SMC_KCl_noise.cellml

Single-cell response experiment

In the Single-cell response experiment, the isolated cell model is configured and parameterised with an applied concentration clamp protocol.

You can change the parameters of stimulation in the component clamp_para. You can also bypass the parameters in the component Para and define your own parameters.

The simulation experiment can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation. We use the Python script simFig2 , simFig2_1, simFig2_2, simFig2_3, and simFig3 to perform the simulation for the following figures.

The cytosolic calcium concentration of an isolated cell in presence of noise

Since we do not know the noise strength, we have tried different values to reproduce Fig 2 in the primary paper.

Figure [1] shows the cytosolic calcium concentration of an isolated cell in presence of noise with the standard deviation of 0.0015 and 0.002.

Figure [2] shows the cytosolic calcium concentration of an isolated cell in presence of noise with the standard deviation of 0.0025 and 0.003.

Dynamics of an isolated SMC stimulated by a receptor-ligand agonist

Figure [3] shows the simulation result of an isolated SMC stimulated by a receptor-ligand agonist (Fig 3 in the primary paper).

The cytosolic calcium concentration of an isolated cell by KCl stimulation in presence of noise

We need confirmation about the parameters for Fig 7 in the primary paper from the original authors.