units="dimensionless"/>
      <variable name="P_FDP" public_interface="out" units="dimensionless"/>
      <variable name="UFDP" public_interface="out" units="dimensionless"/>
      <variable name="HFDP" public_interface="out" units="dimensionless"/>
      <variable name="mgFDP" public_interface="out" units="dimensionless"/>
      <variable name="Navg_FDP" public_interface="out" units="dimensionless"/>
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      <variable name="pKa1_GAP" public_interface="out" units="dimensionless"/>
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      <variable name="UGAP" public_interface="out" units="dimensionless"/>
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      <variable name="UDHAP" public_interface="out" units="dimensionless"/>
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      <variable name="mgDHAP" public_interface="out" units="dimensionless"/>
      <variable name="Navg_DHAP" public_interface="out" units="dimensionless"/>
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      <variable name="pKa1_13DPG" public_interface="out" units="dimensionless"/>
      <variable name="P_13DPG" public_interface="out" units="dimensionless"/>
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      <variable name="Navg_13DPG" public_interface="out" units="dimensionless"/>
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      <variable name="NH_U13DPG" public_interface="out" units="dimensionless"/>
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      <variable name="deltaGpof_U13DPG" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_3PG" public_interface="out" units="dimensionless"/>
      <variable name="P_3PG" public_interface="out" units="dimensionless"/>
      <variable name="U3PG" public_interface="out" units="dimensionless"/>
      <variable name="H3PG" public_interface="out" units="dimensionless"/>
      <variable name="Navg_3PG" public_interface="out" units="dimensionless"/>
      <variable name="dNavg3PGdH" public_interface="out" units="per_molar"/>
      <variable name="NH_U3PG" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_U3PG" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_U3PG" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_2PG" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_2PG" public_interface="out" units="dimensionless"/>
      <variable name="pKak_2PG" public_interface="out" units="dimensionless"/>
      <variable name="P_2PG" public_interface="out" units="dimensionless"/>
      <variable name="U2PG" public_interface="out" units="dimensionless"/>
      <variable name="H2PG" public_interface="out" units="dimensionless"/>
      <variable name="mg2PG" public_interface="out" units="dimensionless"/>
      <variable name="k2PG" public_interface="out" units="dimensionless"/>
      <variable name="Navg_2PG" public_interface="out" units="dimensionless"/>
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      <variable name="deltaGpof_U2PG" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_PEP" public_interface="out" units="dimensionless"/>
      <variable name="pKamg_PEP" public_interface="out" units="dimensionless"/>
      <variable name="pKak_PEP" public_interface="out" units="dimensionless"/>
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      <variable name="UPEP" public_interface="out" units="dimensionless"/>
      <variable name="HPEP" public_interface="out" units="dimensionless"/>
      <variable name="kPEP" public_interface="out" units="dimensionless"/>
      <variable name="mgPEP" public_interface="out" units="dimensionless"/>
      <variable name="Navg_PEP" public_interface="out" units="dimensionless"/>
      <variable name="dNavgPEPdH" public_interface="out" units="per_molar"/>
      <variable name="NH_UPEP" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_UPEP" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_UPEP" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKa1_PYR" public_interface="out" units="dimensionless"/>
      <variable name="P_PYR" public_interface="out" units="dimensionless"/>
      <variable name="UPYR" public_interface="out" units="dimensionless"/>
      <variable name="HPYR" public_interface="out" units="dimensionless"/>
      <variable name="Navg_PYR" public_interface="out" units="dimensionless"/>
      <variable name="dNavgPYRdH" public_interface="out" units="per_molar"/>
      <variable name="dNavgPYRdmg" public_interface="out" units="per_molar"/>
      <variable name="NH_UPYR" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_UPYR" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_UPYR" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="pKamg_LAC" public_interface="out" units="dimensionless"/>
      <variable name="pKa1_LAC" public_interface="out" units="dimensionless"/>
      <variable name="P_LAC" public_interface="out" units="dimensionless"/>
      <variable name="ULAC" public_interface="out" units="dimensionless"/>
      <variable name="HLAC" public_interface="out" units="dimensionless"/>
      <variable name="mgLAC" public_interface="out" units="dimensionless"/>
      <variable name="Navg_LAC" public_interface="out" units="dimensionless"/>
      <variable name="dNavgLACdH" public_interface="out" units="per_molar"/>
      <variable name="dmgLACdmg" public_interface="out" units="per_molar"/>
      <variable name="dmgLACdpH" public_interface="out" units="dimensionless"/>
      <variable name="NH_ULAC" public_interface="out" units="dimensionless"/>
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      <variable name="deltaGpof_ULAC" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="dNH_GLY" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_GLY" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="NH_NAD" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_NAD" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_NAD" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="NH_NADH" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_NADH" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_NADH" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="NH_H2O" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_H2O" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_H2O" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="NH_H" public_interface="out" units="dimensionless"/>
      <variable name="deltaGof_H" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaGpof_H" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="deltaH_CK" public_interface="out" units="dimensionless"/>
      <variable name="slopeint_1" public_interface="out" units="kelvin"/>
      <variable name="slopeint_2" public_interface="out" units="dimensionless"/>
      <variable name="Kref_CKT" public_interface="out" units="dimensionless"/>
      <variable name="I25" public_interface="out" units="molar"/>
      <variable name="alphadebye1" public_interface="out" units="dimensionless"/>
      <variable name="IcorrneglnKrefCK" public_interface="out" units="dimensionless"/>
      <variable name="neglnKrefCK_Iexp" public_interface="out" units="dimensionless"/>
      <variable name="Kref_CK" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_CK" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_CK" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_ADK" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_ADK" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_ADK" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_GP" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_GP" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_GP" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_PGLM" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_PGLM" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_PGLM" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_PGI" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_PGI" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_PGI" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_PFK" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_PFK" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_PFK" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_ALD" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_ALD" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_ALD" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_TPI" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_TPI" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_TPI" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_GAPDH" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_GAPDH" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_GAPDH" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_G3PDH" public_interface="out" units="dimensionless"/>
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      <variable name="deltaGpo_PGM" public_interface="out" units="kilojoule_per_mole"/>
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      <variable name="deltaH_ENOL" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_ENOL" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_ENOL" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_PK" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_PK" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_PK" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_LDH" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_LDH" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_LDH" public_interface="out" units="dimensionless"/>
      <variable name="deltaH_ATPase" public_interface="out" units="dimensionless"/>
      <variable name="deltaGpo_ATPase" public_interface="out" units="kilojoule_per_mole"/>
      <variable name="Kapp_ATPase" public_interface="out" units="dimensionless"/>
      <variable name="mg" public_interface="in" units="molar"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
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            <ci>T</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kelvin">298.15</cn>
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            <ci>I</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">0.17</cn>
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            <ci>k</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">0.14</cn>
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            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_half_molar">1.6</cn>
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            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">0.1</cn>
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            <ci>alphadebye</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_half_molar">1.17582</cn>
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            <ci>RTalpha</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_half_liter_per_3_half_mole">2.91482</cn>
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            <ci>IcorrdeltaGpof</ci>
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                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKak_Pi</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>P_Pi</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_Pi</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_Pi</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>k</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKak_Pi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HPi2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_Pi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>H2Pi1</ci>
            <apply>
               <times/>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_Pi</ci>
                  </apply>
               </apply>
               <ci>HPi2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kPi</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>k</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKak_Pi</ci>
               </apply>
               <ci>HPi2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgPi</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>mg</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_Pi</ci>
               </apply>
               <ci>HPi2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_Pi</ci>
            <ci>H2Pi1</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgPidH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_Pi</ci>
                  </apply>
                  <ci>P_Pi</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>H2Pi1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_Pi</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_HPi2</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_HPi2</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1096.1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_HPi2</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_HPi2</ci>
                  <apply>
                     <times/>
                     <ci>NH_HPi2</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_HPi2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_ATP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.48</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_ATP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.19</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKak_ATP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.17</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_ATP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_ATP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_ATP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>k</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKak_ATP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ATP4</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_ATP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HATP3</ci>
            <apply>
               <times/>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_ATP</ci>
                  </apply>
               </apply>
               <ci>ATP4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgATP2</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>mg</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_ATP</ci>
               </apply>
               <ci>ATP4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kATP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>k</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKak_ATP</ci>
               </apply>
               <ci>ATP4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_ATP</ci>
            <ci>HATP3</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgATPdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_ATP</ci>
                  </apply>
                  <ci>P_ATP</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>HATP3</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_ATP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_ATP4</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">12</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_ATP4</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">2768.1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_ATP4</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_ATP4</ci>
                  <apply>
                     <times/>
                     <ci>NH_ATP4</ci>
                     <ci>R</ci>
                     <ci>T</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">16</cn>
                     <ci>NH_ATP4</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKak_ADP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_ADP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.38</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_ADP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.25</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_ADP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_ADP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_ADP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>k</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKak_ADP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ADP3</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_ADP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HADP2</ci>
            <apply>
               <times/>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_ADP</ci>
                  </apply>
               </apply>
               <ci>ADP3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgADP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>ADP3</ci>
                     <ci>mg</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_ADP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kADP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>ADP3</ci>
                     <ci>k</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKak_ADP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_ADP</ci>
            <ci>HADP2</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgADPdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_ADP</ci>
                  </apply>
                  <ci>P_ADP</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>HADP2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_ADP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_ADP3</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">12</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_ADP3</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1906.13</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_ADP3</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_ADP3</ci>
                  <apply>
                     <times/>
                     <ci>NH_ADP3</ci>
                     <ci>R</ci>
                     <ci>T</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9</cn>
                     <ci>NH_ADP3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_AMP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.29</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_AMP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.92</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_AMP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <minus/>
                     <ci>pKa1_AMP</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_AMP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>AMP2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_AMP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HAMP1</ci>
            <apply>
               <times/>
               <ci>AMP2</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <minus/>
                     <ci>pKa1_AMP</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgAMP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>mg</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_AMP</ci>
               </apply>
               <ci>AMP2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_AMP</ci>
            <ci>HAMP1</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgAMPdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_AMP</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_AMP</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_AMP</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_AMP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_AMP2</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">12</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_AMP2</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1040.45</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_AMP2</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_AMP2</ci>
                  <apply>
                     <times/>
                     <ci>NH_AMP2</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_AMP2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKak_PCR</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.31</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_PCR</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.5</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_PCR</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.6</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_PCR</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_PCR</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_PCR</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>k</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKak_PCR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HPCR</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_PCR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>H2PCR</ci>
            <apply>
               <times/>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_PCR</ci>
                  </apply>
               </apply>
               <ci>HPCR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kPCR</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>k</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKak_PCR</ci>
               </apply>
               <ci>HPCR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgPCR</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>mg</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_PCR</ci>
               </apply>
               <ci>HPCR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_PCR</ci>
            <ci>H2PCR</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgPCRdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_PCR</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_PCR</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_PCR</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_PCR</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_HPCR</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_CR</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>P_CR</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_CR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HCR</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_CR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>H2CR</ci>
            <apply>
               <times/>
               <ci>HCR</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_CR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_CR</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  <ci>HCR</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>H2CR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgCRdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_CR</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_CR</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_CR</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_CR</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_HCR</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_G1P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.09</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_G1P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.48</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_G1P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_G1P</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_G1P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UG1P</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_G1P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HG1P</ci>
            <apply>
               <times/>
               <ci>UG1P</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_G1P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
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            <eq/>
            <ci>mgG1P</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
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                     <times/>
                     <ci>UG1P</ci>
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                  </apply>
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                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_G1P</ci>
               </apply>
            </apply>
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            <eq/>
            <ci>Navg_G1P</ci>
            <ci>HG1P</ci>
         </apply>
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            <eq/>
            <ci>dNavgG1PdH</ci>
            <apply>
               <divide/>
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                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_G1P</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_G1P</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_G1P</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_G1P</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
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            <eq/>
            <ci>NH_UG1P</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
         </apply>
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            <eq/>
            <ci>deltaGof_UG1P</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1756.87</cn>
            </apply>
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            <eq/>
            <ci>deltaGpof_UG1P</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UG1P</ci>
                  <apply>
                     <times/>
                     <ci>NH_UG1P</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_UG1P</ci>
                  </apply>
               </apply>
            </apply>
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            <eq/>
            <ci>pKa1_G6P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.11</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
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                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
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                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
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            <eq/>
            <ci>P_G6P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_G6P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UG6P</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_G6P</ci>
            </apply>
         </apply>
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            <eq/>
            <ci>HG6P</ci>
            <apply>
               <times/>
               <ci>UG6P</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_G6P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_G6P</ci>
            <ci>HG6P</ci>
         </apply>
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            <eq/>
            <ci>dNavgG6PdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_G6P</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_G6P</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_G6P</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_G6P</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgG6Pdmg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_molar">0</cn>
         </apply>
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            <eq/>
            <ci>NH_UG6P</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_UG6P</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1763.94</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_UG6P</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UG6P</ci>
                  <apply>
                     <times/>
                     <ci>NH_UG6P</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_UG6P</ci>
                  </apply>
               </apply>
            </apply>
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            <eq/>
            <ci>pKa1_F6P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.89</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
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                     <minus/>
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                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_F6P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_F6P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UF6P</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_F6P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HF6P</ci>
            <apply>
               <times/>
               <ci>UF6P</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_F6P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_F6P</ci>
            <ci>HF6P</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgF6PdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_F6P</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_F6P</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_F6P</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_F6P</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_UF6P</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_UF6P</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1760.8</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_UF6P</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UF6P</ci>
                  <apply>
                     <times/>
                     <ci>NH_UF6P</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
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                     <ci>pH_cy</ci>
                  </apply>
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                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_UF6P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
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            <eq/>
            <ci>pKa1_FDP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.4</cn>
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         <apply>
            <eq/>
            <ci>pKamg_FDP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.7</cn>
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            <eq/>
            <ci>P_FDP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_FDP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_FDP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UFDP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_FDP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HFDP</ci>
            <apply>
               <times/>
               <ci>UFDP</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_FDP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgFDP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>UFDP</ci>
                     <ci>mg</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_FDP</ci>
               </apply>
            </apply>
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            <eq/>
            <ci>Navg_FDP</ci>
            <ci>HFDP</ci>
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            <eq/>
            <ci>dNavgFDPdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_FDP</ci>
                  </apply>
                  <ci>P_FDP</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>HFDP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_FDP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_UFDP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
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         <apply>
            <eq/>
            <ci>deltaGof_UFDP</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">2601.4</cn>
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         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_UFDP</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UFDP</ci>
                  <apply>
                     <times/>
                     <ci>NH_UFDP</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
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                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">16</cn>
                     <ci>NH_UFDP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_GAP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.45</cn>
         </apply>
         <apply>
            <eq/>
            <ci>P_GAP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_GAP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UGAP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_GAP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HGAP</ci>
            <apply>
               <times/>
               <ci>UGAP</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_GAP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_GAP</ci>
            <ci>HGAP</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgGAPdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_GAP</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_GAP</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_GAP</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_GAP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgGAPdmg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_molar">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>NH_UGAP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_UGAP</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1288.6</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_UGAP</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UGAP</ci>
                  <apply>
                     <times/>
                     <ci>NH_UGAP</ci>
                     <apply>
                        <ln/>
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                  <ci>IcorrdeltaGpof</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_UGAP</ci>
                  </apply>
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            <eq/>
            <ci>pKamg_G3P</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.63</cn>
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            <ci>pKa1_G3P</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.22</cn>
               <apply>
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                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
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                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
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                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
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            <eq/>
            <ci>P_G3P</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
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                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_G3P</ci>
                  </apply>
               </apply>
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                     <divide/>
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                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_G3P</ci>
                  </apply>
               </apply>
            </apply>
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            <eq/>
            <ci>UG3P</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_G3P</ci>
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            <eq/>
            <ci>HG3P</ci>
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               <times/>
               <ci>UG3P</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_G3P</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
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            <eq/>
            <ci>mgG3P</ci>
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               <times/>
               <apply>
                  <divide/>
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                     <times/>
                     <ci>UG3P</ci>
                     <ci>mg</ci>
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                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_G3P</ci>
               </apply>
            </apply>
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            <eq/>
            <ci>Navg_G3P</ci>
            <ci>HG3P</ci>
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            <eq/>
            <ci>dNavgG3PdH</ci>
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               <divide/>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_G3P</ci>
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                     <ci>P_G3P</ci>
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                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_G3P</ci>
                        </apply>
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                  <times/>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
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            <eq/>
            <ci>NH_UG3P</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
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            <eq/>
            <ci>deltaGof_UG3P</ci>
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               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1339.25</cn>
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            <eq/>
            <ci>deltaGpof_UG3P</ci>
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                        <ln/>
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                  <ci>IcorrdeltaGpof</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_UG3P</ci>
                  </apply>
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            <eq/>
            <ci>pKa1_DHAP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.9</cn>
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            <eq/>
            <ci>pKamg_DHAP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.57</cn>
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            <eq/>
            <ci>P_DHAP</ci>
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               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
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                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
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                     <ci>pKa1_DHAP</ci>
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                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_DHAP</ci>
                  </apply>
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            <eq/>
            <ci>UDHAP</ci>
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               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_DHAP</ci>
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            <eq/>
            <ci>HDHAP</ci>
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               <ci>UDHAP</ci>
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                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
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                     <ci>pKa1_DHAP</ci>
                  </apply>
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            <eq/>
            <ci>mgDHAP</ci>
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               <times/>
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                  <divide/>
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                  <ci>pKamg_DHAP</ci>
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               <divide/>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_DHAP</ci>
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                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
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                           <ci>pKa1_DHAP</ci>
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            <eq/>
            <ci>NH_UDHAP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
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            <eq/>
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               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1296.26</cn>
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                  <ci>IcorrdeltaGpof</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_UDHAP</ci>
                  </apply>
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            <eq/>
            <ci>pKa1_13DPG</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7.5</cn>
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            <eq/>
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               <plus/>
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                  <apply>
                     <plus/>
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                        <minus/>
                        <ci>pH_cy</ci>
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                     <ci>pKa1_13DPG</ci>
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            <eq/>
            <ci>U13DPG</ci>
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               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_13DPG</ci>
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            <eq/>
            <ci>H13DPG</ci>
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               <times/>
               <ci>U13DPG</ci>
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                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
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                        <minus/>
                        <ci>pH_cy</ci>
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                     <ci>pKa1_13DPG</ci>
                  </apply>
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            <eq/>
            <ci>Navg_13DPG</ci>
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            <eq/>
            <ci>dNavg13DPGdH</ci>
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                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_13DPG</ci>
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                  <apply>
                     <minus/>
                     <ci>P_13DPG</ci>
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                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
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                           <ci>pKa1_13DPG</ci>
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                  <ci>c0</ci>
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                     <ci>P_13DPG</ci>
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            <eq/>
            <ci>NH_U13DPG</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
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            <eq/>
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               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">2356.14</cn>
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                  <ci>IcorrdeltaGpof</ci>
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                     <ci>NH_U13DPG</ci>
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            <eq/>
            <ci>pKa1_3PG</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.21</cn>
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               <plus/>
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                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.21</cn>
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            <eq/>
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               <divide/>
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            <eq/>
            <ci>H3PG</ci>
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                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.21</cn>
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            <eq/>
            <ci>Navg_3PG</ci>
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            <eq/>
            <ci>dNavg3PGdH</ci>
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               <divide/>
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                  <apply>
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                     <ci>pKa1_3PG</ci>
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                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
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                              <ci>pH_cy</ci>
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                           <ci>pKa1_3PG</ci>
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            <eq/>
            <ci>NH_U3PG</ci>
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            <eq/>
            <ci>deltaGof_U3PG</ci>
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               <minus/>
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            <eq/>
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               <minus/>
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                        <ln/>
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                     <ci>NH_U3PG</ci>
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            <eq/>
            <ci>pKa1_2PG</ci>
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            <eq/>
            <ci>pKamg_2PG</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.45</cn>
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            <eq/>
            <ci>pKak_2PG</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.18</cn>
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            <eq/>
            <ci>P_2PG</ci>
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               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
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                     <ci>pKa1_2PG</ci>
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               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
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                  <apply>
                     <power/>
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                     <ci>pKamg_2PG</ci>
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               </apply>
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                  <times/>
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                     <divide/>
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                  <apply>
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                     <ci>pKak_2PG</ci>
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               </apply>
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            <eq/>
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            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_2PG</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>H2PG</ci>
            <apply>
               <times/>
               <ci>U2PG</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_2PG</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mg2PG</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>U2PG</ci>
                     <ci>mg</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_2PG</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k2PG</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>U2PG</ci>
                     <ci>k</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKak_2PG</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_2PG</ci>
            <ci>H2PG</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavg2PGdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_2PG</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_2PG</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_2PG</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_2PG</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_U2PG</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_U2PG</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1496.38</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_U2PG</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_U2PG</ci>
                  <apply>
                     <times/>
                     <ci>NH_U2PG</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9</cn>
                     <ci>NH_U2PG</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_PEP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.35</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_PEP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.26</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKak_PEP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.08</cn>
         </apply>
         <apply>
            <eq/>
            <ci>P_PEP</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <minus/>
                     <ci>pKa1_PEP</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_PEP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>k</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKak_PEP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UPEP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_PEP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HPEP</ci>
            <apply>
               <times/>
               <ci>UPEP</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <minus/>
                     <ci>pKa1_PEP</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kPEP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>UPEP</ci>
                     <ci>k</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKak_PEP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgPEP</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>UPEP</ci>
                     <ci>mg</ci>
                  </apply>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_PEP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_PEP</ci>
            <ci>HPEP</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgPEPdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_PEP</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_PEP</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_PEP</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_PEP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_UPEP</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_UPEP</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">1263.65</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_UPEP</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UPEP</ci>
                  <apply>
                     <times/>
                     <ci>NH_UPEP</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9</cn>
                     <ci>NH_UPEP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_PYR</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.49</cn>
         </apply>
         <apply>
            <eq/>
            <ci>P_PYR</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_PYR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>UPYR</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_PYR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HPYR</ci>
            <apply>
               <times/>
               <ci>UPYR</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_PYR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_PYR</ci>
            <ci>HPYR</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgPYRdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_PYR</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_PYR</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_PYR</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_PYR</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgPYRdmg</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_molar">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>NH_UPYR</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_UPYR</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">472.27</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_UPYR</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_UPYR</ci>
                  <apply>
                     <times/>
                     <ci>NH_UPYR</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>NH_UPYR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pKamg_LAC</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.98</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pKa1_LAC</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.67</cn>
               <apply>
                  <times/>
                  <ci>IcorrpKa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_LAC</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_LAC</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKamg_LAC</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ULAC</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>P_LAC</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>HLAC</ci>
            <apply>
               <times/>
               <ci>ULAC</ci>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                     <ci>pKa1_LAC</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mgLAC</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>mg</ci>
                  <ci>c0</ci>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <ci>pKamg_LAC</ci>
               </apply>
               <ci>ULAC</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Navg_LAC</ci>
            <ci>HLAC</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNavgLACdH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <ci>pKa1_LAC</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>P_LAC</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                           <ci>pKa1_LAC</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>c0</ci>
                  <apply>
                     <power/>
                     <ci>P_LAC</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dmgLACdmg</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_LAC</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                           <ci>pKamg_LAC</ci>
                        </apply>
                     </apply>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>mg</ci>
                           <ci>c0</ci>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>pKamg_LAC</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>c0</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>P_LAC</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dmgLACdpH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>mg</ci>
                     <ci>c0</ci>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                        <ci>pKa1_LAC</ci>
                        <ci>pKamg_LAC</ci>
                     </apply>
                  </apply>
                  <apply>
                     <ln/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>P_LAC</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_ULAC</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_ULAC</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">516.72</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_ULAC</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_ULAC</ci>
                  <apply>
                     <times/>
                     <ci>NH_ULAC</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>NH_ULAC</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNH_GLY</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_GLY</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">655.7</cn>
               <apply>
                  <times/>
                  <ci>dNH_GLY</ci>
                  <apply>
                     <ln/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
                  <ci>pH_cy</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_NAD</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">26</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_NAD</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_NAD</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_NAD</ci>
                  <apply>
                     <times/>
                     <ci>NH_NAD</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>NH_NAD</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_NADH</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">27</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_NADH</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">22.65</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_NADH</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_NADH</ci>
                  <apply>
                     <times/>
                     <ci>NH_NADH</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>NH_NADH</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_H2O</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_H2O</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">237.19</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_H2O</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGof_H2O</ci>
                  <apply>
                     <times/>
                     <ci>NH_H2O</ci>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                     <ci>R</ci>
                     <ci>T</ci>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrdeltaGpof</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                     <ci>NH_H2O</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>NH_H</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGof_H</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kilojoule_per_mole">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpof_H</ci>
            <apply>
               <plus/>
               <ci>deltaGof_H</ci>
               <apply>
                  <times/>
                  <ci>NH_H</ci>
                  <apply>
                     <ln/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
                  <ci>pH_cy</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_CK</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>Navg_ATP</ci>
                        <ci>Navg_CR</ci>
                     </apply>
                     <ci>Navg_PCR</ci>
                  </apply>
                  <ci>Navg_ADP</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>NH_ATP4</ci>
                        <ci>NH_HCR</ci>
                     </apply>
                     <ci>NH_HPCR</ci>
                  </apply>
                  <ci>NH_ADP3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>slopeint_1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="kelvin">2.04742110212706</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>slopeint_2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.013838383371953</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kref_CKT</ci>
            <apply>
               <exp/>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <ci>slopeint_1</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>slopeint_2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I25</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">0.25</cn>
         </apply>
         <apply>
            <eq/>
            <ci>alphadebye1</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.10708</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_kelvin">1.54508   <sep/>
                     -3</cn>
                     <ci>T</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_kelvin2">5.95584   <sep/>
                  -6</cn>
                  <apply>
                     <power/>
                     <ci>T</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IcorrneglnKrefCK</ci>
            <apply>
               <times/>
               <ci>alphadebye1</ci>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <root/>
                        <ci>I25</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="half_molar">1</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.6</cn>
                           <apply>
                              <root/>
                              <ci>I25</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <root/>
                        <ci>I</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="half_molar">1</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.6</cn>
                           <apply>
                              <root/>
                              <ci>I</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>neglnKrefCK_Iexp</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <ln/>
                     <ci>Kref_CKT</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>IcorrneglnKrefCK</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <power/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              </apply>
                              <apply>
                                 <power/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              </apply>
                           </apply>
                           <apply>
                              <power/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kref_CK</ci>
            <apply>
               <exp/>
               <apply>
                  <minus/>
                  <ci>neglnKrefCK_Iexp</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_CK</ci>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>R</ci>
               </apply>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <ci>Kref_CK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_CK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_CK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
                  <ci>P_ATP</ci>
                  <ci>P_CR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>P_PCR</ci>
                  <ci>P_ADP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_ADK</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>Navg_ADP</ci>
                     </apply>
                     <ci>Navg_ATP</ci>
                  </apply>
                  <ci>Navg_AMP</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>NH_ADP3</ci>
                     </apply>
                     <ci>NH_ATP4</ci>
                  </apply>
                  <ci>NH_AMP2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_ADK</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>deltaGpof_ADP3</ci>
                  </apply>
                  <ci>deltaGpof_ATP4</ci>
               </apply>
               <ci>deltaGpof_AMP2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_ADK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_ADK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <ci>P_ADP</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>P_ATP</ci>
                  <ci>P_AMP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_GP</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_G1P</ci>
                  <ci>Navg_Pi</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>NH_HPi2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_GP</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGpo_GLY</ci>
                  <ci>deltaGpof_UG1P</ci>
               </apply>
               <ci>deltaGpof_HPi2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_GP</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_GP</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_G1P</ci>
               </apply>
               <ci>P_Pi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_PGLM</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_G6P</ci>
                  <ci>Navg_G1P</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>NH_UG6P</ci>
                  <ci>NH_UG1P</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_PGLM</ci>
            <apply>
               <minus/>
               <ci>deltaGpof_UG6P</ci>
               <ci>deltaGpof_UG1P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_PGLM</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_PGLM</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_G6P</ci>
               </apply>
               <ci>P_G1P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_PGI</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_F6P</ci>
                  <ci>Navg_G6P</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>NH_UF6P</ci>
                  <ci>NH_UG6P</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_PGI</ci>
            <apply>
               <minus/>
               <ci>deltaGpof_UF6P</ci>
               <ci>deltaGpof_UG6P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_PGI</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_PGI</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_F6P</ci>
               </apply>
               <ci>P_G6P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_PFK</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>Navg_ADP</ci>
                              <ci>Navg_FDP</ci>
                           </apply>
                           <ci>Navg_F6P</ci>
                        </apply>
                        <ci>Navg_ATP</ci>
                     </apply>
                     <ci>NH_ADP3</ci>
                     <ci>NH_UFDP</ci>
                  </apply>
                  <ci>NH_UF6P</ci>
               </apply>
               <ci>NH_ATP4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_PFK</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>deltaGpof_UFDP</ci>
                     <ci>deltaGpof_ADP3</ci>
                     <ci>deltaGpof_H</ci>
                  </apply>
                  <ci>deltaGpof_UF6P</ci>
               </apply>
               <ci>deltaGpof_ATP4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_PFK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_PFK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_FDP</ci>
                  <ci>P_ADP</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>P_F6P</ci>
                  <ci>P_ATP</ci>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_ALD</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>Navg_DHAP</ci>
                     <ci>Navg_GAP</ci>
                  </apply>
                  <ci>Navg_FDP</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>NH_UDHAP</ci>
                     <ci>NH_UGAP</ci>
                  </apply>
                  <ci>NH_UFDP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_ALD</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGpof_UDHAP</ci>
                  <ci>deltaGpof_UGAP</ci>
               </apply>
               <ci>deltaGpof_UFDP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_ALD</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_ALD</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_GAP</ci>
                  <ci>P_FDP</ci>
               </apply>
               <ci>P_DHAP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_TPI</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_DHAP</ci>
                  <ci>Navg_GAP</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>NH_UDHAP</ci>
                  <ci>NH_UGAP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_TPI</ci>
            <apply>
               <minus/>
               <ci>deltaGpof_UDHAP</ci>
               <ci>deltaGpof_UGAP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_TPI</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_TPI</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_DHAP</ci>
               </apply>
               <ci>P_GAP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_GAPDH</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <ci>Navg_13DPG</ci>
                     <ci>Navg_GAP</ci>
                  </apply>
                  <ci>Navg_Pi</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>NH_U13DPG</ci>
                           <ci>NH_NADH</ci>
                        </apply>
                        <ci>NH_UGAP</ci>
                     </apply>
                     <ci>NH_HPi2</ci>
                  </apply>
                  <ci>NH_NAD</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_GAPDH</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>deltaGpof_U13DPG</ci>
                        <ci>deltaGpof_NADH</ci>
                        <ci>deltaGpof_H</ci>
                     </apply>
                     <ci>deltaGpof_HPi2</ci>
                  </apply>
                  <ci>deltaGpof_UGAP</ci>
               </apply>
               <ci>deltaGpof_NAD</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_GAPDH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_GAPDH</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_13DPG</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>P_Pi</ci>
                  <ci>P_GAP</ci>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_G3PDH</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_DHAP</ci>
                  <ci>Navg_G3P</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>NH_UDHAP</ci>
                        <ci>NH_NADH</ci>
                     </apply>
                     <ci>NH_NAD</ci>
                  </apply>
                  <ci>NH_UG3P</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_G3PDH</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>deltaGpof_H</ci>
                     <ci>deltaGpof_NADH</ci>
                     <ci>deltaGpof_UDHAP</ci>
                  </apply>
                  <ci>deltaGpof_NAD</ci>
               </apply>
               <ci>deltaGpof_UG3P</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_G3PDH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_G3PDH</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_DHAP</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>P_G3P</ci>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_PGK</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>Navg_3PG</ci>
                        <ci>Navg_ATP</ci>
                     </apply>
                     <ci>Navg_13DPG</ci>
                  </apply>
                  <ci>Navg_ADP</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>NH_U3PG</ci>
                        <ci>NH_ATP4</ci>
                     </apply>
                     <ci>NH_U13DPG</ci>
                  </apply>
                  <ci>NH_ADP3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_PGK</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>deltaGpof_ATP4</ci>
                     <ci>deltaGpof_U3PG</ci>
                  </apply>
                  <ci>deltaGpof_U13DPG</ci>
               </apply>
               <ci>deltaGpof_ADP3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_PGK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_PGK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_ATP</ci>
                  <ci>P_3PG</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>P_13DPG</ci>
                  <ci>P_ADP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_PGM</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_2PG</ci>
                  <ci>Navg_3PG</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>NH_U2PG</ci>
                  <ci>NH_U3PG</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_PGM</ci>
            <apply>
               <minus/>
               <ci>deltaGpof_U2PG</ci>
               <ci>deltaGpof_U3PG</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_PGM</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_PGM</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_2PG</ci>
               </apply>
               <ci>P_3PG</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_ENOL</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_PEP</ci>
                  <ci>Navg_2PG</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>NH_H2O</ci>
                     <ci>NH_UPEP</ci>
                  </apply>
                  <ci>NH_U2PG</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_ENOL</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>deltaGpof_H2O</ci>
                  <ci>deltaGpof_UPEP</ci>
               </apply>
               <ci>deltaGpof_U2PG</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_ENOL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_ENOL</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_PEP</ci>
               </apply>
               <ci>P_2PG</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_PK</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>Navg_PYR</ci>
                        <ci>Navg_ATP</ci>
                     </apply>
                     <ci>Navg_PEP</ci>
                  </apply>
                  <ci>Navg_ADP</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>NH_UPYR</ci>
                        <ci>NH_ATP4</ci>
                     </apply>
                     <ci>NH_UPEP</ci>
                  </apply>
                  <ci>NH_ADP3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_PK</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>deltaGpof_UPYR</ci>
                        <ci>deltaGpof_ATP4</ci>
                     </apply>
                     <ci>deltaGpof_H</ci>
                  </apply>
                  <ci>deltaGpof_UPEP</ci>
               </apply>
               <ci>deltaGpof_ADP3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_PK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_PK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_PYR</ci>
                  <ci>P_ATP</ci>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>P_PEP</ci>
                  <ci>P_ADP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_LDH</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>Navg_LAC</ci>
                  <ci>Navg_PYR</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>NH_ULAC</ci>
                        <ci>NH_NAD</ci>
                     </apply>
                     <ci>NH_UPYR</ci>
                  </apply>
                  <ci>NH_NADH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_LDH</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>deltaGpof_ULAC</ci>
                        <ci>deltaGpof_NAD</ci>
                     </apply>
                     <ci>deltaGpof_UPYR</ci>
                  </apply>
                  <ci>deltaGpof_NADH</ci>
               </apply>
               <ci>deltaGpof_H</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_LDH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_LDH</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_LAC</ci>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>P_PYR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaH_ATPase</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>Navg_ADP</ci>
                     <ci>Navg_Pi</ci>
                  </apply>
                  <ci>Navg_ATP</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>NH_ADP3</ci>
                        <ci>NH_HPi2</ci>
                     </apply>
                     <ci>NH_ATP4</ci>
                  </apply>
                  <ci>NH_H2O</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>deltaGpo_ATPase</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>deltaGpof_ADP3</ci>
                     <ci>deltaGpof_HPi2</ci>
                     <ci>deltaGpof_H</ci>
                  </apply>
                  <ci>deltaGpof_H2O</ci>
               </apply>
               <ci>deltaGpof_ATP4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kapp_ATPase</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>deltaGpo_ATPase</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>P_ADP</ci>
                  <ci>P_Pi</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>P_ATP</ci>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="glycogen_phosphorylase_A">
      <variable name="Dglya" public_interface="out" units="dimensionless"/>
      <variable name="pa" public_interface="out" units="dimensionless"/>
      <variable name="VbglyA" public_interface="out" units="molar_per_minute"/>
      <variable name="glyAF" public_interface="out" units="per_minute"/>
      <variable name="glyAR" public_interface="out" units="per_minute"/>
      <variable name="flux_GPa" public_interface="out" units="molar_per_minute"/>
      <variable name="KgpA_glyf" public_interface="in" units="molar"/>
      <variable name="KgpA_glyb" public_interface="in" units="molar"/>
      <variable name="KgpA_igly" public_interface="in" units="molar"/>
      <variable name="KgpA_pi" public_interface="in" units="molar"/>
      <variable name="KgpA_ipi" public_interface="in" units="molar"/>
      <variable name="KgpA_g1p" public_interface="in" units="molar"/>
      <variable name="KgpA_ig1p" public_interface="in" units="molar"/>
      <variable name="Vfgly" public_interface="in" units="molar_per_minute"/>
      <variable name="fracA" public_interface="in" units="dimensionless"/>
      <variable name="Gly" public_interface="in" units="molar"/>
      <variable name="Pi" public_interface="in" units="molar"/>
      <variable name="G1P" public_interface="in" units="molar"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Kapp_GP" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Dglya</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <divide/>
                  <ci>Gly</ci>
                  <ci>KgpA_glyf</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>Pi</ci>
                  <ci>KgpA_pi</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Gly</ci>
                     <ci>Pi</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpA_glyf</ci>
                     <ci>KgpA_ipi</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>Gly</ci>
                  <ci>KgpA_glyb</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>G1P</ci>
                  <ci>KgpA_g1p</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Gly</ci>
                     <ci>G1P</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpA_ig1p</ci>
                     <ci>KgpA_glyb</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pa</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.404</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.94</cn>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7.29</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>VbglyA</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pa</ci>
                  <ci>Vfgly</ci>
                  <ci>KgpA_glyb</ci>
                  <ci>KgpA_ig1p</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>KgpA_igly</ci>
                  <ci>KgpA_pi</ci>
                  <ci>Kapp_GP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>glyAF</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>pa</ci>
                     <ci>Vfgly</ci>
                     <ci>Pi</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpA_igly</ci>
                     <ci>KgpA_pi</ci>
                  </apply>
               </apply>
               <ci>Dglya</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>glyAR</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>VbglyA</ci>
                     <ci>Gly</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpA_glyb</ci>
                     <ci>KgpA_ig1p</ci>
                  </apply>
               </apply>
               <ci>Dglya</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>flux_GPa</ci>
            <apply>
               <times/>
               <ci>fracA</ci>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Gly</ci>
                     <ci>glyAF</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>G1P</ci>
                     <ci>glyAR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="glycogen_phosphorylase_B">
      <variable name="fracB" public_interface="out" units="dimensionless"/>
      <variable name="M" public_interface="out" units="dimensionless"/>
      <variable name="Dglyb" public_interface="out" units="dimensionless"/>
      <variable name="pb" public_interface="out" units="dimensionless"/>
      <variable name="VbglyB" public_interface="out" units="molar_per_minute"/>
      <variable name="glyBF" public_interface="out" units="per_minute"/>
      <variable name="glyBR" public_interface="out" units="per_minute"/>
      <variable name="flux_GPb" public_interface="out" units="molar_per_minute"/>
      <variable name="fracA" public_interface="in" units="dimensionless"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="AMP" public_interface="in" units="molar"/>
      <variable name="Gly" public_interface="in" units="molar"/>
      <variable name="Pi" public_interface="in" units="molar"/>
      <variable name="G1P" public_interface="in" units="molar"/>
      <variable name="Kapp_GP" public_interface="in" units="dimensionless"/>
      <variable name="nH" public_interface="in" units="dimensionless"/>
      <variable name="Vfgly" public_interface="in" units="molar_per_minute"/>
      <variable name="Kgp_amp" public_interface="in" units="molar"/>
      <variable name="KgpB_iglyf" public_interface="in" units="molar"/>
      <variable name="KgpB_iglyb" public_interface="in" units="molar"/>
      <variable name="KgpB_pi" public_interface="in" units="molar"/>
      <variable name="KgpB_ipi" public_interface="in" units="molar"/>
      <variable name="KgpB_g1p" public_interface="in" units="molar"/>
      <variable name="KgpB_ig1p" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fracB</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>fracA</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>M</ci>
            <apply>
               <divide/>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>AMP</ci>
                     <ci>Kgp_amp</ci>
                  </apply>
                  <ci>nH</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>AMP</ci>
                        <ci>Kgp_amp</ci>
                     </apply>
                     <ci>nH</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Dglyb</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <divide/>
                  <ci>Gly</ci>
                  <ci>KgpB_iglyf</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>Pi</ci>
                  <ci>KgpB_ipi</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>Gly</ci>
                  <ci>KgpB_iglyb</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>G1P</ci>
                  <ci>KgpB_ig1p</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Gly</ci>
                     <ci>Pi</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpB_iglyf</ci>
                     <ci>KgpB_pi</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Gly</ci>
                     <ci>G1P</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpB_g1p</ci>
                     <ci>KgpB_iglyb</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pb</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.75</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.12</cn>
                        <ci>pH_cy</ci>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7.03</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>VbglyB</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pb</ci>
                  <ci>Vfgly</ci>
                  <ci>KgpB_g1p</ci>
                  <ci>KgpB_iglyb</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>KgpB_iglyf</ci>
                  <ci>KgpB_pi</ci>
                  <ci>Kapp_GP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>glyBF</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>pb</ci>
                     <ci>M</ci>
                     <ci>Vfgly</ci>
                     <ci>Pi</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpB_iglyf</ci>
                     <ci>KgpB_pi</ci>
                  </apply>
               </apply>
               <ci>Dglyb</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>glyBR</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>M</ci>
                     <ci>VbglyB</ci>
                     <ci>Gly</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>KgpB_g1p</ci>
                     <ci>KgpB_iglyb</ci>
                  </apply>
               </apply>
               <ci>Dglyb</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>flux_GPb</ci>
            <apply>
               <times/>
               <ci>fracB</ci>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Gly</ci>
                     <ci>glyBF</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>G1P</ci>
                     <ci>glyBR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="PGLM">
      <variable name="Vfpglm" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbpglm" public_interface="out" units="molar_per_minute"/>
      <variable name="v_PGLM" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffpglm" public_interface="in" units="molar_per_minute"/>
      <variable name="Kpglm_g1p" public_interface="in" units="molar"/>
      <variable name="Kpglm_g6p" public_interface="in" units="molar"/>
      <variable name="Kapp_PGLM" public_interface="in" units="dimensionless"/>
      <variable name="G1P" public_interface="in" units="molar"/>
      <variable name="G6P" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfpglm</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vffpglm</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.329</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.64</cn>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8.36</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbpglm</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfpglm</ci>
                  <ci>Kpglm_g6p</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpglm_g1p</ci>
                  <ci>Kapp_PGLM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_PGLM</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfpglm</ci>
                        <ci>G1P</ci>
                     </apply>
                     <ci>Kpglm_g1p</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbpglm</ci>
                        <ci>G6P</ci>
                     </apply>
                     <ci>Kpglm_g6p</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>G1P</ci>
                     <ci>Kpglm_g1p</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>G6P</ci>
                     <ci>Kpglm_g6p</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="PGI">
      <variable name="Vbpgi" public_interface="out" units="molar_per_minute"/>
      <variable name="Vfpgi" public_interface="out" units="molar_per_minute"/>
      <variable name="v_PGI" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vbbpgi" public_interface="in" units="molar_per_minute"/>
      <variable name="Kpgi_g6p" public_interface="in" units="molar"/>
      <variable name="Kpgi_f6p" public_interface="in" units="molar"/>
      <variable name="Kapp_PGI" public_interface="in" units="dimensionless"/>
      <variable name="G6P" public_interface="in" units="molar"/>
      <variable name="F6P" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vbpgi</ci>
            <apply>
               <divide/>
               <ci>Vbbpgi</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.94</cn>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9.35</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vfpgi</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Vbpgi</ci>
                     <ci>Kpgi_g6p</ci>
                  </apply>
                  <ci>Kpgi_f6p</ci>
               </apply>
               <ci>Kapp_PGI</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_PGI</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfpgi</ci>
                        <ci>G6P</ci>
                     </apply>
                     <ci>Kpgi_g6p</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbpgi</ci>
                        <ci>F6P</ci>
                     </apply>
                     <ci>Kpgi_f6p</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>F6P</ci>
                     <ci>Kpgi_f6p</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>G6P</ci>
                     <ci>Kpgi_g6p</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="PFK">
      <variable name="Vfpfk" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbpfk" public_interface="out" units="molar_per_minute"/>
      <variable name="L" public_interface="out" units="dimensionless"/>
      <variable name="alpha" public_interface="out" units="dimensionless"/>
      <variable name="Delta" public_interface="out" units="dimensionless"/>
      <variable name="Deltap" public_interface="out" units="dimensionless"/>
      <variable name="v_PFK" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Lo" public_interface="in" units="dimensionless"/>
      <variable name="d" public_interface="in" units="dimensionless"/>
      <variable name="Vffpfk" public_interface="in" units="molar_per_minute"/>
      <variable name="Kpfk_fbp" public_interface="in" units="molar"/>
      <variable name="Kpfk_adp" public_interface="in" units="molar"/>
      <variable name="Kpfk_f6p" public_interface="in" units="molar"/>
      <variable name="Kpfk_atp" public_interface="in" units="molar"/>
      <variable name="Kpfk_fbpT" public_interface="in" units="molar"/>
      <variable name="Kpfk_adpT" public_interface="in" units="molar"/>
      <variable name="Kpfk_f6pT" public_interface="in" units="molar"/>
      <variable name="Kpfk_atpT" public_interface="in" units="molar"/>
      <variable name="Kapp_PFK" public_interface="in" units="dimensionless"/>
      <variable name="Kmpfk" public_interface="in" units="molar"/>
      <variable name="Kpfki" public_interface="in" units="molar"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <variable name="AMP" public_interface="in" units="molar"/>
      <variable name="F6P" public_interface="in" units="molar"/>
      <variable name="FBP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfpfk</ci>
            <apply>
               <divide/>
               <ci>Vffpfk</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.8</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">30</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbpfk</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfpfk</ci>
                  <ci>Kpfk_fbp</ci>
                  <ci>Kpfk_adp</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpfk_f6p</ci>
                  <ci>Kpfk_atp</ci>
                  <ci>Kapp_PFK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>L</ci>
            <apply>
               <times/>
               <ci>Lo</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <apply>
                                 <divide/>
                                 <ci>ATP</ci>
                                 <ci>Kpfki</ci>
                              </apply>
                           </apply>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <ci>d</ci>
                                    <ci>ATP</ci>
                                 </apply>
                                 <ci>Kpfki</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <exponentiale/>
                                 <ci>AMP</ci>
                              </apply>
                              <ci>Kmpfk</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>AMP</ci>
                           <ci>Kmpfk</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Kpfk_f6p</ci>
                  <ci>Kpfk_atp</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpfk_f6pT</ci>
                  <ci>Kpfk_atpT</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Delta</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>F6P</ci>
                        <ci>Kpfk_f6p</ci>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>ATP</ci>
                        <ci>Kpfk_atp</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>FBP</ci>
                  <ci>Kpfk_fbp</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>ADP</ci>
                     <ci>Kpfk_adp</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>FBP</ci>
                        <ci>Kpfk_fbp</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Deltap</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>F6P</ci>
                        <ci>Kpfk_f6pT</ci>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>ATP</ci>
                        <ci>Kpfk_atpT</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>FBP</ci>
                  <ci>Kpfk_fbpT</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>ADP</ci>
                     <ci>Kpfk_adpT</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>FBP</ci>
                        <ci>Kpfk_fbpT</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_PFK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>Vfpfk</ci>
                              <ci>F6P</ci>
                              <ci>ATP</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>Kpfk_f6p</ci>
                              <ci>Kpfk_atp</ci>
                           </apply>
                        </apply>
                        <ci>Delta</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>Vbpfk</ci>
                              <ci>ADP</ci>
                              <ci>FBP</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>Kpfk_adp</ci>
                              <ci>Kpfk_fbp</ci>
                           </apply>
                        </apply>
                        <ci>Delta</ci>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>alpha</ci>
                        <ci>L</ci>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Deltap</ci>
                              <ci>Delta</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <ci>L</ci>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Deltap</ci>
                           <ci>Delta</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ALD">
      <variable name="Vfald" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbald" public_interface="out" units="molar_per_minute"/>
      <variable name="v_ALD" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffald" public_interface="in" units="molar_per_minute"/>
      <variable name="Kald_gap" public_interface="in" units="molar"/>
      <variable name="Kald_fbp" public_interface="in" units="molar"/>
      <variable name="Kald_dhap" public_interface="in" units="molar"/>
      <variable name="Kapp_ALD" public_interface="in" units="dimensionless"/>
      <variable name="FBP" public_interface="in" units="molar"/>
      <variable name="GAP" public_interface="in" units="molar"/>
      <variable name="DHAP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfald</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vffald</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.013</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.32</cn>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9.15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbald</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfald</ci>
                  <ci>Kald_gap</ci>
                  <ci>Kald_dhap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kald_fbp</ci>
                  <ci>Kapp_ALD</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_ALD</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfald</ci>
                        <ci>FBP</ci>
                     </apply>
                     <ci>Kald_fbp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbald</ci>
                        <ci>GAP</ci>
                        <ci>DHAP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kald_gap</ci>
                        <ci>Kald_dhap</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>FBP</ci>
                     <ci>Kald_fbp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>GAP</ci>
                     <ci>Kald_gap</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>DHAP</ci>
                     <ci>Kald_dhap</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="TPI">
      <variable name="Vftpi" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbtpi" public_interface="out" units="molar_per_minute"/>
      <variable name="v_TPI" public_interface="out" units="molar_per_minute"/>
      <variable name="Vfftpi" public_interface="in" units="molar_per_minute"/>
      <variable name="Ktpi_dhap" public_interface="in" units="molar"/>
      <variable name="Ktpi_gap" public_interface="in" units="molar"/>
      <variable name="Kapp_TPI" public_interface="in" units="dimensionless"/>
      <variable name="GAP" public_interface="in" units="molar"/>
      <variable name="DHAP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vftpi</ci>
            <ci>Vfftpi</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Vbtpi</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vftpi</ci>
                  <ci>Ktpi_dhap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Ktpi_gap</ci>
                  <ci>Kapp_TPI</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_TPI</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vftpi</ci>
                        <ci>GAP</ci>
                     </apply>
                     <ci>Ktpi_gap</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbtpi</ci>
                        <ci>DHAP</ci>
                     </apply>
                     <ci>Ktpi_dhap</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>GAP</ci>
                     <ci>Ktpi_gap</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>DHAP</ci>
                     <ci>Ktpi_dhap</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="G3PDH">
      <variable name="Dg3pdh" public_interface="out" units="dimensionless"/>
      <variable name="Vbg3pdh" public_interface="out" units="molar_per_minute"/>
      <variable name="Vfg3pdh" public_interface="out" units="molar_per_minute"/>
      <variable name="v_G3PDH" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbbg3pdh" public_interface="in" units="molar_per_minute"/>
      <variable name="Kg3pdh_dhap" public_interface="in" units="molar"/>
      <variable name="Kg3pdh_g3p" public_interface="in" units="molar"/>
      <variable name="Kg3pdh_nadh" public_interface="in" units="molar"/>
      <variable name="Kg3pdh_nad" public_interface="in" units="molar"/>
      <variable name="Kapp_G3PDH" public_interface="in" units="dimensionless"/>
      <variable name="G3P" public_interface="in" units="molar"/>
      <variable name="NADH" public_interface="in" units="molar"/>
      <variable name="DHAP" public_interface="in" units="molar"/>
      <variable name="NAD" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Dg3pdh</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>G3P</ci>
                     <ci>Kg3pdh_g3p</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>NADH</ci>
                     <ci>Kg3pdh_nadh</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>DHAP</ci>
                     <ci>Kg3pdh_dhap</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>NAD</ci>
                     <ci>Kg3pdh_nadh</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbg3pdh</ci>
            <ci>Vbbg3pdh</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Vfg3pdh</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vbg3pdh</ci>
                  <ci>Kg3pdh_g3p</ci>
                  <ci>Kg3pdh_nad</ci>
                  <ci>Kapp_G3PDH</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kg3pdh_dhap</ci>
                  <ci>Kg3pdh_nadh</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_G3PDH</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfg3pdh</ci>
                        <ci>G3P</ci>
                        <ci>NAD</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kg3pdh_g3p</ci>
                        <ci>Kg3pdh_nad</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbg3pdh</ci>
                        <ci>DHAP</ci>
                        <ci>NADH</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kg3pdh_dhap</ci>
                        <ci>Kg3pdh_nadh</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>Dg3pdh</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="GAPDH">
      <variable name="Dgap" public_interface="out" units="dimensionless"/>
      <variable name="Vfgad" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbgad" public_interface="out" units="molar_per_minute"/>
      <variable name="v_GAPDH" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffgad" public_interface="in" units="molar_per_minute"/>
      <variable name="Kgapdh_bpg" public_interface="in" units="molar"/>
      <variable name="Kgapdh_gap" public_interface="in" units="molar"/>
      <variable name="Kgapdh_pi" public_interface="in" units="molar"/>
      <variable name="Kgapdh_nadh" public_interface="in" units="molar"/>
      <variable name="Kgapdh_nad" public_interface="in" units="molar"/>
      <variable name="Kapp_GAPDH" public_interface="in" units="dimensionless"/>
      <variable name="GAP" public_interface="in" units="molar"/>
      <variable name="BPG" public_interface="in" units="molar"/>
      <variable name="NADH" public_interface="in" units="molar"/>
      <variable name="Pi" public_interface="in" units="molar"/>
      <variable name="NAD" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Dgap</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <divide/>
                  <ci>Pi</ci>
                  <ci>Kgapdh_pi</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>GAP</ci>
                  <ci>Kgapdh_gap</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>NAD</ci>
                  <ci>Kgapdh_nad</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>GAP</ci>
                     <ci>NAD</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kgapdh_gap</ci>
                     <ci>Kgapdh_nad</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>GAP</ci>
                     <ci>NAD</ci>
                     <ci>Pi</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kgapdh_gap</ci>
                     <ci>Kgapdh_nad</ci>
                     <ci>Kgapdh_pi</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>BPG</ci>
                  <ci>Kgapdh_bpg</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>NADH</ci>
                  <ci>Kgapdh_nadh</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>BPG</ci>
                     <ci>NADH</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kgapdh_nadh</ci>
                     <ci>Kgapdh_bpg</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vfgad</ci>
            <apply>
               <times/>
               <ci>Vffgad</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0007</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>pH_cy</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8979</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbgad</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfgad</ci>
                  <ci>Kgapdh_bpg</ci>
                  <ci>Kgapdh_nadh</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">1</cn>
               </apply>
               <apply>
                  <times/>
                  <ci>Kgapdh_gap</ci>
                  <ci>Kgapdh_pi</ci>
                  <ci>Kgapdh_nad</ci>
                  <ci>Kapp_GAPDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_GAPDH</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfgad</ci>
                        <ci>GAP</ci>
                        <ci>NAD</ci>
                        <ci>Pi</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kgapdh_nad</ci>
                        <ci>Kgapdh_gap</ci>
                        <ci>Kgapdh_pi</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbgad</ci>
                        <ci>BPG</ci>
                        <ci>NADH</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kgapdh_bpg</ci>
                        <ci>Kgapdh_nadh</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>Dgap</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="PGK">
      <variable name="Vbpgk" public_interface="out" units="molar_per_minute"/>
      <variable name="Vfpgk" public_interface="out" units="molar_per_minute"/>
      <variable name="D_PGK" public_interface="out" units="dimensionless"/>
      <variable name="v_PGK" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbbpgk" public_interface="in" units="molar_per_minute"/>
      <variable name="Kpgk_bpg" public_interface="in" units="molar"/>
      <variable name="Kpgk_3pg" public_interface="in" units="molar"/>
      <variable name="Kpgk_atp" public_interface="in" units="molar"/>
      <variable name="Kpgk_adp" public_interface="in" units="molar"/>
      <variable name="Kapp_PGK" public_interface="in" units="dimensionless"/>
      <variable name="P3G" public_interface="in" units="molar"/>
      <variable name="BPG" public_interface="in" units="molar"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <variable name="NAD" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vbpgk</ci>
            <ci>Vbbpgk</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Vfpgk</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Vbpgk</ci>
                     <ci>Kpgk_bpg</ci>
                     <ci>Kpgk_adp</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpgk_3pg</ci>
                     <ci>Kpgk_atp</ci>
                  </apply>
               </apply>
               <ci>Kapp_PGK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>D_PGK</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <divide/>
                  <ci>ADP</ci>
                  <ci>Kpgk_adp</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>BPG</ci>
                  <ci>Kpgk_bpg</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>BPG</ci>
                     <ci>ADP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpgk_bpg</ci>
                     <ci>Kpgk_adp</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>P3G</ci>
                  <ci>Kpgk_3pg</ci>
               </apply>
               <apply>
                  <divide/>
                  <ci>ATP</ci>
                  <ci>Kpgk_atp</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>P3G</ci>
                     <ci>ATP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpgk_3pg</ci>
                     <ci>Kpgk_atp</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_PGK</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfpgk</ci>
                        <ci>BPG</ci>
                        <ci>ADP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kpgk_adp</ci>
                        <ci>Kpgk_bpg</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbpgk</ci>
                        <ci>ATP</ci>
                        <ci>P3G</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kpgk_atp</ci>
                        <ci>Kpgk_3pg</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>D_PGK</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="PGM">
      <variable name="Vfpgm" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbpgm" public_interface="out" units="molar_per_minute"/>
      <variable name="v_PGM" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffpgm" public_interface="in" units="molar_per_minute"/>
      <variable name="Kpgm_2pg" public_interface="in" units="molar"/>
      <variable name="Kpgm_3pg" public_interface="in" units="molar"/>
      <variable name="Kapp_PGM" public_interface="in" units="dimensionless"/>
      <variable name="P2G" public_interface="in" units="molar"/>
      <variable name="P3G" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfpgm</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vffpgm</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.989</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.62</cn>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8.74</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbpgm</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfpgm</ci>
                  <ci>Kpgm_2pg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpgm_3pg</ci>
                  <ci>Kapp_PGM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_PGM</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfpgm</ci>
                        <ci>P3G</ci>
                     </apply>
                     <ci>Kpgm_3pg</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbpgm</ci>
                        <ci>P2G</ci>
                     </apply>
                     <ci>Kpgm_2pg</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>P3G</ci>
                     <ci>Kpgm_3pg</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>P2G</ci>
                     <ci>Kpgm_2pg</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ENOL">
      <variable name="Vfen" public_interface="out" units="molar_per_minute"/>
      <variable name="Vben" public_interface="out" units="molar_per_minute"/>
      <variable name="v_ENOL" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffen" public_interface="in" units="molar_per_minute"/>
      <variable name="Ken_2pg" public_interface="in" units="molar"/>
      <variable name="Ken_pep" public_interface="in" units="molar"/>
      <variable name="Kapp_ENOL" public_interface="in" units="dimensionless"/>
      <variable name="P2G" public_interface="in" units="molar"/>
      <variable name="PEP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfen</ci>
            <ci>Vffen</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Vben</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfen</ci>
                  <ci>Ken_pep</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Ken_2pg</ci>
                  <ci>Kapp_ENOL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_ENOL</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfen</ci>
                        <ci>P2G</ci>
                     </apply>
                     <ci>Ken_2pg</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vben</ci>
                        <ci>PEP</ci>
                     </apply>
                     <ci>Ken_pep</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>PEP</ci>
                     <ci>Ken_pep</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>P2G</ci>
                     <ci>Ken_2pg</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="PK">
      <variable name="Vfpk" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbpk" public_interface="out" units="molar_per_minute"/>
      <variable name="v_PK" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffpk" public_interface="in" units="molar_per_minute"/>
      <variable name="Kpk_atp" public_interface="in" units="molar"/>
      <variable name="Kpk_adp" public_interface="in" units="molar"/>
      <variable name="Kpk_pep" public_interface="in" units="molar"/>
      <variable name="Kpk_pyr" public_interface="in" units="molar"/>
      <variable name="Kapp_PK" public_interface="in" units="dimensionless"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <variable name="PEP" public_interface="in" units="molar"/>
      <variable name="PYR" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfpk</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vffpk</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.05</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.58</cn>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_cy</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8.79</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbpk</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfpk</ci>
                  <ci>Kpk_pyr</ci>
                  <ci>Kpk_atp</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpk_pep</ci>
                  <ci>Kpk_adp</ci>
                  <ci>Kapp_PK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_PK</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfpk</ci>
                        <ci>PEP</ci>
                        <ci>ADP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kpk_pep</ci>
                        <ci>Kpk_adp</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbpk</ci>
                        <ci>PYR</ci>
                        <ci>ATP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kpk_pyr</ci>
                        <ci>Kpk_atp</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>PEP</ci>
                     <ci>Kpk_pep</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>ADP</ci>
                     <ci>Kpk_adp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>PEP</ci>
                        <ci>ADP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kpk_pep</ci>
                        <ci>Kpk_adp</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>ATP</ci>
                     <ci>Kpk_atp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>PYR</ci>
                     <ci>Kpk_pyr</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>PYR</ci>
                        <ci>ATP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kpk_pyr</ci>
                        <ci>Kpk_atp</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="LDH">
      <variable name="Vfldh" public_interface="out" units="molar_per_minute"/>
      <variable name="Vbldh" public_interface="out" units="molar_per_minute"/>
      <variable name="v_LDH" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="Vffldh" public_interface="in" units="molar_per_minute"/>
      <variable name="Kldh_lac" public_interface="in" units="molar"/>
      <variable name="Kldh_pyr" public_interface="in" units="molar"/>
      <variable name="Kldh_nad" public_interface="in" units="molar"/>
      <variable name="Kldh_nadh" public_interface="in" units="molar"/>
      <variable name="Kapp_LDH" public_interface="in" units="dimensionless"/>
      <variable name="PYR" public_interface="in" units="molar"/>
      <variable name="LAC" public_interface="in" units="molar"/>
      <variable name="NAD" public_interface="in" units="molar"/>
      <variable name="NADH" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vfldh</ci>
            <apply>
               <times/>
               <ci>Vffldh</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1134</cn>
                     </apply>
                     <ci>pH_cy</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.6069</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vbldh</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfldh</ci>
                  <ci>Kldh_lac</ci>
                  <ci>Kldh_nad</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kldh_pyr</ci>
                  <ci>Kldh_nadh</ci>
                  <ci>Kapp_LDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_LDH</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfldh</ci>
                        <ci>PYR</ci>
                        <ci>NADH</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kldh_pyr</ci>
                        <ci>Kldh_nadh</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vbldh</ci>
                        <ci>LAC</ci>
                        <ci>NAD</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kldh_lac</ci>
                        <ci>Kldh_nad</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>PYR</ci>
                     <ci>Kldh_pyr</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>NADH</ci>
                     <ci>Kldh_nadh</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>PYR</ci>
                        <ci>NADH</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kldh_pyr</ci>
                        <ci>Kldh_nadh</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>LAC</ci>
                     <ci>Kldh_lac</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>NAD</ci>
                     <ci>Kldh_nad</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>LAC</ci>
                        <ci>NAD</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kldh_lac</ci>
                        <ci>Kldh_nad</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="creatine_kinase">
      <variable name="VrevCK" public_interface="out" units="molar_per_minute"/>
      <variable name="CK" public_interface="out" units="molar_per_minute"/>
      <variable name="VforCK" public_interface="in" units="molar_per_minute"/>
      <variable name="Kck_iatp" public_interface="in" units="molar"/>
      <variable name="Kck_iadp" public_interface="in" units="molar"/>
      <variable name="Kck_pcr" public_interface="in" units="molar"/>
      <variable name="Kck_ipcr" public_interface="in" units="molar"/>
      <variable name="Kck_cr" public_interface="in" units="molar"/>
      <variable name="Kapp_CK" public_interface="in" units="dimensionless"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <variable name="Cr" public_interface="in" units="molar"/>
      <variable name="PCr" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>VrevCK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>VforCK</ci>
                     <ci>Kapp_CK</ci>
                  </apply>
                  <ci>Kck_iatp</ci>
                  <ci>Kck_cr</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Kck_iadp</ci>
                  <ci>Kck_pcr</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CK</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>VrevCK</ci>
                        <ci>ATP</ci>
                        <ci>Cr</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kck_iatp</ci>
                        <ci>Kck_cr</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>VforCK</ci>
                        <ci>ADP</ci>
                        <ci>PCr</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kck_iadp</ci>
                        <ci>Kck_pcr</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>ADP</ci>
                     <ci>Kck_iadp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>PCr</ci>
                     <ci>Kck_ipcr</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>PCr</ci>
                        <ci>ADP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kck_iadp</ci>
                        <ci>Kck_pcr</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>ATP</ci>
                     <ci>Kck_iatp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Cr</ci>
                        <ci>ATP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kck_cr</ci>
                        <ci>Kck_iatp</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="adenylate_kinase">
      <variable name="Vbadk" public_interface="out" units="molar_per_minute"/>
      <variable name="ADK" public_interface="out" units="molar_per_minute"/>
      <variable name="Vfadk" public_interface="in" units="molar_per_minute"/>
      <variable name="Kadk_atp" public_interface="in" units="molar"/>
      <variable name="Kadk_adp" public_interface="in" units="molar"/>
      <variable name="Kadk_amp" public_interface="in" units="molar"/>
      <variable name="Kapp_ADK" public_interface="in" units="dimensionless"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <variable name="AMP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Vbadk</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vfadk</ci>
                  <apply>
                     <power/>
                     <ci>Kadk_adp</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Kadk_amp</ci>
                  <ci>Kadk_atp</ci>
                  <ci>Kapp_ADK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ADK</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Vfadk</ci>
                        <ci>ATP</ci>
                        <ci>AMP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kadk_atp</ci>
                        <ci>Kadk_amp</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Vbadk</ci>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>ADP</ci>
                           <ci>Kadk_adp</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>ATP</ci>
                     <ci>Kadk_atp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>AMP</ci>
                     <ci>Kadk_amp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>ATP</ci>
                        <ci>AMP</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kadk_atp</ci>
                        <ci>Kadk_amp</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>ADP</ci>
                     </apply>
                     <ci>Kadk_adp</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <ci>ADP</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Kadk_adp</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ATPase">
      <variable name="ATPase" public_interface="out" units="molar_per_minute"/>
      <variable name="kut" public_interface="in" units="per_minute"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>ATPase</ci>
            <apply>
               <times/>
               <ci>kut</ci>
               <ci>ATP</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="OXPHOS">
      <variable name="oxphos" public_interface="out" units="molar_per_minute"/>
      <variable name="VmaxOxPhos" public_interface="in" units="molar_per_minute"/>
      <variable name="nnHH" public_interface="in" units="dimensionless"/>
      <variable name="Kmadp" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>oxphos</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>VmaxOxPhos</ci>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ADP</ci>
                        <ci>Kmadp</ci>
                     </apply>
                     <ci>nnHH</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ADP</ci>
                        <ci>Kmadp</ci>
                     </apply>
                     <ci>nnHH</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="lactate_transport">
      <variable name="Kh" public_interface="out" units="dimensionless"/>
      <variable name="v_MCT" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="pKmct1" public_interface="in" units="dimensionless"/>
      <variable name="Vmax_MCT" public_interface="in" units="molar_per_minute"/>
      <variable name="nnHH" public_interface="in" units="dimensionless"/>
      <variable name="Klac1" public_interface="in" units="molar"/>
      <variable name="LAC" public_interface="in" units="molar"/>
      <variable name="pH_ec" public_interface="in" units="dimensionless"/>
      <variable name="LAC_ec" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Kh</ci>
            <apply>
               <power/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
               <apply>
                  <minus/>
                  <ci>pKmct1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_MCT</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Vmax_MCT</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>LAC</ci>
                           <apply>
                              <power/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                              <apply>
                                 <minus/>
                                 <ci>pH_cy</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kh</ci>
                           <ci>Klac1</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>LAC_ec</ci>
                           <apply>
                              <power/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                              <apply>
                                 <minus/>
                                 <ci>pH_ec</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kh</ci>
                           <ci>Klac1</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>LAC</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                           <apply>
                              <minus/>
                              <ci>pH_cy</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Kh</ci>
                        <ci>Klac1</ci>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                     </apply>
                     <ci>Kh</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>LAC</ci>
                     <ci>Klac1</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>LAC_ec</ci>
                     <ci>Klac1</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <minus/>
                           <ci>pH_ec</ci>
                        </apply>
                     </apply>
                     <ci>Kh</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>LAC_ec</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                           <apply>
                              <minus/>
                              <ci>pH_ec</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Klac1</ci>
                        <ci>Kh</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CO2_generation_transport">
      <variable name="RQ" public_interface="out" units="dimensionless"/>
      <variable name="PO2ratio" public_interface="out" units="dimensionless"/>
      <variable name="fluxO2" public_interface="out" units="molar_per_minute"/>
      <variable name="fluxCO2" public_interface="out" units="molar_per_minute"/>
      <variable name="oxphos" public_interface="in" units="molar_per_minute"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>RQ</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
         </apply>
         <apply>
            <eq/>
            <ci>PO2ratio</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.2</cn>
         </apply>
         <apply>
            <eq/>
            <ci>fluxO2</ci>
            <apply>
               <divide/>
               <ci>oxphos</ci>
               <ci>PO2ratio</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fluxCO2</ci>
            <apply>
               <times/>
               <ci>RQ</ci>
               <ci>fluxO2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Passive_permeation_flux">
      <variable name="v_psCO2" public_interface="out" units="molar_per_minute"/>
      <variable name="v_hydrCO2cy" public_interface="out" units="molar_per_minute"/>
      <variable name="v_hydrCO2ec" public_interface="out" units="molar_per_minute"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="X_CA" public_interface="in" units="dimensionless"/>
      <variable name="PSVCO2" public_interface="in" units="per_minute"/>
      <variable name="kf_hydrCO2" public_interface="in" units="per_minute"/>
      <variable name="kb_hydrCO2" public_interface="in" units="per_minute"/>
      <variable name="pH_ec" public_interface="in" units="dimensionless"/>
      <variable name="CO2_ec" public_interface="in" units="molar"/>
      <variable name="HCO3_ec" public_interface="in" units="molar"/>
      <variable name="CO2_cy" public_interface="in" units="molar"/>
      <variable name="HCO3_cy" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>v_psCO2</ci>
            <apply>
               <times/>
               <ci>PSVCO2</ci>
               <apply>
                  <minus/>
                  <ci>CO2_cy</ci>
                  <ci>CO2_ec</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_hydrCO2cy</ci>
            <apply>
               <times/>
               <ci>X_CA</ci>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kf_hydrCO2</ci>
                     <ci>CO2_cy</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kb_hydrCO2</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <minus/>
                           <ci>pH_cy</ci>
                        </apply>
                     </apply>
                     <ci>HCO3_cy</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_hydrCO2ec</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kf_hydrCO2</ci>
                     <ci>CO2_ec</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kb_hydrCO2</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <minus/>
                           <ci>pH_ec</ci>
                        </apply>
                     </apply>
                     <ci>HCO3_ec</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="buffer_capacity">
      <variable name="bufcapmetab" public_interface="out" units="molar"/>
      <variable name="c0" public_interface="in" units="molar"/>
      <variable name="pH_cy" public_interface="in" units="dimensionless"/>
      <variable name="PCr" public_interface="in" units="molar"/>
      <variable name="Cr" public_interface="in" units="molar"/>
      <variable name="NAD" public_interface="in" units="molar"/>
      <variable name="NADH" public_interface="in" units="molar"/>
      <variable name="ATP" public_interface="in" units="molar"/>
      <variable name="ADP" public_interface="in" units="molar"/>
      <variable name="AMP" public_interface="in" units="molar"/>
      <variable name="Pi" public_interface="in" units="molar"/>
      <variable name="Gly" public_interface="in" units="molar"/>
      <variable name="G1P" public_interface="in" units="molar"/>
      <variable name="G6P" public_interface="in" units="molar"/>
      <variable name="F6P" public_interface="in" units="molar"/>
      <variable name="FBP" public_interface="in" units="molar"/>
      <variable name="DHAP" public_interface="in" units="molar"/>
      <variable name="G3P" public_interface="in" units="molar"/>
      <variable name="GAP" public_interface="in" units="molar"/>
      <variable name="BPG" public_interface="in" units="molar"/>
      <variable name="P3G" public_interface="in" units="molar"/>
      <variable name="P2G" public_interface="in" units="molar"/>
      <variable name="PEP" public_interface="in" units="molar"/>
      <variable name="PYR" public_interface="in" units="molar"/>
      <variable name="LAC" public_interface="in" units="molar"/>
      <variable name="ADK" public_interface="in" units="molar_per_minute"/>
      <variable name="CK" public_interface="in" units="molar_per_minute"/>
      <variable name="dNavg13DPGdH" public_interface="in" units="per_molar"/>
      <variable name="dNavg3PGdH" public_interface="in" units="per_molar"/>
      <variable name="dNavg2PGdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgADPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgAMPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgATPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgCRdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgDHAPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgF6PdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgFDPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgG1PdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgG3PdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgG6PdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgGAPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgLACdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgPCRdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgPEPdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgPYRdH" public_interface="in" units="per_molar"/>
      <variable name="dNavgPidH" public_interface="in" units="per_molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>bufcapmetab</ci>
            <apply>
               <times/>
               <apply>
                  <ln/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
               </apply>
               <apply>
                  <power/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                  <apply>
                     <minus/>
                     <ci>pH_cy</ci>
                  </apply>
               </apply>
               <ci>c0</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <ci>dNavgPidH</ci>
                     <ci>Pi</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgATPdH</ci>
                     <ci>ATP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgADPdH</ci>
                     <ci>ADP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgAMPdH</ci>
                     <ci>AMP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgPCRdH</ci>
                     <ci>PCr</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgCRdH</ci>
                     <ci>Cr</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgG1PdH</ci>
                     <ci>G1P</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgG6PdH</ci>
                     <ci>G6P</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgF6PdH</ci>
                     <ci>F6P</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgFDPdH</ci>
                     <ci>FBP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgGAPdH</ci>
                     <ci>GAP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgDHAPdH</ci>
                     <ci>DHAP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgG3PdH</ci>
                     <ci>G3P</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavg13DPGdH</ci>
                     <ci>BPG</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavg3PGdH</ci>
                     <ci>P3G</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavg2PGdH</ci>
                     <ci>P2G</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgPEPdH</ci>
                     <ci>PEP</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgPYRdH</ci>
                     <ci>PYR</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>dNavgLACdH</ci>
                     <ci>LAC</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="proton_flux">
      <variable name="CKprtflux" public_interface="out" units="molar_per_minute"/>
      <variable name="glycprtflux" public_interface="out" units="molar_per_minute"/>
      <variable name="protons_consumed" public_interface="out" units="molar_per_minute"/>
      <variable name="pHODEterm1" public_interface="out" units="per_minute"/>
      <variable name="deltaH_ADK" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_ALD" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_CK" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_ENOL" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_G3PDH" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_GAPDH" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_GP" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_LDH" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_PFK" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_PGI" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_PGK" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_PGLM" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_PGM" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_PK" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_TPI" public_interface="in" units="dimensionless"/>
      <variable name="deltaH_ATPase" public_interface="in" units="dimensionless"/>
      <variable name="flux_GPa" public_interface="in" units="molar_per_minute"/>
      <variable name="flux_GPb" public_interface="in" units="molar_per_minute"/>
      <variable name="v_ALD" public_interface="in" units="molar_per_minute"/>
      <variable name="v_ENOL" public_interface="in" units="molar_per_minute"/>
      <variable name="v_G3PDH" public_interface="in" units="molar_per_minute"/>
      <variable name="v_GAPDH" public_interface="in" units="molar_per_minute"/>
      <variable name="v_LDH" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PFK" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGI" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGK" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGLM" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGM" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PK" public_interface="in" units="molar_per_minute"/>
      <variable name="v_TPI" public_interface="in" units="molar_per_minute"/>
      <variable name="v_MCT" public_interface="in" units="molar_per_minute"/>
      <variable name="v_hydrCO2cy" public_interface="in" units="molar_per_minute"/>
      <variable name="CK" public_interface="in" units="molar_per_minute"/>
      <variable name="ADK" public_interface="in" units="molar_per_minute"/>
      <variable name="ATPase" public_interface="in" units="molar_per_minute"/>
      <variable name="oxphos" public_interface="in" units="molar_per_minute"/>
      <variable name="bufcapfixed" public_interface="in" units="molar"/>
      <variable name="bufcapmetab" public_interface="in" units="molar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>CKprtflux</ci>
            <apply>
               <times/>
               <ci>deltaH_CK</ci>
               <apply>
                  <minus/>
                  <ci>CK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>glycprtflux</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>deltaH_PGLM</ci>
                  <ci>v_PGLM</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_GP</ci>
                  <apply>
                     <plus/>
                     <ci>flux_GPa</ci>
                     <ci>flux_GPb</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_PGI</ci>
                  <ci>v_PGI</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_PFK</ci>
                  <ci>v_PFK</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_ALD</ci>
                  <ci>v_ALD</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_TPI</ci>
                  <ci>v_TPI</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_GAPDH</ci>
                  <ci>v_GAPDH</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_PGK</ci>
                  <ci>v_PGK</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_PGM</ci>
                  <ci>v_PGM</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_ENOL</ci>
                  <ci>v_ENOL</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_PK</ci>
                  <ci>v_PK</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_LDH</ci>
                  <ci>v_LDH</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>deltaH_G3PDH</ci>
                  <ci>v_G3PDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>protons_consumed</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>CKprtflux</ci>
                     <ci>glycprtflux</ci>
                     <apply>
                        <times/>
                        <ci>deltaH_ATPase</ci>
                        <ci>ATPase</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>deltaH_ATPase</ci>
                        </apply>
                        <ci>oxphos</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>deltaH_ADK</ci>
                        <ci>ADK</ci>
                     </apply>
                  </apply>
                  <ci>v_hydrCO2cy</ci>
               </apply>
               <ci>v_MCT</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pHODEterm1</ci>
            <apply>
               <divide/>
               <ci>protons_consumed</ci>
               <apply>
                  <plus/>
                  <ci>bufcapfixed</ci>
                  <ci>bufcapmetab</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="differential_equations">
      <variable initial_value="28e-3" name="PCr" public_interface="out" units="molar"/>
      <variable initial_value="0.0149" name="Cr" public_interface="out" units="molar"/>
      <variable initial_value="0.00079297597" name="NAD" public_interface="out" units="molar"/>
      <variable initial_value="0.000000079297597" name="NADH" public_interface="out" units="molar"/>
      <variable initial_value="0.0083" name="ATP" public_interface="out" units="molar"/>
      <variable initial_value="1e-5" name="ADP" public_interface="out" units="molar"/>
      <variable initial_value="1e-8" name="AMP" public_interface="out" units="molar"/>
      <variable initial_value="0.0016" name="Pi" public_interface="out" units="molar"/>
      <variable initial_value="0.026" name="Gly" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="G1P" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="G6P" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="F6P" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="FBP" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="DHAP" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="G3P" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="GAP" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="BPG" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="P3G" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="P2G" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="PEP" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="PYR" public_interface="out" units="molar"/>
      <variable initial_value="1e-9" name="LAC" public_interface="out" units="molar"/>
      <variable initial_value="1e-3" name="mg" public_interface="out" units="molar"/>
      <variable initial_value="7.14" name="pH_calc" public_interface="out" units="dimensionless"/>
      <variable initial_value="0" name="LAC_ec" public_interface="out" units="molar"/>
      <variable initial_value="15e-3" name="HCO3_cy" public_interface="out" units="molar"/>
      <variable initial_value="0.001564425" name="CO2_cy" public_interface="out" units="molar"/>
      <variable initial_value="30e-3" name="HCO3_ec" public_interface="out" units="molar"/>
      <variable initial_value="0.001564425" name="CO2_ec" public_interface="out" units="molar"/>
      <variable initial_value="0" name="MOPS" public_interface="out" units="molar"/>
      <variable initial_value="0" name="MOPSH" public_interface="out" units="molar"/>
      <variable initial_value="7.439766507222684" name="pH_ec" public_interface="out" units="dimensionless"/>
      <variable name="dPCrdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dCrdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dNADdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dNADHdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dATPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dADPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dAMPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dPidt" public_interface="out" units="molar_per_minute"/>
      <variable name="dglydt" public_interface="out" units="molar_per_minute"/>
      <variable name="dG1Pdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dG6Pdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dF6Pdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dFBPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dDHAPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dG3Pdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dGAPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dBPGdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dP3Gdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dP2Gdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dPEPdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dPYRdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dLACdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dmgdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dpH_calcdt" public_interface="out" units="per_minute"/>
      <variable name="dLACecdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dHCO3cydt" public_interface="out" units="molar_per_minute"/>
      <variable name="dCO2cydt" public_interface="out" units="molar_per_minute"/>
      <variable name="dHCO3ecdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dCO2ecdt" public_interface="out" units="molar_per_minute"/>
      <variable name="MOPS_in" public_interface="out" units="molar"/>
      <variable name="MOPSH_in" public_interface="out" units="molar"/>
      <variable name="v_MOPSbuff" public_interface="out" units="molar_per_minute"/>
      <variable name="dMOPSdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dMOPSHdt" public_interface="out" units="molar_per_minute"/>
      <variable name="dpHecdt" public_interface="out" units="per_minute"/>
      <variable name="time" public_interface="in" units="minute"/>
      <variable name="flux_GPa" public_interface="in" units="molar_per_minute"/>
      <variable name="flux_GPb" public_interface="in" units="molar_per_minute"/>
      <variable name="v_ALD" public_interface="in" units="molar_per_minute"/>
      <variable name="v_ENOL" public_interface="in" units="molar_per_minute"/>
      <variable name="v_G3PDH" public_interface="in" units="molar_per_minute"/>
      <variable name="v_GAPDH" public_interface="in" units="molar_per_minute"/>
      <variable name="v_LDH" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PFK" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGI" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGK" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGLM" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PGM" public_interface="in" units="molar_per_minute"/>
      <variable name="v_PK" public_interface="in" units="molar_per_minute"/>
      <variable name="v_TPI" public_interface="in" units="molar_per_minute"/>
      <variable name="v_MCT" public_interface="in" units="molar_per_minute"/>
      <variable name="CK" public_interface="in" units="molar_per_minute"/>
      <variable name="ADK" public_interface="in" units="molar_per_minute"/>
      <variable name="ATPase" public_interface="in" units="molar_per_minute"/>
      <variable name="oxphos" public_interface="in" units="molar_per_minute"/>
      <variable name="pHODEterm1" public_interface="in" units="per_minute"/>
      <variable name="v_psCO2" public_interface="in" units="molar_per_minute"/>
      <variable name="v_hydrCO2cy" public_interface="in" units="molar_per_minute"/>
      <variable name="v_hydrCO2ec" public_interface="in" units="molar_per_minute"/>
      <variable name="fluxCO2" public_interface="in" units="molar_per_minute"/>
      <variable name="Flow" public_interface="in" units="liter_per_minute"/>
      <variable name="V_cell" public_interface="in" units="liter"/>
      <variable name="V_ec" public_interface="in" units="liter"/>
      <variable name="pH_in" public_interface="in" units="dimensionless"/>
      <variable name="MOPSt" public_interface="in" units="molar"/>
      <variable name="CO2_in" public_interface="in" units="molar"/>
      <variable name="HCO3_in" public_interface="in" units="molar"/>
      <variable name="clamp" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>PCr</ci>
            </apply>
            <ci>dPCrdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cr</ci>
            </apply>
            <ci>dCrdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>NAD</ci>
            </apply>
            <ci>dNADdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>NADH</ci>
            </apply>
            <ci>dNADHdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ATP</ci>
            </apply>
            <ci>dATPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ADP</ci>
            </apply>
            <ci>dADPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>AMP</ci>
            </apply>
            <ci>dAMPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Pi</ci>
            </apply>
            <ci>dPidt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Gly</ci>
            </apply>
            <ci>dglydt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>G1P</ci>
            </apply>
            <ci>dG1Pdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>G6P</ci>
            </apply>
            <ci>dG6Pdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>F6P</ci>
            </apply>
            <ci>dF6Pdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>FBP</ci>
            </apply>
            <ci>dFBPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>DHAP</ci>
            </apply>
            <ci>dDHAPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>G3P</ci>
            </apply>
            <ci>dG3Pdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>GAP</ci>
            </apply>
            <ci>dGAPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>BPG</ci>
            </apply>
            <ci>dBPGdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P3G</ci>
            </apply>
            <ci>dP3Gdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P2G</ci>
            </apply>
            <ci>dP2Gdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>PEP</ci>
            </apply>
            <ci>dPEPdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>PYR</ci>
            </apply>
            <ci>dPYRdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LAC</ci>
            </apply>
            <ci>dLACdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>mg</ci>
            </apply>
            <ci>dmgdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pH_calc</ci>
            </apply>
            <ci>dpH_calcdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LAC_ec</ci>
            </apply>
            <ci>dLACecdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HCO3_cy</ci>
            </apply>
            <ci>dHCO3cydt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CO2_cy</ci>
            </apply>
            <ci>dCO2cydt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HCO3_ec</ci>
            </apply>
            <ci>dHCO3ecdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CO2_ec</ci>
            </apply>
            <ci>dCO2ecdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>MOPS</ci>
            </apply>
            <ci>dMOPSdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>MOPSH</ci>
            </apply>
            <ci>dMOPSHdt</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pH_ec</ci>
            </apply>
            <ci>dpHecdt</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dPCrdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <ci>CK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCrdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>CK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNADdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>v_GAPDH</ci>
                     </apply>
                     <ci>v_G3PDH</ci>
                  </apply>
                  <ci>v_LDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNADHdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>v_GAPDH</ci>
                     <ci>v_G3PDH</ci>
                  </apply>
                  <ci>v_LDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dATPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>CK</ci>
                              </apply>
                              <ci>ADK</ci>
                           </apply>
                           <ci>v_PFK</ci>
                        </apply>
                        <ci>v_PGK</ci>
                        <ci>v_PK</ci>
                     </apply>
                     <ci>ATPase</ci>
                  </apply>
                  <ci>oxphos</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dADPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>CK</ci>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>ADK</ci>
                              </apply>
                              <ci>v_PFK</ci>
                           </apply>
                           <ci>v_PGK</ci>
                        </apply>
                        <ci>v_PK</ci>
                     </apply>
                     <ci>ATPase</ci>
                  </apply>
                  <ci>oxphos</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dAMPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>ADK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dPidt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>flux_GPa</ci>
                              <ci>flux_GPb</ci>
                           </apply>
                        </apply>
                        <ci>v_GAPDH</ci>
                     </apply>
                     <ci>ATPase</ci>
                  </apply>
                  <ci>oxphos</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dglydt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>flux_GPa</ci>
                     <ci>flux_GPb</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dG1Pdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>flux_GPa</ci>
                     <ci>flux_GPb</ci>
                  </apply>
                  <ci>v_PGLM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dG6Pdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_PGLM</ci>
                  <ci>v_PGI</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dF6Pdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_PGI</ci>
                  <ci>v_PFK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dFBPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_PFK</ci>
                  <ci>v_ALD</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dDHAPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <plus/>
                  <ci>v_ALD</ci>
                  <ci>v_TPI</ci>
                  <ci>v_G3PDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dG3Pdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_G3PDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dGAPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <ci>v_ALD</ci>
                     <ci>v_TPI</ci>
                  </apply>
                  <ci>v_GAPDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dBPGdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_GAPDH</ci>
                  <ci>v_PGK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dP3Gdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_PGK</ci>
                  <ci>v_PGM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dP2Gdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_PGM</ci>
                  <ci>v_ENOL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dPEPdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_ENOL</ci>
                  <ci>v_PK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dPYRdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_PK</ci>
                  <ci>v_LDH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dLACdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <ci>v_LDH</ci>
                  <ci>v_MCT</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dmgdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar_per_minute">0</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dpH_calcdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <ci>pHODEterm1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dLACecdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>V_cell</ci>
                        <ci>v_MCT</ci>
                     </apply>
                     <ci>V_ec</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Flow</ci>
                        <ci>LAC_ec</ci>
                     </apply>
                     <ci>V_ec</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dHCO3cydt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <ci>v_hydrCO2cy</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCO2cydt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <ci>fluxCO2</ci>
                     <ci>v_hydrCO2cy</ci>
                  </apply>
                  <ci>v_psCO2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dHCO3ecdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Flow</ci>
                        <apply>
                           <minus/>
                           <ci>HCO3_in</ci>
                           <ci>HCO3_ec</ci>
                        </apply>
                     </apply>
                     <ci>V_ec</ci>
                  </apply>
                  <ci>v_hydrCO2ec</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCO2ecdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Flow</ci>
                           <apply>
                              <minus/>
                              <ci>CO2_in</ci>
                              <ci>CO2_ec</ci>
                           </apply>
                        </apply>
                        <ci>V_ec</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>v_psCO2</ci>
                           <ci>V_cell</ci>
                        </apply>
                        <ci>V_ec</ci>
                     </apply>
                  </apply>
                  <ci>v_hydrCO2ec</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>MOPS_in</ci>
            <apply>
               <divide/>
               <ci>MOPSt</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>MOPSH_in</ci>
            <apply>
               <divide/>
               <ci>MOPSt</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_MOPSbuff</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_minute">1   <sep/>
               7</cn>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7.184</cn>
                        </apply>
                     </apply>
                     <ci>MOPS</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>MOPSH</ci>
                     <apply>
                        <power/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <minus/>
                           <ci>pH_ec</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dMOPSdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Flow</ci>
                        <apply>
                           <minus/>
                           <ci>MOPS_in</ci>
                           <ci>MOPS</ci>
                        </apply>
                     </apply>
                     <ci>V_ec</ci>
                  </apply>
                  <ci>v_MOPSbuff</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dMOPSHdt</ci>
            <apply>
               <times/>
               <ci>clamp</ci>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Flow</ci>
                        <apply>
                           <minus/>
                           <ci>MOPSH_in</ci>
                           <ci>MOPSH</ci>
                        </apply>
                     </apply>
                     <ci>V_ec</ci>
                  </apply>
                  <ci>v_MOPSbuff</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dpHecdt</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>clamp</ci>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Flow</ci>
                           <apply>
                              <minus/>
                              <apply>
                                 <power/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                                 <apply>
                                    <minus/>
                                    <ci>pH_in</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <power/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                                 <apply>
                                    <minus/>
                                    <ci>pH_ec</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <ci>V_ec</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>v_hydrCO2ec</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">1</cn>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>v_MOPSbuff</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">1</cn>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>V_cell</ci>
                           <ci>v_MCT</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>V_ec</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="molar">1</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <ln/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     </apply>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                     <apply>
                        <minus/>
                        <ci>pH_ec</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <connection>
      <map_components component_1="environment" component_2="equilibrium_constants"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="glycogen_phosphorylase_A"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="glycogen_phosphorylase_B"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="PGLM"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="PGI"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="PFK"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="ALD"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="GAPDH"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="PGM"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="ENOL"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="PK"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="LDH"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="lactate_transport"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="Passive_permeation_flux"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="buffer_capacity"/>
      <map_variables variable_1="pH_cy" variable_2="pH_cy"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="differential_equations"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="pH_calc" variable_2="pH_calc"/>
      <map_variables variable_1="pH_in" variable_2="pH_in"/>
      <map_variables variable_1="MOPSt" variable_2="MOPSt"/>
      <map_variables variable_1="CO2_in" variable_2="CO2_in"/>
      <map_variables variable_1="HCO3_in" variable_2="HCO3_in"/>
      <map_variables variable_1="clamp" variable_2="clamp"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="glycogen_phosphorylase_A"/>
      <map_variables variable_1="KgpA_glyf" variable_2="KgpA_glyf"/>
      <map_variables variable_1="KgpA_glyb" variable_2="KgpA_glyb"/>
      <map_variables variable_1="KgpA_igly" variable_2="KgpA_igly"/>
      <map_variables variable_1="KgpA_pi" variable_2="KgpA_pi"/>
      <map_variables variable_1="KgpA_ipi" variable_2="KgpA_ipi"/>
      <map_variables variable_1="KgpA_g1p" variable_2="KgpA_g1p"/>
      <map_variables variable_1="KgpA_ig1p" variable_2="KgpA_ig1p"/>
      <map_variables variable_1="Vfgly" variable_2="Vfgly"/>
      <map_variables variable_1="fracA" variable_2="fracA"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="glycogen_phosphorylase_B"/>
      <map_variables variable_1="nH" variable_2="nH"/>
      <map_variables variable_1="Vfgly" variable_2="Vfgly"/>
      <map_variables variable_1="Kgp_amp" variable_2="Kgp_amp"/>
      <map_variables variable_1="KgpB_iglyf" variable_2="KgpB_iglyf"/>
      <map_variables variable_1="KgpB_iglyb" variable_2="KgpB_iglyb"/>
      <map_variables variable_1="KgpB_pi" variable_2="KgpB_pi"/>
      <map_variables variable_1="KgpB_ipi" variable_2="KgpB_ipi"/>
      <map_variables variable_1="KgpB_g1p" variable_2="KgpB_g1p"/>
      <map_variables variable_1="KgpB_ig1p" variable_2="KgpB_ig1p"/>
      <map_variables variable_1="fracA" variable_2="fracA"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="PGLM"/>
      <map_variables variable_1="Vffpglm" variable_2="Vffpglm"/>
      <map_variables variable_1="Kpglm_g1p" variable_2="Kpglm_g1p"/>
      <map_variables variable_1="Kpglm_g6p" variable_2="Kpglm_g6p"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="PGI"/>
      <map_variables variable_1="Vbbpgi" variable_2="Vbbpgi"/>
      <map_variables variable_1="Kpgi_g6p" variable_2="Kpgi_g6p"/>
      <map_variables variable_1="Kpgi_f6p" variable_2="Kpgi_f6p"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="PFK"/>
      <map_variables variable_1="Lo" variable_2="Lo"/>
      <map_variables variable_1="d" variable_2="d"/>
      <map_variables variable_1="Vffpfk" variable_2="Vffpfk"/>
      <map_variables variable_1="Kpfk_fbp" variable_2="Kpfk_fbp"/>
      <map_variables variable_1="Kpfk_adp" variable_2="Kpfk_adp"/>
      <map_variables variable_1="Kpfk_f6p" variable_2="Kpfk_f6p"/>
      <map_variables variable_1="Kpfk_atp" variable_2="Kpfk_atp"/>
      <map_variables variable_1="Kpfk_fbpT" variable_2="Kpfk_fbpT"/>
      <map_variables variable_1="Kpfk_adpT" variable_2="Kpfk_adpT"/>
      <map_variables variable_1="Kpfk_f6pT" variable_2="Kpfk_f6pT"/>
      <map_variables variable_1="Kpfk_atpT" variable_2="Kpfk_atpT"/>
      <map_variables variable_1="Kmpfk" variable_2="Kmpfk"/>
      <map_variables variable_1="Kpfki" variable_2="Kpfki"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="ALD"/>
      <map_variables variable_1="Vffald" variable_2="Vffald"/>
      <map_variables variable_1="Kald_gap" variable_2="Kald_gap"/>
      <map_variables variable_1="Kald_fbp" variable_2="Kald_fbp"/>
      <map_variables variable_1="Kald_dhap" variable_2="Kald_dhap"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="TPI"/>
      <map_variables variable_1="Vfftpi" variable_2="Vfftpi"/>
      <map_variables variable_1="Ktpi_dhap" variable_2="Ktpi_dhap"/>
      <map_variables variable_1="Ktpi_gap" variable_2="Ktpi_gap"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="G3PDH"/>
      <map_variables variable_1="Vbbg3pdh" variable_2="Vbbg3pdh"/>
      <map_variables variable_1="Kg3pdh_dhap" variable_2="Kg3pdh_dhap"/>
      <map_variables variable_1="Kg3pdh_g3p" variable_2="Kg3pdh_g3p"/>
      <map_variables variable_1="Kg3pdh_nadh" variable_2="Kg3pdh_nadh"/>
      <map_variables variable_1="Kg3pdh_nad" variable_2="Kg3pdh_nad"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="GAPDH"/>
      <map_variables variable_1="Vffgad" variable_2="Vffgad"/>
      <map_variables variable_1="Kgapdh_bpg" variable_2="Kgapdh_bpg"/>
      <map_variables variable_1="Kgapdh_gap" variable_2="Kgapdh_gap"/>
      <map_variables variable_1="Kgapdh_pi" variable_2="Kgapdh_pi"/>
      <map_variables variable_1="Kgapdh_nadh" variable_2="Kgapdh_nadh"/>
      <map_variables variable_1="Kgapdh_nad" variable_2="Kgapdh_nad"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="PGK"/>
      <map_variables variable_1="Vbbpgk" variable_2="Vbbpgk"/>
      <map_variables variable_1="Kpgk_bpg" variable_2="Kpgk_bpg"/>
      <map_variables variable_1="Kpgk_3pg" variable_2="Kpgk_3pg"/>
      <map_variables variable_1="Kpgk_atp" variable_2="Kpgk_atp"/>
      <map_variables variable_1="Kpgk_adp" variable_2="Kpgk_adp"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="PGM"/>
      <map_variables variable_1="Vffpgm" variable_2="Vffpgm"/>
      <map_variables variable_1="Kpgm_2pg" variable_2="Kpgm_2pg"/>
      <map_variables variable_1="Kpgm_3pg" variable_2="Kpgm_3pg"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="ENOL"/>
      <map_variables variable_1="Vffen" variable_2="Vffen"/>
      <map_variables variable_1="Ken_2pg" variable_2="Ken_2pg"/>
      <map_variables variable_1="Ken_pep" variable_2="Ken_pep"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="PK"/>
      <map_variables variable_1="Vffpk" variable_2="Vffpk"/>
      <map_variables variable_1="Kpk_atp" variable_2="Kpk_atp"/>
      <map_variables variable_1="Kpk_adp" variable_2="Kpk_adp"/>
      <map_variables variable_1="Kpk_pep" variable_2="Kpk_pep"/>
      <map_variables variable_1="Kpk_pyr" variable_2="Kpk_pyr"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="LDH"/>
      <map_variables variable_1="Vffldh" variable_2="Vffldh"/>
      <map_variables variable_1="Kldh_lac" variable_2="Kldh_lac"/>
      <map_variables variable_1="Kldh_pyr" variable_2="Kldh_pyr"/>
      <map_variables variable_1="Kldh_nad" variable_2="Kldh_nad"/>
      <map_variables variable_1="Kldh_nadh" variable_2="Kldh_nadh"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="creatine_kinase"/>
      <map_variables variable_1="VforCK" variable_2="VforCK"/>
      <map_variables variable_1="Kck_iatp" variable_2="Kck_iatp"/>
      <map_variables variable_1="Kck_iadp" variable_2="Kck_iadp"/>
      <map_variables variable_1="Kck_pcr" variable_2="Kck_pcr"/>
      <map_variables variable_1="Kck_ipcr" variable_2="Kck_ipcr"/>
      <map_variables variable_1="Kck_cr" variable_2="Kck_cr"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="adenylate_kinase"/>
      <map_variables variable_1="Vfadk" variable_2="Vfadk"/>
      <map_variables variable_1="Kadk_atp" variable_2="Kadk_atp"/>
      <map_variables variable_1="Kadk_adp" variable_2="Kadk_adp"/>
      <map_variables variable_1="Kadk_amp" variable_2="Kadk_amp"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="ATPase"/>
      <map_variables variable_1="kut" variable_2="kut"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="OXPHOS"/>
      <map_variables variable_1="VmaxOxPhos" variable_2="VmaxOxPhos"/>
      <map_variables variable_1="nnHH" variable_2="nnHH"/>
      <map_variables variable_1="Kmadp" variable_2="Kmadp"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="lactate_transport"/>
      <map_variables variable_1="pKmct1" variable_2="pKmct1"/>
      <map_variables variable_1="Vmax_MCT" variable_2="Vmax_MCT"/>
      <map_variables variable_1="nnHH" variable_2="nnHH"/>
      <map_variables variable_1="Klac1" variable_2="Klac1"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="Passive_permeation_flux"/>
      <map_variables variable_1="X_CA" variable_2="X_CA"/>
      <map_variables variable_1="PSVCO2" variable_2="PSVCO2"/>
      <map_variables variable_1="kf_hydrCO2" variable_2="kf_hydrCO2"/>
      <map_variables variable_1="kb_hydrCO2" variable_2="kb_hydrCO2"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="proton_flux"/>
      <map_variables variable_1="bufcapfixed" variable_2="bufcapfixed"/>
   </connection>
   <connection>
      <map_components component_1="parameters" component_2="differential_equations"/>
      <map_variables variable_1="Flow" variable_2="Flow"/>
      <map_variables variable_1="V_cell" variable_2="V_cell"/>
      <map_variables variable_1="V_ec" variable_2="V_ec"/>
   </connection>
   <connection>
      <map_components component_1="glycogen_phosphorylase_A" component_2="equilibrium_constants"/>
      <map_variables variable_1="Kapp_GP" variable_2="Kapp_GP"/>
   </connection>
   <connection>
      <map_components component_1="glycogen_phosphorylase_A" component_2="differential_equations"/>
      <map_variables variable_1="G1P" variable_2="G1P"/>
      <map_variables variable_1="Pi" variable_2="Pi"/>
      <map_variables variable_1="Gly" variable_2="Gly"/>
      <map_variables variable_1="flux_GPa" variable_2="flux_GPa"/>
   </connection>
   <connection>
      <map_components component_1="glycogen_phosphorylase_B" component_2="equilibrium_constants"/>
      <map_variables variable_1="Kapp_GP" variable_2="Kapp_GP"/>
   </connection>
   <connection>
      <map_components component_1="glycogen_phosphorylase_B" component_2="differential_equations"/>
      <map_variables variable_1="G1P" variable_2="G1P"/>
      <map_variables variable_1="Pi" variable_2="Pi"/>
      <map_variables variable_1="Gly" variable_2="Gly"/>
      <map_variables variable_1="AMP" variable_2="AMP"/>
      <map_variables variable_1="flux_GPb" variable_2="flux_GPb"/>
   </connection>
   <connection>
      <map_components component_1="PGLM" component_2="equilibrium_constants"/>
      <map_variables variable_1="Kapp_PGLM" variable_2="Kapp_PGLM"/>
   </connection>
   <connection>
      <map_components component_1="PGLM" component_2="differential_equations"/>
      <map_variables variable_1="G1P" variable_2="G1P"/>
      <map_variables variable_1="G6P" variable_2="G6P"/>
      <map_variables variable_1="v_PGLM" variable_2="v_PGLM"/>
   </connection>
   <connection>
      <map_components component_1="PGI" component_2="equilibrium_constants"/>
      <map_variables variable_1="Kapp_PGI" variable_2="Kapp_PGI"/>
   </connection>
   <connection>
      <map_components component_1="PGI" component_2="differential_equations"/>
      <map_variables variable_1="F6P" variable_2="F6P"/>
      <map_variables variable_1="G6P" variable_2="G6P"/>
      <map_variables variable_1="v_PGI" variable_2="v_PGI"/>
   </connection>
   <connection>
      <map_components component_1="PFK" component_2="equilibrium_constants"/>
      <map_variables variable_1="Kapp_PFK" variable_2="Kapp_PFK"/>
   </connection>
   <connection>
      <map_components component_1="PFK" component_2="differential_equations"/>
      <map_variables variable_1="F6P" variable_2="F6P"/>
      <map_variables variable_1="FBP" variable_2="FBP"/>
      <map_variables variable_1="AMP" variable_2="AMP"/>
      <map_variables variable_1="ADP" variable_2="ADP"/>
      <map_variables variable_1="ATP" variable_2="ATP"/>
      <map_variables variable_1="v_PFK" variable_2="v_PFK"/>
   </connection>
   <connection>
      <map_components component_1="ALD" component_2="equilibrium_constants"/>
      <map_variables variable_1="Kapp_ALD" variable_2="Kapp_ALD"/>
   </connection>
   <connection>
      <map_components component_1="ALD" component_2="differential_equations"/>
      <map_variables variable_1="DHAP" variable_2="DHAP"/>
      <map_variables variable_1="FBP" variable_2="FBP"/>
      <map_variables variable_1="GAP" variable_2="GAP"/>
      <map_variables variable_1="v_ALD" variable_2="v_ALD"/>
   </connection>
   <connection>
      <map_components component_1="TPI" component_2="equilibrium_constants"/>
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