A Mathematical Model of the Electrophysiological Alterations in Rat Ventricular Myocytes in Type-I Diabetes

Model Status

This cell model was developed by Penny Noble and represents the electrophysiological alterations in rat ventricular myocytes in type-I diabetes. It reads both in PCenv and COR and is able to produce action potentials under multiple stimuli.

Model Structure

This model is a mathematical representation of the diabetic phenotype by incorporating changes in the ionic mechanisms that are suggested by experimental data to underlie the altered electrophysiological characteristics in the short-term, type-I model of STZ-induced diabetes. The model is able to qualitatively simulate the prolongation of the APD in accordance with experimental results. It provides novel insights into the ionic basis for this changes in the action potential profile during diabetic conditions, and illustrates the complex, nonlinear relationship betweeh the APD and both intracellular Ca²⁺ homeostasis, and E-C coupling.

A mathematical model of the adult rat right ventricular (RV) cell was derived from the Pandit 2001 rat LV epicardial cell model, and used as the control model. Further modifications from the control model were made to represent the short-term, rype-I diabetic myocyte. A variable Diabetes is used to convert from the normal to diabetic model. The default value is 0 for normal and any other value (usually 1) for diabetes.

The complete original paper references are cited below:

A Mathematical Model of Action Potential Heterogeneity in Adult Rat Left Ventricular Myocytes, , Sandeep V. Pandit, Robert B. Clark, Wayne R. Giles and Semahat S. Demir, 2001, Biophysical Journal , 81, 3029-3051. (Original rat LV cell models Full text and PDF versions of the article are available for Journal Members on the Biophysical Journal website.) PubMed ID: 11720973

A Mathematical Model of the Electrophysiological Alterations in Rat Ventricular Myocytes in Type-I Diabetes, , Sandeep V. Pandit, Wayne R. Giles and Semahat S. Demir, 2003 Biophysical Journal , 84, 832 - 841. (Rat RV model Full text and PDF versions of the article are available for Journal Members on the Biophysical Journal website.) PubMed ID: 12547767

A fluid compartment model of the rat epicardial/endocardial ventricular cell.