Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors

Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors

Model Structure

In cardiac muscle, release of activator calcium from the sarcoplasmic reticulum occurs by calcium-induced calcium release through ryanodine receptors (RyRs). In their 1999 paper, Michael D. Stern et al represented the ryanodine receptor with a phenomenological four-state gating scheme, with channel opening resulting from simultaneous binding of two Ca2+ ions, and either calcium-dependent or activation-linked inactivation (see the figure below).

The complete original paper reference is cited below:

Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors , Michael D. Stern, Long-Sheng Song, Heping Cheng, James S.K. Sham, Huang Tian Yang, Kenneth R. Boheler and Eduardo Rios, 1999, The Journal Of General Physiology , 113, 469-489. (Full text and PDF versions of the article are available to subscribers on the JGP website.) PubMed ID: 10051521

The raw CellML description of the kinetic model of cardiac ryanodine receptor gating can be downloaded in various formats as described in .

RyR gating scheme.