Model Mathematics

Component: environment

Component: Ca_influx_across_the_SR

Component: Ca_movement_through_the_SRRC

r_o = cas1 ⁢ 1.0 - cas2 dd time cas1 = k_on1 ⁢ Ca_f ⁢ 1.0 - cas1 - k_off1 2.0 k_on1 ⁢ Ca_f ⁢ cas1 dd time cas2 = k_on2 ⁢ Ca_f ⁢ 1.0 - cas2 - k_off2 ⁢ cas2

Component: Ca_efflux_across_the_SR_by_NaCa_exchange

Component: Ca_movement_between_the_fuzzy_space_and_cytosol

Component: Ca_uptake_by_SR_Ca_ATPase

Component: Ca_buffering_in_the_SR

Component: fuzzy_space_calcium

dd time Ca_f = r_rxn_4 - Rt ⁢ dcas1_dt + dcas2_dt + r_rxn_6 + r_rxn_5 + r_rxn_1 Bmax_f1 ⁢ Kb_f1 Ca_f1 + Kb_f1 2.0 + Bmax_f2 ⁢ Kb_f2 Ca_f2 + Kb_f2 2.0 + V_f

Component: cytosolic_calcium

dd time Ca_c = r_rxn_6 - r_rxn_7 Bmax_c ⁢ Kb_c Ca_c + Kb_c 2.0 + dye_c ⁢ Kb_dye Ca_c + Kb_dye 2.0 + V_c

Component: SR_calcium

dd time Ca_s = r_rxn_7 - r_rxn_4 V_s - r_rxn_8

Component: extracellular_calcium

dd time Ca_e = delta_Ca_e_rxn_1 + delta_Ca_e_rxn_5

Component: calsequestrin_bound_calcium

dd time Ca_CSQ = delta_Ca_CSQ_rxn_8

Component: SRRC_fast_activating_binding_site

dd time S1 = delta_S1_rxn_2

Component: SRRC_slow_inactivating_binding_site

dd time S2 = delta_S2_rxn_3

Component: Ca_bound_to_the_SRRC_fast_activating_binding_site

dd time Ca_2_S1 = delta_Ca_2_S1_rxn_2

Component: Ca_bound_to_the_SRRC_slow_inactivating_binding_site

dd time Ca_S2 = delta_Ca_S2_rxn_3