Patch_clampXi_experiment.cellml

Voltage clamp experiment

In the Voltage clamp experiment, the Clamped current component is configured and parameterised with an applied Patch clamp protocol.

You can change the clamping parameters in the component Clamp_parameters.

You can also bypass the parameters in the component model_parameters and initial_conditions and define your own parameters.

The simulation experiment can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation.

Clamped I_CaL

Figure [1] shows normalized L-type calcium channels peak I–V plot for simulated data derived from the publication (dots) and the current CellML model (solid line) with different intracelluar concentrations.

Clamped I_CaT

Figure [2] shows normalized T-type calcium channels peak I–V plot for simulated data derived from the publication (dots) and the current CellML model (solid line) with different intracelluar concentrations.

Clamped I_Kv

Figure [3] shows normalized I–V plot of whole cell voltage-activated potassium currents for simulated data derived from the publication (dots) and the current CellML model (solid line).

Clamped P_BK

Figure [4] shows Open probability of BK channel versus clamping voltage (@ various Ca^2 +_i) for simulated data derived from the publication (dots) and the current CellML model (solid line).

Clamped I_Na

Figure [5] shows normalized Na_⁺ channel peak I–V plot for simulated data derived from the publication (dots) and the current CellML model (solid line) with different intracelluar concentrations.

Figure [6] shows whole cell current versus time traces subjected to voltage clamp at different holding voltages for simulated data derived from the publication (dots) and the current CellML model (solid line).

Figure [7] shows whole cell normalized I–V data from hJSMC model under near calcium-free conditions for simulated data derived from the publication (dots) and the current CellML model (solid line).