<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 8/07/2008 at 3:23:18 at p.m. using:
COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="wu_yang_vinnakota_beard_2007" cmeta:id="wu_yang_vinnakota_beard_2007">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Computer Modeling of Mitochondrial Tricarboxylic Acid Cycle, Oxidative Phosphorylation, Metabolite Transport, and Electrophysiology</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML version of the model does not run in PCEnv or COR, although the units are consistent throughout. Further curation is necessary, although this model does require non-negative constraints that are not currently available in CellML integration tools.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
A computational model of mitochondrial metabolism and electrophysiology is introduced and applied to analysis of data from isolated cardiac mitochondria and data on phosphate metabolites in striated muscle in vivo. This model is constructed based on detailed kinetics and thermodynamically balanced reaction mechanisms and a strict accounting of rapidly equilibrating biochemical species. Since building such a model requires introducing a large number of adjustable kinetic parameters, a correspondingly large amount of independent data from isolated mitochondria respiring on different substrates and subject to a variety of protocols is used to parameterize the model and ensure that it is challenged by a wide range of data corresponding to diverse conditions. The developed model is further validated by both in vitro data on isolated cardiac mitochondria and in vivo experimental measurements on human skeletal muscle. The validated model is used to predict the roles of NAD and ADP in regulating the tricarboxylic acid cycle dehydrogenase fluxes, demonstrating that NAD is the more important regulator. Further model predictions reveal that a decrease of cytosolic pH value results in decreases in mitochondrial membrane potential and a corresponding drop in the ability of the mitochondria to synthesize ATP at the hydrolysis potential required for cellular function.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.jbc.org/cgi/content/abstract/282/34/24525">Computer Modeling of Mitochondrial Tricarboxylic Acid Cycle, Oxidative Phosphorylation, Metabolite Transport, and Electrophysiology</ulink>, Fan Wu, Feng Yang, Kalyan C. Vinnakota, Daniel A. Beard, 2007, <ulink url="http://www.springerlink.com/content/105728/">
<emphasis>Journal of Biological Chemistry</emphasis>
</ulink>, volume 282, no. 34. (a <ulink url="http://www.jbc.org/cgi/reprint/282/34/24525">PDF</ulink> versions of the article are available on the <emphasis>Journal of Biological Chemistry</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17591785&dopt=Abstract">PubMed ID: 17591785</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="wu_2007.png"/>
</imageobject>
</mediaobject>
<caption>Schematic diagram of the model components. The illustrated components include tricarboxylic acid cycle reactions, oxidative phosphorylation reactions, substrate and cation transport reactions, and passive permeation fluxes. External reactions are not illustrated here. The tricarboxylic acid reactions are numbered 1-11. 1, pyruvate dehydrogenase; 2, citrate synthase; 3, aconitase; 4, isocitrate dehydrogenase; 5, alpha-ketoglutarate dehydrogenase; 6, succinyl-CoA synthetase; 7, succinate dehydrogenase; 8, fumarase; 9, malate dehydrogenase; 10, nucleoside diphosphokinase; 11, glutamate oxaloacetate transaminase.</caption>
</informalfigure>
</sect1>
</article>
</documentation> <units base_units="yes" name="cell"/>
<units base_units="yes" name="cytoplasm"/>
<units base_units="yes" name="mitochondria"/>
<units name="cyto_per_cell">
<unit units="cytoplasm"/>
<unit units="cell" exponent="-1"/>
</units>
<units name="mito_per_cyto">
<unit units="mitochondria"/>
<unit units="cytoplasm" exponent="-1"/>
</units>
<units name="mito_per_cell">
<unit units="mitochondria"/>
<unit units="cell" exponent="-1"/>
</units>
<units name="l_cyto_per_l_mito">
<unit units="cytoplasm"/>
<unit units="mitochondria" exponent="-1"/>
</units>
<units name="l_water_per_l_cyto">
<unit units="cytoplasm" exponent="-1"/>
</units>
<units name="l_water_per_l_mito">
<unit units="mitochondria" exponent="-1"/>
</units>
<units name="mg_per_mitochondria">
<unit units="gram" prefix="milli"/>
<unit units="mitochondria" exponent="-1"/>
</units>
<units name="molar">
<unit units="mole"/>
<unit units="liter" exponent="-1"/>
</units>
<units name="molar_per_second">
<unit units="molar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="molar_squared">
<unit units="molar" exponent="2"/>
</units>
<units name="molar_cubed">
<unit units="molar" exponent="3"/>
</units>
<units name="per_molar">
<unit units="molar" exponent="-1"/>
</units>
<units name="micrometer_per_second">
<unit units="meter" prefix="micro"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_micrometer">
<unit units="meter" prefix="micro" exponent="-1"/>
<unit units="mitochondria" exponent="-1"/>
</units>
<units name="kilojoule_per_mole">
<unit units="joule" prefix="kilo"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="kilojoule_per_mole_per_millivolt">
<unit units="kilojoule_per_mole"/>
<unit units="millivolt" exponent="-1"/>
</units>
<units name="molar_per_cyto">
<unit units="mole"/>
<unit units="liter" exponent="-1"/>
<unit units="cytoplasm" exponent="-1"/>
</units>
<units name="molar_per_mito">
<unit units="mole"/>
<unit units="liter" exponent="-1"/>
<unit units="mitochondria" exponent="-1"/>
</units>
<units name="mole_per_second_per_l_cyto_volume">
<unit units="molar_per_cyto"/>
<unit units="second" exponent="-1"/>
</units>
<units name="mole_per_second_per_l_cyto_volume_per_molar_per_molar">
<unit units="mole_per_second_per_l_cyto_volume"/>
<unit units="molar" exponent="-2"/>
</units>
<units name="mole_per_second_per_l_mito_volume">
<unit units="molar_per_mito"/>
<unit units="second" exponent="-1"/>
</units>
<units name="mole_per_second_per_l_mito_volume_per_molar">
<unit units="mole_per_second_per_l_mito_volume"/>
<unit units="molar" exponent="-1"/>
</units>
<units name="mole_per_second_per_l_mito_volume_per_molar_per_half_molar">
<unit units="mole_per_second_per_l_mito_volume_per_molar"/>
<unit units="molar" exponent="-0.5"/>
</units>
<units name="mole_per_second_per_l_mito_volume_per_molar_per_molar">
<unit units="mole_per_second_per_l_mito_volume_per_molar"/>
<unit units="molar" exponent="-1"/>
</units>
<units name="mole_per_l_mito_volume_per_mv">
<unit units="molar_per_mito"/>
<unit units="millivolt" exponent="-1"/>
</units>
<units name="mole_per_second_per_l_mito_volume_per_molar_per_mv">
<unit units="mole_per_second_per_l_mito_volume_per_molar"/>
<unit units="millivolt" exponent="-1"/>
</units>
<component name="Environment">
<variable units="second" public_interface="out" name="time"/>
<variable units="dimensionless" public_interface="out" name="ExpType" initial_value="2"/>
<variable units="dimensionless" public_interface="out" name="StateType" initial_value="2"/>
</component>
<component name="adjustable_parameters">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_pdh" initial_value="1.22e-1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_cits" initial_value="11.6"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_acon" initial_value="3.21e-2"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_isod" initial_value="4.25e-1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_akgd" initial_value="7.7e-2"/>
<variable units="molar" public_interface="out" name="K_ir_akgd" initial_value="6.04e-7"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_scoas" initial_value="5.82e-1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_sdh" initial_value="6.23e-2"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_fuma" initial_value="7.12e-3"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_mdh" initial_value="6.94e-2"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_ndk" initial_value="2.65e-2"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_got" initial_value="7.96"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_PYRH" initial_value="4.12e8"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_GLUH" initial_value="3.26e8"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_CITMAL" initial_value="7.31e1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_AKGMAL" initial_value="3.46e-1"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_SUCMAL" initial_value="9.54e1"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_MALPI" initial_value="1.58e1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_ASPGLU" initial_value="7.48e-5"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_C1" initial_value="2.47e4"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_half_molar" public_interface="out" name="X_C3" initial_value="6.65e-1"/>
<variable units="molar" public_interface="out" name="k_PI_1" initial_value="2.81e-5"/>
<variable units="molar" public_interface="out" name="k_PI_2" initial_value="3.14e-3"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar" public_interface="out" name="X_C4" initial_value="9.93e-5"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar" public_interface="out" name="X_F1" initial_value="5.95e3"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="X_ANT" initial_value="7.27e-3"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar" public_interface="out" name="X_PiHt" initial_value="2.01e7"/>
<variable units="molar" public_interface="out" name="k_PiHt" initial_value="1.01e-3"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="out" name="X_KH" initial_value="5.65e6"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_mv" public_interface="out" name="X_Hle" initial_value="3.05e2"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="out" name="X_HK"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="out" name="J_AtC" initial_value="0"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>X_HK</ci>
<piecewise>
<piece>
<cn cellml:units="mole_per_second_per_l_cyto_volume">0.191</cn>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_cyto_volume">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="fixed_parameters">
<variable units="kilojoule_per_mole" public_interface="out" name="RT"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="out" name="F" initial_value="0.096484"/>
<variable units="cyto_per_cell" public_interface="out" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="out" name="V_mito"/>
<variable units="l_water_per_l_mito" public_interface="out" name="W_x" initial_value="0.6514"/>
<variable units="l_water_per_l_mito" public_interface="out" name="W_i" initial_value="0.0724"/>
<variable units="l_water_per_l_cyto" public_interface="out" name="W_c"/>
<variable units="per_micrometer" public_interface="out" name="gamma" initial_value="5.99"/>
<variable units="mg_per_mitochondria" public_interface="out" name="rho_m" initial_value="2.725e5"/>
<variable units="dimensionless" public_interface="out" name="n_A" initial_value="3"/>
<variable units="micrometer_per_second" public_interface="out" name="p_PI" initial_value="327"/>
<variable units="micrometer_per_second" public_interface="out" name="p_A" initial_value="85"/>
<variable units="micrometer_per_second" public_interface="out" name="p_TI" initial_value="85"/>
<variable units="molar" public_interface="out" name="k_mADP" initial_value="3.5e-6"/>
<variable units="dimensionless" public_interface="out" name="theta" initial_value="0.6"/>
<variable units="molar" public_interface="out" name="k_O2" initial_value="1.2e-4"/>
<variable units="molar" public_interface="out" name="NAD_tot" initial_value="2.97e-3"/>
<variable units="molar" public_interface="out" name="Q_tot" initial_value="1.35e-3"/>
<variable units="molar" public_interface="out" name="cytC_tot" initial_value="2.7e-3"/>
<variable units="molar" public_interface="out" name="A_tot" initial_value="10e-3"/>
<variable units="molar" public_interface="out" name="CR_tot" initial_value="42.7e-3"/>
<variable units="molar" public_interface="out" name="CO2_tot_x" initial_value="21.4e-3"/>
<variable units="molar" public_interface="out" name="FAD_tot" initial_value="1e-4"/>
<variable units="mole_per_l_mito_volume_per_mv" public_interface="out" name="C_IM" initial_value="6.75e-6"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RT</ci>
<piecewise>
<piece>
<cn cellml:units="kilojoule_per_mole">2.5037</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="kilojoule_per_mole">2.57858</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>W_c</ci>
<piecewise>
<piece>
<cn cellml:units="l_water_per_l_cyto">80</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<piece>
<cn cellml:units="l_water_per_l_cyto">800</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</piece>
<piece>
<cn cellml:units="l_water_per_l_cyto">0.842508</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="l_water_per_l_cyto">80</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>V_mito</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cell">0.2882</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cell">0.056</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mito_per_cell">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>V_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="cyto_per_cell">0.6801</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</piece>
<piece>
<cn cellml:units="cyto_per_cell">0.894</cn>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="cyto_per_cell">1</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_C1">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_C1"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_C1"/>
<variable units="dimensionless" private_interface="in" name="k_eqC1"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_x"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_i"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" private_interface="out" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" private_interface="out" name="RT"/>
<variable units="molar" public_interface="in" name="NAD_x"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar" public_interface="in" name="QH2_x"/>
<variable units="molar" public_interface="in" name="COQ_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_C1</ci>
<apply>
<times/>
<ci>X_C1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_eqC1</ci>
<ci>NADH_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>NAD_x</ci>
<ci>QH2_x</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="k_eqC1">
<variable units="dimensionless" public_interface="out" name="k_eqC1"/>
<variable units="dimensionless" name="k_eqC1_nought"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="kilojoule_per_mole" name="deltaG_C1" initial_value="-109.7"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_eqC1_nought</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaG_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_eqC1</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_eqC1_nought</ci>
<apply>
<power/>
<ci>H_x</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
<apply>
<power/>
<ci>H_i</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<cn cellml:units="molar">1</cn>
</apply>
</apply>
</math>
</component>
<component name="J_C3">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_C3"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_half_molar" public_interface="in" name="X_C3"/>
<variable units="molar" public_interface="in" name="k_PI_1"/>
<variable units="molar" public_interface="in" name="k_PI_2"/>
<variable units="dimensionless" private_interface="in" name="k_eqC3"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_x"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_i"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" private_interface="out" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" private_interface="out" name="RT"/>
<variable units="molar" public_interface="in" name="PI_x"/>
<variable units="molar" public_interface="in" name="QH2_x"/>
<variable units="molar" public_interface="in" name="COQ_x"/>
<variable units="molar" public_interface="in" name="Cred_i"/>
<variable units="molar" public_interface="in" name="Cox_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_C3</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>X_C3</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>PI_x</ci>
<ci>k_PI_1</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>PI_x</ci>
<ci>k_PI_2</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>k_eqC3</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<ci>Cox_i</ci>
<apply>
<power/>
<ci>QH2_x</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Cred_i</ci>
<apply>
<power/>
<ci>COQ_x</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="k_eqC3">
<variable units="dimensionless" public_interface="out" name="k_eqC3"/>
<variable units="dimensionless" name="k_eqC3_nought"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="kilojoule_per_mole" name="deltaG_C3" initial_value="46.69"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_eqC3_nought</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaG_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_eqC3</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<cn cellml:units="molar">1</cn>
<ci>k_eqC3_nought</ci>
<apply>
<power/>
<ci>H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<ci>H_i</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_C4">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_C4"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar" public_interface="in" name="X_C4"/>
<variable units="dimensionless" private_interface="in" name="k_eqC4"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_x"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_i"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" private_interface="out" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" private_interface="out" name="RT"/>
<variable units="molar" public_interface="in" name="O2_x"/>
<variable units="molar" public_interface="in" name="k_O2"/>
<variable units="molar" public_interface="in" name="cytC_tot"/>
<variable units="molar" public_interface="in" name="Cred_i"/>
<variable units="molar" public_interface="in" name="Cox_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_C4</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>X_C4</ci>
<ci>O2_x</ci>
</apply>
<apply>
<plus/>
<ci>O2_x</ci>
<ci>k_O2</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
<ci>RT</ci>
</apply>
</apply>
<ci>Cred_i</ci>
</apply>
<ci>cytC_tot</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>k_eqC4</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>Cred_i</ci>
<apply>
<power/>
<ci>O2_x</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>Cox_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="k_eqC4">
<variable units="dimensionless" public_interface="out" name="k_eqC4"/>
<variable units="dimensionless" name="k_eqC4_nought"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="kilojoule_per_mole" name="deltaG_C4" initial_value="-202.2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_eqC4_nought</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaG_C4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_eqC4</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_eqC4_nought</ci>
<apply>
<power/>
<ci>H_x</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<apply>
<power/>
<ci>H_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<cn cellml:units="molar">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_F1">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_F1"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar" public_interface="in" name="X_F1"/>
<variable units="per_molar" private_interface="in" name="k_eqF1"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_x"/>
<variable units="molar" public_interface="in" private_interface="out" name="H_i"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="P_ATP_x"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="P_ADP_x"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="P_PI_x"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" private_interface="out" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" private_interface="out" name="RT"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="n_A"/>
<variable units="molar" public_interface="in" name="ATP_x"/>
<variable units="molar" public_interface="in" name="ADP_x"/>
<variable units="molar" public_interface="in" name="PI_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_F1</ci>
<apply>
<times/>
<ci>X_F1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_eqF1</ci>
<ci>ADP_x</ci>
<ci>PI_x</ci>
</apply>
<ci>ATP_x</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="k_eqF1">
<variable units="per_molar" public_interface="out" name="k_eqF1"/>
<variable units="dimensionless" name="k_eqF1_nought"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_x"/>
<variable units="dimensionless" public_interface="in" name="P_PI_x"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="dimensionless" public_interface="in" name="n_A"/>
<variable units="kilojoule_per_mole" name="deltaG_F1" initial_value="-4.51"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_eqF1_nought</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>deltaG_F1</ci>
<apply>
<times/>
<ci>n_A</ci>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_eqF1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_eqF1_nought</ci>
<apply>
<power/>
<ci>H_i</ci>
<ci>n_A</ci>
</apply>
<ci>P_ATP_x</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>H_x</ci>
<apply>
<minus/>
<ci>n_A</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>P_ADP_x</ci>
<ci>P_PI_x</ci>
<cn cellml:units="molar">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_pdh">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_pdh"/>
<variable units="molar" public_interface="in" name="PYR_x"/>
<variable units="molar" public_interface="in" name="COASH_x"/>
<variable units="molar" public_interface="in" name="NAD_x"/>
<variable units="molar" public_interface="in" name="CO2_tot_x"/>
<variable units="molar" public_interface="in" name="ACCOA_x"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="dimensionless" public_interface="in" name="P_CO2_tot_x"/>
<variable units="dimensionless" public_interface="in" name="P_PYR_x"/>
<variable units="dimensionless" public_interface="in" name="P_COASH_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="dimensionless" name="K_eq_pdh"/>
<variable units="molar" name="K0_eq_pdh" initial_value="5.02e-4"/>
<variable units="molar" name="K_mA" initial_value="38.3e-6"/>
<variable units="molar" name="K_mB" initial_value="9.9e-6"/>
<variable units="molar" name="K_mC" initial_value="60.7e-6"/>
<variable units="dimensionless" name="alpha_i1"/>
<variable units="dimensionless" name="alpha_i2"/>
<variable units="molar" name="K_iACCOA" initial_value="40.2e-6"/>
<variable units="molar" name="K_iNADH" initial_value="40e-6"/>
<variable units="molar" name="minCon" initial_value="1e-32"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_pdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_pdh</ci>
<ci>P_CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>H_x</ci>
<ci>P_PYR_x</ci>
<ci>P_COASH_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i1</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ACCOA_x</ci>
<ci>K_iACCOA</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i2</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NADH_x</ci>
<ci>K_iNADH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_pdh</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>PYR_x</ci>
<ci>COASH_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>CO2_tot_x</ci>
<ci>ACCOA_x</ci>
<ci>NADH_x</ci>
</apply>
<ci>K_eq_pdh</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mC</ci>
<ci>alpha_i2</ci>
<ci>PYR_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>K_mB</ci>
<ci>alpha_i1</ci>
<ci>PYR_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>K_mA</ci>
<ci>COASH_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>PYR_x</ci>
<ci>COASH_x</ci>
<ci>NAD_x</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>PYR_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>COASH_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>NAD_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_cits">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_cits"/>
<variable units="molar" public_interface="in" name="OAA_x"/>
<variable units="molar" public_interface="in" name="ACCOA_x"/>
<variable units="molar" public_interface="in" name="COASH_x"/>
<variable units="molar" public_interface="in" name="CIT_x"/>
<variable units="molar" public_interface="in" name="ATP_x"/>
<variable units="molar" public_interface="in" name="ADP_x"/>
<variable units="molar" public_interface="in" name="AMP_x"/>
<variable units="molar" public_interface="in" name="SCOA_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="fATP_x"/>
<variable units="molar" public_interface="in" name="fADP_x"/>
<variable units="molar" public_interface="in" name="fAMP_x"/>
<variable units="molar" public_interface="in" name="uCIT_x"/>
<variable units="dimensionless" public_interface="in" name="P_CIT_x"/>
<variable units="dimensionless" public_interface="in" name="P_OAA_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="dimensionless" name="K_eq_cits"/>
<variable units="molar_squared" name="K0_eq_cits" initial_value="7.34e-8"/>
<variable units="molar" name="K_mA" initial_value="4e-6"/>
<variable units="molar" name="K_mB" initial_value="14e-6"/>
<variable units="molar" name="K_ia" initial_value="3.33e-6"/>
<variable units="molar" name="K_iCIT" initial_value="1600e-6"/>
<variable units="molar" name="K_iATP" initial_value="900e-6"/>
<variable units="molar" name="K_iADP" initial_value="1800e-6"/>
<variable units="molar" name="K_iAMP" initial_value="6000e-6"/>
<variable units="molar" name="K_iCOASH" initial_value="67e-6"/>
<variable units="molar" name="K_iSCOA" initial_value="140e-6"/>
<variable units="dimensionless" name="alpha_i1"/>
<variable units="dimensionless" name="alpha_i2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_cits</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_cits</ci>
<ci>P_CIT_x</ci>
</apply>
<apply>
<times/>
<ci>H_x</ci>
<ci>H_x</ci>
<ci>P_OAA_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i1</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>uCIT_x</ci>
<ci>K_iCIT</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i2</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fATP_x</ci>
<ci>K_iATP</ci>
</apply>
<apply>
<divide/>
<ci>fADP_x</ci>
<ci>K_iADP</ci>
</apply>
<apply>
<divide/>
<ci>fAMP_x</ci>
<ci>K_iAMP</ci>
</apply>
<apply>
<divide/>
<ci>COASH_x</ci>
<ci>K_iCOASH</ci>
</apply>
<apply>
<divide/>
<ci>SCOA_x</ci>
<ci>K_iSCOA</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_cits</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ACCOA_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>COASH_x</ci>
<ci>CIT_x</ci>
</apply>
<ci>K_eq_cits</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_ia</ci>
<ci>K_mB</ci>
<ci>alpha_i1</ci>
</apply>
<apply>
<times/>
<ci>K_mA</ci>
<ci>alpha_i1</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>K_mB</ci>
<ci>alpha_i2</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>OAA_x</ci>
<ci>ACCOA_x</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_acon">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_acon"/>
<variable units="molar" public_interface="in" name="CIT_x"/>
<variable units="molar" public_interface="in" name="ICIT_x"/>
<variable units="dimensionless" public_interface="in" name="P_CIT_x"/>
<variable units="dimensionless" public_interface="in" name="P_ICIT_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="dimensionless" name="K_eq_acon"/>
<variable units="dimensionless" name="K0_eq_acon" initial_value="7.59e-2"/>
<variable units="molar" name="K_mA" initial_value="1161e-6"/>
<variable units="molar" name="K_mP" initial_value="434e-6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_acon</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_acon</ci>
<ci>P_ICIT_x</ci>
</apply>
<ci>P_CIT_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mP</ci>
</apply>
<apply>
<times/>
<ci>K_mA</ci>
<ci>K_eq_acon</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_acon</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
<apply>
<minus/>
<ci>CIT_x</ci>
<apply>
<divide/>
<ci>ICIT_x</ci>
<ci>K_eq_acon</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mA</ci>
<ci>V_mr</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>ICIT_x</ci>
</apply>
<ci>K_eq_acon</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_isod">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_isod"/>
<variable units="molar" public_interface="in" name="NAD_x"/>
<variable units="molar" public_interface="in" name="ICIT_x"/>
<variable units="molar" public_interface="in" name="AKG_x"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar" public_interface="in" name="CO2_tot_x"/>
<variable units="molar" public_interface="in" name="fATP_x"/>
<variable units="molar" public_interface="in" name="fADP_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="dimensionless" public_interface="in" name="P_CO2_tot_x"/>
<variable units="dimensionless" public_interface="in" name="P_ICIT_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="molar" name="K_eq_isod"/>
<variable units="molar_cubed" name="K0_eq_isod" initial_value="3.5e-16"/>
<variable units="molar" name="K_mA" initial_value="74e-6"/>
<variable units="molar" name="K_mB" initial_value="183e-6"/>
<variable units="molar" name="K_ib" initial_value="23.8e-6"/>
<variable units="molar" name="K_iq" initial_value="29e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="dimensionless" name="n_H" initial_value="3"/>
<variable units="molar" name="K_aATP" initial_value="91e-6"/>
<variable units="molar" name="K_aADP" initial_value="50e-6"/>
<variable units="molar" name="minCon" initial_value="1e-32"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_isod</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_isod</ci>
<ci>P_CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>H_x</ci>
<ci>H_x</ci>
<ci>P_ICIT_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>K_aADP</ci>
<ci>fADP_x</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fATP_x</ci>
<ci>K_aATP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_isod</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CO2_tot_x</ci>
<ci>AKG_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_isod</ci>
<ci>NAD_x</ci>
<ci>ICIT_x</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>K_mB</ci>
<ci>ICIT_x</ci>
</apply>
<ci>n_H</ci>
</apply>
<ci>alpha_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_mA</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>K_ib</ci>
<ci>ICIT_x</ci>
</apply>
<ci>n_H</ci>
</apply>
<ci>alpha_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>NADH_x</ci>
<ci>alpha_i</ci>
</apply>
<ci>K_iq</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>NAD_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>ICIT_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_akgd">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_akgd"/>
<variable units="molar" public_interface="in" name="AKG_x"/>
<variable units="molar" public_interface="in" name="COASH_x"/>
<variable units="molar" public_interface="in" name="NAD_x"/>
<variable units="molar" public_interface="in" name="CO2_tot_x"/>
<variable units="molar" public_interface="in" name="SCOA_x"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="fATP_x"/>
<variable units="molar" public_interface="in" name="fADP_x"/>
<variable units="dimensionless" public_interface="in" name="P_CO2_tot_x"/>
<variable units="dimensionless" public_interface="in" name="P_SCOA_x"/>
<variable units="dimensionless" public_interface="in" name="P_COASH_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="dimensionless" name="K_eq_akgd"/>
<variable units="molar" name="K0_eq_akgd" initial_value="6.93e-3"/>
<variable units="molar" name="K_mA" initial_value="80e-6"/>
<variable units="molar" name="K_mB" initial_value="55e-6"/>
<variable units="molar" name="K_mC" initial_value="21e-6"/>
<variable units="molar" name="K_iq" initial_value="6.9e-6"/>
<variable units="molar" name="K_ir" initial_value="6.036773936330217e-7"/>
<variable units="molar" name="K_ir2" initial_value="1e3"/>
<variable units="molar" name="K_iATP" initial_value="50e-6"/>
<variable units="molar" name="K_aADP" initial_value="100e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="molar" name="minCon" initial_value="1e-32"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_akgd</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_akgd</ci>
<ci>P_CO2_tot_x</ci>
<ci>P_SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>H_x</ci>
<ci>P_COASH_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>K_aADP</ci>
<ci>fADP_x</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fATP_x</ci>
<ci>K_iATP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_akgd</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CO2_tot_x</ci>
<ci>SCOA_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_akgd</ci>
<ci>AKG_x</ci>
<ci>COASH_x</ci>
<ci>NAD_x</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>K_mA</ci>
<ci>AKG_x</ci>
</apply>
<ci>alpha_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_mB</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>SCOA_x</ci>
<ci>K_iq</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_mC</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NADH_x</ci>
<ci>K_ir</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NADH_x</ci>
<ci>K_ir2</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>AKG_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>COASH_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>NAD_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_scoas">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_scoas"/>
<variable units="molar" public_interface="in" name="GDP_x"/>
<variable units="molar" public_interface="in" name="SCOA_x"/>
<variable units="molar" public_interface="in" name="PI_x"/>
<variable units="molar" public_interface="in" name="COASH_x"/>
<variable units="molar" public_interface="in" name="SUC_x"/>
<variable units="molar" public_interface="in" name="GTP_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="dimensionless" public_interface="in" name="P_COASH_x"/>
<variable units="dimensionless" public_interface="in" name="P_SUC_x"/>
<variable units="dimensionless" public_interface="in" name="P_GTP_x"/>
<variable units="dimensionless" public_interface="in" name="P_GDP_x"/>
<variable units="dimensionless" public_interface="in" name="P_SCOA_x"/>
<variable units="dimensionless" public_interface="in" name="P_PI_x"/>
<variable units="dimensionless" name="K_eq_scoas"/>
<variable units="molar" name="K0_eq_scoas" initial_value="9.54e-9"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="molar" name="K_iGDP" initial_value="5.5e-6"/>
<variable units="molar" name="K_iSCOA" initial_value="100e-6"/>
<variable units="molar" name="K_iPI" initial_value="2000e-6"/>
<variable units="molar" name="K_iCOASH" initial_value="20e-6"/>
<variable units="molar" name="K_iSUC" initial_value="3000e-6"/>
<variable units="molar" name="K_iGTP" initial_value="11.1e-6"/>
<variable units="molar" name="K_mGDP" initial_value="16e-6"/>
<variable units="molar" name="K_mSCOA" initial_value="55e-6"/>
<variable units="molar" name="K_mPI" initial_value="660e-6"/>
<variable units="molar" name="K_mCOASH" initial_value="20e-6"/>
<variable units="molar" name="K_mSUC" initial_value="880e-6"/>
<variable units="molar" name="K_mGTP" initial_value="11.1e-6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_scoas</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_scoas</ci>
<ci>P_COASH_x</ci>
<ci>P_SUC_x</ci>
<ci>P_GTP_x</ci>
</apply>
<apply>
<times/>
<ci>H_x</ci>
<ci>P_GDP_x</ci>
<ci>P_SCOA_x</ci>
<ci>P_PI_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mCOASH</ci>
<ci>K_iSUC</ci>
<ci>K_iGTP</ci>
</apply>
<apply>
<times/>
<ci>K_eq_scoas</ci>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_mPI</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_scoas</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_mCOASH</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_iSCOA</ci>
<ci>K_mCOASH</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_iGDP</ci>
<ci>K_mSCOA</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mCOASH</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mSCOA</ci>
<ci>GDP_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mGDP</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_iGTP</ci>
<ci>K_mSUC</ci>
<ci>COASH_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_iSUC</ci>
<ci>K_mCOASH</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mGTP</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mSUC</ci>
<ci>COASH_x</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mCOASH</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_eq_scoas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mSUC</ci>
<ci>K_iGTP</ci>
<ci>GDP_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_iGDP</ci>
<ci>K_mSCOA</ci>
<ci>PI_x</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_iGTP</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mSUC</ci>
<ci>K_iGTP</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mGDP</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
<ci>GTP_x</ci>
</apply>
<ci>K_iGTP</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mGTP</ci>
<ci>GDP_x</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_iGDP</ci>
<ci>K_mSCOA</ci>
<ci>PI_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>K_iSUC</ci>
<ci>K_iGTP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_iGTP</ci>
<ci>K_mSUC</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_iPI</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_iCOASH</ci>
<ci>K_mGTP</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_iCOASH</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mGTP</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mGDP</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>K_iSUC</ci>
<ci>K_iGTP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mGDP</ci>
<ci>K_iCOASH</ci>
<ci>SCOA_x</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>K_iCOASH</ci>
<ci>K_iSUC</ci>
<ci>K_iGTP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_iGDP</ci>
<ci>K_mSCOA</ci>
<ci>PI_x</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>K_iCOASH</ci>
<ci>K_iSUC</ci>
<ci>K_iGTP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mGTP</ci>
<ci>GDP_x</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGDP</ci>
<ci>K_iSCOA</ci>
<ci>K_iCOASH</ci>
<ci>K_eq_scoas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mGDP</ci>
<ci>SCOA_x</ci>
<ci>PI_x</ci>
<ci>COASH_x</ci>
<ci>SUC_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>K_iCOASH</ci>
<ci>K_iSUC</ci>
<ci>K_iGTP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_sdh">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_sdh"/>
<variable units="molar" public_interface="in" name="SUC_x"/>
<variable units="molar" public_interface="in" name="COQ_x"/>
<variable units="molar" public_interface="in" name="QH2_x"/>
<variable units="molar" public_interface="in" name="FUM_x"/>
<variable units="molar" public_interface="in" name="OAA_x"/>
<variable units="dimensionless" public_interface="in" name="P_FUM_x"/>
<variable units="dimensionless" public_interface="in" name="P_SUC_x"/>
<variable units="dimensionless" name="K_eq_sdh"/>
<variable units="dimensionless" name="K0_eq_sdh" initial_value="1.69"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="molar" name="K_ia" initial_value="120e-6"/>
<variable units="molar" name="K_iq" initial_value="1275e-6"/>
<variable units="molar" name="K_mSUC" initial_value="467e-6"/>
<variable units="molar" name="K_mCOQ" initial_value="480e-6"/>
<variable units="molar" name="K_mQH2" initial_value="2.45e-6"/>
<variable units="molar" name="K_mFUM" initial_value="1200e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="molar" name="K_iOAA" initial_value="1.5e-6"/>
<variable units="molar" name="K_aSUC" initial_value="450e-6"/>
<variable units="molar" name="K_aFUM" initial_value="375e-6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_sdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_sdh</ci>
<ci>P_FUM_x</ci>
</apply>
<ci>P_SUC_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQH2</ci>
<ci>K_iq</ci>
</apply>
<apply>
<times/>
<ci>K_eq_sdh</ci>
<ci>K_ia</ci>
<ci>K_mCOQ</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>OAA_x</ci>
<ci>K_iOAA</ci>
</apply>
<apply>
<divide/>
<ci>SUC_x</ci>
<ci>K_aSUC</ci>
</apply>
<apply>
<divide/>
<ci>FUM_x</ci>
<ci>K_aFUM</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>SUC_x</ci>
<ci>K_aSUC</ci>
</apply>
<apply>
<divide/>
<ci>FUM_x</ci>
<ci>K_aFUM</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_sdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>SUC_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>QH2_x</ci>
<ci>FUM_x</ci>
</apply>
<ci>K_eq_sdh</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_ia</ci>
<ci>K_mCOQ</ci>
<ci>alpha_i</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mCOQ</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mSUC</ci>
<ci>alpha_i</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mFUM</ci>
<ci>alpha_i</ci>
<ci>QH2_x</ci>
</apply>
<ci>K_eq_sdh</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQH2</ci>
<ci>FUM_x</ci>
</apply>
<ci>K_eq_sdh</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>SUC_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mFUM</ci>
<ci>SUC_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_sdh</ci>
<ci>K_ia</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mSUC</ci>
<ci>COQ_x</ci>
<ci>FUM_x</ci>
</apply>
<ci>K_iq</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>QH2_x</ci>
<ci>FUM_x</ci>
</apply>
<ci>K_eq_sdh</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_fum">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_fum"/>
<variable units="molar" public_interface="in" name="FUM_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<variable units="molar" public_interface="in" name="CIT_x"/>
<variable units="molar" public_interface="in" name="fATP_x"/>
<variable units="molar" public_interface="in" name="fADP_x"/>
<variable units="molar" public_interface="in" name="fGTP_x"/>
<variable units="molar" public_interface="in" name="fGDP_x"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_x"/>
<variable units="dimensionless" public_interface="in" name="P_FUM_x"/>
<variable units="dimensionless" name="K_eq_fum"/>
<variable units="dimensionless" name="K0_eq_fum" initial_value="4.4"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="molar" name="K_mFUM" initial_value="44.7e-6"/>
<variable units="molar" name="K_mMAL" initial_value="197.7e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="molar" name="K_iCIT" initial_value="3500e-6"/>
<variable units="molar" name="K_iATP" initial_value="40e-6"/>
<variable units="molar" name="K_iADP" initial_value="400e-6"/>
<variable units="molar" name="K_iGTP" initial_value="80e-6"/>
<variable units="molar" name="K_iGDP" initial_value="330e-6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_fum</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_fum</ci>
<ci>P_MAL_x</ci>
</apply>
<ci>P_FUM_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mMAL</ci>
</apply>
<apply>
<times/>
<ci>K_eq_fum</ci>
<ci>K_mFUM</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>CIT_x</ci>
<ci>K_iCIT</ci>
</apply>
<apply>
<divide/>
<ci>fATP_x</ci>
<ci>K_iATP</ci>
</apply>
<apply>
<divide/>
<ci>fADP_x</ci>
<ci>K_iADP</ci>
</apply>
<apply>
<divide/>
<ci>fGTP_x</ci>
<ci>K_iGTP</ci>
</apply>
<apply>
<divide/>
<ci>fGDP_x</ci>
<ci>K_iGDP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_fum</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>V_mf</ci>
<apply>
<minus/>
<ci>FUM_x</ci>
<apply>
<divide/>
<ci>MAL_x</ci>
<ci>K_eq_fum</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mFUM</ci>
<ci>V_mr</ci>
<ci>alpha_i</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>MAL_x</ci>
</apply>
<ci>K_eq_fum</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_mdh">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_mdh"/>
<variable units="molar" public_interface="in" name="NAD_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<variable units="molar" public_interface="in" name="OAA_x"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="fATP_x"/>
<variable units="molar" public_interface="in" name="fADP_x"/>
<variable units="molar" public_interface="in" name="fAMP_x"/>
<variable units="dimensionless" public_interface="in" name="P_OAA_x"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_x"/>
<variable units="dimensionless" name="K_eq_mdh"/>
<variable units="molar" name="K0_eq_mdh" initial_value="2.27e-12"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="molar" name="K_ia" initial_value="279e-6"/>
<variable units="molar" name="K_ib" initial_value="360e-6"/>
<variable units="molar" name="K_ip" initial_value="5.5e-6"/>
<variable units="molar" name="K_iq" initial_value="3.18e-6"/>
<variable units="molar" name="K_mNAD" initial_value="90.55e-6"/>
<variable units="molar" name="K_mMAL" initial_value="250e-6"/>
<variable units="molar" name="K_mOAA" initial_value="6.128e-6"/>
<variable units="molar" name="K_mNADH" initial_value="2.58e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="molar" name="K_iATP" initial_value="183.2e-6"/>
<variable units="molar" name="K_iADP" initial_value="394.4e-6"/>
<variable units="molar" name="K_iAMP" initial_value="420e-6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_mdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_mdh</ci>
<ci>P_OAA_x</ci>
</apply>
<apply>
<times/>
<ci>H_x</ci>
<ci>P_MAL_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_iq</ci>
<ci>K_mOAA</ci>
</apply>
<apply>
<times/>
<ci>K_eq_mdh</ci>
<ci>K_ia</ci>
<ci>K_mMAL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fATP_x</ci>
<ci>K_iATP</ci>
</apply>
<apply>
<divide/>
<ci>fADP_x</ci>
<ci>K_iADP</ci>
</apply>
<apply>
<divide/>
<ci>fAMP_x</ci>
<ci>K_iAMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_mdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>NAD_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>OAA_x</ci>
<ci>NADH_x</ci>
</apply>
<ci>K_eq_mdh</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_ia</ci>
<ci>K_mMAL</ci>
<ci>alpha_i</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mMAL</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mNAD</ci>
<ci>alpha_i</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mNADH</ci>
<ci>alpha_i</ci>
<ci>OAA_x</ci>
</apply>
<ci>K_eq_mdh</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mOAA</ci>
<ci>NADH_x</ci>
</apply>
<ci>K_eq_mdh</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>NAD_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mNADH</ci>
<ci>NAD_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_mdh</ci>
<ci>K_ia</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>OAA_x</ci>
<ci>NADH_x</ci>
</apply>
<ci>K_eq_mdh</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mNAD</ci>
<ci>MAL_x</ci>
<ci>NADH_x</ci>
</apply>
<ci>K_iq</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>NAD_x</ci>
<ci>MAL_x</ci>
<ci>OAA_x</ci>
</apply>
<ci>K_ip</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>MAL_x</ci>
<ci>OAA_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>K_ib</ci>
<ci>K_eq_mdh</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ndk">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ndk_f"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ndk"/>
<variable units="molar" public_interface="in" name="GTP_x"/>
<variable units="molar" public_interface="in" name="ADP_x"/>
<variable units="molar" public_interface="in" name="GDP_x"/>
<variable units="molar" public_interface="in" name="ATP_x"/>
<variable units="molar" public_interface="in" name="fAMP_x"/>
<variable units="dimensionless" name="K_eq_ndk" initial_value="1"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="molar" name="K_ia" initial_value="170e-6"/>
<variable units="molar" name="K_ib" initial_value="143.6e-6"/>
<variable units="molar" name="K_ip" initial_value="146.6e-6"/>
<variable units="molar" name="K_iq" initial_value="156.5e-6"/>
<variable units="molar" name="K_mA" initial_value="111e-6"/>
<variable units="molar" name="K_mB" initial_value="100e-6"/>
<variable units="molar" name="K_mP" initial_value="260e-6"/>
<variable units="molar" name="K_mQ" initial_value="278e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="molar" name="K_iAMP" initial_value="650e-6"/>
<variable units="molar" name="minCon" initial_value="1e-32"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>K_ip</ci>
</apply>
<apply>
<times/>
<ci>K_eq_ndk</ci>
<ci>K_ia</ci>
<ci>K_mB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fAMP_x</ci>
<ci>K_iAMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ndk_f</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
</apply>
<ci>alpha_i</ci>
</apply>
<ci>GTP_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mB</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>GDP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mP</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>GTP_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>GTP_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_ndk</ci>
<ci>K_ia</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>GDP_x</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>ADP_x</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_iq</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>GTP_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>ADP_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>J_ndk</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>J_ndk_f</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
</apply>
<ci>alpha_i</ci>
</apply>
<ci>GDP_x</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mB</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>GDP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mP</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>GTP_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>GTP_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_ndk</ci>
<ci>K_ia</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>GDP_x</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_eq_ndk</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>ADP_x</ci>
<ci>ATP_x</ci>
</apply>
<ci>K_iq</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>GDP_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>ATP_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<ci>J_ndk_f</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_got">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_got_f"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_got"/>
<variable units="molar" public_interface="in" name="ASP_x"/>
<variable units="molar" public_interface="in" name="AKG_x"/>
<variable units="molar" public_interface="in" name="OAA_x"/>
<variable units="molar" public_interface="in" name="GLU_x"/>
<variable units="dimensionless" public_interface="in" name="P_OAA_x"/>
<variable units="dimensionless" public_interface="in" name="P_ASP_x"/>
<variable units="dimensionless" public_interface="in" name="P_GLU_x"/>
<variable units="dimensionless" name="K_eq_got"/>
<variable units="dimensionless" name="K0_eq_got" initial_value="1.77"/>
<variable units="mole_per_second_per_l_mito_volume" name="V_mr"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="V_mf"/>
<variable units="molar" name="K_ia" initial_value="3480e-6"/>
<variable units="molar" name="K_ib" initial_value="710e-6"/>
<variable units="molar" name="K_ip" initial_value="50e-6"/>
<variable units="molar" name="K_iq" initial_value="8400e-6"/>
<variable units="molar" name="K_mA" initial_value="3900e-6"/>
<variable units="molar" name="K_mB" initial_value="430e-6"/>
<variable units="molar" name="K_mP" initial_value="88e-6"/>
<variable units="molar" name="K_mQ" initial_value="8900e-6"/>
<variable units="dimensionless" name="alpha_i"/>
<variable units="molar" name="K_iAKG" initial_value="16.6e-3"/>
<variable units="molar" name="minCon" initial_value="1e-32"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eq_got</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_eq_got</ci>
<ci>P_GLU_x</ci>
<ci>P_OAA_x</ci>
</apply>
<ci>P_ASP_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_mr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>K_ip</ci>
</apply>
<apply>
<times/>
<ci>K_eq_got</ci>
<ci>K_ia</ci>
<ci>K_mB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>AKG_x</ci>
<ci>K_iAKG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_got_f</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
<ci>ASP_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mB</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>alpha_i</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>alpha_i</ci>
<ci>OAA_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mP</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>ASP_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>ASP_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_got</ci>
<ci>K_ia</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>OAA_x</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>AKG_x</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_iq</ci>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>ASP_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>AKG_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>J_got</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>J_got_f</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>V_mr</ci>
<ci>OAA_x</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mB</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>alpha_i</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>alpha_i</ci>
<ci>OAA_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mP</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<times/>
<ci>V_mr</ci>
<ci>ASP_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>K_mQ</ci>
<ci>ASP_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>K_eq_got</ci>
<ci>K_ia</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mf</ci>
<ci>OAA_x</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_eq_got</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>V_mr</ci>
<ci>K_mA</ci>
<ci>AKG_x</ci>
<ci>GLU_x</ci>
</apply>
<ci>K_iq</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>OAA_x</ci>
<ci>minCon</ci>
</apply>
<apply>
<gt/>
<ci>GLU_x</ci>
<ci>minCon</ci>
</apply>
</apply>
</piece>
<otherwise>
<ci>J_got_f</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_PYRH">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_PYRH"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_PYRH"/>
<variable units="molar" public_interface="in" name="PYR_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="dimensionless" public_interface="in" name="P_PYR_i"/>
<variable units="molar" public_interface="in" name="PYR_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="dimensionless" public_interface="in" name="P_PYR_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_PYRH</ci>
<apply>
<times/>
<ci>X_PYRH</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>PYR_i</ci>
<ci>P_PYR_i</ci>
</apply>
<ci>H_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>PYR_x</ci>
<ci>P_PYR_x</ci>
</apply>
<ci>H_x</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_GLUH">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_GLUH"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_GLUH"/>
<variable units="molar" public_interface="in" name="GLU_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="dimensionless" public_interface="in" name="P_GLU_i"/>
<variable units="molar" public_interface="in" name="GLU_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="dimensionless" public_interface="in" name="P_GLU_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_GLUH</ci>
<apply>
<times/>
<ci>X_GLUH</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>GLU_i</ci>
<ci>P_GLU_i</ci>
</apply>
<ci>H_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>GLU_x</ci>
<ci>P_GLU_x</ci>
</apply>
<ci>H_x</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_CITMAL">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_CITMAL"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_CITMAL"/>
<variable units="molar" public_interface="in" name="hCIT_i"/>
<variable units="molar" public_interface="in" name="MAL_i"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_i"/>
<variable units="molar" public_interface="in" name="hCIT_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_CITMAL</ci>
<apply>
<times/>
<ci>X_CITMAL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>hCIT_i</ci>
<ci>MAL_x</ci>
</apply>
<ci>P_MAL_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>hCIT_x</ci>
<ci>MAL_i</ci>
</apply>
<ci>P_MAL_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_AKGMAL">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_AKGMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="X_AKGMAL"/>
<variable units="molar" name="K_mAKGi" initial_value="0.3e-3"/>
<variable units="molar" name="K_mAKGx" initial_value="0.17e-3"/>
<variable units="molar" name="K_mMALi" initial_value="1.4e-3"/>
<variable units="molar" name="K_mMALx" initial_value="0.7e-3"/>
<variable units="molar" public_interface="in" name="AKG_i"/>
<variable units="molar" public_interface="in" name="MAL_i"/>
<variable units="molar" public_interface="in" name="AKG_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_AKGMAL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>X_AKGMAL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>AKG_i</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>AKG_x</ci>
<ci>MAL_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_mAKGi</ci>
<ci>K_mMALx</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<divide/>
<ci>MAL_i</ci>
<ci>K_mMALi</ci>
</apply>
<apply>
<divide/>
<ci>MAL_x</ci>
<ci>K_mMALx</ci>
</apply>
<apply>
<divide/>
<ci>AKG_i</ci>
<ci>K_mAKGi</ci>
</apply>
<apply>
<divide/>
<ci>AKG_x</ci>
<ci>K_mAKGx</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>MAL_i</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>K_mMALi</ci>
<ci>K_mAKGx</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>MAL_x</ci>
<ci>AKG_i</ci>
</apply>
<apply>
<times/>
<ci>K_mMALx</ci>
<ci>K_mAKGi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_MALPI">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_MALPI"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_MALPI"/>
<variable units="molar" public_interface="in" name="PI_i"/>
<variable units="dimensionless" public_interface="in" name="P_PI_i"/>
<variable units="molar" public_interface="in" name="MAL_i"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_i"/>
<variable units="molar" public_interface="in" name="PI_x"/>
<variable units="dimensionless" public_interface="in" name="P_PI_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_MALPI</ci>
<apply>
<times/>
<ci>X_MALPI</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>MAL_i</ci>
<ci>P_MAL_i</ci>
</apply>
<ci>PI_x</ci>
</apply>
<ci>P_PI_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>MAL_x</ci>
<ci>P_MAL_x</ci>
</apply>
<ci>PI_i</ci>
</apply>
<ci>P_PI_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ASPGLU">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ASPGLU"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="X_ASPGLU"/>
<variable units="dimensionless" name="K_eqASPGLU"/>
<variable units="molar" name="K_hASPGLU"/>
<variable units="molar" name="K_iASPi" initial_value="0.028e-3"/>
<variable units="molar" name="K_iASPx" initial_value="2.8e-3"/>
<variable units="molar" name="K_iGLUi" initial_value="0.18e-3"/>
<variable units="molar" name="K_iGLUx" initial_value="1.6e-3"/>
<variable units="molar" public_interface="in" name="ASP_i"/>
<variable units="molar" public_interface="in" name="GLU_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="ASP_x"/>
<variable units="molar" public_interface="in" name="GLU_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="dimensionless" name="m" initial_value="1.8"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="dimensionless" public_interface="in" name="P_ASP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ASP_i"/>
<variable units="dimensionless" public_interface="in" name="P_GLU_x"/>
<variable units="dimensionless" public_interface="in" name="P_GLU_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_eqASPGLU</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>deltaPsi</ci>
</apply>
<ci>RT</ci>
</apply>
</apply>
<ci>P_ASP_x</ci>
<ci>P_GLU_i</ci>
</apply>
<apply>
<times/>
<ci>P_ASP_i</ci>
<ci>P_GLU_x</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_hASPGLU</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ASPGLU</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>X_ASPGLU</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_eqASPGLU</ci>
<ci>ASP_i</ci>
<ci>GLU_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>ASP_x</ci>
<ci>GLU_i</ci>
<ci>H_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_eqASPGLU</ci>
<ci>K_iASPi</ci>
<ci>K_iGLUx</ci>
<ci>K_hASPGLU</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>ASP_i</ci>
</apply>
<ci>K_iASPi</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>ASP_i</ci>
<ci>GLU_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>K_iASPi</ci>
<ci>K_iGLUx</ci>
<ci>K_hASPGLU</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>ASP_x</ci>
<ci>H_i</ci>
</apply>
<apply>
<times/>
<ci>K_iASPx</ci>
<ci>K_hASPGLU</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>ASP_x</ci>
<ci>GLU_i</ci>
<ci>H_i</ci>
</apply>
<apply>
<times/>
<ci>K_iASPx</ci>
<ci>K_iGLUi</ci>
<ci>K_hASPGLU</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>ASP_x</ci>
</apply>
<ci>K_iASPx</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>ASP_i</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>K_iASPi</ci>
<ci>K_hASPGLU</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>H_x</ci>
</apply>
<ci>K_hASPGLU</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>GLU_i</ci>
<ci>H_i</ci>
</apply>
<apply>
<times/>
<ci>K_iGLUi</ci>
<ci>K_hASPGLU</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>H_i</ci>
</apply>
<ci>K_hASPGLU</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>m</ci>
<ci>GLU_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>K_iGLUx</ci>
<ci>K_hASPGLU</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_SUCMAL">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_SUCMAL"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_SUCMAL"/>
<variable units="molar" public_interface="in" name="SUC_i"/>
<variable units="dimensionless" public_interface="in" name="P_SUC_i"/>
<variable units="molar" public_interface="in" name="MAL_i"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_i"/>
<variable units="molar" public_interface="in" name="SUC_x"/>
<variable units="dimensionless" public_interface="in" name="P_SUC_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_SUCMAL</ci>
<apply>
<times/>
<ci>X_SUCMAL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>SUC_i</ci>
<ci>P_SUC_i</ci>
</apply>
<ci>MAL_x</ci>
</apply>
<ci>P_MAL_x</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>SUC_x</ci>
<ci>P_SUC_x</ci>
</apply>
<ci>MAL_i</ci>
</apply>
<ci>P_MAL_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ATPt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ATPt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_A"/>
<variable units="molar" public_interface="in" name="ATP_c"/>
<variable units="molar" public_interface="in" name="ATP_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_ATPt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_A</ci>
<apply>
<minus/>
<ci>ATP_c</ci>
<ci>ATP_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ADPt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ADPt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_A"/>
<variable units="molar" public_interface="in" name="ADP_c"/>
<variable units="molar" public_interface="in" name="ADP_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_ADPt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_A</ci>
<apply>
<minus/>
<ci>ADP_c</ci>
<ci>ADP_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_AMPt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_AMPt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_A"/>
<variable units="molar" public_interface="in" name="AMP_c"/>
<variable units="molar" public_interface="in" name="AMP_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_AMPt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_A</ci>
<apply>
<minus/>
<ci>AMP_c</ci>
<ci>AMP_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_PIt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_PIt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_PI"/>
<variable units="molar" public_interface="in" name="PI_c"/>
<variable units="molar" public_interface="in" name="PI_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_PIt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_PI</ci>
<apply>
<minus/>
<ci>PI_c</ci>
<ci>PI_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_PYRt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_PYRt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="PYR_c"/>
<variable units="molar" public_interface="in" name="PYR_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_PYRt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>PYR_c</ci>
<ci>PYR_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_CITt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_CITt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="CIT_c"/>
<variable units="molar" public_interface="in" name="CIT_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_CITt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>CIT_c</ci>
<ci>CIT_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ICITt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ICITt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="ICIT_c"/>
<variable units="molar" public_interface="in" name="ICIT_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_ICITt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>ICIT_c</ci>
<ci>ICIT_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_MALt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_MALt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="MAL_c"/>
<variable units="molar" public_interface="in" name="MAL_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_MALt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>MAL_c</ci>
<ci>MAL_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_AKGt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_AKGt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="AKG_c"/>
<variable units="molar" public_interface="in" name="AKG_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_AKGt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>AKG_c</ci>
<ci>AKG_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_SUCt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_SUCt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="SUC_c"/>
<variable units="molar" public_interface="in" name="SUC_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_SUCt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>SUC_c</ci>
<ci>SUC_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_GLUt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_GLUt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="GLU_c"/>
<variable units="molar" public_interface="in" name="GLU_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_GLUt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>GLU_c</ci>
<ci>GLU_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ASPt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ASPt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" public_interface="in" name="p_TI"/>
<variable units="molar" public_interface="in" name="ASP_c"/>
<variable units="molar" public_interface="in" name="ASP_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_ASPt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>ASP_c</ci>
<ci>ASP_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_FUMt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_FUMt"/>
<variable units="per_micrometer" public_interface="in" name="gamma"/>
<variable units="micrometer_per_second" name="p_TI" initial_value="0"/>
<variable units="molar" public_interface="in" name="FUM_c"/>
<variable units="molar" public_interface="in" name="FUM_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_FUMt</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>p_TI</ci>
<apply>
<minus/>
<ci>FUM_c</ci>
<ci>FUM_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_ANT">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_ANT"/>
<variable units="dimensionless" public_interface="in" name="theta"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="X_ANT"/>
<variable units="molar" public_interface="in" name="k_mADP"/>
<variable units="molar" public_interface="in" name="ADP_i"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_i"/>
<variable units="molar" public_interface="in" name="ATP_i"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_i"/>
<variable units="molar" public_interface="in" name="ADP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_x"/>
<variable units="molar" public_interface="in" name="ATP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_x"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="molar" name="minCond" initial_value="1e-9"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_ANT</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<ci>X_ANT</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<divide/>
<ci>k_mADP</ci>
<ci>ADP_i</ci>
</apply>
<ci>P_ADP_i</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<divide/>
<ci>ADP_i</ci>
<ci>P_ADP_i</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<ci>ADP_i</ci>
<ci>P_ADP_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>ATP_i</ci>
<ci>P_ATP_i</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>theta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci>ADP_x</ci>
<ci>P_ADP_x</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<ci>ADP_x</ci>
<ci>P_ADP_x</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>ATP_x</ci>
<ci>P_ATP_x</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>ADP_i</ci>
<ci>minCond</ci>
</apply>
<apply>
<gt/>
<ci>ATP_x</ci>
<ci>minCond</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_PIHt">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_PIHt"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar" public_interface="in" name="X_PIHt"/>
<variable units="molar" public_interface="in" name="k_PIHt"/>
<variable units="molar" public_interface="in" name="hPI_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="hPI_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_PIHt</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>X_PIHt</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>hPI_i</ci>
<ci>H_i</ci>
</apply>
<apply>
<times/>
<ci>hPI_x</ci>
<ci>H_x</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_PIHt</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>hPI_i</ci>
<ci>k_PIHt</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>hPI_x</ci>
<ci>k_PIHt</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_Hle">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_Hle"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_mv" public_interface="in" name="X_Hle"/>
<variable units="millivolt" public_interface="in" name="deltaPsi"/>
<variable units="kilojoule_per_mole_per_millivolt" public_interface="in" name="F"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="dimensionless" public_interface="in" name="n_A"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="millivolt" name="minCond" initial_value="1e-9"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Hle</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>X_Hle</ci>
<ci>deltaPsi</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>H_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
<ci>H_x</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>deltaPsi</ci>
</apply>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>deltaPsi</ci>
</apply>
<ci>minCond</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>X_Hle</ci>
<ci>RT</ci>
<apply>
<minus/>
<ci>H_i</ci>
<ci>H_x</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_KH">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_KH"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" public_interface="in" name="X_KH"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_KH</ci>
<apply>
<times/>
<ci>X_KH</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_i</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>K_x</ci>
<ci>H_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_AKi">
<variable units="mole_per_second_per_l_mito_volume" public_interface="out" name="J_AKi"/>
<variable units="mole_per_second_per_l_mito_volume_per_molar_per_molar" name="X_AK" initial_value="1e7"/>
<variable units="dimensionless" name="K_AKi"/>
<variable units="dimensionless" name="K0_AKi" initial_value="0.13279"/>
<variable units="molar" public_interface="in" name="ATP_i"/>
<variable units="molar" public_interface="in" name="ADP_i"/>
<variable units="molar" public_interface="in" name="AMP_i"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_i"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_i"/>
<variable units="dimensionless" public_interface="in" name="P_AMP_i"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_AKi</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_AKi</ci>
<ci>P_ATP_i</ci>
<ci>P_AMP_i</ci>
</apply>
<apply>
<times/>
<ci>P_ADP_i</ci>
<ci>P_ADP_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AKi</ci>
<piecewise>
<piece>
<cn cellml:units="mole_per_second_per_l_mito_volume">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>X_AK</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_AKi</ci>
<ci>ADP_i</ci>
<ci>ADP_i</ci>
</apply>
<apply>
<times/>
<ci>AMP_i</ci>
<ci>ATP_i</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_AKc">
<variable units="mole_per_second_per_l_cyto_volume" public_interface="out" name="J_AKc"/>
<variable units="mole_per_second_per_l_cyto_volume_per_molar_per_molar" name="X_AK" initial_value="1e7"/>
<variable units="dimensionless" name="K_AKc"/>
<variable units="dimensionless" name="K0_AKc" initial_value="0.13279"/>
<variable units="molar" public_interface="in" name="ATP_c"/>
<variable units="molar" public_interface="in" name="ADP_c"/>
<variable units="molar" public_interface="in" name="AMP_c"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_c"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_c"/>
<variable units="dimensionless" public_interface="in" name="P_AMP_c"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_AKc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K0_AKc</ci>
<ci>P_ATP_c</ci>
<ci>P_AMP_c</ci>
</apply>
<apply>
<times/>
<ci>P_ADP_c</ci>
<ci>P_ADP_c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AKc</ci>
<piecewise>
<piece>
<cn cellml:units="mole_per_second_per_l_cyto_volume">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>X_AK</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_AKc</ci>
<ci>ADP_c</ci>
<ci>ADP_c</ci>
</apply>
<apply>
<times/>
<ci>AMP_c</ci>
<ci>ATP_c</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_CKc">
<variable units="mole_per_second_per_l_cyto_volume" public_interface="out" name="J_CKc"/>
<variable units="mole_per_second_per_l_cyto_volume_per_molar_per_molar" name="X_CK" initial_value="1e7"/>
<variable units="per_molar" name="K_CK"/>
<variable units="molar" public_interface="in" name="ATP_c"/>
<variable units="molar" public_interface="in" name="ADP_c"/>
<variable units="molar" public_interface="in" name="AMP_c"/>
<variable units="molar" public_interface="in" name="H_c"/>
<variable units="molar" public_interface="in" name="PCr_c"/>
<variable units="molar" public_interface="in" name="Cr_c"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_c"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_c"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_CK</ci>
<apply>
<divide/>
<apply>
<exp/>
<apply>
<divide/>
<cn cellml:units="kilojoule_per_mole">50.7</cn>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="molar">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CKc</ci>
<piecewise>
<piece>
<cn cellml:units="mole_per_second_per_l_cyto_volume">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>X_CK</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_CK</ci>
<ci>ADP_c</ci>
</apply>
<ci>P_ADP_c</ci>
</apply>
<ci>PCr_c</ci>
<ci>H_c</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>ATP_c</ci>
<ci>P_ATP_c</ci>
</apply>
<ci>Cr_c</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="J_HK">
<variable units="mole_per_second_per_l_cyto_volume" public_interface="out" name="J_HK"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="X_HK"/>
<variable units="molar" public_interface="in" name="mATP_c"/>
<variable units="molar" public_interface="in" name="mADP_c"/>
<variable units="molar" public_interface="in" name="GLC_c"/>
<variable units="molar" public_interface="in" name="G6P_c"/>
<variable units="molar" public_interface="in" name="H_c"/>
<variable units="molar" name="K_ia" initial_value="1e-3"/>
<variable units="molar" name="K_ib" initial_value="47e-6"/>
<variable units="molar" name="K_ip" initial_value="47e-6"/>
<variable units="molar" name="K_iq" initial_value="1e-3"/>
<variable units="molar" name="K_mA" initial_value="1e-3"/>
<variable units="molar" name="K_mB" initial_value="47e-6"/>
<variable units="molar" name="K_mP" initial_value="47e-6"/>
<variable units="molar" name="K_mQ" initial_value="1e-3"/>
<variable units="molar" name="Ki_G6P" initial_value="10e-6"/>
<variable units="kilojoule_per_mole" public_interface="in" name="RT"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_c"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_c"/>
<variable units="dimensionless" public_interface="in" name="P_G6P_c"/>
<variable units="molar" public_interface="in" name="KMg_ATP"/>
<variable units="molar" public_interface="in" name="KMg_ADP"/>
<variable units="molar" name="Keq_HK"/>
<variable units="dimensionless" name="Kapp_HK"/>
<variable units="dimensionless" name="Kapp_HK_m"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Keq_HK</ci>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">15.38</cn>
</apply>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="molar">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_HK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Keq_HK</ci>
<ci>P_G6P_c</ci>
<ci>P_ADP_c</ci>
</apply>
<apply>
<times/>
<ci>H_c</ci>
<ci>P_ATP_c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_HK_m</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Kapp_HK</ci>
<ci>KMg_ATP</ci>
<ci>P_ATP_c</ci>
</apply>
<apply>
<times/>
<ci>KMg_ADP</ci>
<ci>P_ADP_c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_HK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>X_HK</ci>
<apply>
<times/>
<ci>K_ib</ci>
<ci>K_mA</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>mATP_c</ci>
<ci>GLC_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>G6P_c</ci>
<ci>mADP_c</ci>
</apply>
<ci>Kapp_HK_m</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>mATP_c</ci>
<ci>K_ia</ci>
</apply>
<apply>
<divide/>
<ci>GLC_c</ci>
<ci>K_ib</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>mATP_c</ci>
<ci>GLC_c</ci>
</apply>
<apply>
<times/>
<ci>K_ib</ci>
<ci>K_mA</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>G6P_c</ci>
<ci>K_ip</ci>
</apply>
<apply>
<divide/>
<ci>mADP_c</ci>
<ci>K_iq</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>G6P_c</ci>
<ci>mADP_c</ci>
</apply>
<apply>
<times/>
<ci>K_iq</ci>
<ci>K_mP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>G6P_c</ci>
<ci>GLC_c</ci>
</apply>
<apply>
<times/>
<ci>Ki_G6P</ci>
<ci>K_ib</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_ATP_x">
<variable units="dimensionless" public_interface="out" name="P_ATP_x"/>
<variable units="molar" public_interface="out" name="ATP_xref"/>
<variable units="molar" public_interface="out" name="fATP_x"/>
<variable units="molar" public_interface="in" name="ATP_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.59</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">3.82</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.87</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_ATP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP_xref</ci>
<apply>
<divide/>
<ci>ATP_x</ci>
<ci>P_ATP_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fATP_x</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>ATP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_ATP_x</ci>
</apply>
</apply>
</math>
</component>
<component name="P_ADP_x">
<variable units="dimensionless" public_interface="out" name="P_ADP_x"/>
<variable units="molar" public_interface="out" name="ADP_xref"/>
<variable units="molar" public_interface="out" name="fADP_x"/>
<variable units="molar" public_interface="in" name="ADP_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.42</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.79</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.53</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_ADP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP_xref</ci>
<apply>
<divide/>
<ci>ADP_x</ci>
<ci>P_ADP_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fADP_x</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>ADP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_ADP_x</ci>
</apply>
</apply>
</math>
</component>
<component name="P_AMP_x">
<variable units="dimensionless" public_interface="out" name="P_AMP_x"/>
<variable units="molar" public_interface="out" name="AMP_xref"/>
<variable units="molar" public_interface="out" name="fAMP_x"/>
<variable units="molar" public_interface="in" name="AMP_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.22</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.86</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.05</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_AMP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>AMP_xref</ci>
<apply>
<divide/>
<ci>AMP_x</ci>
<ci>P_AMP_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fAMP_x</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>AMP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_AMP_x</ci>
</apply>
</apply>
</math>
</component>
<component name="P_ATP_i">
<variable units="dimensionless" public_interface="out" name="P_ATP_i"/>
<variable units="molar" public_interface="out" name="ATP_iref"/>
<variable units="molar" public_interface="out" name="fATP_i"/>
<variable units="molar" public_interface="in" name="ATP_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_ATP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP_iref</ci>
<apply>
<divide/>
<ci>ATP_i</ci>
<ci>P_ATP_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fATP_i</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>ATP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_ATP_i</ci>
</apply>
</apply>
</math>
</component>
<component name="P_ADP_i">
<variable units="dimensionless" public_interface="out" name="P_ADP_i"/>
<variable units="molar" public_interface="out" name="ADP_iref"/>
<variable units="molar" public_interface="out" name="fADP_i"/>
<variable units="molar" public_interface="in" name="ADP_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_ADP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP_iref</ci>
<apply>
<divide/>
<ci>ADP_i</ci>
<ci>P_ADP_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fADP_i</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>ADP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_ADP_i</ci>
</apply>
</apply>
</math>
</component>
<component name="P_AMP_i">
<variable units="dimensionless" public_interface="out" name="P_AMP_i"/>
<variable units="molar" public_interface="out" name="AMP_iref"/>
<variable units="molar" public_interface="out" name="fAMP_i"/>
<variable units="molar" public_interface="in" name="AMP_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_AMP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>AMP_iref</ci>
<apply>
<divide/>
<ci>AMP_i</ci>
<ci>P_AMP_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fAMP_i</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>AMP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_AMP_i</ci>
</apply>
</apply>
</math>
</component>
<component name="P_ATP_c">
<variable units="dimensionless" public_interface="out" name="P_ATP_c"/>
<variable units="molar" public_interface="out" name="mATP_c"/>
<variable units="molar" public_interface="in" name="ATP_c"/>
<variable units="molar" public_interface="in" name="H_c"/>
<variable units="molar" public_interface="in" name="Mg_c"/>
<variable units="molar" public_interface="in" name="K_c"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_ATP_c</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_c</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_c</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_c</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mATP_c</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>ATP_c</ci>
<ci>Mg_c</ci>
</apply>
<ci>K_Mg</ci>
</apply>
<ci>P_ATP_c</ci>
</apply>
</apply>
</math>
</component>
<component name="P_ADP_c">
<variable units="dimensionless" public_interface="out" name="P_ADP_c"/>
<variable units="molar" public_interface="out" name="mADP_c"/>
<variable units="molar" public_interface="in" name="ADP_c"/>
<variable units="molar" public_interface="in" name="H_c"/>
<variable units="molar" public_interface="in" name="Mg_c"/>
<variable units="molar" public_interface="in" name="K_c"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_ADP_c</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_c</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_c</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_c</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mADP_c</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>ADP_c</ci>
<ci>Mg_c</ci>
</apply>
<ci>K_Mg</ci>
</apply>
<ci>P_ADP_c</ci>
</apply>
</apply>
</math>
</component>
<component name="P_AMP_c">
<variable units="dimensionless" public_interface="out" name="P_AMP_c"/>
<variable units="molar" public_interface="in" name="H_c"/>
<variable units="molar" public_interface="in" name="Mg_c"/>
<variable units="molar" public_interface="in" name="K_c"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_AMP_c</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_c</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_c</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_c</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_GTP_x">
<variable units="dimensionless" public_interface="out" name="P_GTP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_x"/>
<variable units="molar" public_interface="out" name="fGTP_x"/>
<variable units="molar" public_interface="in" name="fATP_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_GTP_x</ci>
<ci>P_ATP_x</ci>
</apply>
<apply>
<eq/>
<ci>fGTP_x</ci>
<ci>fATP_x</ci>
</apply>
</math>
</component>
<component name="P_GDP_x">
<variable units="dimensionless" public_interface="out" name="P_GDP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_x"/>
<variable units="molar" public_interface="out" name="fGDP_x"/>
<variable units="molar" public_interface="in" name="fADP_x"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_GDP_x</ci>
<ci>P_ADP_x</ci>
</apply>
<apply>
<eq/>
<ci>fGDP_x</ci>
<ci>fADP_x</ci>
</apply>
</math>
</component>
<component name="P_PI_x">
<variable units="dimensionless" public_interface="out" name="P_PI_x"/>
<variable units="molar" public_interface="in" name="PI_x"/>
<variable units="molar" public_interface="out" name="hPI_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.71</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.69</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<cn cellml:units="dimensionless">0.0074</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_PI_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>hPI_x</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>PI_x</ci>
<ci>H_x</ci>
</apply>
<ci>K_H</ci>
</apply>
<ci>P_PI_x</ci>
</apply>
</apply>
</math>
</component>
<component name="P_PI_i">
<variable units="dimensionless" public_interface="out" name="P_PI_i"/>
<variable units="molar" public_interface="in" name="PI_i"/>
<variable units="molar" public_interface="out" name="hPI_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_PI_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>hPI_i</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>PI_i</ci>
<ci>H_i</ci>
</apply>
<ci>K_H</ci>
</apply>
<ci>P_PI_i</ci>
</apply>
</apply>
</math>
</component>
<component name="P_COASH_x">
<variable units="dimensionless" public_interface="out" name="P_COASH_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">8.13</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_COASH_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_OAA_x">
<variable units="dimensionless" public_interface="out" name="P_OAA_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0051</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_OAA_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_CIT_x">
<variable units="dimensionless" public_interface="out" name="P_CIT_x"/>
<variable units="molar" public_interface="out" name="uCIT_x"/>
<variable units="molar" public_interface="out" name="hCIT_x"/>
<variable units="molar" public_interface="in" name="CIT_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">5.63</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">3.37</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.339</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_CIT_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>uCIT_x</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CIT_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_CIT_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>hCIT_x</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>CIT_x</ci>
<ci>H_x</ci>
</apply>
<ci>K_H</ci>
</apply>
<ci>P_CIT_x</ci>
</apply>
</apply>
</math>
</component>
<component name="P_CIT_i">
<variable units="dimensionless" public_interface="out" name="P_CIT_i"/>
<variable units="molar" public_interface="out" name="uCIT_i"/>
<variable units="molar" public_interface="out" name="hCIT_i"/>
<variable units="molar" public_interface="in" name="CIT_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_CIT_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>uCIT_i</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CIT_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
<ci>P_CIT_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>hCIT_i</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>CIT_i</ci>
<ci>H_i</ci>
</apply>
<ci>K_H</ci>
</apply>
<ci>P_CIT_i</ci>
</apply>
</apply>
</math>
</component>
<component name="P_ICIT_x">
<variable units="dimensionless" public_interface="out" name="P_ICIT_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">5.64</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.46</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_ICIT_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_SCOA_x">
<variable units="dimensionless" public_interface="out" name="P_SCOA_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">3.96</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_SCOA_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_SUC_x">
<variable units="dimensionless" public_interface="out" name="P_SUC_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">5.13</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.17</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.503</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_SUC_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_SUC_i">
<variable units="dimensionless" public_interface="out" name="P_SUC_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_SUC_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_FUM_x">
<variable units="dimensionless" public_interface="out" name="P_FUM_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">4.1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_FUM_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_MAL_x">
<variable units="dimensionless" public_interface="out" name="P_MAL_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">4.75</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.55</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_K</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<cn cellml:units="dimensionless">0.17</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_MAL_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_MAL_i">
<variable units="dimensionless" public_interface="out" name="P_MAL_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<variable units="molar" public_interface="in" name="K_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_MAL_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
<apply>
<divide/>
<ci>K_i</ci>
<ci>K_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_CO2_tot_x">
<variable units="dimensionless" public_interface="out" name="P_CO2_tot_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">9.82</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_CO2_tot_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_PYR_x">
<variable units="dimensionless" public_interface="out" name="P_PYR_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.02</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_PYR_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_PYR_i">
<variable units="dimensionless" public_interface="out" name="P_PYR_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_PYR_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_GLU_x">
<variable units="dimensionless" public_interface="out" name="P_GLU_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">4.06</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.82</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_GLU_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_GLU_i">
<variable units="dimensionless" public_interface="out" name="P_GLU_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_GLU_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_ASP_x">
<variable units="dimensionless" public_interface="out" name="P_ASP_x"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="out" name="K_H"/>
<variable units="molar" public_interface="out" name="K_Mg"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">3.65</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Mg</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.32</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_ASP_x</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_ASP_i">
<variable units="dimensionless" public_interface="out" name="P_ASP_i"/>
<variable units="molar" public_interface="in" name="H_i"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<variable units="molar" public_interface="in" name="K_H"/>
<variable units="molar" public_interface="in" name="K_Mg"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_ASP_i</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_i</ci>
<ci>K_H</ci>
</apply>
<apply>
<divide/>
<ci>Mg_i</ci>
<ci>K_Mg</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_NAD_x">
<variable units="dimensionless" public_interface="out" name="P_NAD_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_NADH_x">
<variable units="dimensionless" public_interface="out" name="P_NADH_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_QH2_x">
<variable units="dimensionless" public_interface="out" name="P_QH2_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_COQ_x">
<variable units="dimensionless" public_interface="out" name="P_COQ_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_ACCOA_x">
<variable units="dimensionless" public_interface="out" name="P_ACCOA_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_AKG_x">
<variable units="dimensionless" public_interface="out" name="P_AKG_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_O2_x">
<variable units="dimensionless" public_interface="out" name="P_O2_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_FADH2_x">
<variable units="dimensionless" public_interface="out" name="P_FADH2_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_FAD_x">
<variable units="dimensionless" public_interface="out" name="P_FAD_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_H_x">
<variable units="dimensionless" public_interface="out" name="P_H_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_Mg_x">
<variable units="dimensionless" public_interface="out" name="P_Mg_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_K_x">
<variable units="dimensionless" public_interface="out" name="P_K_x"/>
<variable units="molar" public_interface="out" name="K_H" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_Mg" initial_value="1"/>
<variable units="molar" public_interface="out" name="K_K" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</math>
</component>
<component name="P_G6P_c">
<variable units="dimensionless" public_interface="out" name="P_G6P_c"/>
<variable units="molar" public_interface="in" name="H_c"/>
<variable units="molar" public_interface="out" name="K_H"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_H</ci>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">5.91</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_G6P_c</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_c</ci>
<ci>K_H</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ddeltaPsi_dt">
<variable units="millivolt" public_interface="out" name="deltaPsi" initial_value="-1.41e1"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="mole_per_l_mito_volume_per_mv" public_interface="in" name="C_IM"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C3"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C4"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_F1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ANT"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_Hle"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPGLU"/>
<variable units="dimensionless" public_interface="in" name="n_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>deltaPsi</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>J_C1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_C3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>J_C4</ci>
</apply>
</apply>
<apply>
<times/>
<ci>n_A</ci>
<ci>J_F1</ci>
</apply>
</apply>
<ci>J_ANT</ci>
</apply>
<ci>J_Hle</ci>
</apply>
<ci>J_ASPGLU</ci>
</apply>
<ci>C_IM</ci>
</apply>
</apply>
</math>
</component>
<component name="dATP_x_dt">
<variable units="molar" public_interface="out" name="ATP_x" initial_value="1.03e-11"/>
<variable units="molar_per_second" public_interface="out" name="dATP_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ndk"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_F1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ANT"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_ndk</ci>
<ci>J_F1</ci>
</apply>
<ci>J_ANT</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dATP_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_ndk</ci>
<ci>J_F1</ci>
</apply>
<ci>J_ANT</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dADP_x_dt">
<variable units="molar" public_interface="out" name="ADP_x" initial_value="1e-2"/>
<variable units="molar_per_second" public_interface="out" name="dADP_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ndk"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_F1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ANT"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_ndk</ci>
</apply>
<ci>J_F1</ci>
</apply>
<ci>J_ANT</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dADP_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_ndk</ci>
</apply>
<ci>J_F1</ci>
</apply>
<ci>J_ANT</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dAMP_x_dt">
<variable units="molar" public_interface="out" name="AMP_x" initial_value="1e-6"/>
<variable units="molar_per_second" public_interface="out" name="dAMP_x_dt" initial_value="0"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AMP_x</ci>
</apply>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dGTP_x_dt">
<variable units="molar" public_interface="out" name="GTP_x" initial_value="2.72e-10"/>
<variable units="molar_per_second" public_interface="out" name="dGTP_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ndk"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SCOAS"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GTP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_SCOAS</ci>
<ci>J_ndk</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dGTP_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_SCOAS</ci>
<ci>J_ndk</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dGDP_x_dt">
<variable units="molar" public_interface="out" name="GDP_x" initial_value="5e-3"/>
<variable units="molar_per_second" public_interface="out" name="dGDP_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ndk"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SCOAS"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GDP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SCOAS</ci>
</apply>
<ci>J_ndk</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dGDP_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SCOAS</ci>
</apply>
<ci>J_ndk</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dPI_x_dt">
<variable units="molar" public_interface="out" name="PI_x" initial_value="2.99e-4"/>
<variable units="molar_per_second" public_interface="out" name="dPI_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_F1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SCOAS"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PIHt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_MALPI"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PI_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_SCOAS</ci>
</apply>
<ci>J_F1</ci>
</apply>
<ci>J_PIHt</ci>
</apply>
<ci>J_MALPI</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dPI_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_SCOAS</ci>
</apply>
<ci>J_F1</ci>
</apply>
<ci>J_PIHt</ci>
</apply>
<ci>J_MALPI</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dNADH_x_dt">
<variable units="molar" public_interface="out" name="NADH_x" initial_value="8.48e-21"/>
<variable units="molar_per_second" public_interface="out" name="dNADH_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_pdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_isod"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_akgd"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_mdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NADH_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_pdh</ci>
<ci>J_isod</ci>
<ci>J_akgd</ci>
<ci>J_mdh</ci>
</apply>
<ci>J_C1</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dNADH_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_pdh</ci>
<ci>J_isod</ci>
<ci>J_akgd</ci>
<ci>J_mdh</ci>
</apply>
<ci>J_C1</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dQH2_x_dt">
<variable units="molar" public_interface="out" name="QH2_x" initial_value="1e-32"/>
<variable units="molar_per_second" public_interface="out" name="dQH2_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_sdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>QH2_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_sdh</ci>
<ci>J_C1</ci>
</apply>
<ci>J_C3</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dQH2_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_sdh</ci>
<ci>J_C1</ci>
</apply>
<ci>J_C3</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dPYR_x_dt">
<variable units="molar" public_interface="out" name="PYR_x" initial_value="1.21e-11"/>
<variable units="molar_per_second" public_interface="out" name="dPYR_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_pdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PYRH"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PYR_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_pdh</ci>
</apply>
<ci>J_PYRH</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dPYR_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_pdh</ci>
</apply>
<ci>J_PYRH</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dACCOA_x_dt">
<variable units="molar" public_interface="out" name="ACCOA_x" initial_value="2.55e-12"/>
<variable units="molar_per_second" public_interface="out" name="dACCOA_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_pdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_cits"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ACCOA_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_pdh</ci>
<ci>J_cits</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dACCOA_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_pdh</ci>
<ci>J_cits</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dCIT_x_dt">
<variable units="molar" public_interface="out" name="CIT_x" initial_value="6.82e-5"/>
<variable units="molar_per_second" public_interface="out" name="dCIT_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_acon"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_cits"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITMAL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CIT_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_acon</ci>
</apply>
<ci>J_CITMAL</ci>
<ci>J_cits</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCIT_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_acon</ci>
</apply>
<ci>J_CITMAL</ci>
<ci>J_cits</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dICIT_x_dt">
<variable units="molar" public_interface="out" name="ICIT_x" initial_value="9.36e-7"/>
<variable units="molar_per_second" public_interface="out" name="dICIT_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_acon"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_isod"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ICIT_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_acon</ci>
<ci>J_isod</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dICIT_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_acon</ci>
<ci>J_isod</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dAKG_x_dt">
<variable units="molar" public_interface="out" name="AKG_x" initial_value="4.8e-11"/>
<variable units="molar_per_second" public_interface="out" name="dAKG_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_isod"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_akgd"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_got"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKGMAL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AKG_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_isod</ci>
<ci>J_akgd</ci>
</apply>
<ci>J_got</ci>
</apply>
<ci>J_AKGMAL</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dAKG_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_isod</ci>
<ci>J_akgd</ci>
</apply>
<ci>J_got</ci>
</apply>
<ci>J_AKGMAL</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dSCOA_x_dt">
<variable units="molar" public_interface="out" name="SCOA_x" initial_value="6.96e-10"/>
<variable units="molar_per_second" public_interface="out" name="dSCOA_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_akgd"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_scoas"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SCOA_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_akgd</ci>
<ci>J_scoas</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dSCOA_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_akgd</ci>
<ci>J_scoas</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dCOASH_x_dt">
<variable units="molar" public_interface="out" name="COASH_x" initial_value="3.01e-3"/>
<variable units="molar_per_second" public_interface="out" name="dCOASH_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_pdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_akgd"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_scoas"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_cits"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>COASH_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_pdh</ci>
</apply>
<ci>J_akgd</ci>
</apply>
<ci>J_scoas</ci>
<ci>J_cits</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCOASH_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_pdh</ci>
</apply>
<ci>J_akgd</ci>
</apply>
<ci>J_scoas</ci>
<ci>J_cits</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dSUC_x_dt">
<variable units="molar" public_interface="out" name="SUC_x" initial_value="2.17e-7"/>
<variable units="molar_per_second" public_interface="out" name="dSUC_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_scoas"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_sdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SUCMAL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SUC_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_scoas</ci>
<ci>J_sdh</ci>
</apply>
<ci>J_SUCMAL</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dSUC_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_scoas</ci>
<ci>J_sdh</ci>
</apply>
<ci>J_SUCMAL</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dFUM_x_dt">
<variable units="molar" public_interface="out" name="FUM_x" initial_value="7.85e-9"/>
<variable units="molar_per_second" public_interface="out" name="dFUM_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_sdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_fum"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>FUM_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_sdh</ci>
<ci>J_fum</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dFUM_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_sdh</ci>
<ci>J_fum</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dMAL_x_dt">
<variable units="molar" public_interface="out" name="MAL_x" initial_value="3.22e-8"/>
<variable units="molar_per_second" public_interface="out" name="dMAL_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_fum"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_mdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_MALPI"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKGMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SUCMAL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MAL_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_fum</ci>
<ci>J_mdh</ci>
</apply>
<ci>J_MALPI</ci>
</apply>
<ci>J_AKGMAL</ci>
</apply>
<ci>J_CITMAL</ci>
</apply>
<ci>J_SUCMAL</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dMAL_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_fum</ci>
<ci>J_mdh</ci>
</apply>
<ci>J_MALPI</ci>
</apply>
<ci>J_AKGMAL</ci>
</apply>
<ci>J_CITMAL</ci>
</apply>
<ci>J_SUCMAL</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dOAA_x_dt">
<variable units="molar" public_interface="out" name="OAA_x" initial_value="8.92e-4"/>
<variable units="molar_per_second" public_interface="out" name="dOAA_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_cits"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_mdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_got"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OAA_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_cits</ci>
</apply>
<ci>J_mdh</ci>
<ci>J_got</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dOAA_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_cits</ci>
</apply>
<ci>J_mdh</ci>
<ci>J_got</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dGLU_x_dt">
<variable units="molar" public_interface="out" name="GLU_x" initial_value="9.93e-12"/>
<variable units="molar_per_second" public_interface="out" name="dGLU_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_got"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_GLUH"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPGLU"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GLU_x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_got</ci>
<ci>J_GLUH</ci>
</apply>
<ci>J_ASPGLU</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dGLU_x_dt</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_got</ci>
<ci>J_GLUH</ci>
</apply>
<ci>J_ASPGLU</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dASP_x_dt">
<variable units="molar" public_interface="out" name="ASP_x" initial_value="1.02e-4"/>
<variable units="molar_per_second" public_interface="out" name="dASP_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_got"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPGLU"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ASP_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_got</ci>
</apply>
<ci>J_ASPGLU</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dASP_x_dt</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_got</ci>
</apply>
<ci>J_ASPGLU</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
</math>
</component>
<component name="dO2_x_dt">
<variable units="molar" public_interface="out" name="O2_x" initial_value="6.5e-5"/>
<variable units="molar_per_second" public_interface="out" name="dO2_x_dt" initial_value="0"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2_x</ci>
</apply>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dCO2_tot_x_dt">
<variable units="molar" public_interface="out" name="CO2_tot_x" initial_value="2.14e-2"/>
<variable units="molar_per_second" public_interface="out" name="dCO2_tot_x_dt" initial_value="0"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CO2_tot_x</ci>
</apply>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dNAD_x_dt">
<variable units="molar" public_interface="out" name="NAD_x"/>
<variable units="molar_per_second" public_interface="out" name="dNAD_x_dt"/>
<variable units="molar" public_interface="in" name="NAD_tot"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar_per_second" public_interface="in" name="dNADH_x_dt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>NAD_x</ci>
<piecewise>
<piece>
<cn cellml:units="molar">0</cn>
<apply>
<gt/>
<ci>NADH_x</ci>
<ci>NAD_tot</ci>
</apply>
</piece>
<otherwise>
<apply>
<minus/>
<ci>NAD_tot</ci>
<ci>NADH_x</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>dNAD_x_dt</ci>
<apply>
<minus/>
<ci>dNADH_x_dt</ci>
</apply>
</apply>
</math>
</component>
<component name="dCOQ_x_dt">
<variable units="molar" public_interface="out" name="COQ_x"/>
<variable units="molar_per_second" public_interface="out" name="dCOQ_x_dt"/>
<variable units="molar" public_interface="in" name="Q_tot"/>
<variable units="molar" public_interface="in" name="QH2_x"/>
<variable units="molar_per_second" public_interface="in" name="dQH2_x_dt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>COQ_x</ci>
<apply>
<minus/>
<ci>Q_tot</ci>
<ci>QH2_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCOQ_x_dt</ci>
<apply>
<minus/>
<ci>dQH2_x_dt</ci>
</apply>
</apply>
</math>
</component>
<component name="dFAD_x_dt">
<variable units="molar" public_interface="out" name="FAD_x"/>
<variable units="molar_per_second" public_interface="out" name="dFAD_x_dt" initial_value="0"/>
<variable units="molar_per_second" public_interface="out" name="dFADH2_x_dt" initial_value="0"/>
<variable units="molar" public_interface="out" name="FADH2_x"/>
<variable units="molar" public_interface="in" name="FAD_tot"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FAD_x</ci>
<apply>
<divide/>
<ci>FAD_tot</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>FADH2_x</ci>
<ci>FAD_x</ci>
</apply>
</math>
</component>
<component name="dH_x_dt">
<variable units="molar" public_interface="out" name="H_x" initial_value="5.79e-8"/>
<variable units="molar_per_second" public_interface="out" name="dH_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="D"/>
<variable units="molar_per_second" public_interface="in" name="phi_H"/>
<variable units="molar_per_second" public_interface="in" name="phi_Mg"/>
<variable units="molar_per_second" public_interface="in" name="phi_K"/>
<variable units="dimensionless" public_interface="in" name="dHB_dMg"/>
<variable units="dimensionless" public_interface="in" name="dHB_dK"/>
<variable units="dimensionless" public_interface="in" name="dMgB_dK"/>
<variable units="dimensionless" public_interface="in" name="dKB_dMg"/>
<variable units="dimensionless" public_interface="in" name="alpha_K"/>
<variable units="dimensionless" public_interface="in" name="alpha_Mg"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dH_x_dt</ci>
<cn cellml:units="molar_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>H_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>dKB_dMg</ci>
<ci>dMgB_dK</ci>
</apply>
<apply>
<times/>
<ci>alpha_Mg</ci>
<ci>alpha_K</ci>
</apply>
</apply>
<ci>phi_H</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_K</ci>
<ci>dHB_dMg</ci>
</apply>
<apply>
<times/>
<ci>dHB_dK</ci>
<ci>dKB_dMg</ci>
</apply>
</apply>
<ci>phi_Mg</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_Mg</ci>
<ci>dHB_dK</ci>
</apply>
<apply>
<times/>
<ci>dHB_dMg</ci>
<ci>dMgB_dK</ci>
</apply>
</apply>
<ci>phi_K</ci>
</apply>
</apply>
<ci>D</ci>
</apply>
</apply>
</math>
</component>
<component name="dMg_x_dt">
<variable units="molar" public_interface="out" name="Mg_x" initial_value="4.64e-3"/>
<variable units="molar_per_second" public_interface="out" name="dMg_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="D"/>
<variable units="dimensionless" public_interface="in" name="alpha_H"/>
<variable units="dimensionless" public_interface="in" name="alpha_K"/>
<variable units="molar_per_second" public_interface="in" name="phi_H"/>
<variable units="molar_per_second" public_interface="in" name="phi_Mg"/>
<variable units="molar_per_second" public_interface="in" name="phi_K"/>
<variable units="dimensionless" public_interface="in" name="dHB_dK"/>
<variable units="dimensionless" public_interface="in" name="dKB_dH"/>
<variable units="dimensionless" public_interface="in" name="dMgB_dK"/>
<variable units="dimensionless" public_interface="in" name="dMgB_dH"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_K</ci>
<ci>dMgB_dH</ci>
</apply>
<apply>
<times/>
<ci>dKB_dH</ci>
<ci>dMgB_dK</ci>
</apply>
</apply>
<ci>phi_H</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>dKB_dH</ci>
<ci>dHB_dK</ci>
</apply>
<apply>
<times/>
<ci>alpha_H</ci>
<ci>alpha_K</ci>
</apply>
</apply>
<ci>phi_Mg</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_H</ci>
<ci>dMgB_dK</ci>
</apply>
<apply>
<times/>
<ci>dHB_dK</ci>
<ci>dMgB_dH</ci>
</apply>
</apply>
<ci>phi_K</ci>
</apply>
</apply>
<ci>D</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dMg_x_dt</ci>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dK_x_dt">
<variable units="molar" public_interface="out" name="K_x" initial_value="8.69e-2"/>
<variable units="molar_per_second" public_interface="out" name="dK_x_dt"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="D"/>
<variable units="dimensionless" public_interface="in" name="alpha_H"/>
<variable units="dimensionless" public_interface="in" name="alpha_Mg"/>
<variable units="molar_per_second" public_interface="in" name="phi_H"/>
<variable units="molar_per_second" public_interface="in" name="phi_Mg"/>
<variable units="molar_per_second" public_interface="in" name="phi_K"/>
<variable units="dimensionless" public_interface="in" name="dHB_dMg"/>
<variable units="dimensionless" public_interface="in" name="dMgB_dH"/>
<variable units="dimensionless" public_interface="in" name="dKB_dMg"/>
<variable units="dimensionless" public_interface="in" name="dKB_dH"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_x</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_Mg</ci>
<ci>dKB_dH</ci>
</apply>
<apply>
<times/>
<ci>dKB_dMg</ci>
<ci>dMgB_dH</ci>
</apply>
</apply>
<ci>phi_H</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_H</ci>
<ci>dKB_dMg</ci>
</apply>
<apply>
<times/>
<ci>dKB_dH</ci>
<ci>dHB_dMg</ci>
</apply>
</apply>
<ci>phi_Mg</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>dMgB_dH</ci>
<ci>dHB_dMg</ci>
</apply>
<apply>
<times/>
<ci>alpha_H</ci>
<ci>alpha_Mg</ci>
</apply>
</apply>
<ci>phi_K</ci>
</apply>
</apply>
<ci>D</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dK_x_dt</ci>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dH_i_dt">
<variable units="molar" public_interface="out" name="H_i" initial_value="1e-7"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>H_i</ci>
</apply>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dMg_i_dt">
<variable units="molar" public_interface="out" name="Mg_i" initial_value="5e-3"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg_i</ci>
</apply>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dK_i_dt">
<variable units="molar" public_interface="out" name="K_i" initial_value="150e-3"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<cn cellml:units="molar_per_second">0</cn>
</apply>
</math>
</component>
<component name="dCox_i_dt">
<variable units="molar" public_interface="out" name="Cox_i"/>
<variable units="molar" public_interface="in" name="cytC_tot"/>
<variable units="molar" public_interface="in" name="Cred_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cox_i</ci>
<apply>
<minus/>
<ci>cytC_tot</ci>
<ci>Cred_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dCred_i_dt">
<variable units="molar" public_interface="out" name="Cred_i" initial_value="9.7e-8"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C3"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cred_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_C3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_C4</ci>
</apply>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dATP_i_dt">
<variable units="molar" public_interface="out" name="ATP_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ATPt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ANT"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKi"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATP_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<ci>J_ATPt</ci>
<ci>J_ANT</ci>
<ci>J_AKi</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dADP_i_dt">
<variable units="molar" public_interface="out" name="ADP_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ADPt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ANT"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKi"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_ADPt</ci>
<ci>J_ANT</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_AKi</ci>
</apply>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dAMP_i_dt">
<variable units="molar" public_interface="out" name="AMP_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AMPt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKi"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AMP_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<ci>J_AMPt</ci>
<ci>J_AKi</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dPI_i_dt">
<variable units="molar" public_interface="out" name="PI_i" initial_value="1.16e-4"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PIHt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PIt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_MALPI"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PI_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_PIHt</ci>
</apply>
<ci>J_PIt</ci>
<ci>J_MALPI</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dPYR_i_dt">
<variable units="molar" public_interface="out" name="PYR_i" initial_value="9.18e-10"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PYRH"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PYRt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PYR_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_PYRH</ci>
</apply>
<ci>J_PYRt</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dCIT_i_dt">
<variable units="molar" public_interface="out" name="CIT_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CIT_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_CITMAL</ci>
</apply>
<ci>J_CITt</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dICIT_i_dt">
<variable units="molar" public_interface="out" name="ICIT_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ICITt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ICIT_i</ci>
</apply>
<apply>
<divide/>
<ci>J_ICITt</ci>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dAKG_i_dt">
<variable units="molar" public_interface="out" name="AKG_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKGMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKGt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AKG_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_AKGMAL</ci>
</apply>
<ci>J_AKGt</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dSUC_i_dt">
<variable units="molar" public_interface="out" name="SUC_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SUCt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SUCMAL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SUC_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_SUCt</ci>
<ci>J_SUCMAL</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dFUM_i_dt">
<variable units="molar" public_interface="out" name="FUM_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_FUMt"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>FUM_i</ci>
</apply>
<apply>
<divide/>
<ci>J_FUMt</ci>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dMAL_i_dt">
<variable units="molar" public_interface="out" name="MAL_i" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_MALPI"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_MALt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKGMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SUCMAL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MAL_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_MALPI</ci>
</apply>
<ci>J_MALt</ci>
<ci>J_AKGMAL</ci>
<ci>J_CITMAL</ci>
<ci>J_SUCMAL</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dGLU_i_dt">
<variable units="molar" public_interface="out" name="GLU_i" initial_value="5.75e-12"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_GLUH"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPGLU"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_GLUt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GLU_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_GLUH</ci>
</apply>
<ci>J_ASPGLU</ci>
<ci>J_GLUt</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dASP_i_dt">
<variable units="molar" public_interface="out" name="ASP_i" initial_value="4.44e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_i"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPGLU"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ASP_i</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_ASPGLU</ci>
</apply>
<ci>J_ASPt</ci>
</apply>
<ci>W_i</ci>
</apply>
</apply>
</math>
</component>
<component name="dH_c_dt">
<variable units="molar" public_interface="out" name="H_c"/>
<variable units="molar" public_interface="in" name="H_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>H_c</ci>
<ci>H_i</ci>
</apply>
</math>
</component>
<component name="dMg_c_dt">
<variable units="molar" public_interface="out" name="Mg_c"/>
<variable units="molar" public_interface="in" name="Mg_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mg_c</ci>
<ci>Mg_i</ci>
</apply>
</math>
</component>
<component name="dK_c_dt">
<variable units="molar" public_interface="out" name="K_c"/>
<variable units="molar" public_interface="in" name="K_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_c</ci>
<ci>K_i</ci>
</apply>
</math>
</component>
<component name="dATP_c_dt">
<variable units="molar" public_interface="out" name="ATP_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ATPt"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_CKc"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_AKc"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_AtC"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_HK"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATP_c</ci>
</apply>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="l_water_per_l_cyto">1</cn>
<ci>W_c</ci>
</apply>
</apply>
</apply>
<ci>J_HK</ci>
</apply>
<apply>
<times/>
<ci>Rm_cyto</ci>
<ci>J_ATPt</ci>
</apply>
</apply>
<ci>W_c</ci>
</apply>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_ATPt</ci>
</apply>
<ci>J_CKc</ci>
<ci>J_AKc</ci>
</apply>
<ci>J_AtC</ci>
</apply>
<ci>W_c</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="dADP_c_dt">
<variable units="molar" public_interface="out" name="ADP_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ADPt"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_CKc"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_AKc"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_AtC"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_HK"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP_c</ci>
</apply>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="l_water_per_l_cyto">1</cn>
<ci>W_c</ci>
</apply>
</apply>
<ci>J_HK</ci>
</apply>
<apply>
<times/>
<ci>Rm_cyto</ci>
<ci>J_ADPt</ci>
</apply>
</apply>
<ci>W_c</ci>
</apply>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_ADPt</ci>
</apply>
<ci>J_CKc</ci>
</apply>
<ci>J_AKc</ci>
</apply>
<ci>J_AtC</ci>
</apply>
<ci>W_c</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="dAMP_c_dt">
<variable units="molar" public_interface="out" name="AMP_c" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AMPt"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_AKc"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AMP_c</ci>
</apply>
<piecewise>
<piece>
<cn cellml:units="molar_per_second">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V_mito</ci>
</apply>
<ci>V_cyto</ci>
</apply>
<ci>J_AMPt</ci>
</apply>
<ci>J_AKc</ci>
</apply>
<ci>W_c</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="dPI_c_dt">
<variable units="molar" public_interface="out" name="PI_c" initial_value="1.16e-4"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_AtC"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PIt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PI_c</ci>
</apply>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_PIt</ci>
</apply>
<ci>W_c</ci>
</apply>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V_mito</ci>
</apply>
<ci>V_cyto</ci>
</apply>
<ci>J_PIt</ci>
</apply>
<ci>J_AtC</ci>
</apply>
<ci>W_c</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="dPYR_c_dt">
<variable units="molar" public_interface="out" name="PYR_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PYRt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PYR_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_PYRt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dCIT_c_dt">
<variable units="molar" public_interface="out" name="CIT_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CIT_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_CITt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dICIT_c_dt">
<variable units="molar" public_interface="out" name="ICIT_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ICITt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ICIT_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_ICITt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dAKG_c_dt">
<variable units="molar" public_interface="out" name="AKG_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_AKGt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AKG_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_AKGt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dSUC_c_dt">
<variable units="molar" public_interface="out" name="SUC_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_SUCt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SUC_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_SUCt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dFUM_c_dt">
<variable units="molar" public_interface="out" name="FUM_c" initial_value="1e-9"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_FUMt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>FUM_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_FUMt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dMAL_c_dt">
<variable units="molar" public_interface="out" name="MAL_c" initial_value="1e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="dimensionless" public_interface="in" name="StateType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_MALt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
<apply>
<neq/>
<ci>StateType</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MAL_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_MALt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dGLU_c_dt">
<variable units="molar" public_interface="out" name="GLU_c" initial_value="5.75e-12"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_GLUt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GLU_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_GLUt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dASP_c_dt">
<variable units="molar" public_interface="out" name="ASP_c" initial_value="4.44e-9"/>
<variable units="mito_per_cyto" name="Rm_cyto"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="cyto_per_cell" public_interface="in" name="V_cyto"/>
<variable units="mito_per_cell" public_interface="in" name="V_mito"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rm_cyto</ci>
<piecewise>
<piece>
<cn cellml:units="mito_per_cyto">1</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<ci>V_mito</ci>
<ci>V_cyto</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ASP_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Rm_cyto</ci>
</apply>
<ci>J_ASPt</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dPCr_c_dt">
<variable units="molar" public_interface="out" name="PCr_c" initial_value="1e-9"/>
<variable units="dimensionless" name="multiplier"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_CKc"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>multiplier</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PCr_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>multiplier</ci>
</apply>
<ci>J_CKc</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dCr_c_dt">
<variable units="molar" public_interface="out" name="Cr_c"/>
<variable units="molar" public_interface="in" name="PCr_c"/>
<variable units="molar" public_interface="in" name="CR_tot"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cr_c</ci>
<apply>
<minus/>
<ci>CR_tot</ci>
<ci>PCr_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dGLC_c_dt">
<variable units="molar" public_interface="out" name="GLC_c" initial_value="1e-9"/>
<variable units="dimensionless" name="multiplier"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_HK"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>multiplier</ci>
<piecewise>
<piece>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="l_water_per_l_cyto">1</cn>
<ci>W_c</ci>
</apply>
</apply>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GLC_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>multiplier</ci>
</apply>
<ci>J_HK</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="dG6P_c_dt">
<variable units="molar" public_interface="out" name="G6P_c" initial_value="1e-9"/>
<variable units="dimensionless" name="multiplier"/>
<variable units="second" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="ExpType"/>
<variable units="l_water_per_l_cyto" public_interface="in" name="W_c"/>
<variable units="mole_per_second_per_l_cyto_volume" public_interface="in" name="J_HK"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>multiplier</ci>
<piecewise>
<piece>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="l_water_per_l_cyto">1</cn>
<ci>W_c</ci>
</apply>
</apply>
<apply>
<or/>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>ExpType</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G6P_c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>multiplier</ci>
<ci>J_HK</ci>
</apply>
<ci>W_c</ci>
</apply>
</apply>
</math>
</component>
<component name="BINDING_IONS">
<variable units="dimensionless" public_interface="out" name="dHB_dMg"/>
<variable units="dimensionless" public_interface="out" name="dHB_dK"/>
<variable units="dimensionless" public_interface="out" name="dHB_dH"/>
<variable units="dimensionless" public_interface="out" name="dMgB_dH"/>
<variable units="dimensionless" public_interface="out" name="dMgB_dK"/>
<variable units="dimensionless" public_interface="out" name="dMgB_dMg"/>
<variable units="dimensionless" public_interface="out" name="dKB_dH"/>
<variable units="dimensionless" public_interface="out" name="dKB_dMg"/>
<variable units="dimensionless" public_interface="out" name="dKB_dK"/>
<variable units="molar_per_second" public_interface="out" name="nK_JK"/>
<variable units="molar_per_second" public_interface="out" name="J_H_t"/>
<variable units="molar_per_second" public_interface="out" name="J_Mg_t"/>
<variable units="molar_per_second" public_interface="out" name="J_K_t"/>
<variable units="molar_per_second" public_interface="out" name="phi_H"/>
<variable units="molar_per_second" public_interface="out" name="phi_Mg"/>
<variable units="molar_per_second" public_interface="out" name="phi_K"/>
<variable units="dimensionless" public_interface="out" name="alpha_H"/>
<variable units="dimensionless" public_interface="out" name="alpha_Mg"/>
<variable units="dimensionless" public_interface="out" name="alpha_K"/>
<variable units="dimensionless" public_interface="out" name="D"/>
<variable units="molar" name="B_x" initial_value="0.02"/>
<variable units="molar" name="K_BX" initial_value="1e-7"/>
<variable units="l_water_per_l_mito" public_interface="in" name="W_x"/>
<variable units="dimensionless" public_interface="in" name="n_A"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_pdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_cits"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_akgd"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_scoas"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_mdh"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PYRH"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_GLUH"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_CITMAL"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_ASPGLU"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C3"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_C4"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_F1"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_PIHt"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_Hle"/>
<variable units="mole_per_second_per_l_mito_volume" public_interface="in" name="J_KH"/>
<variable units="molar" public_interface="in" name="H_x"/>
<variable units="molar" public_interface="in" name="ATP_x"/>
<variable units="molar" public_interface="in" name="ADP_x"/>
<variable units="molar" public_interface="in" name="AMP_x"/>
<variable units="molar" public_interface="in" name="GTP_x"/>
<variable units="molar" public_interface="in" name="GDP_x"/>
<variable units="molar" public_interface="in" name="PI_x"/>
<variable units="molar" public_interface="in" name="NADH_x"/>
<variable units="molar" public_interface="in" name="NAD_x"/>
<variable units="molar" public_interface="in" name="QH2_x"/>
<variable units="molar" public_interface="in" name="COQ_x"/>
<variable units="molar" public_interface="in" name="PYR_x"/>
<variable units="molar" public_interface="in" name="OAA_x"/>
<variable units="molar" public_interface="in" name="ACCOA_x"/>
<variable units="molar" public_interface="in" name="CIT_x"/>
<variable units="molar" public_interface="in" name="ICIT_x"/>
<variable units="molar" public_interface="in" name="AKG_x"/>
<variable units="molar" public_interface="in" name="SCOA_x"/>
<variable units="molar" public_interface="in" name="COASH_x"/>
<variable units="molar" public_interface="in" name="SUC_x"/>
<variable units="molar" public_interface="in" name="FUM_x"/>
<variable units="molar" public_interface="in" name="MAL_x"/>
<variable units="molar" public_interface="in" name="GLU_x"/>
<variable units="molar" public_interface="in" name="ASP_x"/>
<variable units="molar" public_interface="in" name="K_x"/>
<variable units="molar" public_interface="in" name="Mg_x"/>
<variable units="molar" public_interface="in" name="O2_x"/>
<variable units="molar" public_interface="in" name="FADH2_x"/>
<variable units="molar" public_interface="in" name="FAD_x"/>
<variable units="molar" public_interface="in" name="CO2_tot_x"/>
<variable units="dimensionless" public_interface="in" name="P_H_x"/>
<variable units="dimensionless" public_interface="in" name="P_ATP_x"/>
<variable units="dimensionless" public_interface="in" name="P_ADP_x"/>
<variable units="dimensionless" public_interface="in" name="P_AMP_x"/>
<variable units="dimensionless" public_interface="in" name="P_GTP_x"/>
<variable units="dimensionless" public_interface="in" name="P_GDP_x"/>
<variable units="dimensionless" public_interface="in" name="P_PI_x"/>
<variable units="dimensionless" public_interface="in" name="P_NADH_x"/>
<variable units="dimensionless" public_interface="in" name="P_NAD_x"/>
<variable units="dimensionless" public_interface="in" name="P_QH2_x"/>
<variable units="dimensionless" public_interface="in" name="P_COQ_x"/>
<variable units="dimensionless" public_interface="in" name="P_PYR_x"/>
<variable units="dimensionless" public_interface="in" name="P_OAA_x"/>
<variable units="dimensionless" public_interface="in" name="P_ACCOA_x"/>
<variable units="dimensionless" public_interface="in" name="P_CIT_x"/>
<variable units="dimensionless" public_interface="in" name="P_ICIT_x"/>
<variable units="dimensionless" public_interface="in" name="P_AKG_x"/>
<variable units="dimensionless" public_interface="in" name="P_SCOA_x"/>
<variable units="dimensionless" public_interface="in" name="P_COASH_x"/>
<variable units="dimensionless" public_interface="in" name="P_SUC_x"/>
<variable units="dimensionless" public_interface="in" name="P_FUM_x"/>
<variable units="dimensionless" public_interface="in" name="P_MAL_x"/>
<variable units="dimensionless" public_interface="in" name="P_GLU_x"/>
<variable units="dimensionless" public_interface="in" name="P_ASP_x"/>
<variable units="dimensionless" public_interface="in" name="P_K_x"/>
<variable units="dimensionless" public_interface="in" name="P_Mg_x"/>
<variable units="dimensionless" public_interface="in" name="P_O2_x"/>
<variable units="dimensionless" public_interface="in" name="P_FADH2_x"/>
<variable units="dimensionless" public_interface="in" name="P_FAD_x"/>
<variable units="dimensionless" public_interface="in" name="P_CO2_tot_x"/>
<variable units="molar" public_interface="in" name="KH_H_x"/>
<variable units="molar" public_interface="in" name="KH_ATP_x"/>
<variable units="molar" public_interface="in" name="KH_ADP_x"/>
<variable units="molar" public_interface="in" name="KH_AMP_x"/>
<variable units="molar" public_interface="in" name="KH_GTP_x"/>
<variable units="molar" public_interface="in" name="KH_GDP_x"/>
<variable units="molar" public_interface="in" name="KH_PI_x"/>
<variable units="molar" public_interface="in" name="KH_NADH_x"/>
<variable units="molar" public_interface="in" name="KH_NAD_x"/>
<variable units="molar" public_interface="in" name="KH_QH2_x"/>
<variable units="molar" public_interface="in" name="KH_COQ_x"/>
<variable units="molar" public_interface="in" name="KH_PYR_x"/>
<variable units="molar" public_interface="in" name="KH_OAA_x"/>
<variable units="molar" public_interface="in" name="KH_ACCOA_x"/>
<variable units="molar" public_interface="in" name="KH_CIT_x"/>
<variable units="molar" public_interface="in" name="KH_ICIT_x"/>
<variable units="molar" public_interface="in" name="KH_AKG_x"/>
<variable units="molar" public_interface="in" name="KH_SCOA_x"/>
<variable units="molar" public_interface="in" name="KH_COASH_x"/>
<variable units="molar" public_interface="in" name="KH_SUC_x"/>
<variable units="molar" public_interface="in" name="KH_FUM_x"/>
<variable units="molar" public_interface="in" name="KH_MAL_x"/>
<variable units="molar" public_interface="in" name="KH_GLU_x"/>
<variable units="molar" public_interface="in" name="KH_ASP_x"/>
<variable units="molar" public_interface="in" name="KH_K_x"/>
<variable units="molar" public_interface="in" name="KH_Mg_x"/>
<variable units="molar" public_interface="in" name="KH_O2_x"/>
<variable units="molar" public_interface="in" name="KH_FADH2_x"/>
<variable units="molar" public_interface="in" name="KH_FAD_x"/>
<variable units="molar" public_interface="in" name="KH_CO2_tot_x"/>
<variable units="molar" public_interface="in" name="KMg_H_x"/>
<variable units="molar" public_interface="in" name="KMg_ATP_x"/>
<variable units="molar" public_interface="in" name="KMg_ADP_x"/>
<variable units="molar" public_interface="in" name="KMg_AMP_x"/>
<variable units="molar" public_interface="in" name="KMg_GTP_x"/>
<variable units="molar" public_interface="in" name="KMg_GDP_x"/>
<variable units="molar" public_interface="in" name="KMg_PI_x"/>
<variable units="molar" public_interface="in" name="KMg_NADH_x"/>
<variable units="molar" public_interface="in" name="KMg_NAD_x"/>
<variable units="molar" public_interface="in" name="KMg_QH2_x"/>
<variable units="molar" public_interface="in" name="KMg_COQ_x"/>
<variable units="molar" public_interface="in" name="KMg_PYR_x"/>
<variable units="molar" public_interface="in" name="KMg_OAA_x"/>
<variable units="molar" public_interface="in" name="KMg_ACCOA_x"/>
<variable units="molar" public_interface="in" name="KMg_CIT_x"/>
<variable units="molar" public_interface="in" name="KMg_ICIT_x"/>
<variable units="molar" public_interface="in" name="KMg_AKG_x"/>
<variable units="molar" public_interface="in" name="KMg_SCOA_x"/>
<variable units="molar" public_interface="in" name="KMg_COASH_x"/>
<variable units="molar" public_interface="in" name="KMg_SUC_x"/>
<variable units="molar" public_interface="in" name="KMg_FUM_x"/>
<variable units="molar" public_interface="in" name="KMg_MAL_x"/>
<variable units="molar" public_interface="in" name="KMg_GLU_x"/>
<variable units="molar" public_interface="in" name="KMg_ASP_x"/>
<variable units="molar" public_interface="in" name="KMg_K_x"/>
<variable units="molar" public_interface="in" name="KMg_Mg_x"/>
<variable units="molar" public_interface="in" name="KMg_O2_x"/>
<variable units="molar" public_interface="in" name="KMg_FADH2_x"/>
<variable units="molar" public_interface="in" name="KMg_FAD_x"/>
<variable units="molar" public_interface="in" name="KMg_CO2_tot_x"/>
<variable units="molar" public_interface="in" name="KK_H_x"/>
<variable units="molar" public_interface="in" name="KK_ATP_x"/>
<variable units="molar" public_interface="in" name="KK_ADP_x"/>
<variable units="molar" public_interface="in" name="KK_AMP_x"/>
<variable units="molar" public_interface="in" name="KK_GTP_x"/>
<variable units="molar" public_interface="in" name="KK_GDP_x"/>
<variable units="molar" public_interface="in" name="KK_PI_x"/>
<variable units="molar" public_interface="in" name="KK_NADH_x"/>
<variable units="molar" public_interface="in" name="KK_NAD_x"/>
<variable units="molar" public_interface="in" name="KK_QH2_x"/>
<variable units="molar" public_interface="in" name="KK_COQ_x"/>
<variable units="molar" public_interface="in" name="KK_PYR_x"/>
<variable units="molar" public_interface="in" name="KK_OAA_x"/>
<variable units="molar" public_interface="in" name="KK_ACCOA_x"/>
<variable units="molar" public_interface="in" name="KK_CIT_x"/>
<variable units="molar" public_interface="in" name="KK_ICIT_x"/>
<variable units="molar" public_interface="in" name="KK_AKG_x"/>
<variable units="molar" public_interface="in" name="KK_SCOA_x"/>
<variable units="molar" public_interface="in" name="KK_COASH_x"/>
<variable units="molar" public_interface="in" name="KK_SUC_x"/>
<variable units="molar" public_interface="in" name="KK_FUM_x"/>
<variable units="molar" public_interface="in" name="KK_MAL_x"/>
<variable units="molar" public_interface="in" name="KK_GLU_x"/>
<variable units="molar" public_interface="in" name="KK_ASP_x"/>
<variable units="molar" public_interface="in" name="KK_K_x"/>
<variable units="molar" public_interface="in" name="KK_Mg_x"/>
<variable units="molar" public_interface="in" name="KK_O2_x"/>
<variable units="molar" public_interface="in" name="KK_FADH2_x"/>
<variable units="molar" public_interface="in" name="KK_FAD_x"/>
<variable units="molar" public_interface="in" name="KK_CO2_tot_x"/>
<variable units="molar_per_second" public_interface="in" name="dH_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dATP_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dADP_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dAMP_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dGTP_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dGDP_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dPI_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dNADH_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dNAD_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dQH2_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dCOQ_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dPYR_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dOAA_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dACCOA_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dCIT_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dICIT_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dAKG_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dSCOA_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dCOASH_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dSUC_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dFUM_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dMAL_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dGLU_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dASP_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dK_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dMg_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dO2_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dFADH2_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dFAD_x_dt"/>
<variable units="molar_per_second" public_interface="in" name="dCO2_tot_x_dt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dHB_dMg</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KH_H_x</ci>
<ci>KMg_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ATP_x</ci>
<ci>KMg_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ADP_x</ci>
<ci>KMg_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_AMP_x</ci>
<ci>KMg_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GTP_x</ci>
<ci>KMg_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GDP_x</ci>
<ci>KMg_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KH_PI_x</ci>
<ci>KMg_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KH_NADH_x</ci>
<ci>KMg_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KH_NAD_x</ci>
<ci>KMg_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_QH2_x</ci>
<ci>KMg_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KH_COQ_x</ci>
<ci>KMg_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KH_PYR_x</ci>
<ci>KMg_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_OAA_x</ci>
<ci>KMg_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ACCOA_x</ci>
<ci>KMg_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KH_CIT_x</ci>
<ci>KMg_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ICIT_x</ci>
<ci>KMg_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KH_AKG_x</ci>
<ci>KMg_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_SCOA_x</ci>
<ci>KMg_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KH_COASH_x</ci>
<ci>KMg_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KH_SUC_x</ci>
<ci>KMg_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FUM_x</ci>
<ci>KMg_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KH_MAL_x</ci>
<ci>KMg_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GLU_x</ci>
<ci>KMg_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ASP_x</ci>
<ci>KMg_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KH_K_x</ci>
<ci>KMg_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KH_Mg_x</ci>
<ci>KMg_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_O2_x</ci>
<ci>KMg_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FADH2_x</ci>
<ci>KMg_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FAD_x</ci>
<ci>KMg_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KH_CO2_tot_x</ci>
<ci>KMg_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dHB_dK</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KH_H_x</ci>
<ci>KK_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ATP_x</ci>
<ci>KK_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ADP_x</ci>
<ci>KK_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_AMP_x</ci>
<ci>KK_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GTP_x</ci>
<ci>KK_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GDP_x</ci>
<ci>KK_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KH_PI_x</ci>
<ci>KK_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KH_NADH_x</ci>
<ci>KK_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KH_NAD_x</ci>
<ci>KK_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_QH2_x</ci>
<ci>KK_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KH_COQ_x</ci>
<ci>KK_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KH_PYR_x</ci>
<ci>KK_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_OAA_x</ci>
<ci>KK_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ACCOA_x</ci>
<ci>KK_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KH_CIT_x</ci>
<ci>KK_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ICIT_x</ci>
<ci>KK_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KH_AKG_x</ci>
<ci>KK_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_SCOA_x</ci>
<ci>KK_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KH_COASH_x</ci>
<ci>KK_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KH_SUC_x</ci>
<ci>KK_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FUM_x</ci>
<ci>KK_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KH_MAL_x</ci>
<ci>KK_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GLU_x</ci>
<ci>KK_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ASP_x</ci>
<ci>KK_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KH_K_x</ci>
<ci>KK_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KH_Mg_x</ci>
<ci>KK_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_O2_x</ci>
<ci>KK_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FADH2_x</ci>
<ci>KK_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FAD_x</ci>
<ci>KK_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KH_CO2_tot_x</ci>
<ci>KK_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dHB_dH</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_H_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_H_x</ci>
</apply>
</apply>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KH_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ATP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ATP_x</ci>
</apply>
</apply>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ADP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ADP_x</ci>
</apply>
</apply>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_AMP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_AMP_x</ci>
</apply>
</apply>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_GTP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_GTP_x</ci>
</apply>
</apply>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_GDP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_GDP_x</ci>
</apply>
</apply>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_PI_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_PI_x</ci>
</apply>
</apply>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KH_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_NADH_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_NADH_x</ci>
</apply>
</apply>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KH_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_NAD_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_NAD_x</ci>
</apply>
</apply>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KH_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_QH2_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_QH2_x</ci>
</apply>
</apply>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_COQ_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_COQ_x</ci>
</apply>
</apply>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KH_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_PYR_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_PYR_x</ci>
</apply>
</apply>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KH_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_OAA_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_OAA_x</ci>
</apply>
</apply>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ACCOA_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ACCOA_x</ci>
</apply>
</apply>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_CIT_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_CIT_x</ci>
</apply>
</apply>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KH_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ICIT_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ICIT_x</ci>
</apply>
</apply>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_AKG_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_AKG_x</ci>
</apply>
</apply>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KH_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_SCOA_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_SCOA_x</ci>
</apply>
</apply>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KH_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_COASH_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_COASH_x</ci>
</apply>
</apply>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KH_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_SUC_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_SUC_x</ci>
</apply>
</apply>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KH_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_FUM_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_FUM_x</ci>
</apply>
</apply>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_MAL_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_MAL_x</ci>
</apply>
</apply>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KH_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_GLU_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_GLU_x</ci>
</apply>
</apply>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KH_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ASP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ASP_x</ci>
</apply>
</apply>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KH_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_K_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_K_x</ci>
</apply>
</apply>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KH_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_Mg_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_Mg_x</ci>
</apply>
</apply>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KH_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_O2_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_O2_x</ci>
</apply>
</apply>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_FADH2_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_FADH2_x</ci>
</apply>
</apply>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_FAD_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_FAD_x</ci>
</apply>
</apply>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KH_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_CO2_tot_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_CO2_tot_x</ci>
</apply>
</apply>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KH_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMgB_dH</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_H_x</ci>
<ci>KH_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ATP_x</ci>
<ci>KH_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ADP_x</ci>
<ci>KH_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_AMP_x</ci>
<ci>KH_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GTP_x</ci>
<ci>KH_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GDP_x</ci>
<ci>KH_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_PI_x</ci>
<ci>KH_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_NADH_x</ci>
<ci>KH_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_NAD_x</ci>
<ci>KH_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_QH2_x</ci>
<ci>KH_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_COQ_x</ci>
<ci>KH_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_PYR_x</ci>
<ci>KH_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_OAA_x</ci>
<ci>KH_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ACCOA_x</ci>
<ci>KH_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_CIT_x</ci>
<ci>KH_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ICIT_x</ci>
<ci>KH_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_AKG_x</ci>
<ci>KH_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_SCOA_x</ci>
<ci>KH_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_COASH_x</ci>
<ci>KH_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_SUC_x</ci>
<ci>KH_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FUM_x</ci>
<ci>KH_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_MAL_x</ci>
<ci>KH_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GLU_x</ci>
<ci>KH_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ASP_x</ci>
<ci>KH_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_K_x</ci>
<ci>KH_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_Mg_x</ci>
<ci>KH_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_O2_x</ci>
<ci>KH_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FADH2_x</ci>
<ci>KH_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FAD_x</ci>
<ci>KH_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_CO2_tot_x</ci>
<ci>KH_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMgB_dK</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_H_x</ci>
<ci>KK_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ATP_x</ci>
<ci>KK_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ADP_x</ci>
<ci>KK_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_AMP_x</ci>
<ci>KK_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GTP_x</ci>
<ci>KK_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GDP_x</ci>
<ci>KK_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_PI_x</ci>
<ci>KK_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_NADH_x</ci>
<ci>KK_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_NAD_x</ci>
<ci>KK_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_QH2_x</ci>
<ci>KK_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_COQ_x</ci>
<ci>KK_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_PYR_x</ci>
<ci>KK_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_OAA_x</ci>
<ci>KK_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ACCOA_x</ci>
<ci>KK_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_CIT_x</ci>
<ci>KK_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ICIT_x</ci>
<ci>KK_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_AKG_x</ci>
<ci>KK_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_SCOA_x</ci>
<ci>KK_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_COASH_x</ci>
<ci>KK_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_SUC_x</ci>
<ci>KK_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FUM_x</ci>
<ci>KK_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_MAL_x</ci>
<ci>KK_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GLU_x</ci>
<ci>KK_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ASP_x</ci>
<ci>KK_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_K_x</ci>
<ci>KK_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_Mg_x</ci>
<ci>KK_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_O2_x</ci>
<ci>KK_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FADH2_x</ci>
<ci>KK_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FAD_x</ci>
<ci>KK_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_CO2_tot_x</ci>
<ci>KK_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMgB_dMg</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_H_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_H_x</ci>
</apply>
</apply>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ATP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ATP_x</ci>
</apply>
</apply>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ADP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ADP_x</ci>
</apply>
</apply>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_AMP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_AMP_x</ci>
</apply>
</apply>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_GTP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_GTP_x</ci>
</apply>
</apply>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_GDP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_GDP_x</ci>
</apply>
</apply>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_PI_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_PI_x</ci>
</apply>
</apply>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_NADH_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_NADH_x</ci>
</apply>
</apply>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_NAD_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_NAD_x</ci>
</apply>
</apply>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_QH2_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_QH2_x</ci>
</apply>
</apply>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_COQ_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_COQ_x</ci>
</apply>
</apply>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_PYR_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_PYR_x</ci>
</apply>
</apply>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_OAA_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_OAA_x</ci>
</apply>
</apply>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ACCOA_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ACCOA_x</ci>
</apply>
</apply>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_CIT_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_CIT_x</ci>
</apply>
</apply>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ICIT_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ICIT_x</ci>
</apply>
</apply>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_AKG_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_AKG_x</ci>
</apply>
</apply>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_SCOA_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_SCOA_x</ci>
</apply>
</apply>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_COASH_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_COASH_x</ci>
</apply>
</apply>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_SUC_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_SUC_x</ci>
</apply>
</apply>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_FUM_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_FUM_x</ci>
</apply>
</apply>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_MAL_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_MAL_x</ci>
</apply>
</apply>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_GLU_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_GLU_x</ci>
</apply>
</apply>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ASP_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_ASP_x</ci>
</apply>
</apply>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_K_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_K_x</ci>
</apply>
</apply>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_Mg_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_Mg_x</ci>
</apply>
</apply>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_O2_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_O2_x</ci>
</apply>
</apply>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_FADH2_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_FADH2_x</ci>
</apply>
</apply>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_FAD_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_FAD_x</ci>
</apply>
</apply>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_CO2_tot_x</ci>
</apply>
<apply>
<divide/>
<ci>K_x</ci>
<ci>KK_CO2_tot_x</ci>
</apply>
</apply>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KMg_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dKB_dH</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KK_H_x</ci>
<ci>KH_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ATP_x</ci>
<ci>KH_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ADP_x</ci>
<ci>KH_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_AMP_x</ci>
<ci>KH_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GTP_x</ci>
<ci>KH_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GDP_x</ci>
<ci>KH_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KK_PI_x</ci>
<ci>KH_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KK_NADH_x</ci>
<ci>KH_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KK_NAD_x</ci>
<ci>KH_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_QH2_x</ci>
<ci>KH_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KK_COQ_x</ci>
<ci>KH_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KK_PYR_x</ci>
<ci>KH_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_OAA_x</ci>
<ci>KH_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ACCOA_x</ci>
<ci>KH_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KK_CIT_x</ci>
<ci>KH_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ICIT_x</ci>
<ci>KH_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KK_AKG_x</ci>
<ci>KH_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_SCOA_x</ci>
<ci>KH_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KK_COASH_x</ci>
<ci>KH_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KK_SUC_x</ci>
<ci>KH_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FUM_x</ci>
<ci>KH_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KK_MAL_x</ci>
<ci>KH_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GLU_x</ci>
<ci>KH_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ASP_x</ci>
<ci>KH_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KK_K_x</ci>
<ci>KH_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KK_Mg_x</ci>
<ci>KH_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_O2_x</ci>
<ci>KH_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FADH2_x</ci>
<ci>KH_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FAD_x</ci>
<ci>KH_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KK_CO2_tot_x</ci>
<ci>KH_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dKB_dMg</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KK_H_x</ci>
<ci>KMg_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ATP_x</ci>
<ci>KMg_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ADP_x</ci>
<ci>KMg_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_AMP_x</ci>
<ci>KMg_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GTP_x</ci>
<ci>KMg_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GDP_x</ci>
<ci>KMg_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KK_PI_x</ci>
<ci>KMg_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KK_NADH_x</ci>
<ci>KMg_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KK_NAD_x</ci>
<ci>KMg_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_QH2_x</ci>
<ci>KMg_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KK_COQ_x</ci>
<ci>KMg_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KK_PYR_x</ci>
<ci>KMg_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_OAA_x</ci>
<ci>KMg_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ACCOA_x</ci>
<ci>KMg_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KK_CIT_x</ci>
<ci>KMg_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ICIT_x</ci>
<ci>KMg_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KK_AKG_x</ci>
<ci>KMg_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_SCOA_x</ci>
<ci>KMg_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KK_COASH_x</ci>
<ci>KMg_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KK_SUC_x</ci>
<ci>KMg_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FUM_x</ci>
<ci>KMg_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KK_MAL_x</ci>
<ci>KMg_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GLU_x</ci>
<ci>KMg_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ASP_x</ci>
<ci>KMg_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KK_K_x</ci>
<ci>KMg_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KK_Mg_x</ci>
<ci>KMg_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_O2_x</ci>
<ci>KMg_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FADH2_x</ci>
<ci>KMg_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FAD_x</ci>
<ci>KMg_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KK_CO2_tot_x</ci>
<ci>KMg_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dKB_dK</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_H_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_H_x</ci>
</apply>
</apply>
<ci>H_x</ci>
</apply>
<apply>
<times/>
<ci>KK_H_x</ci>
<apply>
<power/>
<ci>P_H_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ATP_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ATP_x</ci>
</apply>
</apply>
<ci>ATP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ATP_x</ci>
<apply>
<power/>
<ci>P_ATP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ADP_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ADP_x</ci>
</apply>
</apply>
<ci>ADP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ADP_x</ci>
<apply>
<power/>
<ci>P_ADP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_AMP_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_AMP_x</ci>
</apply>
</apply>
<ci>AMP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_AMP_x</ci>
<apply>
<power/>
<ci>P_AMP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_GTP_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_GTP_x</ci>
</apply>
</apply>
<ci>GTP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GTP_x</ci>
<apply>
<power/>
<ci>P_GTP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_GDP_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_GDP_x</ci>
</apply>
</apply>
<ci>GDP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GDP_x</ci>
<apply>
<power/>
<ci>P_GDP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_PI_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_PI_x</ci>
</apply>
</apply>
<ci>PI_x</ci>
</apply>
<apply>
<times/>
<ci>KK_PI_x</ci>
<apply>
<power/>
<ci>P_PI_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_NADH_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_NADH_x</ci>
</apply>
</apply>
<ci>NADH_x</ci>
</apply>
<apply>
<times/>
<ci>KK_NADH_x</ci>
<apply>
<power/>
<ci>P_NADH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_NAD_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_NAD_x</ci>
</apply>
</apply>
<ci>NAD_x</ci>
</apply>
<apply>
<times/>
<ci>KK_NAD_x</ci>
<apply>
<power/>
<ci>P_NAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_QH2_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_QH2_x</ci>
</apply>
</apply>
<ci>QH2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_QH2_x</ci>
<apply>
<power/>
<ci>P_QH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_COQ_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_COQ_x</ci>
</apply>
</apply>
<ci>COQ_x</ci>
</apply>
<apply>
<times/>
<ci>KK_COQ_x</ci>
<apply>
<power/>
<ci>P_COQ_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_PYR_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_PYR_x</ci>
</apply>
</apply>
<ci>PYR_x</ci>
</apply>
<apply>
<times/>
<ci>KK_PYR_x</ci>
<apply>
<power/>
<ci>P_PYR_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_OAA_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_OAA_x</ci>
</apply>
</apply>
<ci>OAA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_OAA_x</ci>
<apply>
<power/>
<ci>P_OAA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ACCOA_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ACCOA_x</ci>
</apply>
</apply>
<ci>ACCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ACCOA_x</ci>
<apply>
<power/>
<ci>P_ACCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_CIT_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_CIT_x</ci>
</apply>
</apply>
<ci>CIT_x</ci>
</apply>
<apply>
<times/>
<ci>KK_CIT_x</ci>
<apply>
<power/>
<ci>P_CIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ICIT_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ICIT_x</ci>
</apply>
</apply>
<ci>ICIT_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ICIT_x</ci>
<apply>
<power/>
<ci>P_ICIT_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_AKG_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_AKG_x</ci>
</apply>
</apply>
<ci>AKG_x</ci>
</apply>
<apply>
<times/>
<ci>KK_AKG_x</ci>
<apply>
<power/>
<ci>P_AKG_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_SCOA_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_SCOA_x</ci>
</apply>
</apply>
<ci>SCOA_x</ci>
</apply>
<apply>
<times/>
<ci>KK_SCOA_x</ci>
<apply>
<power/>
<ci>P_SCOA_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_COASH_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_COASH_x</ci>
</apply>
</apply>
<ci>COASH_x</ci>
</apply>
<apply>
<times/>
<ci>KK_COASH_x</ci>
<apply>
<power/>
<ci>P_COASH_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_SUC_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_SUC_x</ci>
</apply>
</apply>
<ci>SUC_x</ci>
</apply>
<apply>
<times/>
<ci>KK_SUC_x</ci>
<apply>
<power/>
<ci>P_SUC_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_FUM_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_FUM_x</ci>
</apply>
</apply>
<ci>FUM_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FUM_x</ci>
<apply>
<power/>
<ci>P_FUM_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_MAL_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_MAL_x</ci>
</apply>
</apply>
<ci>MAL_x</ci>
</apply>
<apply>
<times/>
<ci>KK_MAL_x</ci>
<apply>
<power/>
<ci>P_MAL_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_GLU_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_GLU_x</ci>
</apply>
</apply>
<ci>GLU_x</ci>
</apply>
<apply>
<times/>
<ci>KK_GLU_x</ci>
<apply>
<power/>
<ci>P_GLU_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_ASP_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_ASP_x</ci>
</apply>
</apply>
<ci>ASP_x</ci>
</apply>
<apply>
<times/>
<ci>KK_ASP_x</ci>
<apply>
<power/>
<ci>P_ASP_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_K_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_K_x</ci>
</apply>
</apply>
<ci>K_x</ci>
</apply>
<apply>
<times/>
<ci>KK_K_x</ci>
<apply>
<power/>
<ci>P_K_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_Mg_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_Mg_x</ci>
</apply>
</apply>
<ci>Mg_x</ci>
</apply>
<apply>
<times/>
<ci>KK_Mg_x</ci>
<apply>
<power/>
<ci>P_Mg_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_O2_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_O2_x</ci>
</apply>
</apply>
<ci>O2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_O2_x</ci>
<apply>
<power/>
<ci>P_O2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_FADH2_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_FADH2_x</ci>
</apply>
</apply>
<ci>FADH2_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FADH2_x</ci>
<apply>
<power/>
<ci>P_FADH2_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_FAD_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_FAD_x</ci>
</apply>
</apply>
<ci>FAD_x</ci>
</apply>
<apply>
<times/>
<ci>KK_FAD_x</ci>
<apply>
<power/>
<ci>P_FAD_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>KH_CO2_tot_x</ci>
</apply>
<apply>
<divide/>
<ci>Mg_x</ci>
<ci>KMg_CO2_tot_x</ci>
</apply>
</apply>
<ci>CO2_tot_x</ci>
</apply>
<apply>
<times/>
<ci>KK_CO2_tot_x</ci>
<apply>
<power/>
<ci>P_CO2_tot_x</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>nK_JK</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_pdh</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_cits</ci>
</apply>
</apply>
<ci>J_akgd</ci>
</apply>
<ci>J_scoas</ci>
<ci>J_mdh</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_H_t</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_PYRH</ci>
<ci>J_GLUH</ci>
<ci>J_CITMAL</ci>
</apply>
<ci>J_ASPGLU</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">5</cn>
<ci>J_C1</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_C3</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>J_C4</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>n_A</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_F1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_PIHt</ci>
</apply>
<ci>J_Hle</ci>
</apply>
<ci>J_KH</ci>
</apply>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Mg_t</ci>
<cn cellml:units="molar_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>J_K_t</ci>
<apply>
<divide/>
<ci>J_KH</ci>
<ci>W_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>phi_H</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_H_x</ci>
<ci>P_H_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dATP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_ATP_x</ci>
<ci>P_ATP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dADP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_ADP_x</ci>
<ci>P_ADP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dAMP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_AMP_x</ci>
<ci>P_AMP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dGTP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_GTP_x</ci>
<ci>P_GTP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dGDP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_GDP_x</ci>
<ci>P_GDP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dPI_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_PI_x</ci>
<ci>P_PI_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dNADH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_NADH_x</ci>
<ci>P_NADH_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dNAD_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_NAD_x</ci>
<ci>P_NAD_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dQH2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_QH2_x</ci>
<ci>P_QH2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dCOQ_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_COQ_x</ci>
<ci>P_COQ_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dPYR_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_PYR_x</ci>
<ci>P_PYR_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dOAA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_OAA_x</ci>
<ci>P_OAA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dACCOA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_ACCOA_x</ci>
<ci>P_ACCOA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dCIT_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_CIT_x</ci>
<ci>P_CIT_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dICIT_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_ICIT_x</ci>
<ci>P_ICIT_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dAKG_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_AKG_x</ci>
<ci>P_AKG_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dSCOA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_SCOA_x</ci>
<ci>P_SCOA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dCOASH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_COASH_x</ci>
<ci>P_COASH_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dSUC_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_SUC_x</ci>
<ci>P_SUC_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dFUM_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_FUM_x</ci>
<ci>P_FUM_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dMAL_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_MAL_x</ci>
<ci>P_MAL_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dGLU_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_GLU_x</ci>
<ci>P_GLU_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dASP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_ASP_x</ci>
<ci>P_ASP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dK_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_K_x</ci>
<ci>P_K_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dMg_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_Mg_x</ci>
<ci>P_Mg_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dO2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_O2_x</ci>
<ci>P_O2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dFADH2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_FADH2_x</ci>
<ci>P_FADH2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dFAD_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_FAD_x</ci>
<ci>P_FAD_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>H_x</ci>
<ci>dCO2_tot_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KH_CO2_tot_x</ci>
<ci>P_CO2_tot_x</ci>
</apply>
</apply>
<ci>nK_JK</ci>
<ci>J_H_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>phi_Mg</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_H_x</ci>
<ci>P_H_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dATP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_ATP_x</ci>
<ci>P_ATP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dADP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_ADP_x</ci>
<ci>P_ADP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dAMP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_AMP_x</ci>
<ci>P_AMP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dGTP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_GTP_x</ci>
<ci>P_GTP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dGDP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_GDP_x</ci>
<ci>P_GDP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dPI_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_PI_x</ci>
<ci>P_PI_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dNADH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_NADH_x</ci>
<ci>P_NADH_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dNAD_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_NAD_x</ci>
<ci>P_NAD_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dQH2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_QH2_x</ci>
<ci>P_QH2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dCOQ_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_COQ_x</ci>
<ci>P_COQ_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dPYR_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_PYR_x</ci>
<ci>P_PYR_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dOAA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_OAA_x</ci>
<ci>P_OAA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dACCOA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_ACCOA_x</ci>
<ci>P_ACCOA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dCIT_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_CIT_x</ci>
<ci>P_CIT_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dICIT_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_ICIT_x</ci>
<ci>P_ICIT_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dAKG_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_AKG_x</ci>
<ci>P_AKG_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dSCOA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_SCOA_x</ci>
<ci>P_SCOA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dCOASH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_COASH_x</ci>
<ci>P_COASH_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dSUC_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_SUC_x</ci>
<ci>P_SUC_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dFUM_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_FUM_x</ci>
<ci>P_FUM_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dMAL_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_MAL_x</ci>
<ci>P_MAL_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dGLU_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_GLU_x</ci>
<ci>P_GLU_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dASP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_ASP_x</ci>
<ci>P_ASP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dK_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_K_x</ci>
<ci>P_K_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dMg_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_Mg_x</ci>
<ci>P_Mg_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dO2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_O2_x</ci>
<ci>P_O2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dFADH2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_FADH2_x</ci>
<ci>P_FADH2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dFAD_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_FAD_x</ci>
<ci>P_FAD_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Mg_x</ci>
<ci>dCO2_tot_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KMg_CO2_tot_x</ci>
<ci>P_CO2_tot_x</ci>
</apply>
</apply>
<ci>J_Mg_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>phi_K</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_H_x</ci>
<ci>P_H_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dATP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_ATP_x</ci>
<ci>P_ATP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dADP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_ADP_x</ci>
<ci>P_ADP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dAMP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_AMP_x</ci>
<ci>P_AMP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dGTP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_GTP_x</ci>
<ci>P_GTP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dGDP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_GDP_x</ci>
<ci>P_GDP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dPI_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_PI_x</ci>
<ci>P_PI_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dNADH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_NADH_x</ci>
<ci>P_NADH_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dNAD_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_NAD_x</ci>
<ci>P_NAD_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dQH2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_QH2_x</ci>
<ci>P_QH2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dCOQ_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_COQ_x</ci>
<ci>P_COQ_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dPYR_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_PYR_x</ci>
<ci>P_PYR_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dOAA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_OAA_x</ci>
<ci>P_OAA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dACCOA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_ACCOA_x</ci>
<ci>P_ACCOA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dCIT_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_CIT_x</ci>
<ci>P_CIT_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dICIT_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_ICIT_x</ci>
<ci>P_ICIT_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dAKG_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_AKG_x</ci>
<ci>P_AKG_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dSCOA_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_SCOA_x</ci>
<ci>P_SCOA_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dCOASH_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_COASH_x</ci>
<ci>P_COASH_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dSUC_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_SUC_x</ci>
<ci>P_SUC_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dFUM_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_FUM_x</ci>
<ci>P_FUM_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dMAL_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_MAL_x</ci>
<ci>P_MAL_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dGLU_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_GLU_x</ci>
<ci>P_GLU_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dASP_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_ASP_x</ci>
<ci>P_ASP_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dK_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_K_x</ci>
<ci>P_K_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dMg_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_Mg_x</ci>
<ci>P_Mg_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dO2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_O2_x</ci>
<ci>P_O2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dFADH2_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_FADH2_x</ci>
<ci>P_FADH2_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dFAD_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_FAD_x</ci>
<ci>P_FAD_x</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_x</ci>
<ci>dCO2_tot_x_dt</ci>
</apply>
<apply>
<times/>
<ci>KK_CO2_tot_x</ci>
<ci>P_CO2_tot_x</ci>
</apply>
</apply>
<ci>J_K_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_H</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dHB_dH</ci>
<apply>
<divide/>
<ci>B_x</ci>
<apply>
<times/>
<ci>K_BX</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>H_x</ci>
<ci>K_BX</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Mg</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dMgB_dMg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_K</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dKB_dK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>D</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_H</ci>
<ci>dKB_dMg</ci>
<ci>dMgB_dK</ci>
</apply>
<apply>
<times/>
<ci>alpha_K</ci>
<ci>dHB_dMg</ci>
<ci>dMgB_dH</ci>
</apply>
<apply>
<times/>
<ci>alpha_Mg</ci>
<ci>dHB_dK</ci>
<ci>dKB_dH</ci>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_Mg</ci>
<ci>alpha_K</ci>
<ci>alpha_H</ci>
</apply>
</apply>
<apply>
<times/>
<ci>dHB_dK</ci>
<ci>dKB_dMg</ci>
<ci>dMgB_dH</ci>
</apply>
</apply>
<apply>
<times/>
<ci>dHB_dMg</ci>
<ci>dMgB_dK</ci>
<ci>dKB_dH</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="J_C1">
<component_ref component="k_eqC1"/>
</component_ref>
<component_ref component="J_C3">
<component_ref component="k_eqC3"/>
</component_ref>
<component_ref component="J_C4">
<component_ref component="k_eqC4"/>
</component_ref>
<component_ref component="J_F1">
<component_ref component="k_eqF1"/>
</component_ref>
</group>
<connection>
<map_components component_2="adjustable_parameters" component_1="Environment"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="Environment"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="ddeltaPsi_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dATP_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dADP_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dAMP_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dGTP_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dGDP_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dPI_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dNADH_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dQH2_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dPYR_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dACCOA_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dCIT_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dICIT_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dAKG_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dSCOA_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dCOASH_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dSUC_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dFUM_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dMAL_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dOAA_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dGLU_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dASP_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dO2_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dCO2_tot_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dCred_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dATP_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dADP_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dAMP_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dPI_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dPYR_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dCIT_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dICIT_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dAKG_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dSUC_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dFUM_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dMAL_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dGLU_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dASP_i_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="dATP_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dADP_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dAMP_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dPI_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dPYR_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dCIT_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dICIT_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dAKG_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dSUC_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dFUM_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dMAL_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
<map_variables variable_2="StateType" variable_1="StateType"/>
</connection>
<connection>
<map_components component_2="dGLU_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dASP_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dPCr_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dGLC_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="dG6P_c_dt" component_1="Environment"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="J_AKi" component_1="Environment"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="J_AKc" component_1="Environment"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="J_CKc" component_1="Environment"/>
<map_variables variable_2="ExpType" variable_1="ExpType"/>
</connection>
<connection>
<map_components component_2="P_ATP_i" component_1="P_ATP_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="P_ADP_i" component_1="P_ADP_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="P_AMP_i" component_1="P_AMP_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="P_PI_i" component_1="P_PI_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="P_GTP_x" component_1="P_ATP_x"/>
<map_variables variable_2="P_ATP_x" variable_1="P_ATP_x"/>
<map_variables variable_2="fATP_x" variable_1="fATP_x"/>
</connection>
<connection>
<map_components component_2="P_GDP_x" component_1="P_ADP_x"/>
<map_variables variable_2="P_ADP_x" variable_1="P_ADP_x"/>
<map_variables variable_2="fADP_x" variable_1="fADP_x"/>
</connection>
<connection>
<map_components component_2="dATP_x_dt" component_1="P_ATP_x"/>
<map_variables variable_2="ATP_x" variable_1="ATP_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_ATP_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_ATP_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_ATP_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dADP_x_dt" component_1="P_ADP_x"/>
<map_variables variable_2="ADP_x" variable_1="ADP_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_ADP_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_ADP_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_ADP_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dAMP_x_dt" component_1="P_AMP_x"/>
<map_variables variable_2="AMP_x" variable_1="AMP_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_AMP_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_AMP_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_AMP_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dATP_i_dt" component_1="P_ATP_i"/>
<map_variables variable_2="ATP_i" variable_1="ATP_i"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_ATP_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_ATP_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_ATP_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="dADP_i_dt" component_1="P_ADP_i"/>
<map_variables variable_2="ADP_i" variable_1="ADP_i"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_ADP_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_ADP_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_ADP_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="dAMP_i_dt" component_1="P_AMP_i"/>
<map_variables variable_2="AMP_i" variable_1="AMP_i"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_AMP_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_AMP_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_AMP_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="dPI_x_dt" component_1="P_PI_x"/>
<map_variables variable_2="PI_x" variable_1="PI_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_PI_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_PI_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dPI_i_dt" component_1="P_PI_i"/>
<map_variables variable_2="PI_i" variable_1="PI_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_PI_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_COASH_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_OAA_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dCIT_x_dt" component_1="P_CIT_x"/>
<map_variables variable_2="CIT_x" variable_1="CIT_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_CIT_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_CIT_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_CIT_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_ICIT_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_ICIT_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_SCOA_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_SUC_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_SUC_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_SUC_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_FUM_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_MAL_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_MAL_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_MAL_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_CO2_tot_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_PYR_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_ASP_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_ASP_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="P_PI_x"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_PI_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_PI_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="P_ATP_x"/>
<map_variables variable_2="P_ATP_x" variable_1="P_ATP_x"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="P_ADP_x"/>
<map_variables variable_2="P_ADP_x" variable_1="P_ADP_x"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="P_PI_x"/>
<map_variables variable_2="P_PI_x" variable_1="P_PI_x"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="k_eqF1"/>
<map_variables variable_2="P_ATP_x" variable_1="P_ATP_x"/>
<map_variables variable_2="P_ADP_x" variable_1="P_ADP_x"/>
<map_variables variable_2="P_PI_x" variable_1="P_PI_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
<map_variables variable_2="n_A" variable_1="n_A"/>
<map_variables variable_2="k_eqF1" variable_1="k_eqF1"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="P_CO2_tot_x"/>
<map_variables variable_2="P_CO2_tot_x" variable_1="P_CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="P_PYR_x"/>
<map_variables variable_2="P_PYR_x" variable_1="P_PYR_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="P_COASH_x"/>
<map_variables variable_2="P_COASH_x" variable_1="P_COASH_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_pdh"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="P_CIT_x"/>
<map_variables variable_2="P_CIT_x" variable_1="P_CIT_x"/>
<map_variables variable_2="uCIT_x" variable_1="uCIT_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_cits"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_cits"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="P_ATP_x"/>
<map_variables variable_2="fATP_x" variable_1="fATP_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="P_ADP_x"/>
<map_variables variable_2="fADP_x" variable_1="fADP_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="P_AMP_x"/>
<map_variables variable_2="fAMP_x" variable_1="fAMP_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="P_OAA_x"/>
<map_variables variable_2="P_OAA_x" variable_1="P_OAA_x"/>
</connection>
<connection>
<map_components component_2="J_acon" component_1="P_CIT_x"/>
<map_variables variable_2="P_CIT_x" variable_1="P_CIT_x"/>
</connection>
<connection>
<map_components component_2="J_acon" component_1="P_ICIT_x"/>
<map_variables variable_2="P_ICIT_x" variable_1="P_ICIT_x"/>
</connection>
<connection>
<map_components component_2="J_acon" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_acon"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_isod"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="dH_x_dt"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="P_CO2_tot_x"/>
<map_variables variable_2="P_CO2_tot_x" variable_1="P_CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="P_ICIT_x"/>
<map_variables variable_2="P_ICIT_x" variable_1="P_ICIT_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="P_ATP_x"/>
<map_variables variable_2="fATP_x" variable_1="fATP_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="P_ADP_x"/>
<map_variables variable_2="fADP_x" variable_1="fADP_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_akgd"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="dH_x_dt"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="P_CO2_tot_x"/>
<map_variables variable_2="P_CO2_tot_x" variable_1="P_CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="P_SCOA_x"/>
<map_variables variable_2="P_SCOA_x" variable_1="P_SCOA_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="P_COASH_x"/>
<map_variables variable_2="P_COASH_x" variable_1="P_COASH_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="P_ATP_x"/>
<map_variables variable_2="fATP_x" variable_1="fATP_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="P_ADP_x"/>
<map_variables variable_2="fADP_x" variable_1="fADP_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_scoas"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="P_COASH_x"/>
<map_variables variable_2="P_COASH_x" variable_1="P_COASH_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="P_GTP_x"/>
<map_variables variable_2="P_GTP_x" variable_1="P_GTP_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="P_GDP_x"/>
<map_variables variable_2="P_GDP_x" variable_1="P_GDP_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="P_SUC_x"/>
<map_variables variable_2="P_SUC_x" variable_1="P_SUC_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="P_SCOA_x"/>
<map_variables variable_2="P_SCOA_x" variable_1="P_SCOA_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="P_PI_x"/>
<map_variables variable_2="P_PI_x" variable_1="P_PI_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dH_x_dt"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="J_sdh" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_sdh"/>
</connection>
<connection>
<map_components component_2="J_sdh" component_1="P_FUM_x"/>
<map_variables variable_2="P_FUM_x" variable_1="P_FUM_x"/>
</connection>
<connection>
<map_components component_2="J_sdh" component_1="P_SUC_x"/>
<map_variables variable_2="P_SUC_x" variable_1="P_SUC_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_fuma"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="P_ATP_x"/>
<map_variables variable_2="fATP_x" variable_1="fATP_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="P_ADP_x"/>
<map_variables variable_2="fADP_x" variable_1="fADP_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="P_GTP_x"/>
<map_variables variable_2="fGTP_x" variable_1="fGTP_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="P_GDP_x"/>
<map_variables variable_2="fGDP_x" variable_1="fGDP_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="P_MAL_x"/>
<map_variables variable_2="P_MAL_x" variable_1="P_MAL_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="P_FUM_x"/>
<map_variables variable_2="P_FUM_x" variable_1="P_FUM_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_mdh"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="P_ATP_x"/>
<map_variables variable_2="fATP_x" variable_1="fATP_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="P_ADP_x"/>
<map_variables variable_2="fADP_x" variable_1="fADP_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="P_AMP_x"/>
<map_variables variable_2="fAMP_x" variable_1="fAMP_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="P_MAL_x"/>
<map_variables variable_2="P_MAL_x" variable_1="P_MAL_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="P_OAA_x"/>
<map_variables variable_2="P_OAA_x" variable_1="P_OAA_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="dH_x_dt"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="J_ndk" component_1="adjustable_parameters"/>
<map_variables variable_2="V_mf" variable_1="X_ndk"/>
</connection>
<connection>
<map_components component_2="J_ndk" component_1="P_AMP_x"/>
<map_variables variable_2="fAMP_x" variable_1="fAMP_x"/>
</connection>
<connection>
<map_components component_2="P_PYR_i" component_1="P_PYR_x"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_PYR_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="J_PYRH" component_1="P_PYR_x"/>
<map_variables variable_2="P_PYR_x" variable_1="P_PYR_x"/>
</connection>
<connection>
<map_components component_2="J_PYRH" component_1="P_PYR_i"/>
<map_variables variable_2="P_PYR_i" variable_1="P_PYR_i"/>
</connection>
<connection>
<map_components component_2="P_MAL_x" component_1="P_MAL_i"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_MAL_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_MAL_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_MAL_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="P_CIT_x" component_1="P_CIT_i"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_CIT_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_CIT_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_CIT_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="P_ASP_x" component_1="P_ASP_i"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_ASP_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_ASP_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="P_SUC_x" component_1="P_SUC_i"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_SUC_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_SUC_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="P_SUC_i"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="J_C1" component_1="adjustable_parameters"/>
<map_variables variable_2="X_C1" variable_1="X_C1"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="adjustable_parameters"/>
<map_variables variable_2="X_C3" variable_1="X_C3"/>
<map_variables variable_2="k_PI_1" variable_1="k_PI_1"/>
<map_variables variable_2="k_PI_2" variable_1="k_PI_2"/>
</connection>
<connection>
<map_components component_2="J_C4" component_1="adjustable_parameters"/>
<map_variables variable_2="X_C4" variable_1="X_C4"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="adjustable_parameters"/>
<map_variables variable_2="X_F1" variable_1="X_F1"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="adjustable_parameters"/>
<map_variables variable_2="X_ANT" variable_1="X_ANT"/>
</connection>
<connection>
<map_components component_2="J_PIHt" component_1="adjustable_parameters"/>
<map_variables variable_2="X_PIHt" variable_1="X_PiHt"/>
<map_variables variable_2="k_PIHt" variable_1="k_PiHt"/>
</connection>
<connection>
<map_components component_2="J_KH" component_1="adjustable_parameters"/>
<map_variables variable_2="X_KH" variable_1="X_KH"/>
</connection>
<connection>
<map_components component_2="J_PYRH" component_1="adjustable_parameters"/>
<map_variables variable_2="X_PYRH" variable_1="X_PYRH"/>
</connection>
<connection>
<map_components component_2="J_GLUH" component_1="adjustable_parameters"/>
<map_variables variable_2="X_GLUH" variable_1="X_GLUH"/>
</connection>
<connection>
<map_components component_2="J_CITMAL" component_1="adjustable_parameters"/>
<map_variables variable_2="X_CITMAL" variable_1="X_CITMAL"/>
</connection>
<connection>
<map_components component_2="J_AKGMAL" component_1="adjustable_parameters"/>
<map_variables variable_2="X_AKGMAL" variable_1="X_AKGMAL"/>
</connection>
<connection>
<map_components component_2="J_SUCMAL" component_1="adjustable_parameters"/>
<map_variables variable_2="X_SUCMAL" variable_1="X_SUCMAL"/>
</connection>
<connection>
<map_components component_2="J_MALPI" component_1="adjustable_parameters"/>
<map_variables variable_2="X_MALPI" variable_1="X_MALPI"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="adjustable_parameters"/>
<map_variables variable_2="X_ASPGLU" variable_1="X_ASPGLU"/>
</connection>
<connection>
<map_components component_2="J_Hle" component_1="adjustable_parameters"/>
<map_variables variable_2="X_Hle" variable_1="X_Hle"/>
</connection>
<connection>
<map_components component_2="J_C1" component_1="fixed_parameters"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="J_C1" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="J_C1" variable_1="J_C1"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="fixed_parameters"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="J_C3" variable_1="J_C3"/>
</connection>
<connection>
<map_components component_2="J_C4" component_1="fixed_parameters"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
<map_variables variable_2="k_O2" variable_1="k_O2"/>
<map_variables variable_2="cytC_tot" variable_1="cytC_tot"/>
</connection>
<connection>
<map_components component_2="J_C4" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="J_C4" variable_1="J_C4"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="fixed_parameters"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
<map_variables variable_2="n_A" variable_1="n_A"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="J_F1" variable_1="J_F1"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="fixed_parameters"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
<map_variables variable_2="theta" variable_1="theta"/>
<map_variables variable_2="k_mADP" variable_1="k_mADP"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="J_ANT" variable_1="J_ANT"/>
</connection>
<connection>
<map_components component_2="J_Hle" component_1="fixed_parameters"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
<map_variables variable_2="n_A" variable_1="n_A"/>
</connection>
<connection>
<map_components component_2="J_Hle" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="J_Hle" variable_1="J_Hle"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="J_ASPGLU" variable_1="J_ASPGLU"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="ddeltaPsi_dt"/>
<map_variables variable_2="n_A" variable_1="n_A"/>
<map_variables variable_2="C_IM" variable_1="C_IM"/>
</connection>
<connection>
<map_components component_2="J_ndk" component_1="dATP_x_dt"/>
<map_variables variable_2="J_ndk" variable_1="J_ndk"/>
<map_variables variable_2="ATP_x" variable_1="ATP_x"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="dATP_x_dt"/>
<map_variables variable_2="J_F1" variable_1="J_F1"/>
<map_variables variable_2="ATP_x" variable_1="ATP_x"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="dATP_x_dt"/>
<map_variables variable_2="J_ANT" variable_1="J_ANT"/>
<map_variables variable_2="ATP_x" variable_1="ATP_x"/>
</connection>
<connection>
<map_components component_2="J_ndk" component_1="dADP_x_dt"/>
<map_variables variable_2="J_ndk" variable_1="J_ndk"/>
<map_variables variable_2="ADP_x" variable_1="ADP_x"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="dADP_x_dt"/>
<map_variables variable_2="J_F1" variable_1="J_F1"/>
<map_variables variable_2="ADP_x" variable_1="ADP_x"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="dADP_x_dt"/>
<map_variables variable_2="J_ANT" variable_1="J_ANT"/>
<map_variables variable_2="ADP_x" variable_1="ADP_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dGTP_x_dt"/>
<map_variables variable_2="J_scoas" variable_1="J_SCOAS"/>
<map_variables variable_2="GTP_x" variable_1="GTP_x"/>
</connection>
<connection>
<map_components component_2="J_ndk" component_1="dGTP_x_dt"/>
<map_variables variable_2="J_ndk" variable_1="J_ndk"/>
<map_variables variable_2="GTP_x" variable_1="GTP_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dGDP_x_dt"/>
<map_variables variable_2="J_scoas" variable_1="J_SCOAS"/>
<map_variables variable_2="GDP_x" variable_1="GDP_x"/>
</connection>
<connection>
<map_components component_2="J_ndk" component_1="dGDP_x_dt"/>
<map_variables variable_2="J_ndk" variable_1="J_ndk"/>
<map_variables variable_2="GDP_x" variable_1="GDP_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dPI_x_dt"/>
<map_variables variable_2="J_scoas" variable_1="J_SCOAS"/>
<map_variables variable_2="PI_x" variable_1="PI_x"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="dPI_x_dt"/>
<map_variables variable_2="J_F1" variable_1="J_F1"/>
<map_variables variable_2="PI_x" variable_1="PI_x"/>
</connection>
<connection>
<map_components component_2="J_PIHt" component_1="dPI_x_dt"/>
<map_variables variable_2="J_PIHt" variable_1="J_PIHt"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="dPI_x_dt"/>
<map_variables variable_2="PI_x" variable_1="PI_x"/>
</connection>
<connection>
<map_components component_2="J_MALPI" component_1="dPI_x_dt"/>
<map_variables variable_2="J_MALPI" variable_1="J_MALPI"/>
<map_variables variable_2="PI_x" variable_1="PI_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="dNADH_x_dt"/>
<map_variables variable_2="J_pdh" variable_1="J_pdh"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="dNADH_x_dt"/>
<map_variables variable_2="J_isod" variable_1="J_isod"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="dNADH_x_dt"/>
<map_variables variable_2="J_akgd" variable_1="J_akgd"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="dNADH_x_dt"/>
<map_variables variable_2="J_mdh" variable_1="J_mdh"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
</connection>
<connection>
<map_components component_2="J_C1" component_1="dNADH_x_dt"/>
<map_variables variable_2="J_C1" variable_1="J_C1"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
</connection>
<connection>
<map_components component_2="J_sdh" component_1="dQH2_x_dt"/>
<map_variables variable_2="J_sdh" variable_1="J_sdh"/>
<map_variables variable_2="QH2_x" variable_1="QH2_x"/>
</connection>
<connection>
<map_components component_2="J_C1" component_1="dQH2_x_dt"/>
<map_variables variable_2="J_C1" variable_1="J_C1"/>
<map_variables variable_2="QH2_x" variable_1="QH2_x"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="dQH2_x_dt"/>
<map_variables variable_2="J_C3" variable_1="J_C3"/>
<map_variables variable_2="QH2_x" variable_1="QH2_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="dPYR_x_dt"/>
<map_variables variable_2="J_pdh" variable_1="J_pdh"/>
<map_variables variable_2="PYR_x" variable_1="PYR_x"/>
</connection>
<connection>
<map_components component_2="J_PYRH" component_1="dPYR_x_dt"/>
<map_variables variable_2="J_PYRH" variable_1="J_PYRH"/>
<map_variables variable_2="PYR_x" variable_1="PYR_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="dACCOA_x_dt"/>
<map_variables variable_2="J_cits" variable_1="J_cits"/>
<map_variables variable_2="ACCOA_x" variable_1="ACCOA_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="dACCOA_x_dt"/>
<map_variables variable_2="J_pdh" variable_1="J_pdh"/>
<map_variables variable_2="ACCOA_x" variable_1="ACCOA_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="dCIT_x_dt"/>
<map_variables variable_2="J_cits" variable_1="J_cits"/>
<map_variables variable_2="CIT_x" variable_1="CIT_x"/>
</connection>
<connection>
<map_components component_2="J_acon" component_1="dCIT_x_dt"/>
<map_variables variable_2="J_acon" variable_1="J_acon"/>
<map_variables variable_2="CIT_x" variable_1="CIT_x"/>
</connection>
<connection>
<map_components component_2="J_CITMAL" component_1="dCIT_x_dt"/>
<map_variables variable_2="J_CITMAL" variable_1="J_CITMAL"/>
</connection>
<connection>
<map_components component_2="J_acon" component_1="dICIT_x_dt"/>
<map_variables variable_2="J_acon" variable_1="J_acon"/>
<map_variables variable_2="ICIT_x" variable_1="ICIT_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="dICIT_x_dt"/>
<map_variables variable_2="J_isod" variable_1="J_isod"/>
<map_variables variable_2="ICIT_x" variable_1="ICIT_x"/>
</connection>
<connection>
<map_components component_2="J_isod" component_1="dAKG_x_dt"/>
<map_variables variable_2="J_isod" variable_1="J_isod"/>
<map_variables variable_2="AKG_x" variable_1="AKG_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="dAKG_x_dt"/>
<map_variables variable_2="J_akgd" variable_1="J_akgd"/>
<map_variables variable_2="AKG_x" variable_1="AKG_x"/>
</connection>
<connection>
<map_components component_2="J_got" component_1="dAKG_x_dt"/>
<map_variables variable_2="J_got" variable_1="J_got"/>
<map_variables variable_2="AKG_x" variable_1="AKG_x"/>
</connection>
<connection>
<map_components component_2="J_AKGMAL" component_1="dAKG_x_dt"/>
<map_variables variable_2="J_AKGMAL" variable_1="J_AKGMAL"/>
<map_variables variable_2="AKG_x" variable_1="AKG_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="dSCOA_x_dt"/>
<map_variables variable_2="J_akgd" variable_1="J_akgd"/>
<map_variables variable_2="SCOA_x" variable_1="SCOA_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dSCOA_x_dt"/>
<map_variables variable_2="J_scoas" variable_1="J_scoas"/>
<map_variables variable_2="SCOA_x" variable_1="SCOA_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="dCOASH_x_dt"/>
<map_variables variable_2="J_pdh" variable_1="J_pdh"/>
<map_variables variable_2="COASH_x" variable_1="COASH_x"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="dCOASH_x_dt"/>
<map_variables variable_2="J_akgd" variable_1="J_akgd"/>
<map_variables variable_2="COASH_x" variable_1="COASH_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dCOASH_x_dt"/>
<map_variables variable_2="J_scoas" variable_1="J_scoas"/>
<map_variables variable_2="COASH_x" variable_1="COASH_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="dCOASH_x_dt"/>
<map_variables variable_2="J_cits" variable_1="J_cits"/>
<map_variables variable_2="COASH_x" variable_1="COASH_x"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="dSUC_x_dt"/>
<map_variables variable_2="J_scoas" variable_1="J_scoas"/>
<map_variables variable_2="SUC_x" variable_1="SUC_x"/>
</connection>
<connection>
<map_components component_2="J_sdh" component_1="dSUC_x_dt"/>
<map_variables variable_2="J_sdh" variable_1="J_sdh"/>
<map_variables variable_2="SUC_x" variable_1="SUC_x"/>
</connection>
<connection>
<map_components component_2="J_SUCMAL" component_1="dSUC_x_dt"/>
<map_variables variable_2="J_SUCMAL" variable_1="J_SUCMAL"/>
<map_variables variable_2="SUC_x" variable_1="SUC_x"/>
</connection>
<connection>
<map_components component_2="J_sdh" component_1="dFUM_x_dt"/>
<map_variables variable_2="J_sdh" variable_1="J_sdh"/>
<map_variables variable_2="FUM_x" variable_1="FUM_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="dFUM_x_dt"/>
<map_variables variable_2="J_fum" variable_1="J_fum"/>
<map_variables variable_2="FUM_x" variable_1="FUM_x"/>
</connection>
<connection>
<map_components component_2="J_fum" component_1="dMAL_x_dt"/>
<map_variables variable_2="J_fum" variable_1="J_fum"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="dMAL_x_dt"/>
<map_variables variable_2="J_mdh" variable_1="J_mdh"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
</connection>
<connection>
<map_components component_2="J_MALPI" component_1="dMAL_x_dt"/>
<map_variables variable_2="J_MALPI" variable_1="J_MALPI"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
</connection>
<connection>
<map_components component_2="J_AKGMAL" component_1="dMAL_x_dt"/>
<map_variables variable_2="J_AKGMAL" variable_1="J_AKGMAL"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
</connection>
<connection>
<map_components component_2="J_CITMAL" component_1="dMAL_x_dt"/>
<map_variables variable_2="J_CITMAL" variable_1="J_CITMAL"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
</connection>
<connection>
<map_components component_2="J_SUCMAL" component_1="dMAL_x_dt"/>
<map_variables variable_2="J_SUCMAL" variable_1="J_SUCMAL"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="dOAA_x_dt"/>
<map_variables variable_2="J_cits" variable_1="J_cits"/>
<map_variables variable_2="OAA_x" variable_1="OAA_x"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="dOAA_x_dt"/>
<map_variables variable_2="J_mdh" variable_1="J_mdh"/>
<map_variables variable_2="OAA_x" variable_1="OAA_x"/>
</connection>
<connection>
<map_components component_2="J_got" component_1="dOAA_x_dt"/>
<map_variables variable_2="J_got" variable_1="J_got"/>
<map_variables variable_2="OAA_x" variable_1="OAA_x"/>
</connection>
<connection>
<map_components component_2="J_got" component_1="dGLU_x_dt"/>
<map_variables variable_2="J_got" variable_1="J_got"/>
<map_variables variable_2="GLU_x" variable_1="GLU_x"/>
</connection>
<connection>
<map_components component_2="J_GLUH" component_1="dGLU_x_dt"/>
<map_variables variable_2="J_GLUH" variable_1="J_GLUH"/>
<map_variables variable_2="GLU_x" variable_1="GLU_x"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="dGLU_x_dt"/>
<map_variables variable_2="J_ASPGLU" variable_1="J_ASPGLU"/>
<map_variables variable_2="GLU_x" variable_1="GLU_x"/>
</connection>
<connection>
<map_components component_2="J_got" component_1="dASP_x_dt"/>
<map_variables variable_2="J_got" variable_1="J_got"/>
<map_variables variable_2="ASP_x" variable_1="ASP_x"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="dASP_x_dt"/>
<map_variables variable_2="J_ASPGLU" variable_1="J_ASPGLU"/>
<map_variables variable_2="ASP_x" variable_1="ASP_x"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="dCred_i_dt"/>
<map_variables variable_2="J_C3" variable_1="J_C3"/>
<map_variables variable_2="Cred_i" variable_1="Cred_i"/>
</connection>
<connection>
<map_components component_2="J_C4" component_1="dCred_i_dt"/>
<map_variables variable_2="J_C4" variable_1="J_C4"/>
<map_variables variable_2="Cred_i" variable_1="Cred_i"/>
</connection>
<connection>
<map_components component_2="J_ATPt" component_1="dATP_i_dt"/>
<map_variables variable_2="J_ATPt" variable_1="J_ATPt"/>
<map_variables variable_2="ATP_i" variable_1="ATP_i"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="dATP_i_dt"/>
<map_variables variable_2="J_ANT" variable_1="J_ANT"/>
<map_variables variable_2="ATP_i" variable_1="ATP_i"/>
</connection>
<connection>
<map_components component_2="J_AKi" component_1="dATP_i_dt"/>
<map_variables variable_2="J_AKi" variable_1="J_AKi"/>
<map_variables variable_2="ATP_i" variable_1="ATP_i"/>
</connection>
<connection>
<map_components component_2="J_ADPt" component_1="dADP_i_dt"/>
<map_variables variable_2="J_ADPt" variable_1="J_ADPt"/>
<map_variables variable_2="ADP_i" variable_1="ADP_i"/>
</connection>
<connection>
<map_components component_2="J_ANT" component_1="dADP_i_dt"/>
<map_variables variable_2="J_ANT" variable_1="J_ANT"/>
<map_variables variable_2="ADP_i" variable_1="ADP_i"/>
</connection>
<connection>
<map_components component_2="J_AKi" component_1="dADP_i_dt"/>
<map_variables variable_2="J_AKi" variable_1="J_AKi"/>
<map_variables variable_2="ADP_i" variable_1="ADP_i"/>
</connection>
<connection>
<map_components component_2="J_AMPt" component_1="dAMP_i_dt"/>
<map_variables variable_2="J_AMPt" variable_1="J_AMPt"/>
<map_variables variable_2="AMP_i" variable_1="AMP_i"/>
</connection>
<connection>
<map_components component_2="J_AKi" component_1="dAMP_i_dt"/>
<map_variables variable_2="J_AKi" variable_1="J_AKi"/>
<map_variables variable_2="AMP_i" variable_1="AMP_i"/>
</connection>
<connection>
<map_components component_2="J_PIHt" component_1="dPI_i_dt"/>
<map_variables variable_2="J_PIHt" variable_1="J_PIHt"/>
</connection>
<connection>
<map_components component_2="J_PIt" component_1="dPI_i_dt"/>
<map_variables variable_2="J_PIt" variable_1="J_PIt"/>
<map_variables variable_2="PI_i" variable_1="PI_i"/>
</connection>
<connection>
<map_components component_2="J_MALPI" component_1="dPI_i_dt"/>
<map_variables variable_2="J_MALPI" variable_1="J_MALPI"/>
<map_variables variable_2="PI_i" variable_1="PI_i"/>
</connection>
<connection>
<map_components component_2="J_PYRH" component_1="dPYR_i_dt"/>
<map_variables variable_2="J_PYRH" variable_1="J_PYRH"/>
<map_variables variable_2="PYR_i" variable_1="PYR_i"/>
</connection>
<connection>
<map_components component_2="J_PYRt" component_1="dPYR_i_dt"/>
<map_variables variable_2="J_PYRt" variable_1="J_PYRt"/>
<map_variables variable_2="PYR_i" variable_1="PYR_i"/>
</connection>
<connection>
<map_components component_2="J_CITMAL" component_1="dCIT_i_dt"/>
<map_variables variable_2="J_CITMAL" variable_1="J_CITMAL"/>
</connection>
<connection>
<map_components component_2="J_CITt" component_1="dCIT_i_dt"/>
<map_variables variable_2="J_CITt" variable_1="J_CITt"/>
<map_variables variable_2="CIT_i" variable_1="CIT_i"/>
</connection>
<connection>
<map_components component_2="J_ICITt" component_1="dICIT_c_dt"/>
<map_variables variable_2="J_ICITt" variable_1="J_ICITt"/>
<map_variables variable_2="ICIT_c" variable_1="ICIT_c"/>
</connection>
<connection>
<map_components component_2="J_ICITt" component_1="dICIT_i_dt"/>
<map_variables variable_2="J_ICITt" variable_1="J_ICITt"/>
<map_variables variable_2="ICIT_i" variable_1="ICIT_i"/>
</connection>
<connection>
<map_components component_2="J_AKGMAL" component_1="dAKG_i_dt"/>
<map_variables variable_2="J_AKGMAL" variable_1="J_AKGMAL"/>
<map_variables variable_2="AKG_i" variable_1="AKG_i"/>
</connection>
<connection>
<map_components component_2="J_AKGt" component_1="dAKG_i_dt"/>
<map_variables variable_2="J_AKGt" variable_1="J_AKGt"/>
<map_variables variable_2="AKG_i" variable_1="AKG_i"/>
</connection>
<connection>
<map_components component_2="J_SUCMAL" component_1="dSUC_i_dt"/>
<map_variables variable_2="J_SUCMAL" variable_1="J_SUCMAL"/>
<map_variables variable_2="SUC_i" variable_1="SUC_i"/>
</connection>
<connection>
<map_components component_2="J_SUCt" component_1="dSUC_i_dt"/>
<map_variables variable_2="J_SUCt" variable_1="J_SUCt"/>
<map_variables variable_2="SUC_i" variable_1="SUC_i"/>
</connection>
<connection>
<map_components component_2="J_MALPI" component_1="dMAL_i_dt"/>
<map_variables variable_2="J_MALPI" variable_1="J_MALPI"/>
<map_variables variable_2="MAL_i" variable_1="MAL_i"/>
</connection>
<connection>
<map_components component_2="J_MALt" component_1="dMAL_i_dt"/>
<map_variables variable_2="J_MALt" variable_1="J_MALt"/>
<map_variables variable_2="MAL_i" variable_1="MAL_i"/>
</connection>
<connection>
<map_components component_2="J_AKGMAL" component_1="dMAL_i_dt"/>
<map_variables variable_2="J_AKGMAL" variable_1="J_AKGMAL"/>
<map_variables variable_2="MAL_i" variable_1="MAL_i"/>
</connection>
<connection>
<map_components component_2="J_CITMAL" component_1="dMAL_i_dt"/>
<map_variables variable_2="J_CITMAL" variable_1="J_CITMAL"/>
<map_variables variable_2="MAL_i" variable_1="MAL_i"/>
</connection>
<connection>
<map_components component_2="J_SUCMAL" component_1="dMAL_i_dt"/>
<map_variables variable_2="J_SUCMAL" variable_1="J_SUCMAL"/>
<map_variables variable_2="MAL_i" variable_1="MAL_i"/>
</connection>
<connection>
<map_components component_2="J_GLUH" component_1="dGLU_i_dt"/>
<map_variables variable_2="J_GLUH" variable_1="J_GLUH"/>
<map_variables variable_2="GLU_i" variable_1="GLU_i"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="dGLU_i_dt"/>
<map_variables variable_2="J_ASPGLU" variable_1="J_ASPGLU"/>
<map_variables variable_2="GLU_i" variable_1="GLU_i"/>
</connection>
<connection>
<map_components component_2="J_GLUt" component_1="dGLU_i_dt"/>
<map_variables variable_2="J_GLUt" variable_1="J_GLUt"/>
<map_variables variable_2="GLU_i" variable_1="GLU_i"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="dASP_i_dt"/>
<map_variables variable_2="J_ASPGLU" variable_1="J_ASPGLU"/>
<map_variables variable_2="ASP_i" variable_1="ASP_i"/>
</connection>
<connection>
<map_components component_2="J_ASPt" component_1="dASP_i_dt"/>
<map_variables variable_2="J_ASPt" variable_1="J_ASPt"/>
<map_variables variable_2="ASP_i" variable_1="ASP_i"/>
</connection>
<connection>
<map_components component_2="J_ATPt" component_1="dATP_c_dt"/>
<map_variables variable_2="J_ATPt" variable_1="J_ATPt"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="J_CKc" component_1="dATP_c_dt"/>
<map_variables variable_2="J_CKc" variable_1="J_CKc"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="J_AKc" component_1="dATP_c_dt"/>
<map_variables variable_2="J_AKc" variable_1="J_AKc"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="J_ADPt" component_1="dADP_c_dt"/>
<map_variables variable_2="J_ADPt" variable_1="J_ADPt"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="J_CKc" component_1="dADP_c_dt"/>
<map_variables variable_2="J_CKc" variable_1="J_CKc"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="J_AKc" component_1="dADP_c_dt"/>
<map_variables variable_2="J_AKc" variable_1="J_AKc"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="J_AMPt" component_1="dAMP_c_dt"/>
<map_variables variable_2="J_AMPt" variable_1="J_AMPt"/>
<map_variables variable_2="AMP_c" variable_1="AMP_c"/>
</connection>
<connection>
<map_components component_2="J_AKc" component_1="dAMP_c_dt"/>
<map_variables variable_2="J_AKc" variable_1="J_AKc"/>
<map_variables variable_2="AMP_c" variable_1="AMP_c"/>
</connection>
<connection>
<map_components component_2="J_PIt" component_1="dPI_c_dt"/>
<map_variables variable_2="J_PIt" variable_1="J_PIt"/>
<map_variables variable_2="PI_c" variable_1="PI_c"/>
</connection>
<connection>
<map_components component_2="J_PYRt" component_1="dPYR_c_dt"/>
<map_variables variable_2="J_PYRt" variable_1="J_PYRt"/>
<map_variables variable_2="PYR_c" variable_1="PYR_c"/>
</connection>
<connection>
<map_components component_2="J_CITt" component_1="dCIT_c_dt"/>
<map_variables variable_2="J_CITt" variable_1="J_CITt"/>
<map_variables variable_2="CIT_c" variable_1="CIT_c"/>
</connection>
<connection>
<map_components component_2="J_AKGt" component_1="dAKG_c_dt"/>
<map_variables variable_2="J_AKGt" variable_1="J_AKGt"/>
<map_variables variable_2="AKG_c" variable_1="AKG_c"/>
</connection>
<connection>
<map_components component_2="J_SUCt" component_1="dSUC_c_dt"/>
<map_variables variable_2="J_SUCt" variable_1="J_SUCt"/>
<map_variables variable_2="SUC_c" variable_1="SUC_c"/>
</connection>
<connection>
<map_components component_2="J_MALt" component_1="dMAL_c_dt"/>
<map_variables variable_2="J_MALt" variable_1="J_MALt"/>
<map_variables variable_2="MAL_c" variable_1="MAL_c"/>
</connection>
<connection>
<map_components component_2="J_GLUt" component_1="dGLU_c_dt"/>
<map_variables variable_2="J_GLUt" variable_1="J_GLUt"/>
<map_variables variable_2="GLU_c" variable_1="GLU_c"/>
</connection>
<connection>
<map_components component_2="J_ASPt" component_1="dASP_c_dt"/>
<map_variables variable_2="J_ASPt" variable_1="J_ASPt"/>
<map_variables variable_2="ASP_c" variable_1="ASP_c"/>
</connection>
<connection>
<map_components component_2="J_CKc" component_1="dPCr_c_dt"/>
<map_variables variable_2="J_CKc" variable_1="J_CKc"/>
<map_variables variable_2="PCr_c" variable_1="PCr_c"/>
</connection>
<connection>
<map_components component_2="J_ATPt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_A" variable_1="p_A"/>
</connection>
<connection>
<map_components component_2="J_ADPt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_A" variable_1="p_A"/>
</connection>
<connection>
<map_components component_2="J_AMPt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_A" variable_1="p_A"/>
</connection>
<connection>
<map_components component_2="J_PIt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_PI" variable_1="p_PI"/>
</connection>
<connection>
<map_components component_2="J_PYRt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_CITt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_ICITt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_MALt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_AKGt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_SUCt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_GLUt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="J_ASPt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
<map_variables variable_2="p_TI" variable_1="p_TI"/>
</connection>
<connection>
<map_components component_2="k_eqC1" component_1="J_C1"/>
<map_variables variable_2="k_eqC1" variable_1="k_eqC1"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="k_eqC3" component_1="J_C3"/>
<map_variables variable_2="k_eqC3" variable_1="k_eqC3"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="k_eqC4" component_1="J_C4"/>
<map_variables variable_2="k_eqC4" variable_1="k_eqC4"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
<map_variables variable_2="deltaPsi" variable_1="deltaPsi"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="NAD_tot" variable_1="NAD_tot"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="dNADH_x_dt"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
<map_variables variable_2="dNADH_x_dt" variable_1="dNADH_x_dt"/>
</connection>
<connection>
<map_components component_2="dCOQ_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="Q_tot" variable_1="Q_tot"/>
</connection>
<connection>
<map_components component_2="dCOQ_x_dt" component_1="dQH2_x_dt"/>
<map_variables variable_2="QH2_x" variable_1="QH2_x"/>
<map_variables variable_2="dQH2_x_dt" variable_1="dQH2_x_dt"/>
</connection>
<connection>
<map_components component_2="dCox_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="cytC_tot" variable_1="cytC_tot"/>
</connection>
<connection>
<map_components component_2="dCox_i_dt" component_1="dCred_i_dt"/>
<map_variables variable_2="Cred_i" variable_1="Cred_i"/>
</connection>
<connection>
<map_components component_2="dCOQ_x_dt" component_1="J_C1"/>
<map_variables variable_2="COQ_x" variable_1="COQ_x"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="J_C1"/>
<map_variables variable_2="NAD_x" variable_1="NAD_x"/>
</connection>
<connection>
<map_components component_2="dCOQ_x_dt" component_1="J_C3"/>
<map_variables variable_2="COQ_x" variable_1="COQ_x"/>
</connection>
<connection>
<map_components component_2="dCox_i_dt" component_1="J_C3"/>
<map_variables variable_2="Cox_i" variable_1="Cox_i"/>
</connection>
<connection>
<map_components component_2="dATP_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dADP_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dAMP_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dPI_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dPYR_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dCIT_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dICIT_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dAKG_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dSUC_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dMAL_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dGLU_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dASP_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dPCr_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dATP_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dADP_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dPI_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dGTP_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dGDP_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dNADH_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dQH2_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dPYR_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dACCOA_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dCIT_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dICIT_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dAKG_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dSCOA_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dCOASH_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dSUC_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dFUM_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dMAL_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dOAA_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dGLU_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dASP_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="dCred_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dATP_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dADP_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dAMP_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dPI_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dPYR_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dCIT_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dICIT_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dAKG_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dSUC_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dMAL_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dGLU_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dASP_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<connection>
<map_components component_2="dO2_x_dt" component_1="J_C4"/>
<map_variables variable_2="O2_x" variable_1="O2_x"/>
</connection>
<connection>
<map_components component_2="dCox_i_dt" component_1="J_C4"/>
<map_variables variable_2="Cox_i" variable_1="Cox_i"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="J_pdh"/>
<map_variables variable_2="NAD_x" variable_1="NAD_x"/>
</connection>
<connection>
<map_components component_2="dCO2_tot_x_dt" component_1="J_pdh"/>
<map_variables variable_2="CO2_tot_x" variable_1="CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="dATP_x_dt" component_1="J_cits"/>
<map_variables variable_2="ATP_x" variable_1="ATP_x"/>
</connection>
<connection>
<map_components component_2="dADP_x_dt" component_1="J_cits"/>
<map_variables variable_2="ADP_x" variable_1="ADP_x"/>
</connection>
<connection>
<map_components component_2="dAMP_x_dt" component_1="J_cits"/>
<map_variables variable_2="AMP_x" variable_1="AMP_x"/>
</connection>
<connection>
<map_components component_2="dSCOA_x_dt" component_1="J_cits"/>
<map_variables variable_2="SCOA_x" variable_1="SCOA_x"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="J_isod"/>
<map_variables variable_2="NAD_x" variable_1="NAD_x"/>
</connection>
<connection>
<map_components component_2="dCO2_tot_x_dt" component_1="J_isod"/>
<map_variables variable_2="CO2_tot_x" variable_1="CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="J_akgd"/>
<map_variables variable_2="NAD_x" variable_1="NAD_x"/>
</connection>
<connection>
<map_components component_2="dCO2_tot_x_dt" component_1="J_akgd"/>
<map_variables variable_2="CO2_tot_x" variable_1="CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="dCOQ_x_dt" component_1="J_sdh"/>
<map_variables variable_2="COQ_x" variable_1="COQ_x"/>
</connection>
<connection>
<map_components component_2="dOAA_x_dt" component_1="J_sdh"/>
<map_variables variable_2="OAA_x" variable_1="OAA_x"/>
</connection>
<connection>
<map_components component_2="dCIT_x_dt" component_1="J_fum"/>
<map_variables variable_2="CIT_x" variable_1="CIT_x"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="J_mdh"/>
<map_variables variable_2="NAD_x" variable_1="NAD_x"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="dH_i_dt"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_c_dt" component_1="dMg_i_dt"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dK_c_dt" component_1="dK_i_dt"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_C1"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_C1"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_C3"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_C3"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_C4"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_C4"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_F1"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_F1"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_PIHt"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_PIHt"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_KH"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_KH"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="J_KH"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
</connection>
<connection>
<map_components component_2="dK_i_dt" component_1="J_KH"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_PYRH"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_PYRH"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_GLUH"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_GLUH"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_ASPGLU"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_ASPGLU"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_Hle"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="J_Hle"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="J_CKc"/>
<map_variables variable_2="H_c" variable_1="H_c"/>
</connection>
<connection>
<map_components component_2="dAMP_c_dt" component_1="J_CKc"/>
<map_variables variable_2="AMP_c" variable_1="AMP_c"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="J_pdh"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="adjustable_parameters" component_1="J_got"/>
<map_variables variable_2="X_got" variable_1="V_mf"/>
</connection>
<connection>
<map_components component_2="P_OAA_x" component_1="J_got"/>
<map_variables variable_2="P_OAA_x" variable_1="P_OAA_x"/>
</connection>
<connection>
<map_components component_2="P_ASP_x" component_1="J_got"/>
<map_variables variable_2="P_ASP_x" variable_1="P_ASP_x"/>
</connection>
<connection>
<map_components component_2="P_GLU_x" component_1="J_GLUH"/>
<map_variables variable_2="P_GLU_x" variable_1="P_GLU_x"/>
</connection>
<connection>
<map_components component_2="P_GLU_i" component_1="J_GLUH"/>
<map_variables variable_2="P_GLU_i" variable_1="P_GLU_i"/>
</connection>
<connection>
<map_components component_2="P_CIT_i" component_1="J_CITMAL"/>
<map_variables variable_2="hCIT_i" variable_1="hCIT_i"/>
</connection>
<connection>
<map_components component_2="P_CIT_x" component_1="J_CITMAL"/>
<map_variables variable_2="hCIT_x" variable_1="hCIT_x"/>
</connection>
<connection>
<map_components component_2="P_MAL_i" component_1="J_CITMAL"/>
<map_variables variable_2="P_MAL_i" variable_1="P_MAL_i"/>
</connection>
<connection>
<map_components component_2="P_MAL_x" component_1="J_CITMAL"/>
<map_variables variable_2="P_MAL_x" variable_1="P_MAL_x"/>
</connection>
<connection>
<map_components component_2="P_PI_i" component_1="J_MALPI"/>
<map_variables variable_2="P_PI_i" variable_1="P_PI_i"/>
</connection>
<connection>
<map_components component_2="P_PI_x" component_1="J_MALPI"/>
<map_variables variable_2="P_PI_x" variable_1="P_PI_x"/>
</connection>
<connection>
<map_components component_2="P_MAL_i" component_1="J_MALPI"/>
<map_variables variable_2="P_MAL_i" variable_1="P_MAL_i"/>
</connection>
<connection>
<map_components component_2="P_MAL_x" component_1="J_MALPI"/>
<map_variables variable_2="P_MAL_x" variable_1="P_MAL_x"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="J_ASPGLU"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="P_ASP_x" component_1="J_ASPGLU"/>
<map_variables variable_2="P_ASP_x" variable_1="P_ASP_x"/>
</connection>
<connection>
<map_components component_2="P_ASP_i" component_1="J_ASPGLU"/>
<map_variables variable_2="P_ASP_i" variable_1="P_ASP_i"/>
</connection>
<connection>
<map_components component_2="P_GLU_x" component_1="J_ASPGLU"/>
<map_variables variable_2="P_GLU_x" variable_1="P_GLU_x"/>
</connection>
<connection>
<map_components component_2="P_GLU_i" component_1="J_ASPGLU"/>
<map_variables variable_2="P_GLU_i" variable_1="P_GLU_i"/>
</connection>
<connection>
<map_components component_2="P_SUC_x" component_1="J_SUCMAL"/>
<map_variables variable_2="P_SUC_x" variable_1="P_SUC_x"/>
</connection>
<connection>
<map_components component_2="P_SUC_i" component_1="J_SUCMAL"/>
<map_variables variable_2="P_SUC_i" variable_1="P_SUC_i"/>
</connection>
<connection>
<map_components component_2="P_MAL_x" component_1="J_SUCMAL"/>
<map_variables variable_2="P_MAL_x" variable_1="P_MAL_x"/>
</connection>
<connection>
<map_components component_2="P_MAL_i" component_1="J_SUCMAL"/>
<map_variables variable_2="P_MAL_i" variable_1="P_MAL_i"/>
</connection>
<connection>
<map_components component_2="P_ATP_x" component_1="J_ANT"/>
<map_variables variable_2="P_ATP_x" variable_1="P_ATP_x"/>
</connection>
<connection>
<map_components component_2="P_ATP_i" component_1="J_ANT"/>
<map_variables variable_2="P_ATP_i" variable_1="P_ATP_i"/>
</connection>
<connection>
<map_components component_2="P_ADP_x" component_1="J_ANT"/>
<map_variables variable_2="P_ADP_x" variable_1="P_ADP_x"/>
</connection>
<connection>
<map_components component_2="P_ADP_i" component_1="J_ANT"/>
<map_variables variable_2="P_ADP_i" variable_1="P_ADP_i"/>
</connection>
<connection>
<map_components component_2="P_PI_x" component_1="J_PIHt"/>
<map_variables variable_2="hPI_x" variable_1="hPI_x"/>
</connection>
<connection>
<map_components component_2="P_PI_i" component_1="J_PIHt"/>
<map_variables variable_2="hPI_i" variable_1="hPI_i"/>
</connection>
<connection>
<map_components component_2="dCIT_i_dt" component_1="P_CIT_i"/>
<map_variables variable_2="CIT_i" variable_1="CIT_i"/>
</connection>
<connection>
<map_components component_2="dH_i_dt" component_1="P_GLU_i"/>
<map_variables variable_2="H_i" variable_1="H_i"/>
</connection>
<connection>
<map_components component_2="dMg_i_dt" component_1="P_GLU_i"/>
<map_variables variable_2="Mg_i" variable_1="Mg_i"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="P_GLU_x"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="P_GLU_x"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
</connection>
<connection>
<map_components component_2="P_GLU_i" component_1="P_GLU_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
</connection>
<connection>
<map_components component_2="J_FUMt" component_1="fixed_parameters"/>
<map_variables variable_2="gamma" variable_1="gamma"/>
</connection>
<connection>
<map_components component_2="dFUM_c_dt" component_1="J_FUMt"/>
<map_variables variable_2="FUM_c" variable_1="FUM_c"/>
<map_variables variable_2="J_FUMt" variable_1="J_FUMt"/>
</connection>
<connection>
<map_components component_2="dFUM_i_dt" component_1="J_FUMt"/>
<map_variables variable_2="FUM_i" variable_1="FUM_i"/>
<map_variables variable_2="J_FUMt" variable_1="J_FUMt"/>
</connection>
<connection>
<map_components component_2="P_GLU_x" component_1="J_got"/>
<map_variables variable_2="P_GLU_x" variable_1="P_GLU_x"/>
</connection>
<connection>
<map_components component_2="P_ATP_i" component_1="J_AKi"/>
<map_variables variable_2="P_ATP_i" variable_1="P_ATP_i"/>
</connection>
<connection>
<map_components component_2="P_ADP_i" component_1="J_AKi"/>
<map_variables variable_2="P_ADP_i" variable_1="P_ADP_i"/>
</connection>
<connection>
<map_components component_2="P_AMP_i" component_1="J_AKi"/>
<map_variables variable_2="P_AMP_i" variable_1="P_AMP_i"/>
</connection>
<connection>
<map_components component_2="P_ATP_c" component_1="J_AKc"/>
<map_variables variable_2="P_ATP_c" variable_1="P_ATP_c"/>
</connection>
<connection>
<map_components component_2="P_ADP_c" component_1="J_AKc"/>
<map_variables variable_2="P_ADP_c" variable_1="P_ADP_c"/>
</connection>
<connection>
<map_components component_2="P_AMP_c" component_1="J_AKc"/>
<map_variables variable_2="P_AMP_c" variable_1="P_AMP_c"/>
</connection>
<connection>
<map_components component_2="P_ATP_c" component_1="P_ATP_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="P_ADP_c" component_1="P_ADP_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="P_AMP_c" component_1="P_AMP_x"/>
<map_variables variable_2="K_H" variable_1="K_H"/>
<map_variables variable_2="K_Mg" variable_1="K_Mg"/>
<map_variables variable_2="K_K" variable_1="K_K"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="P_ATP_c"/>
<map_variables variable_2="H_c" variable_1="H_c"/>
</connection>
<connection>
<map_components component_2="dMg_c_dt" component_1="P_ATP_c"/>
<map_variables variable_2="Mg_c" variable_1="Mg_c"/>
</connection>
<connection>
<map_components component_2="dK_c_dt" component_1="P_ATP_c"/>
<map_variables variable_2="K_c" variable_1="K_c"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="P_ADP_c"/>
<map_variables variable_2="H_c" variable_1="H_c"/>
</connection>
<connection>
<map_components component_2="dMg_c_dt" component_1="P_ADP_c"/>
<map_variables variable_2="Mg_c" variable_1="Mg_c"/>
</connection>
<connection>
<map_components component_2="dK_c_dt" component_1="P_ADP_c"/>
<map_variables variable_2="K_c" variable_1="K_c"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="P_AMP_c"/>
<map_variables variable_2="H_c" variable_1="H_c"/>
</connection>
<connection>
<map_components component_2="dMg_c_dt" component_1="P_AMP_c"/>
<map_variables variable_2="Mg_c" variable_1="Mg_c"/>
</connection>
<connection>
<map_components component_2="dK_c_dt" component_1="P_AMP_c"/>
<map_variables variable_2="K_c" variable_1="K_c"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="dCr_c_dt"/>
<map_variables variable_2="CR_tot" variable_1="CR_tot"/>
</connection>
<connection>
<map_components component_2="dPCr_c_dt" component_1="dCr_c_dt"/>
<map_variables variable_2="PCr_c" variable_1="PCr_c"/>
</connection>
<connection>
<map_components component_2="J_CKc" component_1="dCr_c_dt"/>
<map_variables variable_2="Cr_c" variable_1="Cr_c"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="J_CKc"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="P_ATP_c" component_1="J_CKc"/>
<map_variables variable_2="P_ATP_c" variable_1="P_ATP_c"/>
</connection>
<connection>
<map_components component_2="P_ADP_c" component_1="J_CKc"/>
<map_variables variable_2="P_ADP_c" variable_1="P_ADP_c"/>
</connection>
<connection>
<map_components component_2="dATP_c_dt" component_1="adjustable_parameters"/>
<map_variables variable_2="J_AtC" variable_1="J_AtC"/>
</connection>
<connection>
<map_components component_2="dADP_c_dt" component_1="adjustable_parameters"/>
<map_variables variable_2="J_AtC" variable_1="J_AtC"/>
</connection>
<connection>
<map_components component_2="dPI_c_dt" component_1="adjustable_parameters"/>
<map_variables variable_2="J_AtC" variable_1="J_AtC"/>
</connection>
<connection>
<map_components component_2="dFAD_x_dt" component_1="fixed_parameters"/>
<map_variables variable_2="FAD_tot" variable_1="FAD_tot"/>
</connection>
<connection>
<map_components component_2="dH_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="H_x" variable_1="H_x"/>
<map_variables variable_2="dH_x_dt" variable_1="dH_x_dt"/>
<map_variables variable_2="D" variable_1="D"/>
<map_variables variable_2="phi_H" variable_1="phi_H"/>
<map_variables variable_2="phi_Mg" variable_1="phi_Mg"/>
<map_variables variable_2="phi_K" variable_1="phi_K"/>
<map_variables variable_2="dHB_dMg" variable_1="dHB_dMg"/>
<map_variables variable_2="dHB_dK" variable_1="dHB_dK"/>
<map_variables variable_2="dMgB_dK" variable_1="dMgB_dK"/>
<map_variables variable_2="dKB_dMg" variable_1="dKB_dMg"/>
<map_variables variable_2="alpha_K" variable_1="alpha_K"/>
<map_variables variable_2="alpha_Mg" variable_1="alpha_Mg"/>
</connection>
<connection>
<map_components component_2="dATP_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="ATP_x" variable_1="ATP_x"/>
<map_variables variable_2="dATP_x_dt" variable_1="dATP_x_dt"/>
</connection>
<connection>
<map_components component_2="dADP_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="ADP_x" variable_1="ADP_x"/>
<map_variables variable_2="dADP_x_dt" variable_1="dADP_x_dt"/>
</connection>
<connection>
<map_components component_2="dAMP_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="AMP_x" variable_1="AMP_x"/>
<map_variables variable_2="dAMP_x_dt" variable_1="dAMP_x_dt"/>
</connection>
<connection>
<map_components component_2="dGTP_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="GTP_x" variable_1="GTP_x"/>
<map_variables variable_2="dGTP_x_dt" variable_1="dGTP_x_dt"/>
</connection>
<connection>
<map_components component_2="dGDP_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="GDP_x" variable_1="GDP_x"/>
<map_variables variable_2="dGDP_x_dt" variable_1="dGDP_x_dt"/>
</connection>
<connection>
<map_components component_2="dPI_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="PI_x" variable_1="PI_x"/>
<map_variables variable_2="dPI_x_dt" variable_1="dPI_x_dt"/>
</connection>
<connection>
<map_components component_2="dNADH_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="NADH_x" variable_1="NADH_x"/>
<map_variables variable_2="dNADH_x_dt" variable_1="dNADH_x_dt"/>
</connection>
<connection>
<map_components component_2="dNAD_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="NAD_x" variable_1="NAD_x"/>
<map_variables variable_2="dNAD_x_dt" variable_1="dNAD_x_dt"/>
</connection>
<connection>
<map_components component_2="dQH2_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="QH2_x" variable_1="QH2_x"/>
<map_variables variable_2="dQH2_x_dt" variable_1="dQH2_x_dt"/>
</connection>
<connection>
<map_components component_2="dCOQ_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="COQ_x" variable_1="COQ_x"/>
<map_variables variable_2="dCOQ_x_dt" variable_1="dCOQ_x_dt"/>
</connection>
<connection>
<map_components component_2="dPYR_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="PYR_x" variable_1="PYR_x"/>
<map_variables variable_2="dPYR_x_dt" variable_1="dPYR_x_dt"/>
</connection>
<connection>
<map_components component_2="dOAA_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="OAA_x" variable_1="OAA_x"/>
<map_variables variable_2="dOAA_x_dt" variable_1="dOAA_x_dt"/>
</connection>
<connection>
<map_components component_2="dACCOA_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="ACCOA_x" variable_1="ACCOA_x"/>
<map_variables variable_2="dACCOA_x_dt" variable_1="dACCOA_x_dt"/>
</connection>
<connection>
<map_components component_2="dCIT_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="CIT_x" variable_1="CIT_x"/>
<map_variables variable_2="dCIT_x_dt" variable_1="dCIT_x_dt"/>
</connection>
<connection>
<map_components component_2="dICIT_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="ICIT_x" variable_1="ICIT_x"/>
<map_variables variable_2="dICIT_x_dt" variable_1="dICIT_x_dt"/>
</connection>
<connection>
<map_components component_2="dAKG_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="AKG_x" variable_1="AKG_x"/>
<map_variables variable_2="dAKG_x_dt" variable_1="dAKG_x_dt"/>
</connection>
<connection>
<map_components component_2="dSCOA_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="SCOA_x" variable_1="SCOA_x"/>
<map_variables variable_2="dSCOA_x_dt" variable_1="dSCOA_x_dt"/>
</connection>
<connection>
<map_components component_2="dCOASH_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="COASH_x" variable_1="COASH_x"/>
<map_variables variable_2="dCOASH_x_dt" variable_1="dCOASH_x_dt"/>
</connection>
<connection>
<map_components component_2="dSUC_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="SUC_x" variable_1="SUC_x"/>
<map_variables variable_2="dSUC_x_dt" variable_1="dSUC_x_dt"/>
</connection>
<connection>
<map_components component_2="dFUM_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="FUM_x" variable_1="FUM_x"/>
<map_variables variable_2="dFUM_x_dt" variable_1="dFUM_x_dt"/>
</connection>
<connection>
<map_components component_2="dMAL_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="MAL_x" variable_1="MAL_x"/>
<map_variables variable_2="dMAL_x_dt" variable_1="dMAL_x_dt"/>
</connection>
<connection>
<map_components component_2="dGLU_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="GLU_x" variable_1="GLU_x"/>
<map_variables variable_2="dGLU_x_dt" variable_1="dGLU_x_dt"/>
</connection>
<connection>
<map_components component_2="dASP_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="ASP_x" variable_1="ASP_x"/>
<map_variables variable_2="dASP_x_dt" variable_1="dASP_x_dt"/>
</connection>
<connection>
<map_components component_2="dK_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="K_x" variable_1="K_x"/>
<map_variables variable_2="dK_x_dt" variable_1="dK_x_dt"/>
<map_variables variable_2="D" variable_1="D"/>
<map_variables variable_2="phi_H" variable_1="phi_H"/>
<map_variables variable_2="phi_Mg" variable_1="phi_Mg"/>
<map_variables variable_2="phi_K" variable_1="phi_K"/>
<map_variables variable_2="dHB_dMg" variable_1="dHB_dMg"/>
<map_variables variable_2="dMgB_dH" variable_1="dMgB_dH"/>
<map_variables variable_2="dKB_dMg" variable_1="dKB_dMg"/>
<map_variables variable_2="dKB_dH" variable_1="dKB_dH"/>
<map_variables variable_2="alpha_H" variable_1="alpha_H"/>
<map_variables variable_2="alpha_Mg" variable_1="alpha_Mg"/>
</connection>
<connection>
<map_components component_2="dMg_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="Mg_x" variable_1="Mg_x"/>
<map_variables variable_2="dMg_x_dt" variable_1="dMg_x_dt"/>
<map_variables variable_2="D" variable_1="D"/>
<map_variables variable_2="phi_H" variable_1="phi_H"/>
<map_variables variable_2="phi_Mg" variable_1="phi_Mg"/>
<map_variables variable_2="phi_K" variable_1="phi_K"/>
<map_variables variable_2="dHB_dK" variable_1="dHB_dK"/>
<map_variables variable_2="dKB_dH" variable_1="dKB_dH"/>
<map_variables variable_2="dMgB_dK" variable_1="dMgB_dK"/>
<map_variables variable_2="dMgB_dH" variable_1="dMgB_dH"/>
<map_variables variable_2="alpha_H" variable_1="alpha_H"/>
<map_variables variable_2="alpha_K" variable_1="alpha_K"/>
</connection>
<connection>
<map_components component_2="dO2_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="O2_x" variable_1="O2_x"/>
<map_variables variable_2="dO2_x_dt" variable_1="dO2_x_dt"/>
</connection>
<connection>
<map_components component_2="dFAD_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="FAD_x" variable_1="FAD_x"/>
<map_variables variable_2="FADH2_x" variable_1="FADH2_x"/>
<map_variables variable_2="dFAD_x_dt" variable_1="dFAD_x_dt"/>
<map_variables variable_2="dFADH2_x_dt" variable_1="dFADH2_x_dt"/>
</connection>
<connection>
<map_components component_2="dCO2_tot_x_dt" component_1="BINDING_IONS"/>
<map_variables variable_2="CO2_tot_x" variable_1="CO2_tot_x"/>
<map_variables variable_2="dCO2_tot_x_dt" variable_1="dCO2_tot_x_dt"/>
</connection>
<connection>
<map_components component_2="P_H_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_H_x" variable_1="P_H_x"/>
<map_variables variable_2="K_H" variable_1="KH_H_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_H_x"/>
<map_variables variable_2="K_K" variable_1="KK_H_x"/>
</connection>
<connection>
<map_components component_2="P_ATP_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_ATP_x" variable_1="P_ATP_x"/>
<map_variables variable_2="K_H" variable_1="KH_ATP_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ATP_x"/>
<map_variables variable_2="K_K" variable_1="KK_ATP_x"/>
<map_variables variable_2="K_H" variable_1="KH_GTP_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_GTP_x"/>
<map_variables variable_2="K_K" variable_1="KK_GTP_x"/>
</connection>
<connection>
<map_components component_2="P_ADP_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_ADP_x" variable_1="P_ADP_x"/>
<map_variables variable_2="K_H" variable_1="KH_ADP_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ADP_x"/>
<map_variables variable_2="K_K" variable_1="KK_ADP_x"/>
<map_variables variable_2="K_H" variable_1="KH_GDP_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_GDP_x"/>
<map_variables variable_2="K_K" variable_1="KK_GDP_x"/>
</connection>
<connection>
<map_components component_2="P_AMP_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_AMP_x" variable_1="P_AMP_x"/>
<map_variables variable_2="K_H" variable_1="KH_AMP_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_AMP_x"/>
<map_variables variable_2="K_K" variable_1="KK_AMP_x"/>
</connection>
<connection>
<map_components component_2="P_GTP_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_GTP_x" variable_1="P_GTP_x"/>
</connection>
<connection>
<map_components component_2="P_GDP_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_GDP_x" variable_1="P_GDP_x"/>
</connection>
<connection>
<map_components component_2="P_PI_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_PI_x" variable_1="P_PI_x"/>
<map_variables variable_2="K_H" variable_1="KH_PI_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_PI_x"/>
<map_variables variable_2="K_K" variable_1="KK_PI_x"/>
</connection>
<connection>
<map_components component_2="P_NADH_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_NADH_x" variable_1="P_NADH_x"/>
<map_variables variable_2="K_H" variable_1="KH_NADH_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_NADH_x"/>
<map_variables variable_2="K_K" variable_1="KK_NADH_x"/>
</connection>
<connection>
<map_components component_2="P_NAD_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_NAD_x" variable_1="P_NAD_x"/>
<map_variables variable_2="K_H" variable_1="KH_NAD_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_NAD_x"/>
<map_variables variable_2="K_K" variable_1="KK_NAD_x"/>
</connection>
<connection>
<map_components component_2="P_QH2_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_QH2_x" variable_1="P_QH2_x"/>
<map_variables variable_2="K_H" variable_1="KH_QH2_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_QH2_x"/>
<map_variables variable_2="K_K" variable_1="KK_QH2_x"/>
</connection>
<connection>
<map_components component_2="P_COQ_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_COQ_x" variable_1="P_COQ_x"/>
<map_variables variable_2="K_H" variable_1="KH_COQ_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_COQ_x"/>
<map_variables variable_2="K_K" variable_1="KK_COQ_x"/>
</connection>
<connection>
<map_components component_2="P_PYR_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_PYR_x" variable_1="P_PYR_x"/>
<map_variables variable_2="K_H" variable_1="KH_PYR_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_PYR_x"/>
<map_variables variable_2="K_K" variable_1="KK_PYR_x"/>
</connection>
<connection>
<map_components component_2="P_OAA_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_OAA_x" variable_1="P_OAA_x"/>
<map_variables variable_2="K_H" variable_1="KH_OAA_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_OAA_x"/>
<map_variables variable_2="K_K" variable_1="KK_OAA_x"/>
</connection>
<connection>
<map_components component_2="P_ACCOA_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_ACCOA_x" variable_1="P_ACCOA_x"/>
<map_variables variable_2="K_H" variable_1="KH_ACCOA_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ACCOA_x"/>
<map_variables variable_2="K_K" variable_1="KK_ACCOA_x"/>
</connection>
<connection>
<map_components component_2="P_CIT_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_CIT_x" variable_1="P_CIT_x"/>
<map_variables variable_2="K_H" variable_1="KH_CIT_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_CIT_x"/>
<map_variables variable_2="K_K" variable_1="KK_CIT_x"/>
</connection>
<connection>
<map_components component_2="P_ICIT_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_ICIT_x" variable_1="P_ICIT_x"/>
<map_variables variable_2="K_H" variable_1="KH_ICIT_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ICIT_x"/>
<map_variables variable_2="K_K" variable_1="KK_ICIT_x"/>
</connection>
<connection>
<map_components component_2="P_AKG_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_AKG_x" variable_1="P_AKG_x"/>
<map_variables variable_2="K_H" variable_1="KH_AKG_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_AKG_x"/>
<map_variables variable_2="K_K" variable_1="KK_AKG_x"/>
</connection>
<connection>
<map_components component_2="P_SCOA_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_SCOA_x" variable_1="P_SCOA_x"/>
<map_variables variable_2="K_H" variable_1="KH_SCOA_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_SCOA_x"/>
<map_variables variable_2="K_K" variable_1="KK_SCOA_x"/>
</connection>
<connection>
<map_components component_2="P_COASH_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_COASH_x" variable_1="P_COASH_x"/>
<map_variables variable_2="K_H" variable_1="KH_COASH_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_COASH_x"/>
<map_variables variable_2="K_K" variable_1="KK_COASH_x"/>
</connection>
<connection>
<map_components component_2="P_SUC_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_SUC_x" variable_1="P_SUC_x"/>
<map_variables variable_2="K_H" variable_1="KH_SUC_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_SUC_x"/>
<map_variables variable_2="K_K" variable_1="KK_SUC_x"/>
</connection>
<connection>
<map_components component_2="P_FUM_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_FUM_x" variable_1="P_FUM_x"/>
<map_variables variable_2="K_H" variable_1="KH_FUM_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_FUM_x"/>
<map_variables variable_2="K_K" variable_1="KK_FUM_x"/>
</connection>
<connection>
<map_components component_2="P_MAL_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_MAL_x" variable_1="P_MAL_x"/>
<map_variables variable_2="K_H" variable_1="KH_MAL_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_MAL_x"/>
<map_variables variable_2="K_K" variable_1="KK_MAL_x"/>
</connection>
<connection>
<map_components component_2="P_GLU_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_GLU_x" variable_1="P_GLU_x"/>
<map_variables variable_2="K_H" variable_1="KH_GLU_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_GLU_x"/>
<map_variables variable_2="K_K" variable_1="KK_GLU_x"/>
</connection>
<connection>
<map_components component_2="P_ASP_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_ASP_x" variable_1="P_ASP_x"/>
<map_variables variable_2="K_H" variable_1="KH_ASP_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ASP_x"/>
<map_variables variable_2="K_K" variable_1="KK_ASP_x"/>
</connection>
<connection>
<map_components component_2="P_K_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_K_x" variable_1="P_K_x"/>
<map_variables variable_2="K_H" variable_1="KH_K_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_K_x"/>
<map_variables variable_2="K_K" variable_1="KK_K_x"/>
</connection>
<connection>
<map_components component_2="P_Mg_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_Mg_x" variable_1="P_Mg_x"/>
<map_variables variable_2="K_H" variable_1="KH_Mg_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_Mg_x"/>
<map_variables variable_2="K_K" variable_1="KK_Mg_x"/>
</connection>
<connection>
<map_components component_2="P_O2_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_O2_x" variable_1="P_O2_x"/>
<map_variables variable_2="K_H" variable_1="KH_O2_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_O2_x"/>
<map_variables variable_2="K_K" variable_1="KK_O2_x"/>
</connection>
<connection>
<map_components component_2="P_FAD_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_FAD_x" variable_1="P_FAD_x"/>
<map_variables variable_2="K_H" variable_1="KH_FAD_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_FAD_x"/>
<map_variables variable_2="K_K" variable_1="KK_FAD_x"/>
</connection>
<connection>
<map_components component_2="P_FADH2_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_FADH2_x" variable_1="P_FADH2_x"/>
<map_variables variable_2="K_H" variable_1="KH_FADH2_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_FADH2_x"/>
<map_variables variable_2="K_K" variable_1="KK_FADH2_x"/>
</connection>
<connection>
<map_components component_2="P_CO2_tot_x" component_1="BINDING_IONS"/>
<map_variables variable_2="P_CO2_tot_x" variable_1="P_CO2_tot_x"/>
<map_variables variable_2="K_H" variable_1="KH_CO2_tot_x"/>
<map_variables variable_2="K_Mg" variable_1="KMg_CO2_tot_x"/>
<map_variables variable_2="K_K" variable_1="KK_CO2_tot_x"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="BINDING_IONS"/>
<map_variables variable_2="n_A" variable_1="n_A"/>
<map_variables variable_2="W_x" variable_1="W_x"/>
</connection>
<connection>
<map_components component_2="J_pdh" component_1="BINDING_IONS"/>
<map_variables variable_2="J_pdh" variable_1="J_pdh"/>
</connection>
<connection>
<map_components component_2="J_cits" component_1="BINDING_IONS"/>
<map_variables variable_2="J_cits" variable_1="J_cits"/>
</connection>
<connection>
<map_components component_2="J_akgd" component_1="BINDING_IONS"/>
<map_variables variable_2="J_akgd" variable_1="J_akgd"/>
</connection>
<connection>
<map_components component_2="J_scoas" component_1="BINDING_IONS"/>
<map_variables variable_2="J_scoas" variable_1="J_scoas"/>
</connection>
<connection>
<map_components component_2="J_mdh" component_1="BINDING_IONS"/>
<map_variables variable_2="J_mdh" variable_1="J_mdh"/>
</connection>
<connection>
<map_components component_2="J_PYRH" component_1="BINDING_IONS"/>
<map_variables variable_2="J_PYRH" variable_1="J_PYRH"/>
</connection>
<connection>
<map_components component_2="J_GLUH" component_1="BINDING_IONS"/>
<map_variables variable_2="J_GLUH" variable_1="J_GLUH"/>
</connection>
<connection>
<map_components component_2="J_CITMAL" component_1="BINDING_IONS"/>
<map_variables variable_2="J_CITMAL" variable_1="J_CITMAL"/>
</connection>
<connection>
<map_components component_2="J_ASPGLU" component_1="BINDING_IONS"/>
<map_variables variable_2="J_ASPGLU" variable_1="J_ASPGLU"/>
</connection>
<connection>
<map_components component_2="J_C1" component_1="BINDING_IONS"/>
<map_variables variable_2="J_C1" variable_1="J_C1"/>
</connection>
<connection>
<map_components component_2="J_C3" component_1="BINDING_IONS"/>
<map_variables variable_2="J_C3" variable_1="J_C3"/>
</connection>
<connection>
<map_components component_2="J_C4" component_1="BINDING_IONS"/>
<map_variables variable_2="J_C4" variable_1="J_C4"/>
</connection>
<connection>
<map_components component_2="J_F1" component_1="BINDING_IONS"/>
<map_variables variable_2="J_F1" variable_1="J_F1"/>
</connection>
<connection>
<map_components component_2="J_PIHt" component_1="BINDING_IONS"/>
<map_variables variable_2="J_PIHt" variable_1="J_PIHt"/>
</connection>
<connection>
<map_components component_2="J_Hle" component_1="BINDING_IONS"/>
<map_variables variable_2="J_Hle" variable_1="J_Hle"/>
</connection>
<connection>
<map_components component_2="J_KH" component_1="BINDING_IONS"/>
<map_variables variable_2="J_KH" variable_1="J_KH"/>
</connection>
<connection>
<map_components component_2="P_ATP_c" component_1="J_HK"/>
<map_variables variable_2="mATP_c" variable_1="mATP_c"/>
<map_variables variable_2="P_ATP_c" variable_1="P_ATP_c"/>
</connection>
<connection>
<map_components component_2="P_ADP_c" component_1="J_HK"/>
<map_variables variable_2="mADP_c" variable_1="mADP_c"/>
<map_variables variable_2="P_ADP_c" variable_1="P_ADP_c"/>
</connection>
<connection>
<map_components component_2="P_ATP_x" component_1="J_HK"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ATP"/>
</connection>
<connection>
<map_components component_2="P_ADP_x" component_1="J_HK"/>
<map_variables variable_2="K_Mg" variable_1="KMg_ADP"/>
</connection>
<connection>
<map_components component_2="P_G6P_c" component_1="J_HK"/>
<map_variables variable_2="P_G6P_c" variable_1="P_G6P_c"/>
</connection>
<connection>
<map_components component_2="dGLC_c_dt" component_1="J_HK"/>
<map_variables variable_2="GLC_c" variable_1="GLC_c"/>
<map_variables variable_2="J_HK" variable_1="J_HK"/>
</connection>
<connection>
<map_components component_2="dG6P_c_dt" component_1="J_HK"/>
<map_variables variable_2="G6P_c" variable_1="G6P_c"/>
<map_variables variable_2="J_HK" variable_1="J_HK"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="J_HK"/>
<map_variables variable_2="H_c" variable_1="H_c"/>
</connection>
<connection>
<map_components component_2="dH_c_dt" component_1="P_G6P_c"/>
<map_variables variable_2="H_c" variable_1="H_c"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="J_HK"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="P_ATP_c" component_1="dATP_c_dt"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="P_ADP_c" component_1="dADP_c_dt"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="fixed_parameters" component_1="dFUM_c_dt"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="V_mito" variable_1="V_mito"/>
</connection>
<connection>
<map_components component_2="dGLC_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="dG6P_c_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_c" variable_1="W_c"/>
</connection>
<connection>
<map_components component_2="J_HK" component_1="adjustable_parameters"/>
<map_variables variable_2="X_HK" variable_1="X_HK"/>
</connection>
<connection>
<map_components component_2="J_HK" component_1="dATP_c_dt"/>
<map_variables variable_2="J_HK" variable_1="J_HK"/>
</connection>
<connection>
<map_components component_2="J_HK" component_1="dADP_c_dt"/>
<map_variables variable_2="J_HK" variable_1="J_HK"/>
</connection>
<connection>
<map_components component_2="dFUM_i_dt" component_1="fixed_parameters"/>
<map_variables variable_2="W_i" variable_1="W_i"/>
</connection>
<rdf:RDF>
<rdf:Seq rdf:about="rdf:#602667cf-fc6d-4ad7-a122-0b9c62ae2eec">
<rdf:li rdf:resource="rdf:#d79247e6-c201-4e88-8cc8-d88160b7b52c"/>
<rdf:li rdf:resource="rdf:#0b935b69-e68e-4037-b2a8-f79ae6962d6d"/>
<rdf:li rdf:resource="rdf:#5cddab0f-e8e7-47a2-bc9d-1beae790013d"/>
<rdf:li rdf:resource="rdf:#24d9fbb8-4b66-49bb-9991-27f252a68160"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#4ae9645f-31bc-4f5b-b42c-1ae0f042faae">
<dc:creator rdf:resource="rdf:#602667cf-fc6d-4ad7-a122-0b9c62ae2eec"/>
<dc:title>Computer Modeling of Mitochondrial Tricarboxylic Acid Cycle, Oxidative Phosphorylation, Metabolite Transport, and Electrophysiology</dc:title>
<bqs:volume>282</bqs:volume>
<bqs:first_page>24525</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#f5235462-5238-4e43-a272-4fb91000e62b"/>
<dcterms:issued rdf:resource="rdf:#7c042106-1b71-4dcc-aba2-df3f92a3f1ae"/>
<bqs:last_page>24537</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher/>
<cmeta:comment rdf:resource="rdf:#3eff4987-37c1-4eaf-b7ae-930ff8ebb49b"/>
<dcterms:created rdf:resource="rdf:#a887fc73-97d9-4d21-9c6f-c691cd09826a"/>
<dc:creator rdf:resource="rdf:#0d67f226-b28f-45c8-8979-d76481bdefaf"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3ad0d938-d4e2-41d0-a5a7-13386385e611">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>gnunns1@jhem.jhu.edu</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9bfed10a-a06b-46bd-82e0-312557d454c5">
<vCard:Given>Geoffrey</vCard:Given>
<vCard:Family>Nunns</vCard:Family>
<vCard:Other>Rogan</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a887fc73-97d9-4d21-9c6f-c691cd09826a">
<dcterms:W3CDTF>2008-07-07T00:00:00+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2cf19cbd-bc1d-4588-8a5c-082253e1170b">
<vCard:Given>Fan</vCard:Given>
<vCard:Family>Wu</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0d67f226-b28f-45c8-8979-d76481bdefaf">
<vCard:ORG rdf:resource="rdf:#eb90235f-33eb-4c36-9641-4442bd01691c"/>
<vCard:EMAIL rdf:resource="rdf:#3ad0d938-d4e2-41d0-a5a7-13386385e611"/>
<vCard:N rdf:resource="rdf:#9bfed10a-a06b-46bd-82e0-312557d454c5"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5cddab0f-e8e7-47a2-bc9d-1beae790013d">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#6539154c-396d-4228-b11b-ae1e3e7b90e3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a32a1a65-5abb-46c5-a717-ad9d968958cc">
<vCard:Given>Feng</vCard:Given>
<vCard:Family>Yang</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0b935b69-e68e-4037-b2a8-f79ae6962d6d">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#a32a1a65-5abb-46c5-a717-ad9d968958cc"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6539154c-396d-4228-b11b-ae1e3e7b90e3">
<vCard:Given>Kalyan</vCard:Given>
<vCard:Family>Vinnakota</vCard:Family>
<vCard:Other>C</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#dece4f6d-e065-433b-9e7e-60bfa5ed891d">
<vCard:FN>Geoff Nunns</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7c042106-1b71-4dcc-aba2-df3f92a3f1ae">
<dcterms:W3CDTF>2007-00-00 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#eb90235f-33eb-4c36-9641-4442bd01691c">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>CellML Team</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="#wu_yang_vinnakota_beard_2007">
<bqs:reference rdf:resource="rdf:#0e9a078a-87a9-4e4c-b32a-f49455aafd19"/>
<cmeta:comment rdf:resource="rdf:#5cbe04ef-0ee0-4ca1-b3f9-9c6235f77a69"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3eff4987-37c1-4eaf-b7ae-930ff8ebb49b">
<dc:creator rdf:resource="rdf:#dece4f6d-e065-433b-9e7e-60bfa5ed891d"/>
<rdf:value>This CellML version of the model does not run in PCEnv or COR, although the units are consistent throughout. Further curation is necessary, although this model does require non-negative constraints that are not currently available in CellML integration tools.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#24d9fbb8-4b66-49bb-9991-27f252a68160">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#cd179cd3-e1a1-468d-8b25-1a3f59f2c852"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5cbe04ef-0ee0-4ca1-b3f9-9c6235f77a69">
<dc:creator rdf:resource="rdf:#d2067397-0dbf-4e99-ad9a-e4a385350fd8"/>
<rdf:value>This CellML version of the model does not run in PCEnv or COR, although the units are consistent throughout. Further curation is necessary, although this model does require non-negative constraints that are not currently available in CellML integration tools.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cd179cd3-e1a1-468d-8b25-1a3f59f2c852">
<vCard:Given>Daniel</vCard:Given>
<vCard:Family>Beard</vCard:Family>
<vCard:Other>A</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f5235462-5238-4e43-a272-4fb91000e62b">
<dc:title>Journal of Biological Chemistry</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0e9a078a-87a9-4e4c-b32a-f49455aafd19">
<bqs:Pubmed_id>17591785</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#4ae9645f-31bc-4f5b-b42c-1ae0f042faae"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d79247e6-c201-4e88-8cc8-d88160b7b52c">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#2cf19cbd-bc1d-4588-8a5c-082253e1170b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d2067397-0dbf-4e99-ad9a-e4a385350fd8">
<vCard:FN>Geoff Nunns</vCard:FN>
</rdf:Description>
</rdf:RDF>
</model>
