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This CellML file was generated on 10/12/2008 at 3:53:27 at p.m. using:
COR (0.9.31.1125)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
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<title>An Integrative Analysis of Cell Cycle Control in Budding Yeast</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
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<title>Model Status</title>
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This CellML version of the model has been checked in COR and PCEnv and the model runs to replicate the results in the original published paper.
</para>
<para>
ValidateCellML verifies this model as valid CellML with full unit consistency.
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
The mitotic cell cycle can be defined as the sequence of events by which a somatic cell replicates all its components, and then divides them equally between two daughter cells. The end product is two genetically identical daughter cells. Cell division is an essential component of the biological processes of growth, reproduction and development. As might be expected for such an important process, the distinct phases and events of the cell cycle are carefully regulated by specific proteins.
</para>
<para>
The cell cycle regulatory system is most fully understood for budding yeast, <emphasis>Saccharomyces cerevisiae</emphasis>. A hypothetical molecular mechanism, potentially underlying cell cycle control in this organism, is outlined in <xref linkend="fig_reaction_diagram"/> below. However, these networks of interacting proteins are so complex that the functional integration of the network cannot be understood by intuition alone. Mathematical models, which describe molecular interactions and reactions with biochemical rate equations, provide an integrative framework with which the complexities of molecular regulatory networks can be studied. In the Chen <emphasis>et al.</emphasis> 2004 publication described here, the authors develop a mathematical model to analyse cell cycle control in budding yeast. Model simulations reveal that the data generated by the model are in accord with the physiological properties of many genetic strains of budding yeast. The mathematical model is also useful in that it can be used to interpret existing experimental data and help to design new experiments.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Chen <emphasis>et al.</emphasis> 2004 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Integrative analysis of cell cycle control in budding yeast, Katherine C. Chen, Laurence Calzone, Attila Csikasz-Nagy, Frederick R. Cross, Bela Novak, and John J. Tyson, 2004,
<emphasis>Molecular Biology of the Cell</emphasis>
. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15169868&dopt=Abstract">PubMed ID: 15169868</ulink>
</para>
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<caption>A schematic diagram of the cell cycle control mechanism in budding yeast.</caption>
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<apply>
<plus/>
<ci>Vd_b2</ci>
<ci>kdi_f2</ci>
</apply>
<ci>F2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b5</ci>
<ci>kdi_f5</ci>
</apply>
<ci>F5</ci>
</apply>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
<ci>Cdc6P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_f2</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>kas_f5</ci>
<ci>Clb5</ci>
</apply>
<ci>Vkp_f6</ci>
</apply>
<ci>Cdc6</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6P">
<variable initial_value="0.0155" name="Cdc6P" public_interface="out" units="dimensionless"/>
<variable name="kd3_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="kpp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_b2" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_b5" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="F2P" public_interface="in" units="dimensionless"/>
<variable name="F5P" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="Cdc6" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc6P</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_f6</ci>
<ci>Cdc6</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_f6</ci>
</apply>
<ci>Cdc6P</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vd_b2</ci>
<ci>F2P</ci>
</apply>
<apply>
<times/>
<ci>Vd_b5</ci>
<ci>F5P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F2">
<variable initial_value="0.2361" name="F2" public_interface="out" units="dimensionless"/>
<variable name="kas_f2" public_interface="in" units="first_order_rate_constant"/>
<variable name="kpp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_b2" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_f2" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="F2P" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="Cdc6" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_f2</ci>
<ci>Clb2</ci>
<ci>Cdc6</ci>
</apply>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
<ci>F2P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_f2</ci>
<ci>Vd_b2</ci>
<ci>Vkp_f6</ci>
</apply>
<ci>F2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Pds1">
<variable cmeta:id="Pds1_Pds1" initial_value="0.0256" name="Pds1" public_interface="out" units="dimensionless"/>
<variable name="ks_pds_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ks1_pds__" public_interface="in" units="first_order_rate_constant"/>
<variable name="ks2_pds__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_esp" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_pds" public_interface="in" units="first_order_rate_constant"/>
<variable name="kas_esp" public_interface="in" units="first_order_rate_constant"/>
<variable name="SBF" public_interface="in" units="dimensionless"/>
<variable name="Mcm1" public_interface="in" units="dimensionless"/>
<variable name="PE" public_interface="in" units="dimensionless"/>
<variable name="Esp1" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Pds1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_pds_</ci>
<apply>
<times/>
<ci>ks1_pds__</ci>
<ci>SBF</ci>
</apply>
<apply>
<times/>
<ci>ks2_pds__</ci>
<ci>Mcm1</ci>
</apply>
<apply>
<times/>
<ci>kdi_esp</ci>
<ci>PE</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_pds</ci>
<apply>
<times/>
<ci>kas_esp</ci>
<ci>Esp1</ci>
</apply>
</apply>
<ci>Pds1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Esp1">
<variable cmeta:id="Esp1_Esp1" initial_value="0.3013" name="Esp1" public_interface="out" units="dimensionless"/>
<variable name="kdi_esp" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_pds" public_interface="in" units="first_order_rate_constant"/>
<variable name="kas_esp" public_interface="in" units="first_order_rate_constant"/>
<variable name="Pds1" public_interface="in" units="dimensionless"/>
<variable name="PE" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Esp1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>kas_esp</ci>
</apply>
<ci>Pds1</ci>
<ci>Esp1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_esp</ci>
<ci>Vd_pds</ci>
</apply>
<ci>PE</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ORI">
<variable initial_value="0.0009" name="ORI" public_interface="out" units="dimensionless"/>
<variable name="ks_ori" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_ori" public_interface="in" units="first_order_rate_constant"/>
<variable name="epsilon_ori_b5" public_interface="in" units="dimensionless"/>
<variable name="epsilon_ori_b2" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ORI</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ks_ori</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_ori_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_ori_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kd_ori</ci>
<ci>ORI</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="BUD">
<variable initial_value="0.0085" name="BUD" public_interface="out" units="dimensionless"/>
<variable name="ks_bud" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_bud" public_interface="in" units="first_order_rate_constant"/>
<variable name="epsilon_bud_n2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_bud_n3" public_interface="in" units="dimensionless"/>
<variable name="epsilon_bud_b5" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BUD</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ks_bud</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_bud_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_bud_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_bud_b5</ci>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kd_bud</ci>
<ci>BUD</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SPN">
<variable initial_value="0.0305" name="SPN" public_interface="out" units="dimensionless"/>
<variable name="ks_spn" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_spn" public_interface="in" units="first_order_rate_constant"/>
<variable name="Jspn" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SPN</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>ks_spn</ci>
<ci>Clb2</ci>
</apply>
<apply>
<plus/>
<ci>Jspn</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_spn</ci>
<ci>SPN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_sbf">
<variable name="G_sbf" public_interface="out" units="dimensionless"/>
<variable name="Ji_sbf" public_interface="in" units="dimensionless"/>
<variable name="Ja_sbf" public_interface="in" units="dimensionless"/>
<variable name="Vi_sbf" public_interface="in" units="first_order_rate_constant"/>
<variable name="Va_sbf" public_interface="in" units="first_order_rate_constant"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_sbf</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vi_sbf</ci>
<apply>
<times/>
<ci>Ja_sbf</ci>
<ci>Vi_sbf</ci>
</apply>
<apply>
<times/>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vi_sbf</ci>
<apply>
<times/>
<ci>Ja_sbf</ci>
<ci>Vi_sbf</ci>
</apply>
<apply>
<times/>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<ci>Vi_sbf</ci>
<ci>Va_sbf</ci>
</apply>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_mcm">
<variable name="G_mcm" public_interface="out" units="dimensionless"/>
<variable name="Ji_mcm" public_interface="in" units="dimensionless"/>
<variable name="Ja_mcm" public_interface="in" units="dimensionless"/>
<variable name="ki_mcm" public_interface="in" units="first_order_rate_constant"/>
<variable name="ka_mcm" public_interface="in" units="first_order_rate_constant"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_mcm</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>Ja_mcm</ci>
<ci>ki_mcm</ci>
</apply>
<apply>
<times/>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>Ja_mcm</ci>
<ci>ki_mcm</ci>
</apply>
<apply>
<times/>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SBF_MBF">
<variable name="SBF" public_interface="out" units="dimensionless"/>
<variable name="MBF" public_interface="out" units="dimensionless"/>
<variable name="G_sbf" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>SBF</ci>
<ci>MBF</ci>
</apply>
<apply>
<eq/>
<ci>MBF</ci>
<ci>G_sbf</ci>
</apply>
</math>
</component>
<component name="Mcm1">
<variable cmeta:id="Mcm1_Mcm1" name="Mcm1" public_interface="out" units="dimensionless"/>
<variable name="G_mcm" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mcm1</ci>
<ci>G_mcm</ci>
</apply>
</math>
</component>
<component name="Cln3">
<variable name="Cln3" public_interface="out" units="dimensionless"/>
<variable name="C0" public_interface="in" units="dimensionless"/>
<variable name="Dn3" public_interface="in" units="dimensionless"/>
<variable name="Jn3" public_interface="in" units="dimensionless"/>
<variable name="mass" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cln3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C0</ci>
<ci>Dn3</ci>
<ci>mass</ci>
</apply>
<apply>
<plus/>
<ci>Jn3</ci>
<apply>
<times/>
<ci>Dn3</ci>
<ci>mass</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Bck2">
<variable name="Bck2" public_interface="out" units="dimensionless"/>
<variable name="B0" public_interface="in" units="dimensionless"/>
<variable name="mass" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Bck2</ci>
<apply>
<times/>
<ci>B0</ci>
<ci>mass</ci>
</apply>
</apply>
</math>
</component>
<component name="Clb5_T">
<variable cmeta:id="Clb5_T_Clb5_T" name="Clb5_T" public_interface="out" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="C5" public_interface="in" units="dimensionless"/>
<variable name="C5P" public_interface="in" units="dimensionless"/>
<variable name="F5" public_interface="in" units="dimensionless"/>
<variable name="F5P" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Clb5_T</ci>
<apply>
<plus/>
<ci>Clb5</ci>
<ci>C5</ci>
<ci>C5P</ci>
<ci>F5</ci>
<ci>F5P</ci>
</apply>
</apply>
</math>
</component>
<component name="Clb2_T">
<variable cmeta:id="Clb2_T_Clb2_T" name="Clb2_T" public_interface="out" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="C2" public_interface="in" units="dimensionless"/>
<variable name="C2P" public_interface="in" units="dimensionless"/>
<variable name="F2" public_interface="in" units="dimensionless"/>
<variable name="F2P" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Clb2_T</ci>
<apply>
<plus/>
<ci>Clb2</ci>
<ci>C2</ci>
<ci>C2P</ci>
<ci>F2</ci>
<ci>F2P</ci>
</apply>
</apply>
</math>
</component>
<component name="Sic1_T">
<variable name="Sic1_T" public_interface="out" units="dimensionless"/>
<variable name="Sic1" public_interface="in" units="dimensionless"/>
<variable name="Sic1P" public_interface="in" units="dimensionless"/>
<variable name="C2" public_interface="in" units="dimensionless"/>
<variable name="C2P" public_interface="in" units="dimensionless"/>
<variable name="C5" public_interface="in" units="dimensionless"/>
<variable name="C5P" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Sic1_T</ci>
<apply>
<plus/>
<ci>Sic1</ci>
<ci>Sic1P</ci>
<ci>C2</ci>
<ci>C2P</ci>
<ci>C5</ci>
<ci>C5P</ci>
</apply>
</apply>
</math>
</component>
<component name="F5">
<variable initial_value="7.2e-5" name="F5" public_interface="out" units="dimensionless"/>
<variable name="kas_f5" public_interface="in" units="first_order_rate_constant"/>
<variable name="kpp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_f5" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_b5" public_interface="in" units="first_order_rate_constant"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cdc6" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="F5P" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_f5</ci>
<ci>Clb5</ci>
<ci>Cdc6</ci>
</apply>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
<ci>F5P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_f5</ci>
<ci>Vd_b5</ci>
<ci>Vkp_f6</ci>
</apply>
<ci>F5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F2P">
<variable initial_value="0.0274" name="F2P" public_interface="out" units="dimensionless"/>
<variable name="kd3_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="kpp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_b2" public_interface="in" units="first_order_rate_constant"/>
<variable name="F2" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F2P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_f6</ci>
<ci>F2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_f6</ci>
<ci>Vd_b2</ci>
</apply>
<ci>F2P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F5P">
<variable initial_value="7.9e-6" name="F5P" public_interface="out" units="dimensionless"/>
<variable name="kd3_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="kpp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_b5" public_interface="in" units="first_order_rate_constant"/>
<variable name="F5" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F5P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_f6</ci>
<ci>F5</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_f6</ci>
<ci>Vd_b5</ci>
</apply>
<ci>F5P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5_T">
<variable initial_value="0.9765" name="Swi5_T" public_interface="out" units="dimensionless"/>
<variable name="ks_swi_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ks_swi__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_swi" public_interface="in" units="first_order_rate_constant"/>
<variable name="Mcm1" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swi5_T</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_swi_</ci>
<apply>
<times/>
<ci>ks_swi__</ci>
<ci>Mcm1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_swi</ci>
<ci>Swi5_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5">
<variable initial_value="0.9562" name="Swi5" public_interface="out" units="dimensionless"/>
<variable name="ks_swi_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ks_swi__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_swi" public_interface="in" units="first_order_rate_constant"/>
<variable name="ka_swi" public_interface="in" units="first_order_rate_constant"/>
<variable name="ki_swi" public_interface="in" units="first_order_rate_constant"/>
<variable name="Mcm1" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="Swi5_T" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swi5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_swi_</ci>
<apply>
<times/>
<ci>ks_swi__</ci>
<ci>Mcm1</ci>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc14</ci>
<apply>
<minus/>
<ci>Swi5_T</ci>
<ci>Swi5</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kd_swi</ci>
<apply>
<times/>
<ci>ki_swi</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Swi5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="APC_P">
<variable cmeta:id="APC_P_APC_P" initial_value="0.1015" name="APC_P" public_interface="out" units="dimensionless"/>
<variable name="ka_apc" public_interface="in" units="first_order_rate_constant"/>
<variable name="ki_apc" public_interface="in" units="first_order_rate_constant"/>
<variable name="Ja_apc" public_interface="in" units="dimensionless"/>
<variable name="Ji_apc" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>APC_P</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>ka_apc</ci>
<ci>Clb2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_apc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>ki_apc</ci>
<ci>APC_P</ci>
</apply>
<apply>
<plus/>
<ci>Ji_apc</ci>
<ci>APC_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_T">
<variable cmeta:id="Cdc20_T_Cdc20_T" initial_value="1.9163" name="Cdc20_T" public_interface="out" units="dimensionless"/>
<variable name="ks_20_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ks_20__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_20" public_interface="in" units="first_order_rate_constant"/>
<variable name="Mcm1" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_T</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_20_</ci>
<apply>
<times/>
<ci>ks_20__</ci>
<ci>Mcm1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_20</ci>
<ci>Cdc20_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_A">
<variable cmeta:id="Cdc20_A_Cdc20_A" initial_value="0.4443" name="Cdc20_A" public_interface="out" units="dimensionless"/>
<variable name="ka_20_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ka_20__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_20" public_interface="in" units="first_order_rate_constant"/>
<variable name="kmad2" public_interface="in" units="first_order_rate_constant"/>
<variable name="APC_P" public_interface="in" units="dimensionless"/>
<variable name="Cdc20_T" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_A</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>ka_20_</ci>
<apply>
<times/>
<ci>ka_20__</ci>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Cdc20_T</ci>
<ci>Cdc20_A</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kmad2</ci>
<ci>kd_20</ci>
</apply>
<ci>Cdc20_A</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1_T">
<variable cmeta:id="Cdh1_T_Cdh1_T" initial_value="1" name="Cdh1_T" public_interface="out" units="dimensionless"/>
<variable name="ks_cdh" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_cdh" public_interface="in" units="first_order_rate_constant"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1_T</ci>
</apply>
<apply>
<minus/>
<ci>ks_cdh</ci>
<apply>
<times/>
<ci>kd_cdh</ci>
<ci>Cdh1_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1">
<variable cmeta:id="Cdh1_Cdh1" initial_value="0.9305" name="Cdh1" public_interface="out" units="dimensionless"/>
<variable name="ks_cdh" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_cdh" public_interface="in" units="first_order_rate_constant"/>
<variable name="Ja_cdh" public_interface="in" units="dimensionless"/>
<variable name="Ji_cdh" public_interface="in" units="dimensionless"/>
<variable name="Va_cdh" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vi_cdh" public_interface="in" units="first_order_rate_constant"/>
<variable name="Cdh1_T" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_cdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Va_cdh</ci>
<apply>
<minus/>
<ci>Cdh1_T</ci>
<ci>Cdh1</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_cdh</ci>
<ci>Cdh1_T</ci>
</apply>
<ci>Cdh1</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kd_cdh</ci>
<ci>Cdh1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vi_cdh</ci>
<ci>Cdh1</ci>
</apply>
<apply>
<plus/>
<ci>Ji_cdh</ci>
<ci>Cdh1</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Tem1">
<variable initial_value="0.9039" name="Tem1" public_interface="out" units="dimensionless"/>
<variable name="kbub2" public_interface="in" units="first_order_rate_constant"/>
<variable name="klte1" public_interface="in" units="first_order_rate_constant"/>
<variable name="Ja_tem" public_interface="in" units="dimensionless"/>
<variable name="Ji_tem" public_interface="in" units="dimensionless"/>
<variable name="Tem1_T" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Tem1</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>klte1</ci>
<apply>
<minus/>
<ci>Tem1_T</ci>
<ci>Tem1</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_tem</ci>
<ci>Tem1_T</ci>
</apply>
<ci>Tem1</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>kbub2</ci>
<ci>Tem1</ci>
</apply>
<apply>
<plus/>
<ci>Ji_tem</ci>
<ci>Tem1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc15">
<variable cmeta:id="Cdc15_Cdc15" initial_value="0.6565" name="Cdc15" public_interface="out" units="dimensionless"/>
<variable name="ka_15_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ka_15__" public_interface="in" units="first_order_rate_constant"/>
<variable name="ka_15___" public_interface="in" units="first_order_rate_constant"/>
<variable name="ki_15" public_interface="in" units="first_order_rate_constant"/>
<variable name="Tem1" public_interface="in" units="dimensionless"/>
<variable name="Tem1_T" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="Cdc15_T" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc15</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>ka_15_</ci>
<apply>
<minus/>
<ci>Tem1_T</ci>
<ci>Tem1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_15__</ci>
<ci>Tem1</ci>
</apply>
<apply>
<times/>
<ci>ka_15___</ci>
<ci>Cdc14</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Cdc15_T</ci>
<ci>Cdc15</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ki_15</ci>
<ci>Cdc15</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc14_T">
<variable initial_value="2" name="Cdc14_T" public_interface="out" units="dimensionless"/>
<variable name="ks_14" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_14" public_interface="in" units="first_order_rate_constant"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc14_T</ci>
</apply>
<apply>
<minus/>
<ci>ks_14</ci>
<apply>
<times/>
<ci>kd_14</ci>
<ci>Cdc14_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc14">
<variable cmeta:id="Cdc14_Cdc14" initial_value="0.4683" name="Cdc14" public_interface="out" units="dimensionless"/>
<variable name="ks_14" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_14" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_rent" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_rentp" public_interface="in" units="first_order_rate_constant"/>
<variable name="kas_rent" public_interface="in" units="first_order_rate_constant"/>
<variable name="kas_rentp" public_interface="in" units="first_order_rate_constant"/>
<variable name="RENT" public_interface="in" units="dimensionless"/>
<variable name="RENTP" public_interface="in" units="dimensionless"/>
<variable name="Net1" public_interface="in" units="dimensionless"/>
<variable name="Net1P" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc14</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_14</ci>
<apply>
<times/>
<ci>kd_net</ci>
<apply>
<plus/>
<ci>RENT</ci>
<ci>RENTP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kdi_rent</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>kdi_rentp</ci>
<ci>RENTP</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kd_14</ci>
<ci>Cdc14</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_rent</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>kas_rentp</ci>
<ci>Net1P</ci>
</apply>
</apply>
<ci>Cdc14</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Net1_T">
<variable initial_value="2.8" name="Net1_T" public_interface="out" units="dimensionless"/>
<variable name="ks_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Net1_T</ci>
</apply>
<apply>
<minus/>
<ci>ks_net</ci>
<apply>
<times/>
<ci>kd_net</ci>
<ci>Net1_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6_T">
<variable name="Cdc6_T" public_interface="out" units="dimensionless"/>
<variable name="Cdc6" public_interface="in" units="dimensionless"/>
<variable name="Cdc6P" public_interface="in" units="dimensionless"/>
<variable name="F2" public_interface="in" units="dimensionless"/>
<variable name="F2P" public_interface="in" units="dimensionless"/>
<variable name="F5" public_interface="in" units="dimensionless"/>
<variable name="F5P" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cdc6_T</ci>
<apply>
<plus/>
<ci>Cdc6</ci>
<ci>Cdc6P</ci>
<ci>F2</ci>
<ci>F2P</ci>
<ci>F5</ci>
<ci>F5P</ci>
</apply>
</apply>
</math>
</component>
<component name="CKI_T">
<variable cmeta:id="CKI_T_CKI_T" name="CKI_T" public_interface="out" units="dimensionless"/>
<variable name="Sic1_T" public_interface="in" units="dimensionless"/>
<variable name="Cdc6_T" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>CKI_T</ci>
<apply>
<plus/>
<ci>Sic1_T</ci>
<ci>Cdc6_T</ci>
</apply>
</apply>
</math>
</component>
<component name="RENTP">
<variable name="RENTP" public_interface="out" units="dimensionless"/>
<variable name="Cdc14_T" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="RENT" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RENTP</ci>
<apply>
<minus/>
<ci>Cdc14_T</ci>
<apply>
<plus/>
<ci>RENT</ci>
<ci>Cdc14</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Net1P">
<variable cmeta:id="Net1P_Net1P" name="Net1P" public_interface="out" units="dimensionless"/>
<variable name="Net1_T" public_interface="in" units="dimensionless"/>
<variable name="Cdc14_T" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="Net1" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Net1P</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>Net1_T</ci>
<ci>Cdc14</ci>
</apply>
<apply>
<plus/>
<ci>Net1</ci>
<ci>Cdc14_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PE">
<variable name="PE" public_interface="out" units="dimensionless"/>
<variable name="Esp1_T" public_interface="in" units="dimensionless"/>
<variable name="Esp1" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PE</ci>
<apply>
<minus/>
<ci>Esp1_T</ci>
<ci>Esp1</ci>
</apply>
</apply>
</math>
</component>
<component name="Vd_b5">
<variable name="Vd_b5" public_interface="out" units="first_order_rate_constant"/>
<variable name="kd_b5_" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_b5__" public_interface="in" units="first_order_rate_constant"/>
<variable name="Cdc20_A" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_b5</ci>
<apply>
<plus/>
<ci>kd_b5_</ci>
<apply>
<times/>
<ci>kd_b5__</ci>
<ci>Cdc20_A</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_b2">
<variable name="Vd_b2" public_interface="out" units="first_order_rate_constant"/>
<variable name="kd_b2_" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_b2__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_b2p" public_interface="in" units="first_order_rate_constant"/>
<variable name="Cdh1" public_interface="in" units="dimensionless"/>
<variable name="Cdc20_A" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_b2</ci>
<apply>
<plus/>
<ci>kd_b2_</ci>
<apply>
<times/>
<ci>kd_b2__</ci>
<ci>Cdh1</ci>
</apply>
<apply>
<times/>
<ci>kd_b2p</ci>
<ci>Cdc20_A</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Va_sbf">
<variable name="Va_sbf" public_interface="out" units="first_order_rate_constant"/>
<variable name="ka_sbf" public_interface="in" units="first_order_rate_constant"/>
<variable name="epsilon_sbf_n2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_sbf_n3" public_interface="in" units="dimensionless"/>
<variable name="epsilon_sbf_b5" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Bck2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Va_sbf</ci>
<apply>
<times/>
<ci>ka_sbf</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_sbf_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_sbf_n3</ci>
<apply>
<plus/>
<ci>Cln3</ci>
<ci>Bck2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>epsilon_sbf_b5</ci>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vi_sbf">
<variable name="Vi_sbf" public_interface="out" units="first_order_rate_constant"/>
<variable name="ki_sbf_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ki_sbf__" public_interface="in" units="first_order_rate_constant"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vi_sbf</ci>
<apply>
<plus/>
<ci>ki_sbf_</ci>
<apply>
<times/>
<ci>ki_sbf__</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_c1">
<variable name="Vkp_c1" public_interface="out" units="first_order_rate_constant"/>
<variable name="kd1_c1" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd2_c1" public_interface="in" units="first_order_rate_constant"/>
<variable name="Jd2_c1" public_interface="in" units="dimensionless"/>
<variable name="epsilon_c1_n2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_c1_n3" public_interface="in" units="dimensionless"/>
<variable name="epsilon_c1_k2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_c1_b5" public_interface="in" units="dimensionless"/>
<variable name="epsilon_c1_b2" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Bck2" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="Sic1_T" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vkp_c1</ci>
<apply>
<plus/>
<ci>kd1_c1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kd2_c1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_c1_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_k2</ci>
<ci>Bck2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Jd2_c1</ci>
<ci>Sic1_T</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_f6">
<variable name="Vkp_f6" public_interface="out" units="first_order_rate_constant"/>
<variable name="Jd2_f6" public_interface="in" units="dimensionless"/>
<variable name="kd1_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd2_f6" public_interface="in" units="first_order_rate_constant"/>
<variable name="epsilon_f6_n2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_f6_n3" public_interface="in" units="dimensionless"/>
<variable name="epsilon_f6_k2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_f6_b5" public_interface="in" units="dimensionless"/>
<variable name="epsilon_f6_b2" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Bck2" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="Cdc6_T" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vkp_f6</ci>
<apply>
<plus/>
<ci>kd1_f6</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kd2_f6</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_f6_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_k2</ci>
<ci>Bck2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Jd2_f6</ci>
<ci>Cdc6_T</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Va_cdh">
<variable name="Va_cdh" public_interface="out" units="first_order_rate_constant"/>
<variable name="ka_cdh_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ka_cdh__" public_interface="in" units="first_order_rate_constant"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Va_cdh</ci>
<apply>
<plus/>
<ci>ka_cdh_</ci>
<apply>
<times/>
<ci>ka_cdh__</ci>
<ci>Cdc14</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vi_cdh">
<variable name="Vi_cdh" public_interface="out" units="first_order_rate_constant"/>
<variable name="ki_cdh_" public_interface="in" units="first_order_rate_constant"/>
<variable name="ki_cdh__" public_interface="in" units="first_order_rate_constant"/>
<variable name="epsilon_cdh_n2" public_interface="in" units="dimensionless"/>
<variable name="epsilon_cdh_n3" public_interface="in" units="dimensionless"/>
<variable name="epsilon_cdh_b5" public_interface="in" units="dimensionless"/>
<variable name="epsilon_cdh_b2" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vi_cdh</ci>
<apply>
<plus/>
<ci>ki_cdh_</ci>
<apply>
<times/>
<ci>ki_cdh__</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_cdh_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_cdh_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_cdh_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_cdh_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vpp_net">
<variable name="Vpp_net" public_interface="out" units="first_order_rate_constant"/>
<variable name="kpp_net_" public_interface="in" units="first_order_rate_constant"/>
<variable name="kpp_net__" public_interface="in" units="first_order_rate_constant"/>
<variable name="PPX" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vpp_net</ci>
<apply>
<plus/>
<ci>kpp_net_</ci>
<apply>
<times/>
<ci>kpp_net__</ci>
<ci>PPX</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_net">
<variable name="Vkp_net" public_interface="out" units="first_order_rate_constant"/>
<variable name="kkp_net_" public_interface="in" units="first_order_rate_constant"/>
<variable name="kkp_net__" public_interface="in" units="first_order_rate_constant"/>
<variable name="Cdc15" public_interface="in" units="dimensionless"/>
<variable name="mass" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vkp_net</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>kkp_net_</ci>
<apply>
<times/>
<ci>kkp_net__</ci>
<ci>Cdc15</ci>
</apply>
</apply>
<ci>mass</ci>
</apply>
</apply>
</math>
</component>
<component name="Net1">
<variable cmeta:id="Net1_Net1" initial_value="0.0186" name="Net1" public_interface="out" units="dimensionless"/>
<variable name="ks_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_14" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_rent" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vpp_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kas_rent" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="RENT" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="Net1P" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Net1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_net</ci>
<apply>
<times/>
<ci>kd_14</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>kdi_rent</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>Vpp_net</ci>
<ci>Net1P</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kd_net</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>kas_rent</ci>
<ci>Cdc14</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>Vkp_net</ci>
<ci>Net1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RENT">
<variable cmeta:id="RENT_RENT" initial_value="1.0495" name="RENT" public_interface="out" units="dimensionless"/>
<variable name="ks_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_14" public_interface="in" units="first_order_rate_constant"/>
<variable name="kdi_rent" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vpp_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="kas_rent" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vkp_net" public_interface="in" units="first_order_rate_constant"/>
<variable name="Net1" public_interface="in" units="dimensionless"/>
<variable name="Cdc14" public_interface="in" units="dimensionless"/>
<variable name="RENTP" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RENT</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_rent</ci>
<ci>Cdc14</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>Vpp_net</ci>
<ci>RENTP</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>kd_14</ci>
<ci>kd_net</ci>
</apply>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>kdi_rent</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>Vkp_net</ci>
<ci>RENT</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PPX">
<variable cmeta:id="PPX_PPX" initial_value="0.1232" name="PPX" public_interface="out" units="dimensionless"/>
<variable name="ks_ppx" public_interface="in" units="first_order_rate_constant"/>
<variable name="Vd_ppx" public_interface="in" units="first_order_rate_constant"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PPX</ci>
</apply>
<apply>
<minus/>
<ci>ks_ppx</ci>
<apply>
<times/>
<ci>Vd_ppx</ci>
<ci>PPX</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_ppx">
<variable name="Vd_ppx" public_interface="out" units="first_order_rate_constant"/>
<variable name="kd_ppx_" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd_ppx__" public_interface="in" units="first_order_rate_constant"/>
<variable name="Pds1" public_interface="in" units="dimensionless"/>
<variable name="Cdc20_A" public_interface="in" units="dimensionless"/>
<variable name="Jpds" public_interface="in" units="dimensionless"/>
<variable name="J20_ppx" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_ppx</ci>
<apply>
<plus/>
<ci>kd_ppx_</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kd_ppx__</ci>
<apply>
<plus/>
<ci>J20_ppx</ci>
<ci>Cdc20_A</ci>
</apply>
<ci>Jpds</ci>
</apply>
<apply>
<plus/>
<ci>Jpds</ci>
<ci>Pds1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_pds">
<variable name="Vd_pds" public_interface="out" units="first_order_rate_constant"/>
<variable name="kd1_pds_" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd2_pds__" public_interface="in" units="first_order_rate_constant"/>
<variable name="kd3_pds__" public_interface="in" units="first_order_rate_constant"/>
<variable name="Cdh1" public_interface="in" units="dimensionless"/>
<variable name="Cdc20_A" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_pds</ci>
<apply>
<plus/>
<ci>kd1_pds_</ci>
<apply>
<times/>
<ci>kd2_pds__</ci>
<ci>Cdc20_A</ci>
</apply>
<apply>
<times/>
<ci>kd3_pds__</ci>
<ci>Cdh1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="model_parameters">
<variable initial_value="0.007702" name="kg" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0" name="ks_n2_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.15" name="ks_n2__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.12" name="kd_n2" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.0008" name="ks_b5_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.005" name="ks_b5__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="kd_b5_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.16" name="kd_b5__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.001" name="ks_b2_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.04" name="ks_b2__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.003" name="kd_b2_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.4" name="kd_b2__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.15" name="kd_b2p" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.012" name="ks_c1_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.12" name="ks_c1__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="kd1_c1" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="1" name="kd2_c1" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="1" name="kd3_c1" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="4" name="kpp_c1" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.024" name="ks_f6_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.12" name="ks_f6__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.004" name="ks_f6___" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="kd1_f6" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="1" name="kd2_f6" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="1" name="kd3_f6" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="4" name="kpp_f6" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="50" name="kas_b5" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.06" name="kdi_b5" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="kas_f5" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="kdi_f5" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="50" name="kas_b2" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.05" name="kdi_b2" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="15" name="kas_f2" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.5" name="kdi_f2" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.005" name="ks_swi_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.08" name="ks_swi__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.08" name="kd_swi" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="2" name="ka_swi" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.05" name="ki_swi" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.1" name="ka_apc" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.15" name="ki_apc" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.006" name="ks_20_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.6" name="ks_20__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.3" name="kd_20" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.05" name="ka_20_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.2" name="ka_20__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="ks_cdh" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="kd_cdh" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="ka_cdh_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.8" name="ka_cdh__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.001" name="ki_cdh_" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.08" name="ki_cdh__" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.2" name="ks_14" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.1" name="kd_14" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.084" name="ks_net" public_interface="out" units="first_order_rate_constant"/>
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<variable name="kbub2" public_interface="out" units="first_order_rate_constant"/>
<variable name="klte1" public_interface="out" units="first_order_rate_constant"/>
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<variable initial_value="1" name="Cdc15_T" public_interface="out" units="dimensionless"/>
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<variable initial_value="6" name="Jn3" public_interface="out" units="dimensionless"/>
<variable initial_value="0.15" name="J20_ppx" public_interface="out" units="dimensionless"/>
<variable initial_value="0.04" name="Jpds" public_interface="out" units="dimensionless"/>
<variable initial_value="0.3" name="Kez" public_interface="out" units="dimensionless"/>
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<variable name="SPN" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
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<eq/>
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<and/>
<apply>
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<ci>ORI</ci>
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<ci>ORI</ci>
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<and/>
<apply>
<gt/>
<ci>SPN</ci>
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<gt/>
<ci>Clb2</ci>
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<map_components component_1="mass" component_2="environment"/>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_1="Cdh1" component_2="environment"/>
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<connection>
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<connection>
<map_components component_1="Cdc15" component_2="environment"/>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_1="RENT" component_2="environment"/>
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<connection>
<map_components component_1="PPX" component_2="environment"/>
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<connection>
<map_components component_1="mass" component_2="model_parameters"/>
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<connection>
<map_components component_1="Cln2" component_2="model_parameters"/>
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<connection>
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<connection>
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<map_variables variable_1="kas_b5" variable_2="kas_b5"/>
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<connection>
<map_components component_1="Sic1P" component_2="model_parameters"/>
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<connection>
<map_components component_1="C2" component_2="model_parameters"/>
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<map_variables variable_1="kpp_c1" variable_2="kpp_c1"/>
<map_variables variable_1="kdi_b2" variable_2="kdi_b2"/>
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<connection>
<map_components component_1="C5" component_2="model_parameters"/>
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<map_variables variable_1="kdi_b5" variable_2="kdi_b5"/>
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<connection>
<map_components component_1="C2P" component_2="model_parameters"/>
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<map_variables variable_1="kpp_c1" variable_2="kpp_c1"/>
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<connection>
<map_components component_1="C5P" component_2="model_parameters"/>
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<connection>
<map_components component_1="Cdc6" component_2="model_parameters"/>
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<map_variables variable_1="ks_f6___" variable_2="ks_f6___"/>
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<map_variables variable_1="kas_f5" variable_2="kas_f5"/>
<map_variables variable_1="kas_f2" variable_2="kas_f2"/>
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<connection>
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<connection>
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<map_variables variable_1="kdi_f2" variable_2="kdi_f2"/>
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<connection>
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<map_variables variable_1="kdi_esp" variable_2="kdi_esp"/>
<map_variables variable_1="kas_esp" variable_2="kas_esp"/>
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<connection>
<map_components component_1="Esp1" component_2="model_parameters"/>
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<map_variables variable_1="kas_esp" variable_2="kas_esp"/>
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<connection>
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<map_variables variable_1="epsilon_ori_b5" variable_2="epsilon_ori_b5"/>
<map_variables variable_1="epsilon_ori_b2" variable_2="epsilon_ori_b2"/>
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<connection>
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<map_variables variable_1="epsilon_bud_b5" variable_2="epsilon_bud_b5"/>
<map_variables variable_1="epsilon_bud_n2" variable_2="epsilon_bud_n2"/>
<map_variables variable_1="epsilon_bud_n3" variable_2="epsilon_bud_n3"/>
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<connection>
<map_components component_1="SPN" component_2="model_parameters"/>
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<map_variables variable_1="SPN" variable_2="SPN"/>
<map_variables variable_1="Jspn" variable_2="Jspn"/>
<map_variables variable_1="kd_spn" variable_2="kd_spn"/>
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<connection>
<map_components component_1="G_sbf" component_2="model_parameters"/>
<map_variables variable_1="Ja_sbf" variable_2="Ja_sbf"/>
<map_variables variable_1="Ji_sbf" variable_2="Ji_sbf"/>
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<connection>
<map_components component_1="G_mcm" component_2="model_parameters"/>
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<map_variables variable_1="Ji_mcm" variable_2="Ji_mcm"/>
<map_variables variable_1="ka_mcm" variable_2="ka_mcm"/>
<map_variables variable_1="ki_mcm" variable_2="ki_mcm"/>
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<connection>
<map_components component_1="Cln3" component_2="model_parameters"/>
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<map_variables variable_1="Dn3" variable_2="Dn3"/>
<map_variables variable_1="Jn3" variable_2="Jn3"/>
</connection>
<connection>
<map_components component_1="Bck2" component_2="model_parameters"/>
<map_variables variable_1="B0" variable_2="B0"/>
</connection>
<connection>
<map_components component_1="F5" component_2="model_parameters"/>
<map_variables variable_1="kas_f5" variable_2="kas_f5"/>
<map_variables variable_1="kpp_f6" variable_2="kpp_f6"/>
<map_variables variable_1="kdi_f5" variable_2="kdi_f5"/>
</connection>
<connection>
<map_components component_1="F2P" component_2="model_parameters"/>
<map_variables variable_1="kd3_f6" variable_2="kd3_f6"/>
<map_variables variable_1="kpp_f6" variable_2="kpp_f6"/>
</connection>
<connection>
<map_components component_1="F5P" component_2="model_parameters"/>
<map_variables variable_1="kd3_f6" variable_2="kd3_f6"/>
<map_variables variable_1="kpp_f6" variable_2="kpp_f6"/>
</connection>
<connection>
<map_components component_1="Swi5_T" component_2="model_parameters"/>
<map_variables variable_1="ks_swi_" variable_2="ks_swi_"/>
<map_variables variable_1="ks_swi__" variable_2="ks_swi__"/>
<map_variables variable_1="kd_swi" variable_2="kd_swi"/>
</connection>
<connection>
<map_components component_1="Swi5" component_2="model_parameters"/>
<map_variables variable_1="ks_swi_" variable_2="ks_swi_"/>
<map_variables variable_1="ks_swi__" variable_2="ks_swi__"/>
<map_variables variable_1="ka_swi" variable_2="ka_swi"/>
<map_variables variable_1="kd_swi" variable_2="kd_swi"/>
<map_variables variable_1="ki_swi" variable_2="ki_swi"/>
</connection>
<connection>
<map_components component_1="APC_P" component_2="model_parameters"/>
<map_variables variable_1="ka_apc" variable_2="ka_apc"/>
<map_variables variable_1="ki_apc" variable_2="ki_apc"/>
<map_variables variable_1="Ja_apc" variable_2="Ja_apc"/>
<map_variables variable_1="Ji_apc" variable_2="Ji_apc"/>
</connection>
<connection>
<map_components component_1="Cdc20_T" component_2="model_parameters"/>
<map_variables variable_1="ks_20_" variable_2="ks_20_"/>
<map_variables variable_1="ks_20__" variable_2="ks_20__"/>
<map_variables variable_1="kd_20" variable_2="kd_20"/>
</connection>
<connection>
<map_components component_1="Cdc20_A" component_2="model_parameters"/>
<map_variables variable_1="ka_20_" variable_2="ka_20_"/>
<map_variables variable_1="ka_20__" variable_2="ka_20__"/>
<map_variables variable_1="kd_20" variable_2="kd_20"/>
<map_variables variable_1="kmad2" variable_2="kmad2"/>
</connection>
<connection>
<map_components component_1="Cdh1" component_2="model_parameters"/>
<map_variables variable_1="ks_cdh" variable_2="ks_cdh"/>
<map_variables variable_1="kd_cdh" variable_2="kd_cdh"/>
<map_variables variable_1="Ja_cdh" variable_2="Ja_cdh"/>
<map_variables variable_1="Ji_cdh" variable_2="Ji_cdh"/>
</connection>
<connection>
<map_components component_1="Cdh1_T" component_2="model_parameters"/>
<map_variables variable_1="ks_cdh" variable_2="ks_cdh"/>
<map_variables variable_1="kd_cdh" variable_2="kd_cdh"/>
</connection>
<connection>
<map_components component_1="Tem1" component_2="model_parameters"/>
<map_variables variable_1="klte1" variable_2="klte1"/>
<map_variables variable_1="kbub2" variable_2="kbub2"/>
<map_variables variable_1="Tem1_T" variable_2="Tem1_T"/>
<map_variables variable_1="Ja_tem" variable_2="Ja_tem"/>
<map_variables variable_1="Ji_tem" variable_2="Ji_tem"/>
</connection>
<connection>
<map_components component_1="Cdc15" component_2="model_parameters"/>
<map_variables variable_1="ka_15_" variable_2="ka_15_"/>
<map_variables variable_1="ka_15__" variable_2="ka_15__"/>
<map_variables variable_1="ka_15___" variable_2="ka_15___"/>
<map_variables variable_1="Tem1_T" variable_2="Tem1_T"/>
<map_variables variable_1="Cdc15_T" variable_2="Cdc15_T"/>
<map_variables variable_1="ki_15" variable_2="ki_15"/>
</connection>
<connection>
<map_components component_1="Cdc14_T" component_2="model_parameters"/>
<map_variables variable_1="ks_14" variable_2="ks_14"/>
<map_variables variable_1="kd_14" variable_2="kd_14"/>
</connection>
<connection>
<map_components component_1="PE" component_2="model_parameters"/>
<map_variables variable_1="Esp1_T" variable_2="Esp1_T"/>
</connection>
<connection>
<map_components component_1="Cdc14" component_2="model_parameters"/>
<map_variables variable_1="ks_14" variable_2="ks_14"/>
<map_variables variable_1="kd_14" variable_2="kd_14"/>
<map_variables variable_1="kd_net" variable_2="kd_net"/>
<map_variables variable_1="kdi_rent" variable_2="kdi_rent"/>
<map_variables variable_1="kdi_rentp" variable_2="kdi_rentp"/>
<map_variables variable_1="kas_rent" variable_2="kas_rent"/>
<map_variables variable_1="kas_rentp" variable_2="kas_rentp"/>
</connection>
<connection>
<map_components component_1="Net1_T" component_2="model_parameters"/>
<map_variables variable_1="ks_net" variable_2="ks_net"/>
<map_variables variable_1="kd_net" variable_2="kd_net"/>
</connection>
<connection>
<map_components component_1="Vd_b5" component_2="model_parameters"/>
<map_variables variable_1="kd_b5_" variable_2="kd_b5_"/>
<map_variables variable_1="kd_b5__" variable_2="kd_b5__"/>
</connection>
<connection>
<map_components component_1="Vd_b2" component_2="model_parameters"/>
<map_variables variable_1="kd_b2_" variable_2="kd_b2_"/>
<map_variables variable_1="kd_b2__" variable_2="kd_b2__"/>
<map_variables variable_1="kd_b2p" variable_2="kd_b2p"/>
</connection>
<connection>
<map_components component_1="Va_sbf" component_2="model_parameters"/>
<map_variables variable_1="ka_sbf" variable_2="ka_sbf"/>
<map_variables variable_1="epsilon_sbf_n2" variable_2="epsilon_sbf_n2"/>
<map_variables variable_1="epsilon_sbf_n3" variable_2="epsilon_sbf_n3"/>
<map_variables variable_1="epsilon_sbf_b5" variable_2="epsilon_sbf_b5"/>
</connection>
<connection>
<map_components component_1="Vi_sbf" component_2="model_parameters"/>
<map_variables variable_1="ki_sbf_" variable_2="ki_sbf_"/>
<map_variables variable_1="ki_sbf__" variable_2="ki_sbf__"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="model_parameters"/>
<map_variables variable_1="kd1_c1" variable_2="kd1_c1"/>
<map_variables variable_1="kd2_c1" variable_2="kd2_c1"/>
<map_variables variable_1="epsilon_c1_n2" variable_2="epsilon_c1_n2"/>
<map_variables variable_1="epsilon_c1_n3" variable_2="epsilon_c1_n3"/>
<map_variables variable_1="epsilon_c1_k2" variable_2="epsilon_c1_k2"/>
<map_variables variable_1="epsilon_c1_b5" variable_2="epsilon_c1_b5"/>
<map_variables variable_1="epsilon_c1_b2" variable_2="epsilon_c1_b2"/>
<map_variables variable_1="Jd2_c1" variable_2="Jd2_c1"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="model_parameters"/>
<map_variables variable_1="kd1_f6" variable_2="kd1_f6"/>
<map_variables variable_1="kd2_f6" variable_2="kd2_f6"/>
<map_variables variable_1="epsilon_f6_n2" variable_2="epsilon_f6_n2"/>
<map_variables variable_1="epsilon_f6_n3" variable_2="epsilon_f6_n3"/>
<map_variables variable_1="epsilon_f6_k2" variable_2="epsilon_f6_k2"/>
<map_variables variable_1="epsilon_f6_b5" variable_2="epsilon_f6_b5"/>
<map_variables variable_1="epsilon_f6_b2" variable_2="epsilon_f6_b2"/>
<map_variables variable_1="Jd2_f6" variable_2="Jd2_f6"/>
</connection>
<connection>
<map_components component_1="Va_cdh" component_2="model_parameters"/>
<map_variables variable_1="ka_cdh_" variable_2="ka_cdh_"/>
<map_variables variable_1="ka_cdh__" variable_2="ka_cdh__"/>
</connection>
<connection>
<map_components component_1="Vi_cdh" component_2="model_parameters"/>
<map_variables variable_1="ki_cdh_" variable_2="ki_cdh_"/>
<map_variables variable_1="ki_cdh__" variable_2="ki_cdh__"/>
<map_variables variable_1="epsilon_cdh_n2" variable_2="epsilon_cdh_n2"/>
<map_variables variable_1="epsilon_cdh_n3" variable_2="epsilon_cdh_n3"/>
<map_variables variable_1="epsilon_cdh_b5" variable_2="epsilon_cdh_b5"/>
<map_variables variable_1="epsilon_cdh_b2" variable_2="epsilon_cdh_b2"/>
</connection>
<connection>
<map_components component_1="Vpp_net" component_2="model_parameters"/>
<map_variables variable_1="kpp_net_" variable_2="kpp_net_"/>
<map_variables variable_1="kpp_net__" variable_2="kpp_net__"/>
</connection>
<connection>
<map_components component_1="Vkp_net" component_2="model_parameters"/>
<map_variables variable_1="kkp_net_" variable_2="kkp_net_"/>
<map_variables variable_1="kkp_net__" variable_2="kkp_net__"/>
</connection>
<connection>
<map_components component_1="Net1" component_2="model_parameters"/>
<map_variables variable_1="ks_net" variable_2="ks_net"/>
<map_variables variable_1="kd_net" variable_2="kd_net"/>
<map_variables variable_1="kd_14" variable_2="kd_14"/>
<map_variables variable_1="kdi_rent" variable_2="kdi_rent"/>
<map_variables variable_1="kas_rent" variable_2="kas_rent"/>
</connection>
<connection>
<map_components component_1="RENT" component_2="model_parameters"/>
<map_variables variable_1="ks_net" variable_2="ks_net"/>
<map_variables variable_1="kd_net" variable_2="kd_net"/>
<map_variables variable_1="kd_14" variable_2="kd_14"/>
<map_variables variable_1="kdi_rent" variable_2="kdi_rent"/>
<map_variables variable_1="kas_rent" variable_2="kas_rent"/>
</connection>
<connection>
<map_components component_1="PPX" component_2="model_parameters"/>
<map_variables variable_1="ks_ppx" variable_2="ks_ppx"/>
</connection>
<connection>
<map_components component_1="Vd_ppx" component_2="model_parameters"/>
<map_variables variable_1="kd_ppx_" variable_2="kd_ppx_"/>
<map_variables variable_1="kd_ppx__" variable_2="kd_ppx__"/>
<map_variables variable_1="J20_ppx" variable_2="J20_ppx"/>
<map_variables variable_1="Jpds" variable_2="Jpds"/>
</connection>
<connection>
<map_components component_1="Vd_pds" component_2="model_parameters"/>
<map_variables variable_1="kd1_pds_" variable_2="kd1_pds_"/>
<map_variables variable_1="kd2_pds__" variable_2="kd2_pds__"/>
<map_variables variable_1="kd3_pds__" variable_2="kd3_pds__"/>
</connection>
<connection>
<map_components component_1="mass" component_2="Cln2"/>
<map_variables variable_1="mass" variable_2="mass"/>
</connection>
<connection>
<map_components component_1="Cln2" component_2="SBF_MBF"/>
<map_variables variable_1="SBF" variable_2="SBF"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="SBF_MBF"/>
<map_variables variable_1="MBF" variable_2="MBF"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="mass"/>
<map_variables variable_1="mass" variable_2="mass"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="C5P"/>
<map_variables variable_1="C5P" variable_2="C5P"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="C5"/>
<map_variables variable_1="C5" variable_2="C5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="F5P"/>
<map_variables variable_1="F5P" variable_2="F5P"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="F5"/>
<map_variables variable_1="F5" variable_2="F5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="Sic1"/>
<map_variables variable_1="Sic1" variable_2="Sic1"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="Cdc6"/>
<map_variables variable_1="Cdc6" variable_2="Cdc6"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="G_mcm"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="mass"/>
<map_variables variable_1="mass" variable_2="mass"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Mcm1"/>
<map_variables variable_1="Mcm1" variable_2="Mcm1"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="C2P"/>
<map_variables variable_1="C2P" variable_2="C2P"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="C2"/>
<map_variables variable_1="C2" variable_2="C2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="F2P"/>
<map_variables variable_1="F2P" variable_2="F2P"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="F2"/>
<map_variables variable_1="F2" variable_2="F2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Sic1"/>
<map_variables variable_1="Sic1" variable_2="Sic1"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Cdc6"/>
<map_variables variable_1="Cdc6" variable_2="Cdc6"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="Swi5"/>
<map_variables variable_1="Swi5" variable_2="Swi5"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="Vkp_c1"/>
<map_variables variable_1="Vkp_c1" variable_2="Vkp_c1"/>
</connection>
<connection>
<map_components component_1="Sic1P" component_2="Vkp_c1"/>
<map_variables variable_1="Vkp_c1" variable_2="Vkp_c1"/>
</connection>
<connection>
<map_components component_1="C2" component_2="Vkp_c1"/>
<map_variables variable_1="Vkp_c1" variable_2="Vkp_c1"/>
</connection>
<connection>
<map_components component_1="C5" component_2="Vkp_c1"/>
<map_variables variable_1="Vkp_c1" variable_2="Vkp_c1"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="C2"/>
<map_variables variable_1="C2" variable_2="C2"/>
<map_variables variable_1="Sic1" variable_2="Sic1"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="C5"/>
<map_variables variable_1="C5" variable_2="C5"/>
<map_variables variable_1="Sic1" variable_2="Sic1"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="Sic1P"/>
<map_variables variable_1="Sic1P" variable_2="Sic1P"/>
<map_variables variable_1="Sic1" variable_2="Sic1"/>
</connection>
<connection>
<map_components component_1="Sic1P" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Sic1P" component_2="C2P"/>
<map_variables variable_1="C2P" variable_2="C2P"/>
</connection>
<connection>
<map_components component_1="Sic1P" component_2="C5P"/>
<map_variables variable_1="C5P" variable_2="C5P"/>
</connection>
<connection>
<map_components component_1="C2" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="C2" component_2="C2P"/>
<map_variables variable_1="C2P" variable_2="C2P"/>
<map_variables variable_1="C2" variable_2="C2"/>
</connection>
<connection>
<map_components component_1="C5" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="C5" component_2="C5P"/>
<map_variables variable_1="C5P" variable_2="C5P"/>
<map_variables variable_1="C5" variable_2="C5"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="Swi5"/>
<map_variables variable_1="Swi5" variable_2="Swi5"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="SBF_MBF"/>
<map_variables variable_1="SBF" variable_2="SBF"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="F2"/>
<map_variables variable_1="F2" variable_2="F2"/>
<map_variables variable_1="Cdc6" variable_2="Cdc6"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="F5"/>
<map_variables variable_1="F5" variable_2="F5"/>
<map_variables variable_1="Cdc6" variable_2="Cdc6"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="Cdc6P"/>
<map_variables variable_1="Cdc6P" variable_2="Cdc6P"/>
<map_variables variable_1="Cdc6" variable_2="Cdc6"/>
</connection>
<connection>
<map_components component_1="Cdc6P" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Cdc6P" component_2="F2P"/>
<map_variables variable_1="F2P" variable_2="F2P"/>
</connection>
<connection>
<map_components component_1="Cdc6P" component_2="F5P"/>
<map_variables variable_1="F5P" variable_2="F5P"/>
</connection>
<connection>
<map_components component_1="F2" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="F2" component_2="F2P"/>
<map_variables variable_1="F2P" variable_2="F2P"/>
<map_variables variable_1="F2" variable_2="F2"/>
</connection>
<connection>
<map_components component_1="Pds1" component_2="SBF_MBF"/>
<map_variables variable_1="SBF" variable_2="SBF"/>
</connection>
<connection>
<map_components component_1="Pds1" component_2="Mcm1"/>
<map_variables variable_1="Mcm1" variable_2="Mcm1"/>
</connection>
<connection>
<map_components component_1="Pds1" component_2="PE"/>
<map_variables variable_1="PE" variable_2="PE"/>
</connection>
<connection>
<map_components component_1="Pds1" component_2="Esp1"/>
<map_variables variable_1="Esp1" variable_2="Esp1"/>
<map_variables variable_1="Pds1" variable_2="Pds1"/>
</connection>
<connection>
<map_components component_1="Esp1" component_2="PE"/>
<map_variables variable_1="PE" variable_2="PE"/>
<map_variables variable_1="Esp1" variable_2="Esp1"/>
</connection>
<connection>
<map_components component_1="ORI" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="ORI" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="BUD" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="BUD" component_2="Cln2"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="BUD" component_2="Cln3"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="SPN" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="SBF_MBF" component_2="G_sbf"/>
<map_variables variable_1="G_sbf" variable_2="G_sbf"/>
</connection>
<connection>
<map_components component_1="Mcm1" component_2="G_mcm"/>
<map_variables variable_1="G_mcm" variable_2="G_mcm"/>
</connection>
<connection>
<map_components component_1="Cln3" component_2="mass"/>
<map_variables variable_1="mass" variable_2="mass"/>
</connection>
<connection>
<map_components component_1="Bck2" component_2="mass"/>
<map_variables variable_1="mass" variable_2="mass"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="C5"/>
<map_variables variable_1="C5" variable_2="C5"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="C5P"/>
<map_variables variable_1="C5P" variable_2="C5P"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="F5"/>
<map_variables variable_1="F5" variable_2="F5"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="F5P"/>
<map_variables variable_1="F5P" variable_2="F5P"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="C2"/>
<map_variables variable_1="C2" variable_2="C2"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="C2P"/>
<map_variables variable_1="C2P" variable_2="C2P"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="F2"/>
<map_variables variable_1="F2" variable_2="F2"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="F2P"/>
<map_variables variable_1="F2P" variable_2="F2P"/>
</connection>
<connection>
<map_components component_1="Sic1_T" component_2="Sic1"/>
<map_variables variable_1="Sic1" variable_2="Sic1"/>
</connection>
<connection>
<map_components component_1="Sic1_T" component_2="Sic1P"/>
<map_variables variable_1="Sic1P" variable_2="Sic1P"/>
</connection>
<connection>
<map_components component_1="Sic1_T" component_2="C2"/>
<map_variables variable_1="C2" variable_2="C2"/>
</connection>
<connection>
<map_components component_1="Sic1_T" component_2="C2P"/>
<map_variables variable_1="C2P" variable_2="C2P"/>
</connection>
<connection>
<map_components component_1="Sic1_T" component_2="C5"/>
<map_variables variable_1="C5" variable_2="C5"/>
</connection>
<connection>
<map_components component_1="Sic1_T" component_2="C5P"/>
<map_variables variable_1="C5P" variable_2="C5P"/>
</connection>
<connection>
<map_components component_1="Cdc6_T" component_2="Cdc6"/>
<map_variables variable_1="Cdc6" variable_2="Cdc6"/>
</connection>
<connection>
<map_components component_1="Cdc6_T" component_2="Cdc6P"/>
<map_variables variable_1="Cdc6P" variable_2="Cdc6P"/>
</connection>
<connection>
<map_components component_1="Cdc6_T" component_2="F2"/>
<map_variables variable_1="F2" variable_2="F2"/>
</connection>
<connection>
<map_components component_1="Cdc6_T" component_2="F2P"/>
<map_variables variable_1="F2P" variable_2="F2P"/>
</connection>
<connection>
<map_components component_1="Cdc6_T" component_2="F5"/>
<map_variables variable_1="F5" variable_2="F5"/>
</connection>
<connection>
<map_components component_1="Cdc6_T" component_2="F5P"/>
<map_variables variable_1="F5P" variable_2="F5P"/>
</connection>
<connection>
<map_components component_1="CKI_T" component_2="Sic1_T"/>
<map_variables variable_1="Sic1_T" variable_2="Sic1_T"/>
</connection>
<connection>
<map_components component_1="CKI_T" component_2="Cdc6_T"/>
<map_variables variable_1="Cdc6_T" variable_2="Cdc6_T"/>
</connection>
<connection>
<map_components component_1="RENTP" component_2="Cdc14_T"/>
<map_variables variable_1="Cdc14_T" variable_2="Cdc14_T"/>
</connection>
<connection>
<map_components component_1="RENTP" component_2="RENT"/>
<map_variables variable_1="RENT" variable_2="RENT"/>
<map_variables variable_1="RENTP" variable_2="RENTP"/>
</connection>
<connection>
<map_components component_1="RENTP" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
<map_variables variable_1="RENTP" variable_2="RENTP"/>
</connection>
<connection>
<map_components component_1="Net1P" component_2="Net1_T"/>
<map_variables variable_1="Net1_T" variable_2="Net1_T"/>
</connection>
<connection>
<map_components component_1="Net1P" component_2="Net1"/>
<map_variables variable_1="Net1P" variable_2="Net1P"/>
<map_variables variable_1="Net1" variable_2="Net1"/>
</connection>
<connection>
<map_components component_1="Net1P" component_2="Cdc14_T"/>
<map_variables variable_1="Cdc14_T" variable_2="Cdc14_T"/>
</connection>
<connection>
<map_components component_1="Net1P" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
<map_variables variable_1="Net1P" variable_2="Net1P"/>
</connection>
<connection>
<map_components component_1="F5" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="F5" component_2="F5P"/>
<map_variables variable_1="F5P" variable_2="F5P"/>
<map_variables variable_1="F5" variable_2="F5"/>
</connection>
<connection>
<map_components component_1="F2P" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="F5P" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Swi5_T" component_2="Mcm1"/>
<map_variables variable_1="Mcm1" variable_2="Mcm1"/>
</connection>
<connection>
<map_components component_1="Swi5" component_2="Mcm1"/>
<map_variables variable_1="Mcm1" variable_2="Mcm1"/>
</connection>
<connection>
<map_components component_1="Swi5" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Swi5" component_2="Swi5_T"/>
<map_variables variable_1="Swi5_T" variable_2="Swi5_T"/>
</connection>
<connection>
<map_components component_1="Swi5" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="APC_P" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Cdc20_T" component_2="Mcm1"/>
<map_variables variable_1="Mcm1" variable_2="Mcm1"/>
</connection>
<connection>
<map_components component_1="Cdc20_A" component_2="APC_P"/>
<map_variables variable_1="APC_P" variable_2="APC_P"/>
</connection>
<connection>
<map_components component_1="Cdc20_A" component_2="Cdc20_T"/>
<map_variables variable_1="Cdc20_T" variable_2="Cdc20_T"/>
</connection>
<connection>
<map_components component_1="Cdh1" component_2="Cdh1_T"/>
<map_variables variable_1="Cdh1_T" variable_2="Cdh1_T"/>
</connection>
<connection>
<map_components component_1="Cdc15" component_2="Tem1"/>
<map_variables variable_1="Tem1" variable_2="Tem1"/>
</connection>
<connection>
<map_components component_1="Cdc15" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Cdc14" component_2="RENT"/>
<map_variables variable_1="RENT" variable_2="RENT"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Cdc14" component_2="Net1"/>
<map_variables variable_1="Net1" variable_2="Net1"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Vd_b5" component_2="Cdc20_A"/>
<map_variables variable_1="Cdc20_A" variable_2="Cdc20_A"/>
</connection>
<connection>
<map_components component_1="Vd_b2" component_2="Cdc20_A"/>
<map_variables variable_1="Cdc20_A" variable_2="Cdc20_A"/>
</connection>
<connection>
<map_components component_1="Vd_b2" component_2="Cdh1"/>
<map_variables variable_1="Cdh1" variable_2="Cdh1"/>
</connection>
<connection>
<map_components component_1="Va_sbf" component_2="Cln3"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Va_sbf" component_2="Cln2"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Va_sbf" component_2="Bck2"/>
<map_variables variable_1="Bck2" variable_2="Bck2"/>
</connection>
<connection>
<map_components component_1="Va_sbf" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Vi_sbf" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="Cln3"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="Cln2"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="Bck2"/>
<map_variables variable_1="Bck2" variable_2="Bck2"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Vkp_c1" component_2="Sic1_T"/>
<map_variables variable_1="Sic1_T" variable_2="Sic1_T"/>
</connection>
<connection>
<map_components component_1="Va_cdh" component_2="Cdc14"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Vkp_net" component_2="Cdc15"/>
<map_variables variable_1="Cdc15" variable_2="Cdc15"/>
</connection>
<connection>
<map_components component_1="Vkp_net" component_2="mass"/>
<map_variables variable_1="mass" variable_2="mass"/>
</connection>
<connection>
<map_components component_1="Net1" component_2="RENT"/>
<map_variables variable_1="RENT" variable_2="RENT"/>
<map_variables variable_1="Net1" variable_2="Net1"/>
</connection>
<connection>
<map_components component_1="Vd_ppx" component_2="Cdc20_A"/>
<map_variables variable_1="Cdc20_A" variable_2="Cdc20_A"/>
</connection>
<connection>
<map_components component_1="Vd_ppx" component_2="Pds1"/>
<map_variables variable_1="Pds1" variable_2="Pds1"/>
</connection>
<connection>
<map_components component_1="Vd_pds" component_2="Cdc20_A"/>
<map_variables variable_1="Cdc20_A" variable_2="Cdc20_A"/>
</connection>
<connection>
<map_components component_1="Vd_pds" component_2="Cdh1"/>
<map_variables variable_1="Cdh1" variable_2="Cdh1"/>
</connection>
<connection>
<map_components component_1="Sic1P" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Sic1P" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="Clb5" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Sic1" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="C2" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="C5" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="C2P" component_2="Vkp_c1"/>
<map_variables variable_1="Vkp_c1" variable_2="Vkp_c1"/>
</connection>
<connection>
<map_components component_1="C2P" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="C5P" component_2="Vkp_c1"/>
<map_variables variable_1="Vkp_c1" variable_2="Vkp_c1"/>
</connection>
<connection>
<map_components component_1="C5P" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Cdc6" component_2="Vkp_f6"/>
<map_variables variable_1="Vkp_f6" variable_2="Vkp_f6"/>
</connection>
<connection>
<map_components component_1="Cdc6P" component_2="Vkp_f6"/>
<map_variables variable_1="Vkp_f6" variable_2="Vkp_f6"/>
</connection>
<connection>
<map_components component_1="Cdc6P" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="Cdc6P" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="F2" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="F2" component_2="Vkp_f6"/>
<map_variables variable_1="Vkp_f6" variable_2="Vkp_f6"/>
</connection>
<connection>
<map_components component_1="Pds1" component_2="Vd_pds"/>
<map_variables variable_1="Vd_pds" variable_2="Vd_pds"/>
</connection>
<connection>
<map_components component_1="Esp1" component_2="Vd_pds"/>
<map_variables variable_1="Vd_pds" variable_2="Vd_pds"/>
</connection>
<connection>
<map_components component_1="G_sbf" component_2="Va_sbf"/>
<map_variables variable_1="Va_sbf" variable_2="Va_sbf"/>
</connection>
<connection>
<map_components component_1="G_sbf" component_2="Vi_sbf"/>
<map_variables variable_1="Vi_sbf" variable_2="Vi_sbf"/>
</connection>
<connection>
<map_components component_1="F5" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="F5" component_2="Vkp_f6"/>
<map_variables variable_1="Vkp_f6" variable_2="Vkp_f6"/>
</connection>
<connection>
<map_components component_1="F5P" component_2="Vkp_f6"/>
<map_variables variable_1="Vkp_f6" variable_2="Vkp_f6"/>
</connection>
<connection>
<map_components component_1="F2P" component_2="Vkp_f6"/>
<map_variables variable_1="Vkp_f6" variable_2="Vkp_f6"/>
</connection>
<connection>
<map_components component_1="F2P" component_2="Vd_b2"/>
<map_variables variable_1="Vd_b2" variable_2="Vd_b2"/>
</connection>
<connection>
<map_components component_1="F5P" component_2="Vd_b5"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Cdh1" component_2="Va_cdh"/>
<map_variables variable_1="Va_cdh" variable_2="Va_cdh"/>
</connection>
<connection>
<map_components component_1="Cdh1" component_2="Vi_cdh"/>
<map_variables variable_1="Vi_cdh" variable_2="Vi_cdh"/>
</connection>
<connection>
<map_components component_1="Net1" component_2="Vpp_net"/>
<map_variables variable_1="Vpp_net" variable_2="Vpp_net"/>
</connection>
<connection>
<map_components component_1="Net1" component_2="Vkp_net"/>
<map_variables variable_1="Vkp_net" variable_2="Vkp_net"/>
</connection>
<connection>
<map_components component_1="RENT" component_2="Vpp_net"/>
<map_variables variable_1="Vpp_net" variable_2="Vpp_net"/>
</connection>
<connection>
<map_components component_1="RENT" component_2="Vkp_net"/>
<map_variables variable_1="Vkp_net" variable_2="Vkp_net"/>
</connection>
<connection>
<map_components component_1="PPX" component_2="Vd_ppx"/>
<map_variables variable_1="Vd_ppx" variable_2="Vd_ppx"/>
</connection>
<connection>
<map_components component_1="Cdc14" component_2="C2P"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Cdc14" component_2="C5P"/>
<map_variables variable_1="Cdc14" variable_2="Cdc14"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="Cln2"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Vi_cdh" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
<connection>
<map_components component_1="Vi_cdh" component_2="Cln2"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Vi_cdh" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Vi_cdh" component_2="Cln3"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="Cdc6_T"/>
<map_variables variable_1="Cdc6_T" variable_2="Cdc6_T"/>
</connection>
<connection>
<map_components component_1="Vpp_net" component_2="PPX"/>
<map_variables variable_1="PPX" variable_2="PPX"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="Clb2"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="Bck2"/>
<map_variables variable_1="Bck2" variable_2="Bck2"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="Cln3"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Vkp_f6" component_2="Clb5"/>
<map_variables variable_1="Clb5" variable_2="Clb5"/>
</connection>
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xml:lang="en">The University of Auckland, Bioengineering Institute</publisher></rdf:Description><rdf:Description rdf:about="rdf:#cc55bfe8-3ea9-481e-97fb-4dc73d284e70"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#4a6aea4e-affd-4707-8822-fb03a60434a4"/></N></rdf:Description><rdf:Description rdf:about="rdf:#e3b63460-8397-4747-a2e9-741b8454c9b9"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2008-12-10T16:45:51+13:00</W3CDTF></rdf:Description><rdf:Description rdf:nodeID="n3"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n2"/></boundIntervals></rdf:Description><rdf:Description rdf:about="rdf:#c2d392d1-4251-4ad9-b93f-16261956acb3"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The Bioengineering Institute</Orgunit></rdf:Description><rdf:Description rdf:about="rdf:#62cb3de8-533f-4993-af27-5454de0f3d0b"><rdf:value xml:lang="en">updated curation status, removed reference link from documentation</rdf:value><cmeta:modifier><rdf:Description rdf:about="rdf:#b95113f4-d258-4261-a061-7e92e38f989c"/></cmeta:modifier><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#551255ec-d4b7-4167-a519-72550e3fc6aa"/></modified></rdf:Description><rdf:Description rdf:about="rdf:#a96d60ae-bb0d-4efa-bd1c-b529a74ec3dc"><rdf:value><rdf:Description rdf:about="rdf:#5171a8e5-a07e-4dd3-a4d0-a377a1edf4dc"/></rdf:value><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type></rdf:Description><rdf:Description rdf:about="rdf:#49430aa6-5351-4373-bbe5-c78b96d5a84e"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Calzone</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" 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2004 mathematical model of cell cyc1e control in budding yeast.</title><cmeta:comment><rdf:Description rdf:about="rdf:#2ce41319-ab33-4491-bad3-9a891bb3b7ae"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#d7a3abbd-959e-4db6-a5fd-d2ca2cbcab0a"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#b92a6b33-d6c7-4ba6-9df2-88e44503d8e8"/></reference><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></simulation></rdf:Description><rdf:Description rdf:about="rdf:#361dbe73-17f7-484b-a007-db9c466da3f5"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Chen</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Katherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">C</Other></rdf:Description><rdf:Description rdf:about="rdf:#d300f656-0cf7-42dd-8b45-3b244afa98e2"><Family 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