Membrane_potential.cellml

Membrane potential model

The Membrane potential component defines the complete equations of the membrane potential and total ionic current. It combines the imported ionic current components and ionic concentrations components:

• L-type Ca^2 + channels: ICaL

It instantiates the imported Ionic currents component with computed PO using ICaL channel states component, while the Nernst potential E_Ca computation is defined by the Nernst potential component.

• T-type Ca^2 + channels: ICaT

It instantiates the imported Ionic currents component with computed PO using ICaT channel states component, while the Nernst potential E_Ca computation is defined by the Nernst potential component.

• Voltage dependent K⁺ channels: IKv

It instantiates the imported Ionic currents component with computed P_Kv = x_Kv*y_Kv. The gating kinetics is defined in the imported gating kinetics component, while the steady states of x and y gate are defined by the imported IKv gating steady state component, the Nernst potential E_K computation is defined by the Nernst potential component.

• Large conductance Ca^2 + and voltage activated K⁺ channels: IBK

It instantiates the imported Ionic currents component with computed PO using IBK channel states component, while the Nernst potential E_K computation is defined by the Nernst potential component.

• Na⁺ channels: INa

It instantiates the imported Ionic currents component with computed PO using INa channel states component, while the Nernst potential E_Na computation is defined by the Nernst potential component.

• Na⁺- K⁺ pump: INaK
• Na⁺- Ca^2 + exchanger: INCX
• Non-selective sodium leak current: INS_Na
• Non-selective potassium leak current: INS_K
• The imported ionic concentrations components include Ca^2 +_i, Na⁺_i and K⁺_i.